ID   CLAP1_CAEBR             Reviewed;        1333 AA.
AC   Q61KX5; A8X885;
DT   23-JAN-2007, integrated into UniProtKB/Swiss-Prot.
DT   13-OCT-2009, sequence version 2.
DT   25-MAY-2022, entry version 83.
DE   RecName: Full=Protein CLASP-1;
GN   ORFNames=CBG09173;
OS   Caenorhabditis briggsae.
OC   Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida;
OC   Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae;
OC   Caenorhabditis.
OX   NCBI_TaxID=6238;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=AF16;
RX   PubMed=14624247; DOI=10.1371/journal.pbio.0000045;
RA   Stein L.D., Bao Z., Blasiar D., Blumenthal T., Brent M.R., Chen N.,
RA   Chinwalla A., Clarke L., Clee C., Coghlan A., Coulson A., D'Eustachio P.,
RA   Fitch D.H.A., Fulton L.A., Fulton R.E., Griffiths-Jones S., Harris T.W.,
RA   Hillier L.W., Kamath R., Kuwabara P.E., Mardis E.R., Marra M.A.,
RA   Miner T.L., Minx P., Mullikin J.C., Plumb R.W., Rogers J., Schein J.E.,
RA   Sohrmann M., Spieth J., Stajich J.E., Wei C., Willey D., Wilson R.K.,
RA   Durbin R.M., Waterston R.H.;
RT   "The genome sequence of Caenorhabditis briggsae: a platform for comparative
RT   genomics.";
RL   PLoS Biol. 1:166-192(2003).
CC   -!- FUNCTION: Microtubule plus-end tracking protein that promotes the
CC       stabilization of dynamic microtubules. {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Cytoplasm, cytoskeleton {ECO:0000250}.
CC   -!- SIMILARITY: Belongs to the CLASP family. {ECO:0000305}.
CC   ---------------------------------------------------------------------------
CC   Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC   Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC   ---------------------------------------------------------------------------
DR   EMBL; HE601302; CAP28846.3; -; Genomic_DNA.
DR   AlphaFoldDB; Q61KX5; -.
DR   STRING; 6238.CBG09173; -.
DR   EnsemblMetazoa; CBG09173a.1; CBG09173a.1; WBGene00030813.
DR   WormBase; CBG09173a; CBP37580; WBGene00030813; -.
DR   eggNOG; KOG2956; Eukaryota.
DR   HOGENOM; CLU_005060_1_0_1; -.
DR   InParanoid; Q61KX5; -.
DR   OMA; KISTRDM; -.
DR   OrthoDB; 66632at2759; -.
DR   Proteomes; UP000008549; Chromosome III.
DR   GO; GO:0045180; C:basal cortex; IBA:GO_Central.
DR   GO; GO:0005881; C:cytoplasmic microtubule; IBA:GO_Central.
DR   GO; GO:0000776; C:kinetochore; IBA:GO_Central.
DR   GO; GO:0005815; C:microtubule organizing center; IBA:GO_Central.
DR   GO; GO:0072686; C:mitotic spindle; IBA:GO_Central.
DR   GO; GO:0005876; C:spindle microtubule; IBA:GO_Central.
DR   GO; GO:0008017; F:microtubule binding; IBA:GO_Central.
DR   GO; GO:0030953; P:astral microtubule organization; IEA:EnsemblMetazoa.
DR   GO; GO:0040001; P:establishment of mitotic spindle localization; IBA:GO_Central.
DR   GO; GO:0000226; P:microtubule cytoskeleton organization; IBA:GO_Central.
DR   GO; GO:0090307; P:mitotic spindle assembly; IBA:GO_Central.
DR   GO; GO:0031117; P:positive regulation of microtubule depolymerization; IEA:EnsemblMetazoa.
DR   GO; GO:0051231; P:spindle elongation; IEA:EnsemblMetazoa.
DR   Gene3D; 1.25.10.10; -; 4.
DR   InterPro; IPR011989; ARM-like.
DR   InterPro; IPR016024; ARM-type_fold.
DR   InterPro; IPR024395; CLASP_N_dom.
DR   InterPro; IPR000357; HEAT.
DR   InterPro; IPR021133; HEAT_type_2.
DR   InterPro; IPR034085; TOG.
DR   Pfam; PF12348; CLASP_N; 1.
DR   Pfam; PF02985; HEAT; 1.
DR   SMART; SM01349; TOG; 3.
DR   SUPFAM; SSF48371; SSF48371; 1.
DR   PROSITE; PS50077; HEAT_REPEAT; 1.
PE   3: Inferred from homology;
KW   Coiled coil; Cytoplasm; Cytoskeleton; Microtubule; Reference proteome;
KW   Repeat.
FT   CHAIN           1..1333
FT                   /note="Protein CLASP-1"
FT                   /id="PRO_0000272277"
FT   REPEAT          168..206
FT                   /note="HEAT 1"
FT   REPEAT          1266..1304
FT                   /note="HEAT 2"
FT   REGION          269..311
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          579..711
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          764..792
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COILED          360..389
FT                   /evidence="ECO:0000255"
FT   COMPBIAS        269..286
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        583..711
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   1333 AA;  148065 MW;  98DC058741F5DD95 CRC64;
     MDTNWLYVLL QKSTADPLER LKLGNVILNE ISQRKVSPHP KLVNDFLDVM SGWLTGSNFK
     VTIIGLEILD AALRTSPEVL ASYYFDRLSV LIERMGDAKV QVREMAINLC RQLAYLENSS
     PVMLLDRLCV HGTGFEHKQW LVKVGSLNIL RDFLSDSFAL VIPQAINLIP QLCRLTNDPN
     SEVRDASTNC LVDLMVFGGK SIIAKIANTR ILNEQKMATL LQRYESTIAT RGDLPPKHSI
     PIETSSIPRN NLLRRSLRSP AKIIHPSAST TSFTSSARLS TPPRTNAPSL SPSPSTPSPL
     SLPAANGRSR DLARSSLRAP AGMSLSRYRS SSCAPAAQCA ITLDDFKKAF NAVPKISIYS
     NSDVREKLET ANSVLRNANE DWSKRANQLK LIRSVILNSD DSIDQRLLLS LINELADALE
     FSIRDLRSQI VREAAITCSF LFEHFGMDVR NVAECVLPAA LAQVAVSTKI MASSAATLTV
     FIVQKIQTRQ IFQTLFDLST SKSKEQRRQL ANLLETLISS WDLKVKQPIL KSISQLVQNA
     ICDADGETRV AGRKAFAKLE QLHGAAADQI FRELDPAKQK MLRDGVSSSS SSLNSDRDNN
     NQKQPQQPQQ NISQKFLSQR SASALDNKSQ VLSIAKPQQS NPSRPTAMPV NNRLPKSSTS
     SSFSAVRSSG YGQSRAKTPS DGFGGTNFNN NNNNNNKSSS SSPSTSTHQT PIQRVASNLG
     SSSFVASLTQ EQASSLQNAM DLAKDEMSKN NEDDEFLLAE VRKTPPKETS PPASLYARGY
     GNGSNGSNNS SNNSIQSVEH ILKACTSSSI NEKRDAIISL SQKLLDRNLD SLECKNIGDT
     LSRLLAEGNT TLIISILETI SIFVKCHYKK LDGWLKLALG KLFAKMGADS LPNVKSALSS
     TQKMFLTTFD PSTQLKEVCD FMCDPVHLLA PKSRLALLEY ICLLFEEIWP EDPRCLERQT
     QLDTPYTRAA VRKMFAWMFD PRIGAILMPA CERLVCALFA LNAADFTMIF GDLPPECRDW
     AYRILQLNGQ QQSAQRQQIM EKEAITMTNN NYKPCPPEVE KFEKVSVKAS FSTYEATRVP
     EPQDYRKPTV HLAKNHVEQA AYIRNQMDLM RDFQKPDRVN EAMANLHGMM CEGSFTLWNQ
     FFDELLDEIY QILSTLSQSI RKKLAMRILQ KMCTAQATKL FDSTEIAISK VLQCACTSED
     NTMSVAAEDC LRILATHLPL PRIVQISRRI LSQDDDDQRG VLILKMLTRM FQDIDVDELH
     MIVDDVAPCF VSAYDSTSSS VRKCAVFGLV ALVQRVGMPR LETHLRKLNA TKLNLIDLYV
     GRAKSSESGT SSN