ID   CLAA_PASFU              Reviewed;         411 AA.
AC   P0CU73;
DT   05-DEC-2018, integrated into UniProtKB/Swiss-Prot.
DT   05-DEC-2018, sequence version 1.
DT   03-AUG-2022, entry version 10.
DE   RecName: Full=Cladofulvin cluster transcriptional coactivator claA {ECO:0000303|PubMed:27274078};
DE   AltName: Full=Cladofulvin biosynthesis cluster protein A {ECO:0000303|PubMed:27274078};
GN   Name=claA {ECO:0000303|PubMed:27274078}; ORFNames=Clafu184393;
OS   Passalora fulva (Tomato leaf mold) (Cladosporium fulvum).
OC   Eukaryota; Fungi; Dikarya; Ascomycota; Pezizomycotina; Dothideomycetes;
OC   Dothideomycetidae; Mycosphaerellales; Mycosphaerellaceae; Fulvia.
OX   NCBI_TaxID=5499;
RN   [1]
RP   INDUCTION.
RX   PubMed=24521437; DOI=10.1111/mmi.12535;
RA   Okmen B., Collemare J., Griffiths S., van der Burgt A., Cox R.,
RA   de Wit P.J.;
RT   "Functional analysis of the conserved transcriptional regulator CfWor1 in
RT   Cladosporium fulvum reveals diverse roles in the virulence of plant
RT   pathogenic fungi.";
RL   Mol. Microbiol. 92:10-27(2014).
RN   [2]
RP   IDENTIFICATION, FUNCTION, AND INDUCTION.
RX   PubMed=24465762; DOI=10.1371/journal.pone.0085877;
RA   Collemare J., Griffiths S., Iida Y., Karimi Jashni M., Battaglia E.,
RA   Cox R.J., de Wit P.J.;
RT   "Secondary metabolism and biotrophic lifestyle in the tomato pathogen
RT   Cladosporium fulvum.";
RL   PLoS ONE 9:E85877-E85877(2014).
RN   [3]
RP   FUNCTION.
RX   PubMed=27274078; DOI=10.1073/pnas.1603528113;
RA   Griffiths S., Mesarich C.H., Saccomanno B., Vaisberg A., De Wit P.J.,
RA   Cox R., Collemare J.;
RT   "Elucidation of cladofulvin biosynthesis reveals a cytochrome P450
RT   monooxygenase required for anthraquinone dimerization.";
RL   Proc. Natl. Acad. Sci. U.S.A. 113:6851-6856(2016).
RN   [4]
RP   INDUCTION.
RX   PubMed=27997759; DOI=10.1111/mpp.12527;
RA   Griffiths S., Mesarich C.H., Overdijk E.J.R., Saccomanno B.,
RA   de Wit P.J.G.M., Collemare J.;
RT   "Down-regulation of cladofulvin biosynthesis is required for biotrophic
RT   growth of Cladosporium fulvum on tomato.";
RL   Mol. Plant Pathol. 19:369-380(2018).
CC   -!- FUNCTION: Transcriptional coactivator; part of the gene cluster that
CC       mediates the biosynthesis of cladofulvin, a conidial pigment not
CC       required for virulence but that plays a role in fitness and resistance
CC       to environmental stresses including UV light and low-temperature
CC       stress. With claE, coregulates the production of cladofulvin.
CC       {ECO:0000269|PubMed:24521437}.
CC   -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000305}.
CC   -!- INDUCTION: Expression is positively regulated by the transcriptional
CC       regulator wor1 (PubMed:24521437). Expression is down-regulated during
CC       biotrophic growth within tomato leaves (PubMed:27997759). The
CC       expression is induced at later stages of infection when conidiophores
CC       emerge from the plant and produce conidia (PubMed:24465762).
CC       {ECO:0000269|PubMed:24465762, ECO:0000269|PubMed:24521437,
CC       ECO:0000269|PubMed:27997759}.
CC   ---------------------------------------------------------------------------
CC   Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC   Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC   ---------------------------------------------------------------------------
DR   AlphaFoldDB; P0CU73; -.
DR   SMR; P0CU73; -.
DR   OMA; LLACIQW; -.
DR   GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR   GO; GO:0003677; F:DNA binding; IEA:UniProtKB-KW.
DR   Gene3D; 1.10.10.10; -; 1.
DR   Gene3D; 3.40.50.150; -; 1.
DR   InterPro; IPR029063; SAM-dependent_MTases_sf.
DR   InterPro; IPR036388; WH-like_DNA-bd_sf.
DR   InterPro; IPR036390; WH_DNA-bd_sf.
DR   SUPFAM; SSF46785; SSF46785; 1.
PE   2: Evidence at transcript level;
KW   DNA-binding; Nucleus; Transcription; Transcription regulation.
FT   CHAIN           1..411
FT                   /note="Cladofulvin cluster transcriptional coactivator
FT                   claA"
FT                   /id="PRO_0000445893"
FT   DOMAIN          47..117
FT                   /note="HTH iclR-type"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00393"
FT   DNA_BIND        77..96
FT                   /note="H-T-H motif"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00393"
FT   REGION          1..32
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        1..29
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   411 AA;  44661 MW;  2EA954D039070620 CRC64;
     MSDSLAGNGM RQNLNRSSTS SNHTGHAQNG RAPQDPLVDA GHFIKQLACQ VQSLACLKWL
     SELQILACIP LEGSRPLHDV AELANVPASQ LSRVVRIVAT IGFLNEPDPG HIAHTALSAQ
     FVVDFSLFDS ILFLLTTVVP CSMQMSTLTQ RHGSAFPTND GAYRIAFNTS QSFDAACVEG
     SRLRREWLAY KSNTTIVDET IADVLLRQDW HSLGHVKVVD ACAQSTDFGN SLAERCSTLR
     VVVQLDTATT NGHSEIDSSM SRGRAVIQRR PQGTRQMVED AAVCILKIEA PSTTIRARVT
     AELLAHLEVL RNNESAVLIV AAPLLPEPGT VSTSAEASAR SSDLTTLQLS NSPQLELDRL
     IDIVENVPNA RDSLKVVQRI LFRNGMVAAI EVRYRASSED QFATPAGTID W