ACDH_ARATH
ID ACDH_ARATH Reviewed; 229 AA.
AC Q8L7U7; O65654;
DT 01-APR-2015, integrated into UniProtKB/Swiss-Prot.
DT 01-OCT-2002, sequence version 1.
DT 03-AUG-2022, entry version 119.
DE RecName: Full=ACD11 homolog protein {ECO:0000303|PubMed:18657186};
DE AltName: Full=Probable ceramide-1-phosphate transfer protein {ECO:0000305};
GN OrderedLocusNames=At4g39670 {ECO:0000312|Araport:AT4G39670};
GN ORFNames=T19P19.60 {ECO:0000312|EMBL:CAA18753.1};
OS Arabidopsis thaliana (Mouse-ear cress).
OC Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta;
OC Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae;
OC rosids; malvids; Brassicales; Brassicaceae; Camelineae; Arabidopsis.
OX NCBI_TaxID=3702 {ECO:0000312|EMBL:AAM83214.1};
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=cv. Columbia;
RX PubMed=10617198; DOI=10.1038/47134;
RA Mayer K.F.X., Schueller C., Wambutt R., Murphy G., Volckaert G., Pohl T.,
RA Duesterhoeft A., Stiekema W., Entian K.-D., Terryn N., Harris B.,
RA Ansorge W., Brandt P., Grivell L.A., Rieger M., Weichselgartner M.,
RA de Simone V., Obermaier B., Mache R., Mueller M., Kreis M., Delseny M.,
RA Puigdomenech P., Watson M., Schmidtheini T., Reichert B., Portetelle D.,
RA Perez-Alonso M., Boutry M., Bancroft I., Vos P., Hoheisel J.,
RA Zimmermann W., Wedler H., Ridley P., Langham S.-A., McCullagh B.,
RA Bilham L., Robben J., van der Schueren J., Grymonprez B., Chuang Y.-J.,
RA Vandenbussche F., Braeken M., Weltjens I., Voet M., Bastiaens I., Aert R.,
RA Defoor E., Weitzenegger T., Bothe G., Ramsperger U., Hilbert H., Braun M.,
RA Holzer E., Brandt A., Peters S., van Staveren M., Dirkse W., Mooijman P.,
RA Klein Lankhorst R., Rose M., Hauf J., Koetter P., Berneiser S., Hempel S.,
RA Feldpausch M., Lamberth S., Van den Daele H., De Keyser A., Buysshaert C.,
RA Gielen J., Villarroel R., De Clercq R., van Montagu M., Rogers J.,
RA Cronin A., Quail M.A., Bray-Allen S., Clark L., Doggett J., Hall S.,
RA Kay M., Lennard N., McLay K., Mayes R., Pettett A., Rajandream M.A.,
RA Lyne M., Benes V., Rechmann S., Borkova D., Bloecker H., Scharfe M.,
RA Grimm M., Loehnert T.-H., Dose S., de Haan M., Maarse A.C., Schaefer M.,
RA Mueller-Auer S., Gabel C., Fuchs M., Fartmann B., Granderath K., Dauner D.,
RA Herzl A., Neumann S., Argiriou A., Vitale D., Liguori R., Piravandi E.,
RA Massenet O., Quigley F., Clabauld G., Muendlein A., Felber R., Schnabl S.,
RA Hiller R., Schmidt W., Lecharny A., Aubourg S., Chefdor F., Cooke R.,
RA Berger C., Monfort A., Casacuberta E., Gibbons T., Weber N., Vandenbol M.,
RA Bargues M., Terol J., Torres A., Perez-Perez A., Purnelle B., Bent E.,
RA Johnson S., Tacon D., Jesse T., Heijnen L., Schwarz S., Scholler P.,
RA Heber S., Francs P., Bielke C., Frishman D., Haase D., Lemcke K.,
RA Mewes H.-W., Stocker S., Zaccaria P., Bevan M., Wilson R.K.,
RA de la Bastide M., Habermann K., Parnell L., Dedhia N., Gnoj L., Schutz K.,
RA Huang E., Spiegel L., Sekhon M., Murray J., Sheet P., Cordes M.,
RA Abu-Threideh J., Stoneking T., Kalicki J., Graves T., Harmon G.,
RA Edwards J., Latreille P., Courtney L., Cloud J., Abbott A., Scott K.,
RA Johnson D., Minx P., Bentley D., Fulton B., Miller N., Greco T., Kemp K.,
RA Kramer J., Fulton L., Mardis E., Dante M., Pepin K., Hillier L.W.,
RA Nelson J., Spieth J., Ryan E., Andrews S., Geisel C., Layman D., Du H.,
RA Ali J., Berghoff A., Jones K., Drone K., Cotton M., Joshu C., Antonoiu B.,
RA Zidanic M., Strong C., Sun H., Lamar B., Yordan C., Ma P., Zhong J.,
RA Preston R., Vil D., Shekher M., Matero A., Shah R., Swaby I.K.,
RA O'Shaughnessy A., Rodriguez M., Hoffman J., Till S., Granat S., Shohdy N.,
RA Hasegawa A., Hameed A., Lodhi M., Johnson A., Chen E., Marra M.A.,
RA Martienssen R., McCombie W.R.;
RT "Sequence and analysis of chromosome 4 of the plant Arabidopsis thaliana.";
RL Nature 402:769-777(1999).
RN [2]
RP GENOME REANNOTATION.
RC STRAIN=cv. Columbia;
RX PubMed=27862469; DOI=10.1111/tpj.13415;
RA Cheng C.Y., Krishnakumar V., Chan A.P., Thibaud-Nissen F., Schobel S.,
RA Town C.D.;
RT "Araport11: a complete reannotation of the Arabidopsis thaliana reference
RT genome.";
RL Plant J. 89:789-804(2017).
RN [3]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC STRAIN=cv. Columbia;
RX PubMed=14593172; DOI=10.1126/science.1088305;
RA Yamada K., Lim J., Dale J.M., Chen H., Shinn P., Palm C.J., Southwick A.M.,
RA Wu H.C., Kim C.J., Nguyen M., Pham P.K., Cheuk R.F., Karlin-Newmann G.,
RA Liu S.X., Lam B., Sakano H., Wu T., Yu G., Miranda M., Quach H.L.,
RA Tripp M., Chang C.H., Lee J.M., Toriumi M.J., Chan M.M., Tang C.C.,
RA Onodera C.S., Deng J.M., Akiyama K., Ansari Y., Arakawa T., Banh J.,
RA Banno F., Bowser L., Brooks S.Y., Carninci P., Chao Q., Choy N., Enju A.,
RA Goldsmith A.D., Gurjal M., Hansen N.F., Hayashizaki Y., Johnson-Hopson C.,
RA Hsuan V.W., Iida K., Karnes M., Khan S., Koesema E., Ishida J., Jiang P.X.,
RA Jones T., Kawai J., Kamiya A., Meyers C., Nakajima M., Narusaka M.,
RA Seki M., Sakurai T., Satou M., Tamse R., Vaysberg M., Wallender E.K.,
RA Wong C., Yamamura Y., Yuan S., Shinozaki K., Davis R.W., Theologis A.,
RA Ecker J.R.;
RT "Empirical analysis of transcriptional activity in the Arabidopsis
RT genome.";
RL Science 302:842-846(2003).
RN [4]
RP IDENTIFICATION.
RX PubMed=11850411; DOI=10.1101/gad.218202;
RA Brodersen P., Petersen M., Pike H.M., Olszak B., Skov S., Odum N.,
RA Jorgensen L.B., Brown R.E., Mundy J.;
RT "Knockout of Arabidopsis accelerated-cell-death11 encoding a sphingosine
RT transfer protein causes activation of programmed cell death and defense.";
RL Genes Dev. 16:490-502(2002).
RN [5]
RP INDUCTION.
RX PubMed=18657186; DOI=10.1111/j.1742-4658.2008.06584.x;
RA Petersen N.H., McKinney L.V., Pike H., Hofius D., Zakaria A., Brodersen P.,
RA Petersen M., Brown R.E., Mundy J.;
RT "Human GLTP and mutant forms of ACD11 suppress cell death in the
RT Arabidopsis acd11 mutant.";
RL FEBS J. 275:4378-4388(2008).
CC -!- INDUCTION: Highly up-regulated during programmed cell death (PCD)
CC induced in acd11 mutant. {ECO:0000305|PubMed:18657186}.
CC -!- SIMILARITY: Belongs to the GLTP family. {ECO:0000305}.
CC -!- SEQUENCE CAUTION:
CC Sequence=CAA18753.1; Type=Erroneous gene model prediction; Evidence={ECO:0000305};
CC Sequence=CAB80630.1; Type=Erroneous gene model prediction; Evidence={ECO:0000305};
CC ---------------------------------------------------------------------------
CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC ---------------------------------------------------------------------------
DR EMBL; AL022605; CAA18753.1; ALT_SEQ; Genomic_DNA.
DR EMBL; AL161595; CAB80630.1; ALT_SEQ; Genomic_DNA.
DR EMBL; CP002687; AEE87101.1; -; Genomic_DNA.
DR EMBL; AY126985; AAM83214.1; -; mRNA.
DR EMBL; BT000526; AAN18095.1; -; mRNA.
DR PIR; T05004; T05004.
DR RefSeq; NP_195677.2; NM_120127.3.
DR AlphaFoldDB; Q8L7U7; -.
DR SMR; Q8L7U7; -.
DR IntAct; Q8L7U7; 1.
DR STRING; 3702.AT4G39670.1; -.
DR PaxDb; Q8L7U7; -.
DR PRIDE; Q8L7U7; -.
DR ProteomicsDB; 244640; -.
DR EnsemblPlants; AT4G39670.1; AT4G39670.1; AT4G39670.
DR GeneID; 830121; -.
DR Gramene; AT4G39670.1; AT4G39670.1; AT4G39670.
DR KEGG; ath:AT4G39670; -.
DR Araport; AT4G39670; -.
DR TAIR; locus:2135252; AT4G39670.
DR eggNOG; KOG4189; Eukaryota.
DR HOGENOM; CLU_082630_1_0_1; -.
DR InParanoid; Q8L7U7; -.
DR OMA; MFEDAVC; -.
DR OrthoDB; 1423493at2759; -.
DR PhylomeDB; Q8L7U7; -.
DR PRO; PR:Q8L7U7; -.
DR Proteomes; UP000006548; Chromosome 4.
DR ExpressionAtlas; Q8L7U7; baseline and differential.
DR Genevisible; Q8L7U7; AT.
DR GO; GO:0005737; C:cytoplasm; IDA:TAIR.
DR GO; GO:0005829; C:cytosol; IBA:GO_Central.
DR GO; GO:0005634; C:nucleus; IDA:TAIR.
DR GO; GO:1902387; F:ceramide 1-phosphate binding; IBA:GO_Central.
DR GO; GO:1902388; F:ceramide 1-phosphate transfer activity; IDA:TAIR.
DR GO; GO:0035627; P:ceramide transport; IBA:GO_Central.
DR GO; GO:0120009; P:intermembrane lipid transfer; IBA:GO_Central.
DR Gene3D; 1.10.3520.10; -; 1.
DR InterPro; IPR036497; GLTP_sf.
DR InterPro; IPR014830; Glycolipid_transfer_prot_dom.
DR Pfam; PF08718; GLTP; 1.
DR SUPFAM; SSF110004; SSF110004; 1.
PE 2: Evidence at transcript level;
KW Lipid transport; Reference proteome; Transport.
FT CHAIN 1..229
FT /note="ACD11 homolog protein"
FT /id="PRO_0000432643"
FT BINDING 84
FT /ligand="an N-acylsphingoid base 1-phosphate"
FT /ligand_id="ChEBI:CHEBI:84404"
FT /evidence="ECO:0000250|UniProtKB:O64587"
FT BINDING 88
FT /ligand="an N-acylsphingoid base 1-phosphate"
FT /ligand_id="ChEBI:CHEBI:84404"
FT /evidence="ECO:0000250|UniProtKB:O64587"
FT BINDING 123
FT /ligand="an N-acylsphingoid base 1-phosphate"
FT /ligand_id="ChEBI:CHEBI:84404"
FT /evidence="ECO:0000250|UniProtKB:O64587"
FT BINDING 127
FT /ligand="an N-acylsphingoid base 1-phosphate"
FT /ligand_id="ChEBI:CHEBI:84404"
FT /evidence="ECO:0000250|UniProtKB:O64587"
FT BINDING 166
FT /ligand="an N-acylsphingoid base 1-phosphate"
FT /ligand_id="ChEBI:CHEBI:84404"
FT /evidence="ECO:0000250|UniProtKB:O64587"
SQ SEQUENCE 229 AA; 26514 MW; 080ED9B7CB90B812 CRC64;
MEAEVEEEEE DMFEDAVCTT QARVNTPLSV ITEAFEDLAD LVKPQRSDEI DEDELRLDDF
CSACTHVSVL FNCLGFAFKF AEMEYIAKVK DLVEASKTFE TLHNILDLDV EKETVKTPGS
HSRNLRRVRQ GLDLIRAIFE QFLIADDYSL KDAATTAYTE VCAPFHTWAV RTAVYAGMYT
LPTRDQLLLR LNETDQSVEK NMRRYMEASR PIIEYIDKLY IERNIKLDW
