ID   CFT1_NEUCR              Reviewed;        1487 AA.
AC   Q7SEY2;
DT   12-JUN-2007, integrated into UniProtKB/Swiss-Prot.
DT   19-MAR-2014, sequence version 3.
DT   25-MAY-2022, entry version 84.
DE   RecName: Full=Protein cft1;
DE   AltName: Full=Cleavage factor two protein 1;
DE   AltName: Full=Polyadenylation factor 3;
GN   Name=paa-3; Synonyms=cft1; ORFNames=NCU02082;
OS   Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 /
OS   FGSC 987).
OC   Eukaryota; Fungi; Dikarya; Ascomycota; Pezizomycotina; Sordariomycetes;
OC   Sordariomycetidae; Sordariales; Sordariaceae; Neurospora.
OX   NCBI_TaxID=367110;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987;
RX   PubMed=12712197; DOI=10.1038/nature01554;
RA   Galagan J.E., Calvo S.E., Borkovich K.A., Selker E.U., Read N.D.,
RA   Jaffe D.B., FitzHugh W., Ma L.-J., Smirnov S., Purcell S., Rehman B.,
RA   Elkins T., Engels R., Wang S., Nielsen C.B., Butler J., Endrizzi M.,
RA   Qui D., Ianakiev P., Bell-Pedersen D., Nelson M.A., Werner-Washburne M.,
RA   Selitrennikoff C.P., Kinsey J.A., Braun E.L., Zelter A., Schulte U.,
RA   Kothe G.O., Jedd G., Mewes H.-W., Staben C., Marcotte E., Greenberg D.,
RA   Roy A., Foley K., Naylor J., Stange-Thomann N., Barrett R., Gnerre S.,
RA   Kamal M., Kamvysselis M., Mauceli E.W., Bielke C., Rudd S., Frishman D.,
RA   Krystofova S., Rasmussen C., Metzenberg R.L., Perkins D.D., Kroken S.,
RA   Cogoni C., Macino G., Catcheside D.E.A., Li W., Pratt R.J., Osmani S.A.,
RA   DeSouza C.P.C., Glass N.L., Orbach M.J., Berglund J.A., Voelker R.,
RA   Yarden O., Plamann M., Seiler S., Dunlap J.C., Radford A., Aramayo R.,
RA   Natvig D.O., Alex L.A., Mannhaupt G., Ebbole D.J., Freitag M., Paulsen I.,
RA   Sachs M.S., Lander E.S., Nusbaum C., Birren B.W.;
RT   "The genome sequence of the filamentous fungus Neurospora crassa.";
RL   Nature 422:859-868(2003).
CC   -!- FUNCTION: RNA-binding component of the cleavage and polyadenylation
CC       factor (CPF) complex, which plays a key role in polyadenylation-
CC       dependent pre-mRNA 3'-end formation and cooperates with cleavage
CC       factors including the CFIA complex and hrp1/CFIB. Involved in poly(A)
CC       site recognition. May be involved in coupling transcription termination
CC       and mRNA 3'-end formation (By similarity). {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000250}.
CC   -!- SIMILARITY: Belongs to the CFT1 family. {ECO:0000305}.
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DR   EMBL; CM002236; EAA35373.3; -; Genomic_DNA.
DR   RefSeq; XP_964609.3; XM_959516.3.
DR   AlphaFoldDB; Q7SEY2; -.
DR   SMR; Q7SEY2; -.
DR   STRING; 5141.EFNCRP00000001333; -.
DR   EnsemblFungi; EAA35373; EAA35373; NCU02082.
DR   GeneID; 3880749; -.
DR   KEGG; ncr:NCU02082; -.
DR   VEuPathDB; FungiDB:NCU02082; -.
DR   HOGENOM; CLU_002414_2_1_1; -.
DR   InParanoid; Q7SEY2; -.
DR   Proteomes; UP000001805; Chromosome 1, Linkage Group I.
DR   GO; GO:0005847; C:mRNA cleavage and polyadenylation specificity factor complex; IBA:GO_Central.
DR   GO; GO:0005634; C:nucleus; IBA:GO_Central.
DR   GO; GO:0003723; F:RNA binding; IEA:UniProtKB-KW.
DR   GO; GO:0006378; P:mRNA polyadenylation; IBA:GO_Central.
DR   Gene3D; 2.130.10.10; -; 2.
DR   InterPro; IPR004871; Cleavage/polyA-sp_fac_asu_C.
DR   InterPro; IPR018846; Cleavage/polyA-sp_fac_asu_N.
DR   InterPro; IPR015943; WD40/YVTN_repeat-like_dom_sf.
DR   Pfam; PF03178; CPSF_A; 1.
DR   Pfam; PF10433; MMS1_N; 1.
PE   3: Inferred from homology;
KW   mRNA processing; Nucleus; Reference proteome; RNA-binding.
FT   CHAIN           1..1487
FT                   /note="Protein cft1"
FT                   /id="PRO_0000290633"
FT   REGION          486..513
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        486..506
FT                   /note="Acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   1487 AA;  160921 MW;  9158CA575E0EEF6A CRC64;
     MQCYTELTPP TAVTHSVTLQ LVPGQGTNLA VAKASLLQIF KTKVVSAEID TYATLNGTNT
     SSKAAAAGRY DSRLVNDDDG FEASFLGGDN IAARADRANS AKLVLVAEVT LPGTMTGLAR
     IKKPSGSSSG GADCLLLSFR DARLSLVEWN VERNTLETVS IHYYEKEELV GSPWVAPLHQ
     YPTLLVADPA SRCAALKFSE RNLAILPFKQ PDEDMDMDNW DEELDGPRPK KDLSGAVANG
     ASTIEDTPYS PSFVLRLSKL EASLLHPVHL AFLHEYRDPT IGVLSSTKTA SNSLGHKDHF
     TYMVFTLDLQ QRASTTILAV NGLPQDLFRV VALPAPVGGA LLVGANELIH IDQSGKSNGI
     AVNPLTKQTT SFSLVDQADL DLRLEGCAID VLAAELGEFL LILNDGRLGL ITFRIDGRTV
     SGLSIKMIAP EAGGSVIQSR VTSLSRMGRS TMFVGSEEGD SVLLGWTRRQ GQTQKRKSRL
     QDADLDLDLD DEDLEDDDDD DLYGEESASP EQAMSAAKAI KSGDLNFRIH DRLLSIAPIQ
     KMTYGQPVTL PDSEEERNSE GVRSDLQLVC AVGRGKASAL AIMNLAIQPK IIGRFEFPEA
     RGFWTVCAKK PIPKTLVGDK GPMNNDYDTS GQYHKFMIVA KVDLDGYETS DVYALTAAGF
     ESLTGTEFEP AAGFTVEAGT MGKDSRILQV LKSEVRCYDG DLGLSQIVPM LDEETGAEPR
     VRTASIADPF LLLIRDDFSV FIAEMSPKLL ELEEVEKEDQ ILTSTKWLAG CLYTDTSGVF
     ADETVGKGTK DNILMFLLST SGVLYIYRLP DLTKPVYVAE GLSYIPPGLS ADYAARKGTA
     KESVAEILVA DLGDTTHKSP YLILRHANDD LTLYQPYRLK ATAGQPFSKS LFFQKVPNST
     FAKAPEEKPA DDDEPHNAQR FLPMRRCSNI SGYSTVFLPG SSPSFILKTA KSSPRVLSLQ
     GSGVQAMSSF HTEGCEHGFI YADTNGIARV TQIPTDSSYA ELGLSVKKIP IGVDTQSVAY
     HPPTQAYVVG CNDVEPFELP KDDDYHKEWA RENITFKPMV DRGVLKLLSG ITWTVIDTVE
     MEPCETVLCV ETLNLEVSES TNERKQLIAV GTALIKGEDL PTRGRVYVFD IADVIPEPGK
     PETSKKLKLV AKEDIPRGAV TALSEVGTQG LMLVAQGQKC MVRGLKEDGT LLPVAFMDMN
     CYVTSVKELP GTGLCLMADA FKGVWFTGYT EEPYKMMLFG KSSTRMEVLN ADFLPDGKEL
     YIVASDADGH IHILQFDPEH PKSLQGHLLL HRTTFNTGAH HPTSSLLLPA VYPNPSSLSS
     NSEENSPHIL LLASPTGVLA TLRPLQENAY RRLSSLAVQL TNGLPHPAGL NPKGYRLPSP
     SASASMQLPG VDAGIGRNIV DGKILERFLE LGTGKRQEMA GRAGYVVGTG AHGVNPAGSG
     KMMGGGGGLS LGGLRLNGLH GQEGGMEWEE VRGELGVVLG WSGLGYF