ID   CF157_CHLRE             Reviewed;        1206 AA.
AC   A8JID5;
DT   05-OCT-2016, integrated into UniProtKB/Swiss-Prot.
DT   04-DEC-2007, sequence version 1.
DT   03-AUG-2022, entry version 43.
DE   RecName: Full=Cilia- and flagella-associated protein 157;
DE   AltName: Full=Flagellar-associated protein 77 {ECO:0000303|PubMed:15998802};
GN   Name=CFAP157 {ECO:0000250|UniProtKB:Q5JU67};
GN   Synonyms=FAP157 {ECO:0000303|PubMed:15998802};
GN   ORFNames=CHLREDRAFT_180708 {ECO:0000312|EMBL:EDO96356.1};
OS   Chlamydomonas reinhardtii (Chlamydomonas smithii).
OC   Eukaryota; Viridiplantae; Chlorophyta; core chlorophytes; Chlorophyceae;
OC   CS clade; Chlamydomonadales; Chlamydomonadaceae; Chlamydomonas.
OX   NCBI_TaxID=3055;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=CC-503;
RX   PubMed=17932292; DOI=10.1126/science.1143609;
RA   Merchant S.S., Prochnik S.E., Vallon O., Harris E.H., Karpowicz S.J.,
RA   Witman G.B., Terry A., Salamov A., Fritz-Laylin L.K., Marechal-Drouard L.,
RA   Marshall W.F., Qu L.H., Nelson D.R., Sanderfoot A.A., Spalding M.H.,
RA   Kapitonov V.V., Ren Q., Ferris P., Lindquist E., Shapiro H., Lucas S.M.,
RA   Grimwood J., Schmutz J., Cardol P., Cerutti H., Chanfreau G., Chen C.L.,
RA   Cognat V., Croft M.T., Dent R., Dutcher S., Fernandez E., Fukuzawa H.,
RA   Gonzalez-Ballester D., Gonzalez-Halphen D., Hallmann A., Hanikenne M.,
RA   Hippler M., Inwood W., Jabbari K., Kalanon M., Kuras R., Lefebvre P.A.,
RA   Lemaire S.D., Lobanov A.V., Lohr M., Manuell A., Meier I., Mets L.,
RA   Mittag M., Mittelmeier T., Moroney J.V., Moseley J., Napoli C.,
RA   Nedelcu A.M., Niyogi K., Novoselov S.V., Paulsen I.T., Pazour G.J.,
RA   Purton S., Ral J.P., Riano-Pachon D.M., Riekhof W., Rymarquis L.,
RA   Schroda M., Stern D., Umen J., Willows R., Wilson N., Zimmer S.L.,
RA   Allmer J., Balk J., Bisova K., Chen C.J., Elias M., Gendler K., Hauser C.,
RA   Lamb M.R., Ledford H., Long J.C., Minagawa J., Page M.D., Pan J.,
RA   Pootakham W., Roje S., Rose A., Stahlberg E., Terauchi A.M., Yang P.,
RA   Ball S., Bowler C., Dieckmann C.L., Gladyshev V.N., Green P., Jorgensen R.,
RA   Mayfield S., Mueller-Roeber B., Rajamani S., Sayre R.T., Brokstein P.,
RA   Dubchak I., Goodstein D., Hornick L., Huang Y.W., Jhaveri J., Luo Y.,
RA   Martinez D., Ngau W.C., Otillar B., Poliakov A., Porter A., Szajkowski L.,
RA   Werner G., Zhou K., Grigoriev I.V., Rokhsar D.S., Grossman A.R.;
RT   "The Chlamydomonas genome reveals the evolution of key animal and plant
RT   functions.";
RL   Science 318:245-250(2007).
RN   [2]
RP   IDENTIFICATION BY MASS SPECTROMETRY, AND SUBCELLULAR LOCATION.
RX   PubMed=15998802; DOI=10.1083/jcb.200504008;
RA   Pazour G.J., Agrin N., Leszyk J., Witman G.B.;
RT   "Proteomic analysis of a eukaryotic cilium.";
RL   J. Cell Biol. 170:103-113(2005).
CC   -!- SUBCELLULAR LOCATION: Cell projection, cilium, flagellum
CC       {ECO:0000269|PubMed:15998802}.
CC   -!- SIMILARITY: Belongs to the CFAP157 family. {ECO:0000305}.
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DR   EMBL; DS496202; EDO96356.1; -; Genomic_DNA.
DR   RefSeq; XP_001703716.1; XM_001703664.1.
DR   AlphaFoldDB; A8JID5; -.
DR   SMR; A8JID5; -.
DR   STRING; 3055.EDO96356; -.
DR   PaxDb; A8JID5; -.
DR   PRIDE; A8JID5; -.
DR   GeneID; 5729271; -.
DR   eggNOG; ENOG502R31A; Eukaryota.
DR   HOGENOM; CLU_270257_0_0_1; -.
DR   OrthoDB; 1171749at2759; -.
DR   GO; GO:0031514; C:motile cilium; IEA:UniProtKB-SubCell.
DR   InterPro; IPR038844; CFAP157.
DR   PANTHER; PTHR31954; PTHR31954; 1.
PE   1: Evidence at protein level;
KW   Cell projection; Cilium; Coiled coil; Flagellum.
FT   CHAIN           1..1206
FT                   /note="Cilia- and flagella-associated protein 157"
FT                   /id="PRO_0000437490"
FT   REGION          26..52
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          79..109
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          125..173
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          327..405
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          936..990
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          1011..1072
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          1168..1206
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COILED          634..732
FT                   /evidence="ECO:0000255"
FT   COILED          799..833
FT                   /evidence="ECO:0000255"
FT   COILED          876..903
FT                   /evidence="ECO:0000255"
FT   COMPBIAS        89..109
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        125..145
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        1173..1206
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   1206 AA;  126128 MW;  98DAA1D8EF58F78D CRC64;
     MWAVARLGLR LRASWWEAQA GRLMPGGGGG SAAAAAMQEE QGEQEGPTGR DLSNALYALG
     EGVVANTLWA LQQLLAPARA EQEHPQEGRP QQQEQGGEAR QEQQGQQAPR QLWWALLERS
     RQHMEATCVQ QQGQGRGQAA DGKSTSSRGA AGGGVAKAVA RGPRGAGTAR GPLGTAAAPL
     RRVLWGAGRQ DVCVYLSGLR RLHMPPPPSL AVPLMQRLEQ QLLAAEGEAQ AEAAVPARAP
     PSTASTAAPP SARCLVYLAV ELSHMGPLGP LGPLGPLGKA QAGGQQVPVQ VQVPGVEADV
     GSLGARECAD LCVALVRLGV SLPRGAGSGK ATMPHPHPSP HLRYDEQPQL SGADLGPSAD
     MAPLPLDTGE RALPEPSSHP PVARQQLGEQ PGEQPGGPHE DEEDWDPAFV ADGYEAEAGE
     LPKRPSASGG GMEGSFSLPQ QLALAQSLHW LDQAAAHMMQ TGAEDAASVD EEAEAPEADA
     VLAAALAAAR DDTALYLFCS WAPSSLSSLS SLSATATATA AALRLRLTGA AHVVEGAALQ
     AAAAALDAAC WKQQGAGPGV VVGKDREVQA AAPAGPPGDL EAEQVVCAPC MCTGSIDTPD
     QPPAPNNLNN PHPSAFHRYQ DHGDRLQVDV VRLTDELETQ KLNLRDINEF LTNELKSKVA
     ELNGLMDEVK KSHEASLARL RGDKDRELER LEGVVREHER KARITQEFLD KKEALEAEMQ
     SLKETLARKT KDFEQQLTDI DRQHIQDREK WKREMAGRIK ETKLQMMKLT DNQLEMTTKR
     TIMENEQMSI ELSYQSRQTE KLLNKNNKLM EENAELRRQL ELSKQTEEEL ARRNNLYQKT
     IKTLLSKLQD QGYQAAESEE VLGALDGRLG DLAAHLHLAQ LQLEEKSAEA DALRERLESK
     TAEAAALTSG YDDTARFLLA CMADVRDKVV TVVRTTTTNN TSSDERLPPL AGADAAGGSR
     SGSPTPPGAS SSAAGGGDIT VLPGRLDELS PEQRERVLGW LLERLHYATG LSHGPLSQSS
     PAPLSAGGMG SALAGEWGPG SPGGSRLGRL PTREQDGSAG GMGGPQGLGA TSGAAAAAAG
     AGGGLDGVSS LGGLGYGLGY GGVGVSSSVM AGMSPGPGVP GYSVSTGDVM PGGGMLGGAG
     VIGGGTGGGA GGAVVDEALA KVLSEVRPWG KRSEQQPLTT TKHSGTFLRK GNGPSNNTGS
     RGSLKV