ID   CF141_HUMAN             Reviewed;         244 AA.
AC   Q5SZD1; A8K1H4; Q8N400; Q96NQ1;
DT   19-JUL-2005, integrated into UniProtKB/Swiss-Prot.
DT   11-JAN-2011, sequence version 3.
DT   03-AUG-2022, entry version 113.
DE   RecName: Full=Uncharacterized protein C6orf141;
GN   Name=C6orf141;
OS   Homo sapiens (Human).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC   Homo.
OX   NCBI_TaxID=9606;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA], AND VARIANT GLU-137.
RC   TISSUE=Cerebellum, and Corpus callosum;
RX   PubMed=14702039; DOI=10.1038/ng1285;
RA   Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R.,
RA   Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H.,
RA   Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.,
RA   Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K.,
RA   Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H.,
RA   Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M.,
RA   Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K.,
RA   Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T.,
RA   Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M.,
RA   Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S.,
RA   Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H.,
RA   Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K.,
RA   Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N.,
RA   Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S.,
RA   Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O.,
RA   Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H.,
RA   Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B.,
RA   Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y.,
RA   Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K.,
RA   Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T.,
RA   Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T.,
RA   Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y.,
RA   Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H.,
RA   Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y.,
RA   Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H.,
RA   Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O.,
RA   Isogai T., Sugano S.;
RT   "Complete sequencing and characterization of 21,243 full-length human
RT   cDNAs.";
RL   Nat. Genet. 36:40-45(2004).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA], AND VARIANT GLU-137.
RX   PubMed=14574404; DOI=10.1038/nature02055;
RA   Mungall A.J., Palmer S.A., Sims S.K., Edwards C.A., Ashurst J.L.,
RA   Wilming L., Jones M.C., Horton R., Hunt S.E., Scott C.E., Gilbert J.G.R.,
RA   Clamp M.E., Bethel G., Milne S., Ainscough R., Almeida J.P., Ambrose K.D.,
RA   Andrews T.D., Ashwell R.I.S., Babbage A.K., Bagguley C.L., Bailey J.,
RA   Banerjee R., Barker D.J., Barlow K.F., Bates K., Beare D.M., Beasley H.,
RA   Beasley O., Bird C.P., Blakey S.E., Bray-Allen S., Brook J., Brown A.J.,
RA   Brown J.Y., Burford D.C., Burrill W., Burton J., Carder C., Carter N.P.,
RA   Chapman J.C., Clark S.Y., Clark G., Clee C.M., Clegg S., Cobley V.,
RA   Collier R.E., Collins J.E., Colman L.K., Corby N.R., Coville G.J.,
RA   Culley K.M., Dhami P., Davies J., Dunn M., Earthrowl M.E., Ellington A.E.,
RA   Evans K.A., Faulkner L., Francis M.D., Frankish A., Frankland J.,
RA   French L., Garner P., Garnett J., Ghori M.J., Gilby L.M., Gillson C.J.,
RA   Glithero R.J., Grafham D.V., Grant M., Gribble S., Griffiths C.,
RA   Griffiths M.N.D., Hall R., Halls K.S., Hammond S., Harley J.L., Hart E.A.,
RA   Heath P.D., Heathcott R., Holmes S.J., Howden P.J., Howe K.L., Howell G.R.,
RA   Huckle E., Humphray S.J., Humphries M.D., Hunt A.R., Johnson C.M.,
RA   Joy A.A., Kay M., Keenan S.J., Kimberley A.M., King A., Laird G.K.,
RA   Langford C., Lawlor S., Leongamornlert D.A., Leversha M., Lloyd C.R.,
RA   Lloyd D.M., Loveland J.E., Lovell J., Martin S., Mashreghi-Mohammadi M.,
RA   Maslen G.L., Matthews L., McCann O.T., McLaren S.J., McLay K., McMurray A.,
RA   Moore M.J.F., Mullikin J.C., Niblett D., Nickerson T., Novik K.L.,
RA   Oliver K., Overton-Larty E.K., Parker A., Patel R., Pearce A.V., Peck A.I.,
RA   Phillimore B.J.C.T., Phillips S., Plumb R.W., Porter K.M., Ramsey Y.,
RA   Ranby S.A., Rice C.M., Ross M.T., Searle S.M., Sehra H.K., Sheridan E.,
RA   Skuce C.D., Smith S., Smith M., Spraggon L., Squares S.L., Steward C.A.,
RA   Sycamore N., Tamlyn-Hall G., Tester J., Theaker A.J., Thomas D.W.,
RA   Thorpe A., Tracey A., Tromans A., Tubby B., Wall M., Wallis J.M.,
RA   West A.P., White S.S., Whitehead S.L., Whittaker H., Wild A., Willey D.J.,
RA   Wilmer T.E., Wood J.M., Wray P.W., Wyatt J.C., Young L., Younger R.M.,
RA   Bentley D.R., Coulson A., Durbin R.M., Hubbard T., Sulston J.E., Dunham I.,
RA   Rogers J., Beck S.;
RT   "The DNA sequence and analysis of human chromosome 6.";
RL   Nature 425:805-811(2003).
RN   [3]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RA   Mural R.J., Istrail S., Sutton G.G., Florea L., Halpern A.L., Mobarry C.M.,
RA   Lippert R., Walenz B., Shatkay H., Dew I., Miller J.R., Flanigan M.J.,
RA   Edwards N.J., Bolanos R., Fasulo D., Halldorsson B.V., Hannenhalli S.,
RA   Turner R., Yooseph S., Lu F., Nusskern D.R., Shue B.C., Zheng X.H.,
RA   Zhong F., Delcher A.L., Huson D.H., Kravitz S.A., Mouchard L., Reinert K.,
RA   Remington K.A., Clark A.G., Waterman M.S., Eichler E.E., Adams M.D.,
RA   Hunkapiller M.W., Myers E.W., Venter J.C.;
RL   Submitted (JUL-2005) to the EMBL/GenBank/DDBJ databases.
RN   [4]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA], AND VARIANT GLU-137.
RC   TISSUE=Lung;
RX   PubMed=15489334; DOI=10.1101/gr.2596504;
RG   The MGC Project Team;
RT   "The status, quality, and expansion of the NIH full-length cDNA project:
RT   the Mammalian Gene Collection (MGC).";
RL   Genome Res. 14:2121-2127(2004).
CC   -!- INTERACTION:
CC       Q5SZD1; P54253: ATXN1; NbExp=6; IntAct=EBI-10697767, EBI-930964;
CC       Q5SZD1; P14136: GFAP; NbExp=3; IntAct=EBI-10697767, EBI-744302;
CC       Q5SZD1; Q8WXH2: JPH3; NbExp=3; IntAct=EBI-10697767, EBI-1055254;
CC       Q5SZD1; P29474: NOS3; NbExp=3; IntAct=EBI-10697767, EBI-1391623;
CC       Q5SZD1; O60437: PPL; NbExp=3; IntAct=EBI-10697767, EBI-368321;
CC       Q5SZD1; P37840: SNCA; NbExp=3; IntAct=EBI-10697767, EBI-985879;
CC       Q5SZD1; P00441: SOD1; NbExp=3; IntAct=EBI-10697767, EBI-990792;
CC       Q5SZD1; Q13148: TARDBP; NbExp=6; IntAct=EBI-10697767, EBI-372899;
CC   -!- SEQUENCE CAUTION:
CC       Sequence=AAH36917.1; Type=Erroneous initiation; Note=Extended N-terminus.; Evidence={ECO:0000305};
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DR   EMBL; AK054918; BAB70828.1; -; mRNA.
DR   EMBL; AK289889; BAF82578.1; -; mRNA.
DR   EMBL; AL590244; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; CH471081; EAX04335.1; -; Genomic_DNA.
DR   EMBL; BC036917; AAH36917.1; ALT_INIT; mRNA.
DR   CCDS; CCDS55018.1; -.
DR   RefSeq; NP_001139124.1; NM_001145652.1.
DR   RefSeq; XP_005248907.1; XM_005248850.3.
DR   RefSeq; XP_005248909.1; XM_005248852.2.
DR   RefSeq; XP_005248910.1; XM_005248853.2.
DR   RefSeq; XP_006715060.1; XM_006714997.2.
DR   RefSeq; XP_011512605.1; XM_011514303.2.
DR   RefSeq; XP_016865783.1; XM_017010294.1.
DR   RefSeq; XP_016865784.1; XM_017010295.1.
DR   RefSeq; XP_016865785.1; XM_017010296.1.
DR   RefSeq; XP_016865786.1; XM_017010297.1.
DR   RefSeq; XP_016865787.1; XM_017010298.1.
DR   AlphaFoldDB; Q5SZD1; -.
DR   BioGRID; 126429; 94.
DR   IntAct; Q5SZD1; 82.
DR   STRING; 9606.ENSP00000434602; -.
DR   iPTMnet; Q5SZD1; -.
DR   PhosphoSitePlus; Q5SZD1; -.
DR   BioMuta; C6orf141; -.
DR   DMDM; 317373454; -.
DR   jPOST; Q5SZD1; -.
DR   MassIVE; Q5SZD1; -.
DR   PaxDb; Q5SZD1; -.
DR   PeptideAtlas; Q5SZD1; -.
DR   PRIDE; Q5SZD1; -.
DR   ProteomicsDB; 64054; -.
DR   Antibodypedia; 65113; 36 antibodies from 11 providers.
DR   DNASU; 135398; -.
DR   Ensembl; ENST00000371194.7; ENSP00000431184.1; ENSG00000197261.12.
DR   Ensembl; ENST00000414696.5; ENSP00000436754.1; ENSG00000197261.12.
DR   Ensembl; ENST00000529246.4; ENSP00000434602.2; ENSG00000197261.12.
DR   GeneID; 135398; -.
DR   KEGG; hsa:135398; -.
DR   MANE-Select; ENST00000529246.4; ENSP00000434602.2; NM_001145652.2; NP_001139124.2.
DR   UCSC; uc011dwo.3; human.
DR   CTD; 135398; -.
DR   DisGeNET; 135398; -.
DR   GeneCards; C6orf141; -.
DR   HGNC; HGNC:21351; C6orf141.
DR   HPA; ENSG00000197261; Low tissue specificity.
DR   neXtProt; NX_Q5SZD1; -.
DR   OpenTargets; ENSG00000197261; -.
DR   PharmGKB; PA134885117; -.
DR   VEuPathDB; HostDB:ENSG00000197261; -.
DR   eggNOG; ENOG502SVK6; Eukaryota.
DR   GeneTree; ENSGT00390000007738; -.
DR   HOGENOM; CLU_099670_0_0_1; -.
DR   InParanoid; Q5SZD1; -.
DR   OMA; FQREKRI; -.
DR   OrthoDB; 1359414at2759; -.
DR   PhylomeDB; Q5SZD1; -.
DR   TreeFam; TF336881; -.
DR   PathwayCommons; Q5SZD1; -.
DR   SignaLink; Q5SZD1; -.
DR   BioGRID-ORCS; 135398; 9 hits in 1048 CRISPR screens.
DR   GenomeRNAi; 135398; -.
DR   Pharos; Q5SZD1; Tdark.
DR   PRO; PR:Q5SZD1; -.
DR   Proteomes; UP000005640; Chromosome 6.
DR   RNAct; Q5SZD1; protein.
DR   Bgee; ENSG00000197261; Expressed in gall bladder and 119 other tissues.
DR   ExpressionAtlas; Q5SZD1; baseline and differential.
DR   Genevisible; Q5SZD1; HS.
DR   InterPro; IPR037739; C6orf141.
DR   PANTHER; PTHR36880; PTHR36880; 1.
PE   1: Evidence at protein level;
KW   Reference proteome.
FT   CHAIN           1..244
FT                   /note="Uncharacterized protein C6orf141"
FT                   /id="PRO_0000089537"
FT   REGION          1..79
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          100..130
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          219..244
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        61..79
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        100..125
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   VARIANT         137
FT                   /note="Q -> E (in dbSNP:rs6919674)"
FT                   /evidence="ECO:0000269|PubMed:14574404,
FT                   ECO:0000269|PubMed:14702039, ECO:0000269|PubMed:15489334"
FT                   /id="VAR_022939"
FT   VARIANT         235
FT                   /note="P -> L (in dbSNP:rs9473588)"
FT                   /id="VAR_030643"
SQ   SEQUENCE   244 AA;  26754 MW;  B2EE557D7AE9FBF2 CRC64;
     MNDPFARMET RGPQGAANPM DSSRSLGDLG PFPREVGRGA PLAPGARNPA TAGASRSQGG
     GHEDRTADRA LGPRAGEELD RESWVREKVL FLLHPERWLG TRGDPAREEV AGAEDLPHAG
     GEDHGEEPNY PSVFQRQKRI SGRRVAPPRD AADPPKYVLV RVEDYQVTQE VLQTSWAKGR
     MTTRTEEHFV TALTFRSSRE GQPGERWGPA ESRALQARTG ASRVHAAGRR VSPSPGTWLE
     EIKL