CF132_MOUSE
ID CF132_MOUSE Reviewed; 1206 AA.
AC Q91Z58; Q8K108;
DT 26-FEB-2008, integrated into UniProtKB/Swiss-Prot.
DT 22-JUL-2008, sequence version 2.
DT 03-AUG-2022, entry version 97.
DE RecName: Full=Uncharacterized protein C6orf132 homolog;
OS Mus musculus (Mouse).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC Murinae; Mus; Mus.
OX NCBI_TaxID=10090;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=C57BL/6J;
RX PubMed=19468303; DOI=10.1371/journal.pbio.1000112;
RA Church D.M., Goodstadt L., Hillier L.W., Zody M.C., Goldstein S., She X.,
RA Bult C.J., Agarwala R., Cherry J.L., DiCuccio M., Hlavina W., Kapustin Y.,
RA Meric P., Maglott D., Birtle Z., Marques A.C., Graves T., Zhou S.,
RA Teague B., Potamousis K., Churas C., Place M., Herschleb J., Runnheim R.,
RA Forrest D., Amos-Landgraf J., Schwartz D.C., Cheng Z., Lindblad-Toh K.,
RA Eichler E.E., Ponting C.P.;
RT "Lineage-specific biology revealed by a finished genome assembly of the
RT mouse.";
RL PLoS Biol. 7:E1000112-E1000112(2009).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2), AND NUCLEOTIDE SEQUENCE
RP [LARGE SCALE MRNA] OF 1010-1206 (ISOFORM 1).
RC STRAIN=FVB/N; TISSUE=Liver, and Mammary tumor;
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RT "The status, quality, and expansion of the NIH full-length cDNA project:
RT the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
RN [3]
RP PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-255, AND IDENTIFICATION BY
RP MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
RC TISSUE=Kidney, and Lung;
RX PubMed=21183079; DOI=10.1016/j.cell.2010.12.001;
RA Huttlin E.L., Jedrychowski M.P., Elias J.E., Goswami T., Rad R.,
RA Beausoleil S.A., Villen J., Haas W., Sowa M.E., Gygi S.P.;
RT "A tissue-specific atlas of mouse protein phosphorylation and expression.";
RL Cell 143:1174-1189(2010).
RN [4]
RP METHYLATION [LARGE SCALE ANALYSIS] AT ARG-1051, AND IDENTIFICATION BY MASS
RP SPECTROMETRY [LARGE SCALE ANALYSIS].
RC TISSUE=Embryo;
RX PubMed=24129315; DOI=10.1074/mcp.o113.027870;
RA Guo A., Gu H., Zhou J., Mulhern D., Wang Y., Lee K.A., Yang V., Aguiar M.,
RA Kornhauser J., Jia X., Ren J., Beausoleil S.A., Silva J.C., Vemulapalli V.,
RA Bedford M.T., Comb M.J.;
RT "Immunoaffinity enrichment and mass spectrometry analysis of protein
RT methylation.";
RL Mol. Cell. Proteomics 13:372-387(2014).
CC -!- ALTERNATIVE PRODUCTS:
CC Event=Alternative splicing; Named isoforms=2;
CC Name=1;
CC IsoId=Q91Z58-1; Sequence=Displayed;
CC Name=2;
CC IsoId=Q91Z58-2; Sequence=VSP_034436, VSP_034437;
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DR EMBL; AC139214; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; BC006605; AAH06605.1; -; mRNA.
DR EMBL; BC029008; AAH29008.1; -; mRNA.
DR CCDS; CCDS50131.1; -. [Q91Z58-1]
DR RefSeq; NP_663464.2; NM_145489.2. [Q91Z58-1]
DR AlphaFoldDB; Q91Z58; -.
DR STRING; 10090.ENSMUSP00000120133; -.
DR iPTMnet; Q91Z58; -.
DR PhosphoSitePlus; Q91Z58; -.
DR MaxQB; Q91Z58; -.
DR PaxDb; Q91Z58; -.
DR PeptideAtlas; Q91Z58; -.
DR PRIDE; Q91Z58; -.
DR Antibodypedia; 52363; 40 antibodies from 9 providers.
DR DNASU; 224833; -.
DR Ensembl; ENSMUST00000037701; ENSMUSP00000045345; ENSMUSG00000034382. [Q91Z58-2]
DR Ensembl; ENSMUST00000150819; ENSMUSP00000120133; ENSMUSG00000034382. [Q91Z58-1]
DR GeneID; 224833; -.
DR KEGG; mmu:224833; -.
DR UCSC; uc008cvg.2; mouse. [Q91Z58-1]
DR MGI; MGI:2146908; AI661453.
DR VEuPathDB; HostDB:ENSMUSG00000034382; -.
DR eggNOG; ENOG502QQKX; Eukaryota.
DR GeneTree; ENSGT00940000163431; -.
DR HOGENOM; CLU_106116_1_0_1; -.
DR InParanoid; Q91Z58; -.
DR OMA; EVPCLYK; -.
DR OrthoDB; 580416at2759; -.
DR TreeFam; TF338477; -.
DR BioGRID-ORCS; 224833; 4 hits in 71 CRISPR screens.
DR PRO; PR:Q91Z58; -.
DR Proteomes; UP000000589; Chromosome 17.
DR RNAct; Q91Z58; protein.
DR Bgee; ENSMUSG00000034382; Expressed in lip and 122 other tissues.
DR Genevisible; Q91Z58; MM.
PE 1: Evidence at protein level;
KW Alternative splicing; Methylation; Phosphoprotein; Reference proteome.
FT CHAIN 1..1206
FT /note="Uncharacterized protein C6orf132 homolog"
FT /id="PRO_0000320613"
FT REGION 133..547
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 568..837
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 859..1206
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 136..236
FT /note="Pro residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 258..273
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 287..307
FT /note="Pro residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 382..417
FT /note="Pro residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 421..435
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 451..465
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 473..493
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 634..650
FT /note="Pro residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 667..683
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 689..707
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 720..734
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 750..768
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 808..822
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 863..899
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 915..946
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 971..985
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1023..1051
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1088..1102
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1171..1188
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT MOD_RES 255
FT /note="Phosphoserine"
FT /evidence="ECO:0007744|PubMed:21183079"
FT MOD_RES 680
FT /note="Phosphothreonine"
FT /evidence="ECO:0000250|UniProtKB:Q5T0Z8"
FT MOD_RES 1051
FT /note="Omega-N-methylarginine"
FT /evidence="ECO:0007744|PubMed:24129315"
FT MOD_RES 1083
FT /note="Omega-N-methylarginine"
FT /evidence="ECO:0000250|UniProtKB:Q5T0Z8"
FT MOD_RES 1094
FT /note="Omega-N-methylarginine"
FT /evidence="ECO:0000250|UniProtKB:Q5T0Z8"
FT VAR_SEQ 180..193
FT /note="EPPPPPSTAPPPPP -> GGRTRYYRSQLRHS (in isoform 2)"
FT /evidence="ECO:0000303|PubMed:15489334"
FT /id="VSP_034436"
FT VAR_SEQ 194..1206
FT /note="Missing (in isoform 2)"
FT /evidence="ECO:0000303|PubMed:15489334"
FT /id="VSP_034437"
SQ SEQUENCE 1206 AA; 127881 MW; 284786F24EAA9198 CRC64;
MKKNQTMQGT FSKLFGKKHA HPSTTSLYAT NPPWIFTHEA QEEGTRDFDG IYYGDNRFNT
VSESGTATLK ARPRVRPLLT FIPLNAQENH GLAVPTPSVP EDFADKEVGG TSTLVNGNLR
LYSSVGDLRP ACYDLDSSIP PPPPGPAPGP PQDISQPPGE SPPPPPPSVP PPPPPPLLVE
PPPPPSTAPP PPPPLDILSP PSTPTPPDFI PPAPPSAFLS PPPPSLPAPG PPAPVSLHTP
GTHLFPPGAI TKWKSEVALN GRHPEDPRTS PPKSPAELKR SPLGPSPEPH LTFPRSPKVP
PPTPVRTSSI PVQEAPGASP EEEEATQKTS APSPLPPSFN IRPASQIYPD RALEPEQPRE
PRPETPGSPR LRQSEPQTNG QAGAPPPAPP LPPPAPPLPP PAPSLPPAAP PLPSTELAAP
PSSGFMKTSK SNSPALKPKP KPPSVEDTAS SEPVDWRDPR QMEKLRSELS AYLCGTRKED
RSLSHRPGPT VALKDKENNK GTSLSEEAAP PSLPEKVHPC IPEKSPSSSS LPEREATSSL
VLPPVDYIAQ DTPAPSVRQI RSELEARFAS SAEKEAKPSL ASLPPKPRLE GGRTFENGTD
NGRFHKPATK NPPQPSTTPL PTTILQPKVV PGPATSPKVT PGPATPFKPT PGQAILPKAT
PGLTLPLKPT PEQTTSPKNT PGKATPLKDT PGQATTPKDT PGQDTPPKDT PGQAAVLKNA
PELSTPSSQL MAEKDLASVR QREKPETQED PVATQLSTNG TLSPPALPPK MSTSGEEAPF
LYRPHRSQNS HSRGVAVVTP TRARGEAPDS GDVVDEKELQ NHPAKSLTPG QPADQLLRHP
VTGEVVERGS PMALLLAARQ RAQKTRTGGT AIGRSSLPGS LRDHSNQPEA SSDSIFYRGS
RPNSFIVVPK VPSETEDSHL TSARPTGPSH WKPQQGPDTQ GSEPTYRHGW TKAETPAPVA
RERPAPSSLP QSRALPKSFS SPPSPSYKRE EEEEEFSFDI IPPPPEFSND PEPPAPGQQH
QGRRGSPPRN NFSDLGQSWG PNPTPGFSRF RGTQYPESGG LDRFSGSGRS LIKKRLYVGE
SHRNPGMPRG STGRSLSSPN CFGPQPGGPE MRRVNSAGRA APGGLHARRL SLEGARGATE
VKFKAPGGGG GSSSKAGDYG FVPAKGSRSP HGNTHYGSPI NTFTVRPGTR HPISYAYPGT
HRKATS
