CF107_HUMAN
ID CF107_HUMAN Reviewed; 194 AA.
AC Q8N1D5; Q5VUY4;
DT 25-JUL-2006, integrated into UniProtKB/Swiss-Prot.
DT 23-FEB-2022, sequence version 3.
DT 03-AUG-2022, entry version 116.
DE RecName: Full=Cilia- and flagella-associated protein 107 {ECO:0000312|HGNC:HGNC:28567};
GN Name=CFAP107 {ECO:0000312|HGNC:HGNC:28567};
GN Synonyms=C1orf158 {ECO:0000312|HGNC:HGNC:28567};
OS Homo sapiens (Human).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC Homo.
OX NCBI_TaxID=9606;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=16710414; DOI=10.1038/nature04727;
RA Gregory S.G., Barlow K.F., McLay K.E., Kaul R., Swarbreck D., Dunham A.,
RA Scott C.E., Howe K.L., Woodfine K., Spencer C.C.A., Jones M.C., Gillson C.,
RA Searle S., Zhou Y., Kokocinski F., McDonald L., Evans R., Phillips K.,
RA Atkinson A., Cooper R., Jones C., Hall R.E., Andrews T.D., Lloyd C.,
RA Ainscough R., Almeida J.P., Ambrose K.D., Anderson F., Andrew R.W.,
RA Ashwell R.I.S., Aubin K., Babbage A.K., Bagguley C.L., Bailey J.,
RA Beasley H., Bethel G., Bird C.P., Bray-Allen S., Brown J.Y., Brown A.J.,
RA Buckley D., Burton J., Bye J., Carder C., Chapman J.C., Clark S.Y.,
RA Clarke G., Clee C., Cobley V., Collier R.E., Corby N., Coville G.J.,
RA Davies J., Deadman R., Dunn M., Earthrowl M., Ellington A.G., Errington H.,
RA Frankish A., Frankland J., French L., Garner P., Garnett J., Gay L.,
RA Ghori M.R.J., Gibson R., Gilby L.M., Gillett W., Glithero R.J.,
RA Grafham D.V., Griffiths C., Griffiths-Jones S., Grocock R., Hammond S.,
RA Harrison E.S.I., Hart E., Haugen E., Heath P.D., Holmes S., Holt K.,
RA Howden P.J., Hunt A.R., Hunt S.E., Hunter G., Isherwood J., James R.,
RA Johnson C., Johnson D., Joy A., Kay M., Kershaw J.K., Kibukawa M.,
RA Kimberley A.M., King A., Knights A.J., Lad H., Laird G., Lawlor S.,
RA Leongamornlert D.A., Lloyd D.M., Loveland J., Lovell J., Lush M.J.,
RA Lyne R., Martin S., Mashreghi-Mohammadi M., Matthews L., Matthews N.S.W.,
RA McLaren S., Milne S., Mistry S., Moore M.J.F., Nickerson T., O'Dell C.N.,
RA Oliver K., Palmeiri A., Palmer S.A., Parker A., Patel D., Pearce A.V.,
RA Peck A.I., Pelan S., Phelps K., Phillimore B.J., Plumb R., Rajan J.,
RA Raymond C., Rouse G., Saenphimmachak C., Sehra H.K., Sheridan E.,
RA Shownkeen R., Sims S., Skuce C.D., Smith M., Steward C., Subramanian S.,
RA Sycamore N., Tracey A., Tromans A., Van Helmond Z., Wall M., Wallis J.M.,
RA White S., Whitehead S.L., Wilkinson J.E., Willey D.L., Williams H.,
RA Wilming L., Wray P.W., Wu Z., Coulson A., Vaudin M., Sulston J.E.,
RA Durbin R.M., Hubbard T., Wooster R., Dunham I., Carter N.P., McVean G.,
RA Ross M.T., Harrow J., Olson M.V., Beck S., Rogers J., Bentley D.R.;
RT "The DNA sequence and biological annotation of human chromosome 1.";
RL Nature 441:315-321(2006).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC TISSUE=Brain;
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RT "The status, quality, and expansion of the NIH full-length cDNA project:
RT the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
CC -!- FUNCTION: Microtubule inner protein (MIP) part of the dynein-decorated
CC doublet microtubules (DMTs) in cilia axoneme, which is required for
CC motile cilia beating. {ECO:0000250|UniProtKB:Q2TA11}.
CC -!- SUBCELLULAR LOCATION: Cytoplasm, cytoskeleton, cilium axoneme
CC {ECO:0000250|UniProtKB:Q2TA11}.
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DR EMBL; AL513016; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; BC029894; AAH29894.1; -; mRNA.
DR CCDS; CCDS147.1; -.
DR RefSeq; NP_689503.3; NM_152290.3.
DR AlphaFoldDB; Q8N1D5; -.
DR BioGRID; 125012; 15.
DR STRING; 9606.ENSP00000477802; -.
DR iPTMnet; Q8N1D5; -.
DR PhosphoSitePlus; Q8N1D5; -.
DR BioMuta; C1orf158; -.
DR MassIVE; Q8N1D5; -.
DR PaxDb; Q8N1D5; -.
DR PeptideAtlas; Q8N1D5; -.
DR PRIDE; Q8N1D5; -.
DR Antibodypedia; 28545; 48 antibodies from 12 providers.
DR DNASU; 93190; -.
DR Ensembl; ENST00000614859.5; ENSP00000477802.1; ENSG00000157330.10.
DR GeneID; 93190; -.
DR KEGG; hsa:93190; -.
DR MANE-Select; ENST00000614859.5; ENSP00000477802.1; NM_152290.4; NP_689503.3.
DR UCSC; uc001auh.4; human.
DR CTD; 93190; -.
DR GeneCards; C1orf158; -.
DR HGNC; HGNC:28567; CFAP107.
DR HPA; ENSG00000157330; Group enriched (choroid plexus, fallopian tube, testis).
DR neXtProt; NX_Q8N1D5; -.
DR OpenTargets; ENSG00000157330; -.
DR VEuPathDB; HostDB:ENSG00000157330; -.
DR eggNOG; ENOG502RZRC; Eukaryota.
DR GeneTree; ENSGT00390000014553; -.
DR InParanoid; Q8N1D5; -.
DR OrthoDB; 1255878at2759; -.
DR PhylomeDB; Q8N1D5; -.
DR TreeFam; TF328903; -.
DR PathwayCommons; Q8N1D5; -.
DR BioGRID-ORCS; 93190; 12 hits in 1040 CRISPR screens.
DR GenomeRNAi; 93190; -.
DR Pharos; Q8N1D5; Tdark.
DR PRO; PR:Q8N1D5; -.
DR Proteomes; UP000005640; Chromosome 1.
DR RNAct; Q8N1D5; protein.
DR Bgee; ENSG00000157330; Expressed in right uterine tube and 76 other tissues.
DR ExpressionAtlas; Q8N1D5; baseline and differential.
DR Genevisible; Q8N1D5; HS.
DR GO; GO:0005879; C:axonemal microtubule; ISS:UniProtKB.
DR InterPro; IPR037662; CFAP107.
DR PANTHER; PTHR31180; PTHR31180; 1.
PE 2: Evidence at transcript level;
KW Cell projection; Cytoplasm; Cytoskeleton; Reference proteome.
FT CHAIN 1..194
FT /note="Cilia- and flagella-associated protein 107"
FT /id="PRO_0000247260"
SQ SEQUENCE 194 AA; 23033 MW; 234715695C85238F CRC64;
MFLTAVNPQP LSTPSWQIET KYSTKVLTGN WMEERRKFTR DTDKTPQSIY RKEYIPFPDH
RPDQISRWYG KRKVEGLPYK HLITHHQEPP HRYLISTYDD HYNRHGYNPG LPPLRTWNGQ
KLLWLPEKSD FPLLAPPTNY GLYEQLKQRQ LTPKAGLKQS TYTSSYPRPP LCAMSWREHA
VPVPPHRLHP LPHF
