CF062_HUMAN
ID CF062_HUMAN Reviewed; 229 AA.
AC Q9GZU0; Q3LIB6; Q5JVZ2; Q5JVZ3; Q6IA63; Q9H1Z2;
DT 16-MAY-2003, integrated into UniProtKB/Swiss-Prot.
DT 01-MAR-2001, sequence version 1.
DT 03-AUG-2022, entry version 138.
DE RecName: Full=Uncharacterized protein C6orf62;
DE AltName: Full=HBV X-transactivated gene 12 protein;
DE AltName: Full=HBV XAg-transactivated protein 12;
GN Name=C6orf62; Synonyms=XTP12; ORFNames=Nbla00237;
OS Homo sapiens (Human).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC Homo.
OX NCBI_TaxID=9606;
RN [1]
RP NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1).
RA Gong M., Cheng J., Ji D., Liu Y., Guo J.;
RT "Screening and cloning of the target genes transactivated by hepatitis B
RT virus X protein by microarray assay.";
RL Submitted (APR-2004) to the EMBL/GenBank/DDBJ databases.
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
RC TISSUE=Brain;
RX PubMed=11230166; DOI=10.1101/gr.gr1547r;
RA Wiemann S., Weil B., Wellenreuther R., Gassenhuber J., Glassl S.,
RA Ansorge W., Boecher M., Bloecker H., Bauersachs S., Blum H., Lauber J.,
RA Duesterhoeft A., Beyer A., Koehrer K., Strack N., Mewes H.-W.,
RA Ottenwaelder B., Obermaier B., Tampe J., Heubner D., Wambutt R., Korn B.,
RA Klein M., Poustka A.;
RT "Towards a catalog of human genes and proteins: sequencing and analysis of
RT 500 novel complete protein coding human cDNAs.";
RL Genome Res. 11:422-435(2001).
RN [3]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
RC TISSUE=Neuroblastoma;
RX PubMed=12880961; DOI=10.1016/s0304-3835(03)00085-5;
RA Ohira M., Morohashi A., Nakamura Y., Isogai E., Furuya K., Hamano S.,
RA Machida T., Aoyama M., Fukumura M., Miyazaki K., Suzuki Y., Sugano S.,
RA Hirato J., Nakagawara A.;
RT "Neuroblastoma oligo-capping cDNA project: toward the understanding of the
RT genesis and biology of neuroblastoma.";
RL Cancer Lett. 197:63-68(2003).
RN [4]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
RX PubMed=14702039; DOI=10.1038/ng1285;
RA Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R.,
RA Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H.,
RA Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.,
RA Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K.,
RA Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H.,
RA Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M.,
RA Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K.,
RA Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T.,
RA Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M.,
RA Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S.,
RA Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H.,
RA Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K.,
RA Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N.,
RA Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S.,
RA Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O.,
RA Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H.,
RA Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B.,
RA Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y.,
RA Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K.,
RA Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T.,
RA Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T.,
RA Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y.,
RA Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H.,
RA Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y.,
RA Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H.,
RA Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O.,
RA Isogai T., Sugano S.;
RT "Complete sequencing and characterization of 21,243 full-length human
RT cDNAs.";
RL Nat. Genet. 36:40-45(2004).
RN [5]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
RA Ebert L., Schick M., Neubert P., Schatten R., Henze S., Korn B.;
RT "Cloning of human full open reading frames in Gateway(TM) system entry
RT vector (pDONR201).";
RL Submitted (JUN-2004) to the EMBL/GenBank/DDBJ databases.
RN [6]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=14574404; DOI=10.1038/nature02055;
RA Mungall A.J., Palmer S.A., Sims S.K., Edwards C.A., Ashurst J.L.,
RA Wilming L., Jones M.C., Horton R., Hunt S.E., Scott C.E., Gilbert J.G.R.,
RA Clamp M.E., Bethel G., Milne S., Ainscough R., Almeida J.P., Ambrose K.D.,
RA Andrews T.D., Ashwell R.I.S., Babbage A.K., Bagguley C.L., Bailey J.,
RA Banerjee R., Barker D.J., Barlow K.F., Bates K., Beare D.M., Beasley H.,
RA Beasley O., Bird C.P., Blakey S.E., Bray-Allen S., Brook J., Brown A.J.,
RA Brown J.Y., Burford D.C., Burrill W., Burton J., Carder C., Carter N.P.,
RA Chapman J.C., Clark S.Y., Clark G., Clee C.M., Clegg S., Cobley V.,
RA Collier R.E., Collins J.E., Colman L.K., Corby N.R., Coville G.J.,
RA Culley K.M., Dhami P., Davies J., Dunn M., Earthrowl M.E., Ellington A.E.,
RA Evans K.A., Faulkner L., Francis M.D., Frankish A., Frankland J.,
RA French L., Garner P., Garnett J., Ghori M.J., Gilby L.M., Gillson C.J.,
RA Glithero R.J., Grafham D.V., Grant M., Gribble S., Griffiths C.,
RA Griffiths M.N.D., Hall R., Halls K.S., Hammond S., Harley J.L., Hart E.A.,
RA Heath P.D., Heathcott R., Holmes S.J., Howden P.J., Howe K.L., Howell G.R.,
RA Huckle E., Humphray S.J., Humphries M.D., Hunt A.R., Johnson C.M.,
RA Joy A.A., Kay M., Keenan S.J., Kimberley A.M., King A., Laird G.K.,
RA Langford C., Lawlor S., Leongamornlert D.A., Leversha M., Lloyd C.R.,
RA Lloyd D.M., Loveland J.E., Lovell J., Martin S., Mashreghi-Mohammadi M.,
RA Maslen G.L., Matthews L., McCann O.T., McLaren S.J., McLay K., McMurray A.,
RA Moore M.J.F., Mullikin J.C., Niblett D., Nickerson T., Novik K.L.,
RA Oliver K., Overton-Larty E.K., Parker A., Patel R., Pearce A.V., Peck A.I.,
RA Phillimore B.J.C.T., Phillips S., Plumb R.W., Porter K.M., Ramsey Y.,
RA Ranby S.A., Rice C.M., Ross M.T., Searle S.M., Sehra H.K., Sheridan E.,
RA Skuce C.D., Smith S., Smith M., Spraggon L., Squares S.L., Steward C.A.,
RA Sycamore N., Tamlyn-Hall G., Tester J., Theaker A.J., Thomas D.W.,
RA Thorpe A., Tracey A., Tromans A., Tubby B., Wall M., Wallis J.M.,
RA West A.P., White S.S., Whitehead S.L., Whittaker H., Wild A., Willey D.J.,
RA Wilmer T.E., Wood J.M., Wray P.W., Wyatt J.C., Young L., Younger R.M.,
RA Bentley D.R., Coulson A., Durbin R.M., Hubbard T., Sulston J.E., Dunham I.,
RA Rogers J., Beck S.;
RT "The DNA sequence and analysis of human chromosome 6.";
RL Nature 425:805-811(2003).
RN [7]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RA Mural R.J., Istrail S., Sutton G.G., Florea L., Halpern A.L., Mobarry C.M.,
RA Lippert R., Walenz B., Shatkay H., Dew I., Miller J.R., Flanigan M.J.,
RA Edwards N.J., Bolanos R., Fasulo D., Halldorsson B.V., Hannenhalli S.,
RA Turner R., Yooseph S., Lu F., Nusskern D.R., Shue B.C., Zheng X.H.,
RA Zhong F., Delcher A.L., Huson D.H., Kravitz S.A., Mouchard L., Reinert K.,
RA Remington K.A., Clark A.G., Waterman M.S., Eichler E.E., Adams M.D.,
RA Hunkapiller M.W., Myers E.W., Venter J.C.;
RL Submitted (JUL-2005) to the EMBL/GenBank/DDBJ databases.
RN [8]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
RC TISSUE=Uterus;
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RT "The status, quality, and expansion of the NIH full-length cDNA project:
RT the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
CC -!- ALTERNATIVE PRODUCTS:
CC Event=Alternative splicing; Named isoforms=2;
CC Name=1;
CC IsoId=Q9GZU0-1; Sequence=Displayed;
CC Name=2;
CC IsoId=Q9GZU0-2; Sequence=VSP_015616, VSP_015617;
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DR EMBL; AY598792; AAT09203.1; -; mRNA.
DR EMBL; AL136632; CAB66567.1; -; mRNA.
DR EMBL; AB075502; BAE45752.1; -; mRNA.
DR EMBL; AK022681; BAB14175.1; -; mRNA.
DR EMBL; CR533486; CAG38517.1; -; mRNA.
DR EMBL; CR457292; CAG33573.1; -; mRNA.
DR EMBL; AL031775; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AL133264; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; CH471087; EAW55461.1; -; Genomic_DNA.
DR EMBL; BC047866; AAH47866.1; -; mRNA.
DR CCDS; CCDS4559.1; -. [Q9GZU0-1]
DR RefSeq; NP_112201.1; NM_030939.4. [Q9GZU0-1]
DR RefSeq; XP_011513230.1; XM_011514928.2. [Q9GZU0-2]
DR AlphaFoldDB; Q9GZU0; -.
DR BioGRID; 123568; 18.
DR IntAct; Q9GZU0; 2.
DR STRING; 9606.ENSP00000367359; -.
DR iPTMnet; Q9GZU0; -.
DR PhosphoSitePlus; Q9GZU0; -.
DR BioMuta; C6orf62; -.
DR DMDM; 30912736; -.
DR EPD; Q9GZU0; -.
DR MassIVE; Q9GZU0; -.
DR MaxQB; Q9GZU0; -.
DR PaxDb; Q9GZU0; -.
DR PeptideAtlas; Q9GZU0; -.
DR PRIDE; Q9GZU0; -.
DR ProteomicsDB; 80141; -. [Q9GZU0-1]
DR ProteomicsDB; 80142; -. [Q9GZU0-2]
DR Antibodypedia; 25335; 135 antibodies from 15 providers.
DR DNASU; 81688; -.
DR Ensembl; ENST00000378102.3; ENSP00000367342.3; ENSG00000112308.13. [Q9GZU0-2]
DR Ensembl; ENST00000378119.9; ENSP00000367359.4; ENSG00000112308.13. [Q9GZU0-1]
DR GeneID; 81688; -.
DR KEGG; hsa:81688; -.
DR MANE-Select; ENST00000378119.9; ENSP00000367359.4; NM_030939.5; NP_112201.1.
DR UCSC; uc003nel.5; human. [Q9GZU0-1]
DR CTD; 81688; -.
DR GeneCards; C6orf62; -.
DR HGNC; HGNC:20998; C6orf62.
DR HPA; ENSG00000112308; Low tissue specificity.
DR neXtProt; NX_Q9GZU0; -.
DR OpenTargets; ENSG00000112308; -.
DR PharmGKB; PA134946342; -.
DR VEuPathDB; HostDB:ENSG00000112308; -.
DR eggNOG; ENOG502QQ5Z; Eukaryota.
DR GeneTree; ENSGT00390000008115; -.
DR HOGENOM; CLU_105473_0_0_1; -.
DR InParanoid; Q9GZU0; -.
DR OMA; QDQLTHW; -.
DR PhylomeDB; Q9GZU0; -.
DR TreeFam; TF329480; -.
DR PathwayCommons; Q9GZU0; -.
DR SignaLink; Q9GZU0; -.
DR BioGRID-ORCS; 81688; 20 hits in 1054 CRISPR screens.
DR ChiTaRS; C6orf62; human.
DR GenomeRNAi; 81688; -.
DR Pharos; Q9GZU0; Tdark.
DR PRO; PR:Q9GZU0; -.
DR Proteomes; UP000005640; Chromosome 6.
DR RNAct; Q9GZU0; protein.
DR Bgee; ENSG00000112308; Expressed in pylorus and 207 other tissues.
DR ExpressionAtlas; Q9GZU0; baseline and differential.
DR Genevisible; Q9GZU0; HS.
DR InterPro; IPR027903; DUF4566.
DR PANTHER; PTHR28336; PTHR28336; 1.
DR Pfam; PF15130; DUF4566; 1.
PE 2: Evidence at transcript level;
KW Alternative splicing; Reference proteome.
FT CHAIN 1..229
FT /note="Uncharacterized protein C6orf62"
FT /id="PRO_0000089514"
FT VAR_SEQ 1..29
FT /note="Missing (in isoform 2)"
FT /evidence="ECO:0000305"
FT /id="VSP_015616"
FT VAR_SEQ 30..43
FT /note="FDFKMYIAFVFKEK -> MSENLSDPVSPVVR (in isoform 2)"
FT /evidence="ECO:0000305"
FT /id="VSP_015617"
FT VARIANT 116
FT /note="W -> C (in dbSNP:rs34238213)"
FT /id="VAR_050803"
FT VARIANT 140
FT /note="R -> S (in dbSNP:rs35050510)"
FT /id="VAR_050804"
FT CONFLICT 229
FT /note="E -> D (in Ref. 5; CAG33573)"
FT /evidence="ECO:0000305"
SQ SEQUENCE 229 AA; 27083 MW; 816716AD3837FAB9 CRC64;
MGDPNSRKKQ ALNRLRAQLR KKKESLADQF DFKMYIAFVF KEKKKKSALF EVSEVIPVMT
NNYEENILKG VRDSSYSLES SLELLQKDVV QLHAPRYQSM RRDVIGCTQE MDFILWPRND
IEKIVCLLFS RWKESDEPFR PVQAKFEFHH GDYEKQFLHV LSRKDKTGIV VNNPNQSVFL
FIDRQHLQTP KNKATIFKLC SICLYLPQEQ LTHWAVGTIE DHLRPYMPE
