CF047_HUMAN
ID CF047_HUMAN Reviewed; 294 AA.
AC O95873; B0UXA1; B0UZ50; Q5SSS6; Q95IG0;
DT 19-JUL-2005, integrated into UniProtKB/Swiss-Prot.
DT 11-JAN-2011, sequence version 2.
DT 03-AUG-2022, entry version 148.
DE RecName: Full=Uncharacterized protein C6orf47;
DE AltName: Full=Protein G4;
GN Name=C6orf47; Synonyms=G4;
OS Homo sapiens (Human).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC Homo.
OX NCBI_TaxID=9606;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA], AND VARIANT ARG-68.
RX PubMed=14656967; DOI=10.1101/gr.1736803;
RA Xie T., Rowen L., Aguado B., Ahearn M.E., Madan A., Qin S., Campbell R.D.,
RA Hood L.;
RT "Analysis of the gene-dense major histocompatibility complex class III
RT region and its comparison to mouse.";
RL Genome Res. 13:2621-2636(2003).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA], AND VARIANT ARG-68.
RA Shiina S., Tamiya G., Oka A., Inoko H.;
RT "Homo sapiens 2,229,817bp genomic DNA of 6p21.3 HLA class I region.";
RL Submitted (SEP-1999) to the EMBL/GenBank/DDBJ databases.
RN [3]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA], AND VARIANT ARG-68.
RX PubMed=14574404; DOI=10.1038/nature02055;
RA Mungall A.J., Palmer S.A., Sims S.K., Edwards C.A., Ashurst J.L.,
RA Wilming L., Jones M.C., Horton R., Hunt S.E., Scott C.E., Gilbert J.G.R.,
RA Clamp M.E., Bethel G., Milne S., Ainscough R., Almeida J.P., Ambrose K.D.,
RA Andrews T.D., Ashwell R.I.S., Babbage A.K., Bagguley C.L., Bailey J.,
RA Banerjee R., Barker D.J., Barlow K.F., Bates K., Beare D.M., Beasley H.,
RA Beasley O., Bird C.P., Blakey S.E., Bray-Allen S., Brook J., Brown A.J.,
RA Brown J.Y., Burford D.C., Burrill W., Burton J., Carder C., Carter N.P.,
RA Chapman J.C., Clark S.Y., Clark G., Clee C.M., Clegg S., Cobley V.,
RA Collier R.E., Collins J.E., Colman L.K., Corby N.R., Coville G.J.,
RA Culley K.M., Dhami P., Davies J., Dunn M., Earthrowl M.E., Ellington A.E.,
RA Evans K.A., Faulkner L., Francis M.D., Frankish A., Frankland J.,
RA French L., Garner P., Garnett J., Ghori M.J., Gilby L.M., Gillson C.J.,
RA Glithero R.J., Grafham D.V., Grant M., Gribble S., Griffiths C.,
RA Griffiths M.N.D., Hall R., Halls K.S., Hammond S., Harley J.L., Hart E.A.,
RA Heath P.D., Heathcott R., Holmes S.J., Howden P.J., Howe K.L., Howell G.R.,
RA Huckle E., Humphray S.J., Humphries M.D., Hunt A.R., Johnson C.M.,
RA Joy A.A., Kay M., Keenan S.J., Kimberley A.M., King A., Laird G.K.,
RA Langford C., Lawlor S., Leongamornlert D.A., Leversha M., Lloyd C.R.,
RA Lloyd D.M., Loveland J.E., Lovell J., Martin S., Mashreghi-Mohammadi M.,
RA Maslen G.L., Matthews L., McCann O.T., McLaren S.J., McLay K., McMurray A.,
RA Moore M.J.F., Mullikin J.C., Niblett D., Nickerson T., Novik K.L.,
RA Oliver K., Overton-Larty E.K., Parker A., Patel R., Pearce A.V., Peck A.I.,
RA Phillimore B.J.C.T., Phillips S., Plumb R.W., Porter K.M., Ramsey Y.,
RA Ranby S.A., Rice C.M., Ross M.T., Searle S.M., Sehra H.K., Sheridan E.,
RA Skuce C.D., Smith S., Smith M., Spraggon L., Squares S.L., Steward C.A.,
RA Sycamore N., Tamlyn-Hall G., Tester J., Theaker A.J., Thomas D.W.,
RA Thorpe A., Tracey A., Tromans A., Tubby B., Wall M., Wallis J.M.,
RA West A.P., White S.S., Whitehead S.L., Whittaker H., Wild A., Willey D.J.,
RA Wilmer T.E., Wood J.M., Wray P.W., Wyatt J.C., Young L., Younger R.M.,
RA Bentley D.R., Coulson A., Durbin R.M., Hubbard T., Sulston J.E., Dunham I.,
RA Rogers J., Beck S.;
RT "The DNA sequence and analysis of human chromosome 6.";
RL Nature 425:805-811(2003).
RN [4]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA], AND VARIANT ARG-68.
RA Mural R.J., Istrail S., Sutton G.G., Florea L., Halpern A.L., Mobarry C.M.,
RA Lippert R., Walenz B., Shatkay H., Dew I., Miller J.R., Flanigan M.J.,
RA Edwards N.J., Bolanos R., Fasulo D., Halldorsson B.V., Hannenhalli S.,
RA Turner R., Yooseph S., Lu F., Nusskern D.R., Shue B.C., Zheng X.H.,
RA Zhong F., Delcher A.L., Huson D.H., Kravitz S.A., Mouchard L., Reinert K.,
RA Remington K.A., Clark A.G., Waterman M.S., Eichler E.E., Adams M.D.,
RA Hunkapiller M.W., Myers E.W., Venter J.C.;
RL Submitted (JUL-2005) to the EMBL/GenBank/DDBJ databases.
RN [5]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA], AND VARIANT ARG-68.
RC TISSUE=Eye;
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RT "The status, quality, and expansion of the NIH full-length cDNA project:
RT the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
RN [6]
RP PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-71 AND SER-90, AND
RP IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
RC TISSUE=Erythroleukemia;
RX PubMed=23186163; DOI=10.1021/pr300630k;
RA Zhou H., Di Palma S., Preisinger C., Peng M., Polat A.N., Heck A.J.,
RA Mohammed S.;
RT "Toward a comprehensive characterization of a human cancer cell
RT phosphoproteome.";
RL J. Proteome Res. 12:260-271(2013).
CC -!- INTERACTION:
CC O95873; Q5EB52: MEST; NbExp=3; IntAct=EBI-719613, EBI-1050204;
CC O95873; Q9UI14: RABAC1; NbExp=3; IntAct=EBI-719613, EBI-712367;
CC O95873; Q9Y6D0: SELENOK; NbExp=3; IntAct=EBI-719613, EBI-9679163;
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DR EMBL; AF129756; AAD18083.1; -; Genomic_DNA.
DR EMBL; BA000025; BAB63388.1; -; Genomic_DNA.
DR EMBL; AL662801; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AL662899; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AL670886; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AL805934; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; BX511262; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; CR753842; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; CR354443; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; CR759761; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; CH471081; EAX03465.1; -; Genomic_DNA.
DR EMBL; BC012950; AAH12950.1; -; mRNA.
DR CCDS; CCDS34399.1; -.
DR RefSeq; NP_067007.3; NM_021184.3.
DR AlphaFoldDB; O95873; -.
DR BioGRID; 121786; 79.
DR IntAct; O95873; 8.
DR STRING; 9606.ENSP00000365076; -.
DR iPTMnet; O95873; -.
DR PhosphoSitePlus; O95873; -.
DR BioMuta; C6orf47; -.
DR EPD; O95873; -.
DR jPOST; O95873; -.
DR MassIVE; O95873; -.
DR MaxQB; O95873; -.
DR PaxDb; O95873; -.
DR PeptideAtlas; O95873; -.
DR PRIDE; O95873; -.
DR ProteomicsDB; 51113; -.
DR Antibodypedia; 49928; 16 antibodies from 8 providers.
DR DNASU; 57827; -.
DR Ensembl; ENST00000366431.2; ENSP00000375392.1; ENSG00000235360.2.
DR Ensembl; ENST00000366432.2; ENSP00000375400.1; ENSG00000203623.4.
DR Ensembl; ENST00000375911.2; ENSP00000365076.1; ENSG00000204439.4.
DR Ensembl; ENST00000413113.1; ENSP00000395128.1; ENSG00000226103.2.
DR Ensembl; ENST00000418357.1; ENSP00000398221.1; ENSG00000226531.2.
DR Ensembl; ENST00000431256.1; ENSP00000406870.1; ENSG00000228435.2.
DR Ensembl; ENST00000442972.1; ENSP00000407188.1; ENSG00000228177.2.
DR GeneID; 57827; -.
DR KEGG; hsa:57827; -.
DR MANE-Select; ENST00000375911.2; ENSP00000365076.1; NM_021184.4; NP_067007.3.
DR UCSC; uc003nvm.1; human.
DR CTD; 57827; -.
DR DisGeNET; 57827; -.
DR GeneCards; C6orf47; -.
DR HGNC; HGNC:19076; C6orf47.
DR HPA; ENSG00000204439; Low tissue specificity.
DR neXtProt; NX_O95873; -.
DR OpenTargets; ENSG00000204439; -.
DR PharmGKB; PA38785; -.
DR VEuPathDB; HostDB:ENSG00000204439; -.
DR eggNOG; ENOG502SNQC; Eukaryota.
DR GeneTree; ENSGT00390000009270; -.
DR HOGENOM; CLU_081876_0_0_1; -.
DR InParanoid; O95873; -.
DR OMA; PETMGDV; -.
DR OrthoDB; 1410459at2759; -.
DR PhylomeDB; O95873; -.
DR TreeFam; TF339331; -.
DR PathwayCommons; O95873; -.
DR SignaLink; O95873; -.
DR BioGRID-ORCS; 57827; 20 hits in 1058 CRISPR screens.
DR GenomeRNAi; 57827; -.
DR Pharos; O95873; Tdark.
DR PRO; PR:O95873; -.
DR Proteomes; UP000005640; Chromosome 6.
DR RNAct; O95873; protein.
DR Bgee; ENSG00000204439; Expressed in granulocyte and 97 other tissues.
DR ExpressionAtlas; O95873; baseline and differential.
DR Genevisible; O95873; HS.
DR InterPro; IPR029073; DUF4661.
DR PANTHER; PTHR14307; PTHR14307; 1.
DR Pfam; PF15576; DUF4661; 1.
PE 1: Evidence at protein level;
KW Phosphoprotein; Reference proteome.
FT CHAIN 1..294
FT /note="Uncharacterized protein C6orf47"
FT /id="PRO_0000089504"
FT REGION 1..148
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 268..294
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 16..30
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 92..106
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT MOD_RES 34
FT /note="Phosphoserine"
FT /evidence="ECO:0000250|UniProtKB:Q6MG51"
FT MOD_RES 35
FT /note="Phosphoserine"
FT /evidence="ECO:0000250|UniProtKB:Q6MG51"
FT MOD_RES 71
FT /note="Phosphoserine"
FT /evidence="ECO:0007744|PubMed:23186163"
FT MOD_RES 90
FT /note="Phosphoserine"
FT /evidence="ECO:0007744|PubMed:23186163"
FT VARIANT 68
FT /note="G -> R (in dbSNP:rs3130617)"
FT /evidence="ECO:0000269|PubMed:14574404,
FT ECO:0000269|PubMed:14656967, ECO:0000269|PubMed:15489334,
FT ECO:0000269|Ref.2, ECO:0000269|Ref.4"
FT /id="VAR_022911"
FT VARIANT 92
FT /note="K -> N (in dbSNP:rs2242655)"
FT /id="VAR_056797"
SQ SEQUENCE 294 AA; 31710 MW; 59ACE578FB60284D CRC64;
MFLRRLGGWL PRPWGRRKPM RPDPPYPEPR RVDSSSENSG SDWDSAPETM EDVGHPKTKD
SGALRVSGAA SEPSKEEPQV EQLGSKRMDS LKWDQPISST QESGRLEAGG ASPKLRWDHV
DSGGTRRPGV SPEGGLSVPG PGAPLEKPGR REKLLGWLRG EPGAPSRYLG GPEECLQIST
NLTLHLLELL ASALLALCSR PLRAALDTLG LRGPLGLWLH GLLSFLAALH GLHAVLSLLT
AHPLHFACLF GLLQALVLAV SLREPNGDEA ATDWESEGLE REGEEQRGDP GKGL
