CENPL_SCHPO
ID CENPL_SCHPO Reviewed; 280 AA.
AC O36024;
DT 19-JUL-2004, integrated into UniProtKB/Swiss-Prot.
DT 01-JAN-1998, sequence version 1.
DT 25-MAY-2022, entry version 96.
DE RecName: Full=Inner kinetochore subunit fta1;
DE AltName: Full=CENP-L homolog;
DE AltName: Full=Constitutive centromere-associated network protein fta1;
DE AltName: Full=Sim4 complex subunit fta1;
DE AltName: Full=Sim4-mal2-associated protein 1;
GN Name=fta1; Synonyms=sma1; ORFNames=SPAC4F10.12;
OS Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast).
OC Eukaryota; Fungi; Dikarya; Ascomycota; Taphrinomycotina;
OC Schizosaccharomycetes; Schizosaccharomycetales; Schizosaccharomycetaceae;
OC Schizosaccharomyces.
OX NCBI_TaxID=284812;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=972 / ATCC 24843;
RX PubMed=11859360; DOI=10.1038/nature724;
RA Wood V., Gwilliam R., Rajandream M.A., Lyne M.H., Lyne R., Stewart A.,
RA Sgouros J.G., Peat N., Hayles J., Baker S.G., Basham D., Bowman S.,
RA Brooks K., Brown D., Brown S., Chillingworth T., Churcher C.M., Collins M.,
RA Connor R., Cronin A., Davis P., Feltwell T., Fraser A., Gentles S.,
RA Goble A., Hamlin N., Harris D.E., Hidalgo J., Hodgson G., Holroyd S.,
RA Hornsby T., Howarth S., Huckle E.J., Hunt S., Jagels K., James K.D.,
RA Jones L., Jones M., Leather S., McDonald S., McLean J., Mooney P.,
RA Moule S., Mungall K.L., Murphy L.D., Niblett D., Odell C., Oliver K.,
RA O'Neil S., Pearson D., Quail M.A., Rabbinowitsch E., Rutherford K.M.,
RA Rutter S., Saunders D., Seeger K., Sharp S., Skelton J., Simmonds M.N.,
RA Squares R., Squares S., Stevens K., Taylor K., Taylor R.G., Tivey A.,
RA Walsh S.V., Warren T., Whitehead S., Woodward J.R., Volckaert G., Aert R.,
RA Robben J., Grymonprez B., Weltjens I., Vanstreels E., Rieger M.,
RA Schaefer M., Mueller-Auer S., Gabel C., Fuchs M., Duesterhoeft A.,
RA Fritzc C., Holzer E., Moestl D., Hilbert H., Borzym K., Langer I., Beck A.,
RA Lehrach H., Reinhardt R., Pohl T.M., Eger P., Zimmermann W., Wedler H.,
RA Wambutt R., Purnelle B., Goffeau A., Cadieu E., Dreano S., Gloux S.,
RA Lelaure V., Mottier S., Galibert F., Aves S.J., Xiang Z., Hunt C.,
RA Moore K., Hurst S.M., Lucas M., Rochet M., Gaillardin C., Tallada V.A.,
RA Garzon A., Thode G., Daga R.R., Cruzado L., Jimenez J., Sanchez M.,
RA del Rey F., Benito J., Dominguez A., Revuelta J.L., Moreno S.,
RA Armstrong J., Forsburg S.L., Cerutti L., Lowe T., McCombie W.R.,
RA Paulsen I., Potashkin J., Shpakovski G.V., Ussery D., Barrell B.G.,
RA Nurse P.;
RT "The genome sequence of Schizosaccharomyces pombe.";
RL Nature 415:871-880(2002).
RN [2]
RP FUNCTION, IDENTIFICATION IN THE SIM4 COMPLEX, AND SUBCELLULAR LOCATION.
RX PubMed=16079914; DOI=10.1038/sj.emboj.7600762;
RA Liu X., McLeod I., Anderson S., Yates J.R. III, He X.;
RT "Molecular analysis of kinetochore architecture in fission yeast.";
RL EMBO J. 24:2919-2930(2005).
CC -!- FUNCTION: Component of the kinetochore, a multiprotein complex that
CC assembles on centromeric DNA and attaches chromosomes to spindle
CC microtubules, mediating chromosome segregation and sister chromatid
CC segregation during meiosis and mitosis. Component of the inner
CC kinetochore constitutive centromere-associated network (CCAN), which
CC serves as a structural platform for outer kinetochore assembly.
CC {ECO:0000269|PubMed:16079914}.
CC -!- SUBUNIT: Component of the inner kinetochore constitutive centromere-
CC associated network (CCAN) (also known as central kinetochore Sim4
CC complex in fission yeast), which is composed of at least cnl2, cnp3,
CC cnp20, fta1, fta2, fta3, fta4, fta6, fta7, mal2, mhf1, mhf2, mis6,
CC mis15, mis17, sim4 and wip1. {ECO:0000269|PubMed:16079914}.
CC -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000269|PubMed:16079914}.
CC Chromosome, centromere, kinetochore {ECO:0000269|PubMed:16079914}.
CC -!- SIMILARITY: Belongs to the CENP-L/IML3 family. {ECO:0000305}.
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DR EMBL; CU329670; CAB11715.1; -; Genomic_DNA.
DR PIR; T38816; T38816.
DR RefSeq; NP_594755.1; NM_001020182.2.
DR AlphaFoldDB; O36024; -.
DR BioGRID; 280064; 8.
DR STRING; 4896.SPAC4F10.12.1; -.
DR MaxQB; O36024; -.
DR PaxDb; O36024; -.
DR PRIDE; O36024; -.
DR EnsemblFungi; SPAC4F10.12.1; SPAC4F10.12.1:pep; SPAC4F10.12.
DR GeneID; 2543650; -.
DR KEGG; spo:SPAC4F10.12; -.
DR PomBase; SPAC4F10.12; fta1.
DR VEuPathDB; FungiDB:SPAC4F10.12; -.
DR HOGENOM; CLU_998049_0_0_1; -.
DR InParanoid; O36024; -.
DR OMA; HIKRCTS; -.
DR PRO; PR:O36024; -.
DR Proteomes; UP000002485; Chromosome I.
DR GO; GO:0000776; C:kinetochore; IDA:PomBase.
DR GO; GO:0005874; C:microtubule; IEA:UniProtKB-KW.
DR GO; GO:0031511; C:Mis6-Sim4 complex; IDA:PomBase.
DR GO; GO:0005634; C:nucleus; IC:PomBase.
DR GO; GO:0051315; P:attachment of mitotic spindle microtubules to kinetochore; IMP:PomBase.
DR GO; GO:0051301; P:cell division; IEA:UniProtKB-KW.
DR GO; GO:0051455; P:monopolar spindle attachment to meiosis I kinetochore; IMP:PomBase.
DR InterPro; IPR025204; CENP-L.
DR PANTHER; PTHR31740; PTHR31740; 1.
DR Pfam; PF13092; CENP-L; 1.
PE 1: Evidence at protein level;
KW Cell cycle; Cell division; Centromere; Chromosome; Chromosome partition;
KW Kinetochore; Microtubule; Mitosis; Nucleus; Reference proteome.
FT CHAIN 1..280
FT /note="Inner kinetochore subunit fta1"
FT /id="PRO_0000116724"
SQ SEQUENCE 280 AA; 32337 MW; CB174C7174CC9C6B CRC64;
MTLRDHHFYN VTYTAYRLSP LFGFEYSNLT EIGKKLTRFL RYGTDRTGYF TNSTRFADLI
IEKATFTEFG NTSSFPKFLK LDISYETSSD LEVKRKGQMF FFESFRKFSH AEADRTRLSL
EGNSVFFSLA LVRMDGALWM AVEQFLQQEF DTQILPCLIA PEILLEFLKI WQNHVNSQTA
LPLELTWTTG NPNLSSVTIS IRPEDLKKIF RSSSFFYPIL MEHIKRCTSL DLTNSVFSLS
KVNTDCAILT SSGKLKIFSK AQNIVFDVLL ALEPMQLPEY
