CDAN1_MOUSE
ID CDAN1_MOUSE Reviewed; 1239 AA.
AC Q8CC12; A2AW10; Q149P8; Q3U032;
DT 07-NOV-2003, integrated into UniProtKB/Swiss-Prot.
DT 24-JUL-2007, sequence version 2.
DT 03-AUG-2022, entry version 114.
DE RecName: Full=Codanin-1;
GN Name=Cdan1;
OS Mus musculus (Mouse).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC Murinae; Mus; Mus.
OX NCBI_TaxID=10090;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2).
RC STRAIN=C57BL/6J, and NOD; TISSUE=Diencephalon, and Spleen;
RX PubMed=16141072; DOI=10.1126/science.1112014;
RA Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N.,
RA Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K.,
RA Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.,
RA Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R.,
RA Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T.,
RA Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A.,
RA Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B.,
RA Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M.,
RA Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S.,
RA Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E.,
RA Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D.,
RA Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M.,
RA Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H.,
RA Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V.,
RA Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S.,
RA Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H.,
RA Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N.,
RA Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F.,
RA Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G.,
RA Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z.,
RA Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C.,
RA Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y.,
RA Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S.,
RA Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K.,
RA Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R.,
RA van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H.,
RA Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M.,
RA Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C.,
RA Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S.,
RA Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K.,
RA Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M.,
RA Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C.,
RA Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A.,
RA Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.;
RT "The transcriptional landscape of the mammalian genome.";
RL Science 309:1559-1563(2005).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=C57BL/6J;
RX PubMed=19468303; DOI=10.1371/journal.pbio.1000112;
RA Church D.M., Goodstadt L., Hillier L.W., Zody M.C., Goldstein S., She X.,
RA Bult C.J., Agarwala R., Cherry J.L., DiCuccio M., Hlavina W., Kapustin Y.,
RA Meric P., Maglott D., Birtle Z., Marques A.C., Graves T., Zhou S.,
RA Teague B., Potamousis K., Churas C., Place M., Herschleb J., Runnheim R.,
RA Forrest D., Amos-Landgraf J., Schwartz D.C., Cheng Z., Lindblad-Toh K.,
RA Eichler E.E., Ponting C.P.;
RT "Lineage-specific biology revealed by a finished genome assembly of the
RT mouse.";
RL PLoS Biol. 7:E1000112-E1000112(2009).
RN [3]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 3).
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RT "The status, quality, and expansion of the NIH full-length cDNA project:
RT the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
RN [4]
RP IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
RC TISSUE=Spleen, and Testis;
RX PubMed=21183079; DOI=10.1016/j.cell.2010.12.001;
RA Huttlin E.L., Jedrychowski M.P., Elias J.E., Goswami T., Rad R.,
RA Beausoleil S.A., Villen J., Haas W., Sowa M.E., Gygi S.P.;
RT "A tissue-specific atlas of mouse protein phosphorylation and expression.";
RL Cell 143:1174-1189(2010).
RN [5]
RP DEVELOPMENTAL STAGE, TISSUE SPECIFICITY, AND DISRUPTION PHENOTYPE.
RX PubMed=21364188; DOI=10.1182/blood-2010-09-308478;
RA Renella R., Roberts N.A., Brown J.M., De Gobbi M., Bird L.E., Hassanali T.,
RA Sharpe J.A., Sloane-Stanley J., Ferguson D.J., Cordell J., Buckle V.J.,
RA Higgs D.R., Wood W.G.;
RT "Codanin-1 mutations in congenital dyserythropoietic anemia type 1 affect
RT HP1-alpha localization in erythroblasts.";
RL Blood 117:6928-6938(2011).
CC -!- FUNCTION: May act as a negative regulator of ASF1 in chromatin
CC assembly. {ECO:0000250}.
CC -!- SUBUNIT: Interacts with ASF1A and ASF1B. Found in a cytosolic complex
CC with ASF1A, ASF1B, IPO4 and histones H3.1 and H4. {ECO:0000250}.
CC -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000250}. Nucleus {ECO:0000250}.
CC Membrane {ECO:0000305}; Multi-pass membrane protein {ECO:0000305}.
CC Note=Mainly detected as a cytoplasmic protein.
CC -!- ALTERNATIVE PRODUCTS:
CC Event=Alternative splicing; Named isoforms=3;
CC Name=1;
CC IsoId=Q8CC12-1; Sequence=Displayed;
CC Name=2;
CC IsoId=Q8CC12-2; Sequence=VSP_027100;
CC Name=3;
CC IsoId=Q8CC12-3; Sequence=VSP_027099;
CC -!- TISSUE SPECIFICITY: Widely expressed in adult mice, the highest levels
CC can be measured in erythropoietic cells. {ECO:0000269|PubMed:21364188}.
CC -!- DEVELOPMENTAL STAGE: Expressed ubiquitously during early embryogenesis.
CC {ECO:0000269|PubMed:21364188}.
CC -!- DISRUPTION PHENOTYPE: Embryonic lethal; embryos die before 7.5 days of
CC gestation. {ECO:0000269|PubMed:21364188}.
CC -!- SEQUENCE CAUTION:
CC Sequence=BAE34023.1; Type=Frameshift; Evidence={ECO:0000305};
CC Sequence=CAM21399.1; Type=Erroneous gene model prediction; Evidence={ECO:0000305};
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DR EMBL; AK034144; BAC28605.1; -; mRNA.
DR EMBL; AK157271; BAE34023.1; ALT_FRAME; mRNA.
DR EMBL; AL935168; CAM21399.1; ALT_SEQ; Genomic_DNA.
DR EMBL; BC117555; AAI17556.1; -; mRNA.
DR CCDS; CCDS38212.1; -. [Q8CC12-1]
DR RefSeq; NP_081167.2; NM_026891.2. [Q8CC12-1]
DR AlphaFoldDB; Q8CC12; -.
DR SMR; Q8CC12; -.
DR BioGRID; 213146; 1.
DR IntAct; Q8CC12; 2.
DR MINT; Q8CC12; -.
DR STRING; 10090.ENSMUSP00000106329; -.
DR iPTMnet; Q8CC12; -.
DR PhosphoSitePlus; Q8CC12; -.
DR EPD; Q8CC12; -.
DR jPOST; Q8CC12; -.
DR MaxQB; Q8CC12; -.
DR PaxDb; Q8CC12; -.
DR PeptideAtlas; Q8CC12; -.
DR PRIDE; Q8CC12; -.
DR ProteomicsDB; 283760; -. [Q8CC12-1]
DR ProteomicsDB; 283761; -. [Q8CC12-2]
DR ProteomicsDB; 283762; -. [Q8CC12-3]
DR Antibodypedia; 42152; 136 antibodies from 20 providers.
DR Ensembl; ENSMUST00000110701; ENSMUSP00000106329; ENSMUSG00000027284. [Q8CC12-1]
DR GeneID; 68968; -.
DR KEGG; mmu:68968; -.
DR UCSC; uc008lwu.1; mouse. [Q8CC12-1]
DR UCSC; uc008lwv.1; mouse. [Q8CC12-2]
DR CTD; 146059; -.
DR MGI; MGI:1916218; Cdan1.
DR VEuPathDB; HostDB:ENSMUSG00000027284; -.
DR eggNOG; ENOG502QPWR; Eukaryota.
DR GeneTree; ENSGT00390000000491; -.
DR HOGENOM; CLU_007378_0_0_1; -.
DR InParanoid; Q8CC12; -.
DR OMA; CVVKDAQ; -.
DR OrthoDB; 664227at2759; -.
DR PhylomeDB; Q8CC12; -.
DR TreeFam; TF328405; -.
DR BioGRID-ORCS; 68968; 16 hits in 70 CRISPR screens.
DR ChiTaRS; Cdan1; mouse.
DR PRO; PR:Q8CC12; -.
DR Proteomes; UP000000589; Chromosome 2.
DR RNAct; Q8CC12; protein.
DR Bgee; ENSMUSG00000027284; Expressed in spermatocyte and 225 other tissues.
DR ExpressionAtlas; Q8CC12; baseline and differential.
DR Genevisible; Q8CC12; MM.
DR GO; GO:0005737; C:cytoplasm; ISS:UniProtKB.
DR GO; GO:0005829; C:cytosol; ISO:MGI.
DR GO; GO:0012505; C:endomembrane system; IDA:MGI.
DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR GO; GO:0005634; C:nucleus; IDA:MGI.
DR GO; GO:0005886; C:plasma membrane; ISO:MGI.
DR GO; GO:0031497; P:chromatin assembly; ISS:UniProtKB.
DR GO; GO:0006325; P:chromatin organization; ISO:MGI.
DR GO; GO:0008156; P:negative regulation of DNA replication; ISS:UniProtKB.
DR GO; GO:0006998; P:nuclear envelope organization; TAS:MGI.
DR GO; GO:0008104; P:protein localization; ISO:MGI.
DR InterPro; IPR040031; Codanin-1.
DR InterPro; IPR028171; Codanin-1_C.
DR PANTHER; PTHR28678; PTHR28678; 1.
DR Pfam; PF15296; Codanin-1_C; 1.
PE 1: Evidence at protein level;
KW Acetylation; Alternative splicing; Cytoplasm; Membrane; Nucleus;
KW Phosphoprotein; Reference proteome; Transmembrane; Transmembrane helix.
FT INIT_MET 1
FT /note="Removed"
FT /evidence="ECO:0000250|UniProtKB:Q8IWY9"
FT CHAIN 2..1239
FT /note="Codanin-1"
FT /id="PRO_0000089440"
FT TRANSMEM 317..337
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 631..651
FT /note="Helical"
FT /evidence="ECO:0000255"
FT REGION 61..249
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 193..213
FT /note="Interaction with ASF1A/B"
FT /evidence="ECO:0000250"
FT REGION 261..299
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 198..239
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 264..289
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT MOD_RES 2
FT /note="N-acetylalanine"
FT /evidence="ECO:0000250|UniProtKB:Q8IWY9"
FT MOD_RES 70
FT /note="Phosphothreonine"
FT /evidence="ECO:0000250|UniProtKB:Q8IWY9"
FT MOD_RES 270
FT /note="Phosphoserine"
FT /evidence="ECO:0000250|UniProtKB:Q8IWY9"
FT VAR_SEQ 1..341
FT /note="Missing (in isoform 3)"
FT /evidence="ECO:0000303|PubMed:15489334"
FT /id="VSP_027099"
FT VAR_SEQ 1038..1044
FT /note="Missing (in isoform 2)"
FT /evidence="ECO:0000303|PubMed:16141072"
FT /id="VSP_027100"
FT CONFLICT 140
FT /note="A -> P (in Ref. 2; BAE34023)"
FT /evidence="ECO:0000305"
FT CONFLICT 1220
FT /note="P -> L (in Ref. 2; BAE34023)"
FT /evidence="ECO:0000305"
SQ SEQUENCE 1239 AA; 135883 MW; 7A07DFAB1CBB7FB9 CRC64;
MAAVLESLLR EEVPVAAAVR WIARSTPSSE DSSEVAALSA LRPLRKEFVP FLLNFLREQS
SRVLPQGPST PAKTPVASAA LPARQGAPAR GGRGARSQLF PAAEPLSAAA EAPLARRAGR
RRGPGPGPSR ERGGRGSGAA EEGASGESPP WAGGRKPKGS GSPGSPRLSL SDPPNLSNLE
EFPPVGTVPP GSAGRTKPSR RINPTPVSEE RSLSKPKTCF TSPPISCVPS SQPSTLDTSP
WGLGLPPGCR SLQEEREMLR KARTKQLQQS PTPASPIPES GSPVPSRTGN LTAEPADPAR
VSSRQRLELV ALIYSSCIAE NLVPNLFLEL FFVLQLLTAR RMVATKDSDL ESSQGALDSL
DTPLFRSIHD CVFFAVQVLE HQFQVLSYLD KGTLKLLAEN ERLLCFSPAL QGRLRAAYEG
SVAKVSLVIP PSAQAVSFQP ETDNRANFSS DRAFHTFKKQ RDVFYEVLRE WEDHHEEPSW
DFEKGLGSRI RAMMGQLSAA CSHSHFVRLF QKQLLQMCQS PGGAGGSVLG EAPDVLNMLG
ADKLGRLRQL QERLIAPQSS GGPCPPPTFP GCQGFFRDFI MSASSFHFNQ HLMDSLSLKI
RELNGLRLPQ HEPGDEDGES DMDWQGERRQ FAVVLLSLRL LAKFLGFVAF LPYRGHEPPP
TRELQDSILA LRSQVPPVLD IRALLQQGLW ARRAVLTVPW LVEFLSFADH IVPLLDYYRS
VFTLLLRLHR SLVLSKENEG EMCFLNKLLL LAVLGWLFQI PTVPEDLFFL EDGQVDAFEV
TTTASEHGLD SVPVVDQQLL YTCCPYIGEL RKLLASWVSG SSGRSGGFVR KITPTTTSSL
GALPLQTSQG LQAQLAEAFF HNQPPSLRRT VEFVAERIGS NCVKHIKATL VADLVHQAES
LLQEQLVARG QEGGDPAQLL ESLCSQLCPH GAQALTQGRE FCQRKSPTAV RALLPEETPA
AVLSSAENIA VGLATEKACS WLSANITALI RREVKAAVSR MLRAQGPEPT ARVERRGCSR
ACEHHAPLPS HLISEIKFHH CSLQDVLSLA AGPRDPEEGV SPEHLEQLLN QMGQSLRCRQ
FLCPTAEQHL AKCSVELASL LVADQIPILG PPTQHRLERG HARRLLHMLL SLWKDDFQGP
VPLQLLLSPR NVGLLADTRP REWDLLLFLL RELVEKDLMG HLEIEACLGR LNEAQWPGDF
SEELSTLFRL FLAEPHLLEP QLRACELMQP NRGTVLAQS
