ID   CCL5_MACMU              Reviewed;          91 AA.
AC   Q8HYQ1; Q8HYN5;
DT   16-AUG-2005, integrated into UniProtKB/Swiss-Prot.
DT   01-MAR-2003, sequence version 1.
DT   25-MAY-2022, entry version 87.
DE   RecName: Full=C-C motif chemokine 5;
DE   AltName: Full=Small-inducible cytokine A5;
DE   AltName: Full=T-cell-specific protein RANTES;
DE   Flags: Precursor;
GN   Name=CCL5;
OS   Macaca mulatta (Rhesus macaque).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini;
OC   Cercopithecidae; Cercopithecinae; Macaca.
OX   NCBI_TaxID=9544;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [MRNA].
RX   PubMed=12126650; DOI=10.1006/cyto.2002.0875;
RA   Basu S., Schaefer T.M., Ghosh M., Fuller C.L., Reinhart T.A.;
RT   "Molecular cloning and sequencing of 25 different rhesus macaque chemokine
RT   cDNAs reveals evolutionary conservation among C, CC, CXC, and CX3C families
RT   of chemokines.";
RL   Cytokine 18:140-148(2002).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [MRNA] OF 32-81.
RX   PubMed=12079558; DOI=10.1089/088922202760019329;
RA   Hofmann-Lehmann R., Williams A.L., Swenerton R.K., Li P.-L.,
RA   Rasmussen R.A., Chenine A.-L., McClure H.M., Ruprecht R.M.;
RT   "Quantitation of simian cytokine and beta-chemokine mRNAs, using real-time
RT   reverse transcriptase-polymerase chain reaction: variations in expression
RT   during chronic primate lentivirus infection.";
RL   AIDS Res. Hum. Retroviruses 18:627-639(2002).
CC   -!- FUNCTION: Chemoattractant for blood monocytes, memory T-helper cells
CC       and eosinophils. Causes the release of histamine from basophils and
CC       activates eosinophils. May activate several chemokine receptors
CC       including CCR1, CCR3, CCR4 and CCR5. May also be an agonist of the G
CC       protein-coupled receptor GPR75. Together with GPR75, may play a role in
CC       neuron survival through activation of a downstream signaling pathway
CC       involving the PI3, Akt and MAP kinases. By activating GPR75 may also
CC       play a role in insulin secretion by islet cells.
CC       {ECO:0000250|UniProtKB:P13501}.
CC   -!- SUBCELLULAR LOCATION: Secreted {ECO:0000250}.
CC   -!- SIMILARITY: Belongs to the intercrine beta (chemokine CC) family.
CC       {ECO:0000305}.
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DR   EMBL; AF449268; AAN76072.1; -; mRNA.
DR   EMBL; AF457194; AAN76984.1; -; mRNA.
DR   RefSeq; NP_001028022.1; NM_001032850.1.
DR   AlphaFoldDB; Q8HYQ1; -.
DR   SMR; Q8HYQ1; -.
DR   STRING; 9544.ENSMMUP00000006410; -.
DR   GeneID; 574178; -.
DR   KEGG; mcc:574178; -.
DR   CTD; 6352; -.
DR   eggNOG; ENOG502S8D1; Eukaryota.
DR   InParanoid; Q8HYQ1; -.
DR   OrthoDB; 1575018at2759; -.
DR   Proteomes; UP000006718; Unplaced.
DR   GO; GO:0005615; C:extracellular space; IBA:GO_Central.
DR   GO; GO:0048020; F:CCR chemokine receptor binding; IBA:GO_Central.
DR   GO; GO:0008009; F:chemokine activity; IBA:GO_Central.
DR   GO; GO:0071346; P:cellular response to interferon-gamma; IBA:GO_Central.
DR   GO; GO:0071347; P:cellular response to interleukin-1; IBA:GO_Central.
DR   GO; GO:0071356; P:cellular response to tumor necrosis factor; IBA:GO_Central.
DR   GO; GO:0070098; P:chemokine-mediated signaling pathway; ISS:UniProtKB.
DR   GO; GO:0007186; P:G protein-coupled receptor signaling pathway; ISS:UniProtKB.
DR   GO; GO:0006954; P:inflammatory response; IBA:GO_Central.
DR   GO; GO:0048247; P:lymphocyte chemotaxis; IBA:GO_Central.
DR   GO; GO:0002548; P:monocyte chemotaxis; IBA:GO_Central.
DR   GO; GO:0030593; P:neutrophil chemotaxis; IBA:GO_Central.
DR   GO; GO:0070374; P:positive regulation of ERK1 and ERK2 cascade; IBA:GO_Central.
DR   GO; GO:0043547; P:positive regulation of GTPase activity; IBA:GO_Central.
DR   GO; GO:0010820; P:positive regulation of T cell chemotaxis; IBA:GO_Central.
DR   GO; GO:0050796; P:regulation of insulin secretion; ISS:UniProtKB.
DR   GO; GO:1901214; P:regulation of neuron death; ISS:UniProtKB.
DR   InterPro; IPR039809; Chemokine_b/g/d.
DR   InterPro; IPR000827; Chemokine_CC_CS.
DR   InterPro; IPR001811; Chemokine_IL8-like_dom.
DR   InterPro; IPR036048; Interleukin_8-like_sf.
DR   PANTHER; PTHR12015; PTHR12015; 1.
DR   Pfam; PF00048; IL8; 1.
DR   SMART; SM00199; SCY; 1.
DR   SUPFAM; SSF54117; SSF54117; 1.
DR   PROSITE; PS00472; SMALL_CYTOKINES_CC; 1.
PE   3: Inferred from homology;
KW   Chemotaxis; Cytokine; Disulfide bond; Inflammatory response;
KW   Reference proteome; Secreted; Signal.
FT   SIGNAL          1..23
FT                   /evidence="ECO:0000255"
FT   CHAIN           24..91
FT                   /note="C-C motif chemokine 5"
FT                   /id="PRO_0000005178"
FT   DISULFID        33..57
FT                   /evidence="ECO:0000250"
FT   DISULFID        34..73
FT                   /evidence="ECO:0000250"
SQ   SEQUENCE   91 AA;  10019 MW;  BCBD69ED0573803B CRC64;
     MKVSAARLAV ILVATALCAP ASASPHASDT TPCCFAYIAR PLPRAHIKEY FYTSGKCSNP
     AVVFVTRKNR QVCANPEKKW VREYINSLEM S