ID   CCL5_FELCA              Reviewed;          92 AA.
AC   Q8SQ40;
DT   13-APR-2004, integrated into UniProtKB/Swiss-Prot.
DT   01-JUN-2002, sequence version 1.
DT   25-MAY-2022, entry version 87.
DE   RecName: Full=C-C motif chemokine 5;
DE   AltName: Full=Small-inducible cytokine A5;
DE   AltName: Full=T-cell-specific protein RANTES;
DE   Flags: Precursor;
GN   Name=CCL5; Synonyms=SCYA5;
OS   Felis catus (Cat) (Felis silvestris catus).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Laurasiatheria; Carnivora; Feliformia; Felidae; Felinae; Felis.
OX   NCBI_TaxID=9685;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [MRNA].
RA   Kimura T., Kano R., Hasegawa A.;
RT   "Molecular cloning of feline RANTES gene.";
RL   Submitted (APR-2002) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: Chemoattractant for blood monocytes, memory T-helper cells
CC       and eosinophils. Causes the release of histamine from basophils and
CC       activates eosinophils. May activate several chemokine receptors
CC       including CCR1, CCR3, CCR4 and CCR5. May also be an agonist of the G
CC       protein-coupled receptor GPR75. Together with GPR75, may play a role in
CC       neuron survival through activation of a downstream signaling pathway
CC       involving the PI3, Akt and MAP kinases. By activating GPR75 may also
CC       play a role in insulin secretion by islet cells.
CC       {ECO:0000250|UniProtKB:P13501}.
CC   -!- SUBCELLULAR LOCATION: Secreted.
CC   -!- SIMILARITY: Belongs to the intercrine beta (chemokine CC) family.
CC       {ECO:0000305}.
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DR   EMBL; AB083479; BAB88940.1; -; mRNA.
DR   RefSeq; NP_001009827.1; NM_001009827.1.
DR   AlphaFoldDB; Q8SQ40; -.
DR   SMR; Q8SQ40; -.
DR   STRING; 9685.ENSFCAP00000001170; -.
DR   GeneID; 493689; -.
DR   KEGG; fca:493689; -.
DR   CTD; 6352; -.
DR   eggNOG; ENOG502S8D1; Eukaryota.
DR   InParanoid; Q8SQ40; -.
DR   OrthoDB; 1575018at2759; -.
DR   Proteomes; UP000011712; Unplaced.
DR   GO; GO:0005615; C:extracellular space; IBA:GO_Central.
DR   GO; GO:0048020; F:CCR chemokine receptor binding; IBA:GO_Central.
DR   GO; GO:0008009; F:chemokine activity; IBA:GO_Central.
DR   GO; GO:0071346; P:cellular response to interferon-gamma; IBA:GO_Central.
DR   GO; GO:0071347; P:cellular response to interleukin-1; IBA:GO_Central.
DR   GO; GO:0071356; P:cellular response to tumor necrosis factor; IBA:GO_Central.
DR   GO; GO:0070098; P:chemokine-mediated signaling pathway; ISS:UniProtKB.
DR   GO; GO:0007186; P:G protein-coupled receptor signaling pathway; ISS:UniProtKB.
DR   GO; GO:0006954; P:inflammatory response; IBA:GO_Central.
DR   GO; GO:0048247; P:lymphocyte chemotaxis; IBA:GO_Central.
DR   GO; GO:0002548; P:monocyte chemotaxis; IBA:GO_Central.
DR   GO; GO:0030593; P:neutrophil chemotaxis; IBA:GO_Central.
DR   GO; GO:0070374; P:positive regulation of ERK1 and ERK2 cascade; IBA:GO_Central.
DR   GO; GO:0043547; P:positive regulation of GTPase activity; IBA:GO_Central.
DR   GO; GO:0010820; P:positive regulation of T cell chemotaxis; IBA:GO_Central.
DR   GO; GO:0050796; P:regulation of insulin secretion; ISS:UniProtKB.
DR   GO; GO:1901214; P:regulation of neuron death; ISS:UniProtKB.
DR   InterPro; IPR039809; Chemokine_b/g/d.
DR   InterPro; IPR000827; Chemokine_CC_CS.
DR   InterPro; IPR001811; Chemokine_IL8-like_dom.
DR   InterPro; IPR036048; Interleukin_8-like_sf.
DR   PANTHER; PTHR12015; PTHR12015; 1.
DR   Pfam; PF00048; IL8; 1.
DR   SMART; SM00199; SCY; 1.
DR   SUPFAM; SSF54117; SSF54117; 1.
DR   PROSITE; PS00472; SMALL_CYTOKINES_CC; 1.
PE   3: Inferred from homology;
KW   Chemotaxis; Cytokine; Disulfide bond; Inflammatory response;
KW   Reference proteome; Secreted; Signal.
FT   SIGNAL          1..23
FT                   /evidence="ECO:0000255"
FT   CHAIN           24..92
FT                   /note="C-C motif chemokine 5"
FT                   /id="PRO_0000005173"
FT   DISULFID        33..57
FT                   /evidence="ECO:0000250"
FT   DISULFID        34..73
FT                   /evidence="ECO:0000250"
SQ   SEQUENCE   92 AA;  10167 MW;  2E6F087140BA3CE8 CRC64;
     MKVSTAAFAV LLTAAAFCTP ASASPYASDT TPCCFAYLSH PLPLTHLQEY FYTSSKCSMP
     AVVFVTRRKR QVCANPQKKW VRDKGINSLE MN