CCL4_MOUSE
ID CCL4_MOUSE Reviewed; 92 AA.
AC P14097;
DT 01-JAN-1990, integrated into UniProtKB/Swiss-Prot.
DT 01-FEB-1996, sequence version 3.
DT 03-AUG-2022, entry version 172.
DE RecName: Full=C-C motif chemokine 4;
DE AltName: Full=Immune activation protein 2;
DE Short=ACT-2;
DE Short=ACT2;
DE AltName: Full=Macrophage inflammatory protein 1-beta;
DE Short=MIP-1-beta;
DE AltName: Full=Protein H400;
DE AltName: Full=SIS-gamma;
DE AltName: Full=Small-inducible cytokine A4;
DE Flags: Precursor;
GN Name=Ccl4; Synonyms=Mip1b, Scya4;
OS Mus musculus (Mouse).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC Murinae; Mus; Mus.
OX NCBI_TaxID=10090;
RN [1]
RP NUCLEOTIDE SEQUENCE [MRNA].
RC TISSUE=Macrophage;
RX PubMed=3058856; DOI=10.1084/jem.168.6.2251;
RA Sherry B., Tekamp-Olson P., Gallegos C., Bauer D., Davatelis G.,
RA Wolpe S.D., Masiarz F., Coit D., Cerami A.;
RT "Resolution of the two components of macrophage inflammatory protein 1, and
RT cloning and characterization of one of those components, macrophage
RT inflammatory protein 1 beta.";
RL J. Exp. Med. 168:2251-2259(1988).
RN [2]
RP NUCLEOTIDE SEQUENCE [MRNA].
RC TISSUE=Helper T-cell;
RX PubMed=2521353;
RA Brown K.D., Zurawski S.M., Mosmann T.R., Zurawski G.;
RT "A family of small inducible proteins secreted by leukocytes are members of
RT a new superfamily that includes leukocyte and fibroblast-derived
RT inflammatory agents, growth factors, and indicators of various activation
RT processes.";
RL J. Immunol. 142:679-687(1989).
RN [3]
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RC STRAIN=DBA/2J; TISSUE=Liver;
RA Daubersies P., Lepretre F., Bailleul B., Grove M., Pragnell I., Plumb M.A.;
RT "Sequence of the murine macrophage inflammatory protein 1b gene.";
RL Submitted (OCT-1991) to the EMBL/GenBank/DDBJ databases.
RN [4]
RP NUCLEOTIDE SEQUENCE [MRNA].
RC STRAIN=B10.S/J, and SJL/J; TISSUE=Spleen;
RX PubMed=10438970;
RA Teuscher C., Butterfield R.J., Ma R.Z., Zachary J.F., Doerge R.W.,
RA Blankenhorn E.P.;
RT "Sequence polymorphisms in the chemokines Scya1 (TCA-3), Scya2 (monocyte
RT chemoattractant protein (MCP)-1), and Scya12 (MCP-5) are candidates for
RT eae7, a locus controlling susceptibility to monophasic
RT remitting/nonrelapsing experimental allergic encephalomyelitis.";
RL J. Immunol. 163:2262-2266(1999).
CC -!- FUNCTION: Monokine with inflammatory and chemokinetic properties.
CC -!- SUBUNIT: Homodimer. {ECO:0000250}.
CC -!- SUBCELLULAR LOCATION: Secreted.
CC -!- SIMILARITY: Belongs to the intercrine beta (chemokine CC) family.
CC {ECO:0000305}.
CC ---------------------------------------------------------------------------
CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC ---------------------------------------------------------------------------
DR EMBL; M35590; AAA39708.1; -; mRNA.
DR EMBL; M23503; AAA40148.1; -; mRNA.
DR EMBL; X62502; CAA44364.1; -; Genomic_DNA.
DR EMBL; AF128218; AAF22559.1; -; mRNA.
DR EMBL; AF128219; AAF22560.1; -; mRNA.
DR CCDS; CCDS36256.1; -.
DR PIR; C30552; C30552.
DR RefSeq; NP_038680.1; NM_013652.2.
DR RefSeq; XP_011247134.1; XM_011248832.1.
DR AlphaFoldDB; P14097; -.
DR SMR; P14097; -.
DR STRING; 10090.ENSMUSP00000019074; -.
DR PaxDb; P14097; -.
DR PeptideAtlas; P14097; -.
DR PRIDE; P14097; -.
DR ProteomicsDB; 281332; -.
DR DNASU; 20303; -.
DR Ensembl; ENSMUST00000019074; ENSMUSP00000019074; ENSMUSG00000018930.
DR GeneID; 20303; -.
DR KEGG; mmu:20303; -.
DR UCSC; uc007kpp.1; mouse.
DR CTD; 6351; -.
DR MGI; MGI:98261; Ccl4.
DR VEuPathDB; HostDB:ENSMUSG00000018930; -.
DR eggNOG; ENOG502S8M4; Eukaryota.
DR GeneTree; ENSGT01050000244851; -.
DR HOGENOM; CLU_141716_4_2_1; -.
DR InParanoid; P14097; -.
DR OMA; DWVQEYM; -.
DR OrthoDB; 1575018at2759; -.
DR PhylomeDB; P14097; -.
DR TreeFam; TF334888; -.
DR Reactome; R-MMU-380108; Chemokine receptors bind chemokines.
DR Reactome; R-MMU-418594; G alpha (i) signalling events.
DR BioGRID-ORCS; 20303; 4 hits in 73 CRISPR screens.
DR PRO; PR:P14097; -.
DR Proteomes; UP000000589; Chromosome 11.
DR RNAct; P14097; protein.
DR Bgee; ENSMUSG00000018930; Expressed in granulocyte and 54 other tissues.
DR ExpressionAtlas; P14097; baseline and differential.
DR Genevisible; P14097; MM.
DR GO; GO:0005615; C:extracellular space; IDA:MGI.
DR GO; GO:0048020; F:CCR chemokine receptor binding; IBA:GO_Central.
DR GO; GO:0031726; F:CCR1 chemokine receptor binding; ISO:MGI.
DR GO; GO:0031730; F:CCR5 chemokine receptor binding; ISO:MGI.
DR GO; GO:0008009; F:chemokine activity; ISO:MGI.
DR GO; GO:0042802; F:identical protein binding; ISO:MGI.
DR GO; GO:0071346; P:cellular response to interferon-gamma; IBA:GO_Central.
DR GO; GO:0071347; P:cellular response to interleukin-1; IBA:GO_Central.
DR GO; GO:0071356; P:cellular response to tumor necrosis factor; IBA:GO_Central.
DR GO; GO:0071466; P:cellular response to xenobiotic stimulus; IDA:MGI.
DR GO; GO:0070098; P:chemokine-mediated signaling pathway; IBA:GO_Central.
DR GO; GO:0048245; P:eosinophil chemotaxis; IBA:GO_Central.
DR GO; GO:0007186; P:G protein-coupled receptor signaling pathway; IBA:GO_Central.
DR GO; GO:0006954; P:inflammatory response; ISO:MGI.
DR GO; GO:0030595; P:leukocyte chemotaxis; ISO:MGI.
DR GO; GO:0048247; P:lymphocyte chemotaxis; IBA:GO_Central.
DR GO; GO:0002548; P:monocyte chemotaxis; IBA:GO_Central.
DR GO; GO:0030593; P:neutrophil chemotaxis; IBA:GO_Central.
DR GO; GO:0070374; P:positive regulation of ERK1 and ERK2 cascade; IBA:GO_Central.
DR GO; GO:0043547; P:positive regulation of GTPase activity; IBA:GO_Central.
DR GO; GO:0032760; P:positive regulation of tumor necrosis factor production; ISO:MGI.
DR GO; GO:0043117; P:positive regulation of vascular permeability; ISO:MGI.
DR InterPro; IPR039809; Chemokine_b/g/d.
DR InterPro; IPR000827; Chemokine_CC_CS.
DR InterPro; IPR001811; Chemokine_IL8-like_dom.
DR InterPro; IPR036048; Interleukin_8-like_sf.
DR PANTHER; PTHR12015; PTHR12015; 1.
DR Pfam; PF00048; IL8; 1.
DR SMART; SM00199; SCY; 1.
DR SUPFAM; SSF54117; SSF54117; 1.
DR PROSITE; PS00472; SMALL_CYTOKINES_CC; 1.
PE 3: Inferred from homology;
KW Chemotaxis; Cytokine; Disulfide bond; Inflammatory response;
KW Reference proteome; Secreted; Signal.
FT SIGNAL 1..23
FT CHAIN 24..92
FT /note="C-C motif chemokine 4"
FT /id="PRO_0000005166"
FT DISULFID 34..58
FT /evidence="ECO:0000250"
FT DISULFID 35..74
FT /evidence="ECO:0000250"
SQ SEQUENCE 92 AA; 10168 MW; 8853FD58FDE61BAC CRC64;
MKLCVSALSL LLLVAAFCAP GFSAPMGSDP PTSCCFSYTS RQLHRSFVMD YYETSSLCSK
PAVVFLTKRG RQICANPSEP WVTEYMSDLE LN
