ID   CCL28_CANLF             Reviewed;         128 AA.
AC   Q68A91;
DT   12-APR-2005, integrated into UniProtKB/Swiss-Prot.
DT   11-OCT-2004, sequence version 1.
DT   03-AUG-2022, entry version 102.
DE   RecName: Full=C-C motif chemokine 28;
DE   AltName: Full=Small-inducible cytokine A28;
DE   Flags: Precursor;
GN   Name=CCL28; Synonyms=SCYA28;
OS   Canis lupus familiaris (Dog) (Canis familiaris).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Laurasiatheria; Carnivora; Caniformia; Canidae; Canis.
OX   NCBI_TaxID=9615;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [MRNA].
RA   Tsukui T., Sakaguchi M., Maeda S., Koyanagi M., Masuda K., Ohno K.,
RA   Tsujimoto H., Iwabuchi S.;
RT   "Expression analysis of gene in canine atopic dermatitis.";
RL   Submitted (MAR-2004) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: Chemotactic activity for resting CD4, CD8 T-cells and
CC       eosinophils. Binds to CCR3 and CCR10 and induces calcium mobilization
CC       in a dose-dependent manner (By similarity). {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Secreted {ECO:0000250}.
CC   -!- SIMILARITY: Belongs to the intercrine beta (chemokine CC) family.
CC       {ECO:0000305}.
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DR   EMBL; AB164619; BAD42448.1; -; mRNA.
DR   RefSeq; NP_001005257.1; NM_001005257.1.
DR   AlphaFoldDB; Q68A91; -.
DR   SMR; Q68A91; -.
DR   STRING; 9612.ENSCAFP00000031374; -.
DR   PaxDb; Q68A91; -.
DR   GeneID; 448795; -.
DR   KEGG; cfa:448795; -.
DR   CTD; 56477; -.
DR   eggNOG; ENOG502SVUE; Eukaryota.
DR   HOGENOM; CLU_2003113_0_0_1; -.
DR   InParanoid; Q68A91; -.
DR   OMA; HVIKQWM; -.
DR   OrthoDB; 1574270at2759; -.
DR   TreeFam; TF337014; -.
DR   Proteomes; UP000002254; Unplaced.
DR   GO; GO:0005576; C:extracellular region; IBA:GO_Central.
DR   GO; GO:0005615; C:extracellular space; IEA:UniProtKB-KW.
DR   GO; GO:0008009; F:chemokine activity; IBA:GO_Central.
DR   GO; GO:0060326; P:cell chemotaxis; IBA:GO_Central.
DR   GO; GO:0006955; P:immune response; IEA:InterPro.
DR   GO; GO:0001954; P:positive regulation of cell-matrix adhesion; IBA:GO_Central.
DR   InterPro; IPR000827; Chemokine_CC_CS.
DR   InterPro; IPR001811; Chemokine_IL8-like_dom.
DR   InterPro; IPR036048; Interleukin_8-like_sf.
DR   Pfam; PF00048; IL8; 1.
DR   SUPFAM; SSF54117; SSF54117; 1.
DR   PROSITE; PS00472; SMALL_CYTOKINES_CC; 1.
PE   2: Evidence at transcript level;
KW   Chemotaxis; Cytokine; Disulfide bond; Reference proteome; Secreted; Signal.
FT   SIGNAL          1..24
FT                   /evidence="ECO:0000255"
FT   CHAIN           25..128
FT                   /note="C-C motif chemokine 28"
FT                   /id="PRO_0000005241"
FT   REGION          89..128
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        97..111
FT                   /note="Basic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        112..128
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   DISULFID        32..60
FT                   /evidence="ECO:0000250"
FT   DISULFID        33..75
FT                   /evidence="ECO:0000250"
SQ   SEQUENCE   128 AA;  14258 MW;  617666AA64BDF1F5 CRC64;
     MQQTGLTLAL VALAVCVALP SSEAILPIAS SCCTEVSHHI SRRLLERVNI CRIQRADGDC
     DLAAVILHVR RRRLCVSPHS HVIKQWMKEQ AAKKNTKGNI CHKKQAGKRK SKGAHQEKPE
     IHSHKSPY