CCL24_MOUSE
ID CCL24_MOUSE Reviewed; 119 AA.
AC Q9JKC0;
DT 27-APR-2001, integrated into UniProtKB/Swiss-Prot.
DT 01-OCT-2000, sequence version 1.
DT 03-AUG-2022, entry version 154.
DE RecName: Full=C-C motif chemokine 24;
DE AltName: Full=Eosinophil chemotactic protein 2 {ECO:0000303|PubMed:11067944};
DE Short=Eotaxin-2 {ECO:0000303|PubMed:11067944};
DE AltName: Full=Small-inducible cytokine A24;
DE Flags: Precursor;
GN Name=Ccl24 {ECO:0000303|Ref.2, ECO:0000312|MGI:MGI:1928953};
GN Synonyms=Scya24;
OS Mus musculus (Mouse).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC Murinae; Mus; Mus.
OX NCBI_TaxID=10090;
RN [1]
RP NUCLEOTIDE SEQUENCE [MRNA], TISSUE SPECIFICITY, AND INDUCTION.
RX PubMed=11067944; DOI=10.4049/jimmunol.165.10.5839;
RA Zimmermann N., Hogan S.P., Mishra A., Brandt E.B., Bodette T.R., Pope S.M.,
RA Finkelman F.D., Rothenberg M.E.;
RT "Murine eotaxin-2: a constitutive eosinophil chemokine induced by allergen
RT challenge and IL-4 overexpression.";
RL J. Immunol. 165:5839-5846(2000).
RN [2]
RP NUCLEOTIDE SEQUENCE [MRNA].
RA Rossi D., Zlotnik A.;
RT "Identification of a mouse homolog of CC chemokine CCL24/MPIF-2/Eotaxin-
RT 2.";
RL Submitted (MAR-2000) to the EMBL/GenBank/DDBJ databases.
RN [3]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC STRAIN=C57BL/6J; TISSUE=Thymus;
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RT "The status, quality, and expansion of the NIH full-length cDNA project:
RT the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
RN [4]
RP FUNCTION, INDUCTION, AND DISRUPTION PHENOTYPE.
RX PubMed=15647285; DOI=10.1074/jbc.m406037200;
RA Pope S.M., Fulkerson P.C., Blanchard C., Saito Akei H., Nikolaidis N.M.,
RA Zimmermann N., Molkentin J.D., Rothenberg M.E.;
RT "Identification of a cooperative mechanism involving interleukin-13 and
RT eotaxin-2 in experimental allergic lung inflammation.";
RL J. Biol. Chem. 280:13952-13961(2005).
CC -!- FUNCTION: Chemotactic for resting T-lymphocytes, and eosinophils
CC (PubMed:15647285). Has lower chemotactic activity for neutrophils but
CC none for monocytes and activated lymphocytes. Is a strong suppressor of
CC colony formation by a multipotential hematopoietic progenitor cell
CC line. Binds to CCR3 (By similarity). {ECO:0000250|UniProtKB:O00175,
CC ECO:0000269|PubMed:15647285}.
CC -!- SUBCELLULAR LOCATION: Secreted {ECO:0000250|UniProtKB:O00175}.
CC -!- TISSUE SPECIFICITY: Highest expression in jejunum and spleen. Lower
CC levels found in liver and lung. No expression detected in kidney,
CC thymus, brain or testis. {ECO:0000269|PubMed:11067944}.
CC -!- INDUCTION: By interleukin-4 and allergen challenge with A.fumigatus
CC (PubMed:11067944). By interleukin-13 (IL13) (PubMed:15647285).
CC {ECO:0000269|PubMed:11067944, ECO:0000269|PubMed:15647285}.
CC -!- DISRUPTION PHENOTYPE: No visible phenotype in normal conditions
CC (PubMed:15647285). Mice display a normal base-line eosinophil levels in
CC the hematopoietic tissues and gastrointestinal tract (PubMed:15647285).
CC However, following intratracheal IL13 administration, mice show a
CC profound reduction in airway eosinophilia (PubMed:15647285).
CC {ECO:0000269|PubMed:15647285}.
CC -!- SIMILARITY: Belongs to the intercrine beta (chemokine CC) family.
CC {ECO:0000305}.
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DR EMBL; AF281075; AAG32664.1; -; mRNA.
DR EMBL; AF244367; AAF61736.1; -; mRNA.
DR EMBL; BC065389; AAH65389.1; -; mRNA.
DR CCDS; CCDS19742.1; -.
DR RefSeq; NP_062523.1; NM_019577.4.
DR RefSeq; XP_006504507.1; XM_006504444.3.
DR RefSeq; XP_006504508.1; XM_006504445.3.
DR AlphaFoldDB; Q9JKC0; -.
DR SMR; Q9JKC0; -.
DR STRING; 10090.ENSMUSP00000004936; -.
DR GlyGen; Q9JKC0; 2 sites.
DR MaxQB; Q9JKC0; -.
DR PaxDb; Q9JKC0; -.
DR PRIDE; Q9JKC0; -.
DR ProteomicsDB; 265612; -.
DR Antibodypedia; 14858; 489 antibodies from 31 providers.
DR DNASU; 56221; -.
DR Ensembl; ENSMUST00000004936; ENSMUSP00000004936; ENSMUSG00000004814.
DR Ensembl; ENSMUST00000201401; ENSMUSP00000144002; ENSMUSG00000004814.
DR GeneID; 56221; -.
DR KEGG; mmu:56221; -.
DR UCSC; uc008zyn.1; mouse.
DR CTD; 6369; -.
DR MGI; MGI:1928953; Ccl24.
DR VEuPathDB; HostDB:ENSMUSG00000004814; -.
DR eggNOG; ENOG502S6ZP; Eukaryota.
DR GeneTree; ENSGT01050000244851; -.
DR HOGENOM; CLU_141716_1_1_1; -.
DR InParanoid; Q9JKC0; -.
DR OMA; KLPWVQK; -.
DR OrthoDB; 1575018at2759; -.
DR PhylomeDB; Q9JKC0; -.
DR TreeFam; TF334888; -.
DR BioGRID-ORCS; 56221; 4 hits in 71 CRISPR screens.
DR PRO; PR:Q9JKC0; -.
DR Proteomes; UP000000589; Chromosome 5.
DR RNAct; Q9JKC0; protein.
DR Bgee; ENSMUSG00000004814; Expressed in small intestine Peyer's patch and 47 other tissues.
DR ExpressionAtlas; Q9JKC0; baseline and differential.
DR Genevisible; Q9JKC0; MM.
DR GO; GO:0005615; C:extracellular space; IBA:GO_Central.
DR GO; GO:0048020; F:CCR chemokine receptor binding; IBA:GO_Central.
DR GO; GO:0031728; F:CCR3 chemokine receptor binding; ISO:MGI.
DR GO; GO:0008009; F:chemokine activity; ISO:MGI.
DR GO; GO:0005125; F:cytokine activity; IDA:MGI.
DR GO; GO:0048018; F:receptor ligand activity; ISO:MGI.
DR GO; GO:0071346; P:cellular response to interferon-gamma; IBA:GO_Central.
DR GO; GO:0071347; P:cellular response to interleukin-1; IBA:GO_Central.
DR GO; GO:0071356; P:cellular response to tumor necrosis factor; IBA:GO_Central.
DR GO; GO:0070098; P:chemokine-mediated signaling pathway; IBA:GO_Central.
DR GO; GO:0006935; P:chemotaxis; IDA:MGI.
DR GO; GO:0007010; P:cytoskeleton organization; ISO:MGI.
DR GO; GO:0048245; P:eosinophil chemotaxis; ISO:MGI.
DR GO; GO:0007186; P:G protein-coupled receptor signaling pathway; IBA:GO_Central.
DR GO; GO:0006954; P:inflammatory response; IBA:GO_Central.
DR GO; GO:0048247; P:lymphocyte chemotaxis; IBA:GO_Central.
DR GO; GO:0002548; P:monocyte chemotaxis; IBA:GO_Central.
DR GO; GO:0030593; P:neutrophil chemotaxis; IBA:GO_Central.
DR GO; GO:0030838; P:positive regulation of actin filament polymerization; ISO:MGI.
DR GO; GO:0045766; P:positive regulation of angiogenesis; IMP:BHF-UCL.
DR GO; GO:0030335; P:positive regulation of cell migration; ISO:MGI.
DR GO; GO:0001938; P:positive regulation of endothelial cell proliferation; ISO:MGI.
DR GO; GO:2000418; P:positive regulation of eosinophil migration; IMP:MGI.
DR GO; GO:0070374; P:positive regulation of ERK1 and ERK2 cascade; IBA:GO_Central.
DR GO; GO:0043547; P:positive regulation of GTPase activity; ISO:MGI.
DR GO; GO:0050729; P:positive regulation of inflammatory response; IMP:BHF-UCL.
DR GO; GO:0008360; P:regulation of cell shape; ISO:MGI.
DR InterPro; IPR039809; Chemokine_b/g/d.
DR InterPro; IPR000827; Chemokine_CC_CS.
DR InterPro; IPR001811; Chemokine_IL8-like_dom.
DR InterPro; IPR036048; Interleukin_8-like_sf.
DR PANTHER; PTHR12015; PTHR12015; 1.
DR Pfam; PF00048; IL8; 1.
DR SMART; SM00199; SCY; 1.
DR SUPFAM; SSF54117; SSF54117; 1.
DR PROSITE; PS00472; SMALL_CYTOKINES_CC; 1.
PE 2: Evidence at transcript level;
KW Chemotaxis; Cytokine; Disulfide bond; Glycoprotein; Inflammatory response;
KW Reference proteome; Secreted; Signal.
FT SIGNAL 1..26
FT /evidence="ECO:0000255"
FT CHAIN 27..119
FT /note="C-C motif chemokine 24"
FT /id="PRO_0000005233"
FT REGION 96..119
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT CARBOHYD 54
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT CARBOHYD 115
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT DISULFID 33..58
FT /evidence="ECO:0000250|UniProtKB:O00175"
FT DISULFID 34..74
FT /evidence="ECO:0000250|UniProtKB:O00175"
SQ SEQUENCE 119 AA; 12871 MW; 1EA921B3F13138A8 CRC64;
MAGSATIVAG LLLLVACACC IFPIDSVTIP SSCCTSFISK KIPENRVVSY QLANGSICPK
AGVIFITKKG HKICTDPKLL WVQRHIQKLD AKKNQPSKGA KAVRTKFAVQ RRRGNSTEV
