CCL11_CAVPO
ID CCL11_CAVPO Reviewed; 96 AA.
AC P80325;
DT 01-JUN-1994, integrated into UniProtKB/Swiss-Prot.
DT 01-OCT-1996, sequence version 2.
DT 03-AUG-2022, entry version 128.
DE RecName: Full=Eotaxin;
DE AltName: Full=C-C motif chemokine 11;
DE AltName: Full=Eosinophil chemotactic protein;
DE AltName: Full=Small-inducible cytokine A11;
DE Flags: Precursor;
GN Name=CCL11; Synonyms=SCYA11;
OS Cavia porcellus (Guinea pig).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Glires; Rodentia; Hystricomorpha; Caviidae;
OC Cavia.
OX NCBI_TaxID=10141;
RN [1]
RP NUCLEOTIDE SEQUENCE [MRNA], AND TISSUE SPECIFICITY.
RC TISSUE=Lung;
RX PubMed=7869037; DOI=10.1084/jem.181.3.1211;
RA Rothenberg M.E., Luster A.D., Lilly C.M., Drazen J.M., Leder P.;
RT "Constitutive and allergen-induced expression of eotaxin mRNA in the guinea
RT pig lung.";
RL J. Exp. Med. 181:1211-1216(1995).
RN [2]
RP NUCLEOTIDE SEQUENCE [MRNA].
RX PubMed=7999113; DOI=10.1006/bbrc.1994.2734;
RA Jose P.J., Adcock I.M., Griffiths-Johnson D.A., Berkman N., Wells T.C.,
RA Williams T.J., Power C.A.;
RT "Eotaxin: cloning of an eosinophil chemoattractant cytokine and increased
RT mRNA expression in allergen-challenged guinea-pig lungs.";
RL Biochem. Biophys. Res. Commun. 205:788-794(1994).
RN [3]
RP PROTEIN SEQUENCE OF 24-96.
RC STRAIN=Hartley; TISSUE=Lung;
RX PubMed=7509365; DOI=10.1084/jem.179.3.881;
RA Jose P.J., Griffiths-Johnson D.A., Collins P.D., Walsh D.T., Moqbel R.,
RA Totty N.F., Truong O., Hsuan J.J., Williams T.J.;
RT "Eotaxin: a potent eosinophil chemoattractant cytokine detected in a guinea
RT pig model of allergic airways inflammation.";
RL J. Exp. Med. 179:881-887(1994).
CC -!- FUNCTION: In response to the presence of allergens, this protein
CC directly promotes the accumulation of eosinophils (a prominent feature
CC of allergic inflammatory reactions), but not lymphocytes, macrophages
CC or neutrophils (By similarity). Binds to CCR3 (By similarity).
CC {ECO:0000250|UniProtKB:P48298, ECO:0000250|UniProtKB:P51671}.
CC -!- SUBCELLULAR LOCATION: Secreted {ECO:0000250|UniProtKB:P97545}.
CC -!- TISSUE SPECIFICITY: Lung. {ECO:0000269|PubMed:7869037}.
CC -!- SIMILARITY: Belongs to the intercrine beta (chemokine CC) family.
CC {ECO:0000305}.
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DR EMBL; U18941; AAC52180.1; -; mRNA.
DR EMBL; X77603; CAA54698.1; -; mRNA.
DR PIR; I48099; I48099.
DR PIR; JC2478; JC2478.
DR RefSeq; NP_001166295.1; NM_001172824.1.
DR AlphaFoldDB; P80325; -.
DR SMR; P80325; -.
DR STRING; 10141.ENSCPOP00000012128; -.
DR PRIDE; P80325; -.
DR Ensembl; ENSCPOT00000043419; ENSCPOP00000024152; ENSCPOG00000032138.
DR GeneID; 100135493; -.
DR KEGG; cpoc:100135493; -.
DR CTD; 6356; -.
DR eggNOG; ENOG502S8M4; Eukaryota.
DR GeneTree; ENSGT01050000244851; -.
DR HOGENOM; CLU_141716_1_0_1; -.
DR InParanoid; P80325; -.
DR OMA; DKMICAD; -.
DR OrthoDB; 1575018at2759; -.
DR TreeFam; TF334888; -.
DR Proteomes; UP000005447; Unassembled WGS sequence.
DR Bgee; ENSCPOG00000032138; Expressed in heart left ventricle and 7 other tissues.
DR GO; GO:0005615; C:extracellular space; IEA:UniProtKB-KW.
DR GO; GO:0031728; F:CCR3 chemokine receptor binding; IEA:Ensembl.
DR GO; GO:0008009; F:chemokine activity; IEA:Ensembl.
DR GO; GO:0046983; F:protein dimerization activity; IEA:Ensembl.
DR GO; GO:0060444; P:branching involved in mammary gland duct morphogenesis; IEA:Ensembl.
DR GO; GO:0007010; P:cytoskeleton organization; IEA:Ensembl.
DR GO; GO:0048245; P:eosinophil chemotaxis; IEA:Ensembl.
DR GO; GO:0006955; P:immune response; IEA:InterPro.
DR GO; GO:0006954; P:inflammatory response; IEA:UniProtKB-KW.
DR GO; GO:0007611; P:learning or memory; IEA:Ensembl.
DR GO; GO:0060763; P:mammary duct terminal end bud growth; IEA:Ensembl.
DR GO; GO:0050768; P:negative regulation of neurogenesis; IEA:Ensembl.
DR GO; GO:0030838; P:positive regulation of actin filament polymerization; IEA:Ensembl.
DR GO; GO:0045766; P:positive regulation of angiogenesis; IEA:Ensembl.
DR GO; GO:0030335; P:positive regulation of cell migration; IEA:Ensembl.
DR GO; GO:0001938; P:positive regulation of endothelial cell proliferation; IEA:Ensembl.
DR GO; GO:0043547; P:positive regulation of GTPase activity; IEA:Ensembl.
DR GO; GO:0008360; P:regulation of cell shape; IEA:Ensembl.
DR InterPro; IPR039809; Chemokine_b/g/d.
DR InterPro; IPR000827; Chemokine_CC_CS.
DR InterPro; IPR001811; Chemokine_IL8-like_dom.
DR InterPro; IPR036048; Interleukin_8-like_sf.
DR PANTHER; PTHR12015; PTHR12015; 1.
DR Pfam; PF00048; IL8; 1.
DR SMART; SM00199; SCY; 1.
DR SUPFAM; SSF54117; SSF54117; 1.
DR PROSITE; PS00472; SMALL_CYTOKINES_CC; 1.
PE 1: Evidence at protein level;
KW Chemotaxis; Cytokine; Direct protein sequencing; Disulfide bond;
KW Glycoprotein; Inflammatory response; Reference proteome; Secreted; Signal.
FT SIGNAL 1..23
FT /evidence="ECO:0000269|PubMed:7509365"
FT CHAIN 24..96
FT /note="Eotaxin"
FT /id="PRO_0000005193"
FT CARBOHYD 93
FT /note="O-linked (GalNAc...) threonine"
FT /evidence="ECO:0000250|UniProtKB:P51671"
FT DISULFID 31..56
FT /evidence="ECO:0000250|UniProtKB:P51671"
FT DISULFID 32..72
FT /evidence="ECO:0000250|UniProtKB:P51671"
FT CONFLICT 88
FT /note="D -> G (in Ref. 2; CAA54698)"
FT /evidence="ECO:0000305"
SQ SEQUENCE 96 AA; 10753 MW; 62C856645BC6AC99 CRC64;
MKVSTAFLCL LLTVSAFSAQ VLAHPGIPSA CCFRVTNKKI SFQRLKSYKI ITSSKCPQTA
IVFEIKPDKM ICADPKKKWV QDAKKYLDQI SQTTKP
