ID   CCER1_HUMAN             Reviewed;         406 AA.
AC   Q8TC90; Q8TC47;
DT   29-MAY-2007, integrated into UniProtKB/Swiss-Prot.
DT   01-JUN-2002, sequence version 1.
DT   03-AUG-2022, entry version 119.
DE   RecName: Full=Coiled-coil domain-containing glutamate-rich protein 1;
GN   Name=CCER1; Synonyms=C12orf12;
OS   Homo sapiens (Human).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC   Homo.
OX   NCBI_TaxID=9606;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA], AND VARIANT MET-379.
RC   TISSUE=Testis;
RX   PubMed=15489334; DOI=10.1101/gr.2596504;
RG   The MGC Project Team;
RT   "The status, quality, and expansion of the NIH full-length cDNA project:
RT   the Mammalian Gene Collection (MGC).";
RL   Genome Res. 14:2121-2127(2004).
CC   -!- INTERACTION:
CC       Q8TC90; A8MQ03: CYSRT1; NbExp=3; IntAct=EBI-746041, EBI-3867333;
CC       Q8TC90; Q15323: KRT31; NbExp=3; IntAct=EBI-746041, EBI-948001;
CC       Q8TC90; Q6A162: KRT40; NbExp=3; IntAct=EBI-746041, EBI-10171697;
CC       Q8TC90; Q9BYR5: KRTAP4-2; NbExp=3; IntAct=EBI-746041, EBI-10172511;
CC       Q8TC90; Q3LI66: KRTAP6-2; NbExp=3; IntAct=EBI-746041, EBI-11962084;
CC       Q8TC90; Q9BYQ3: KRTAP9-3; NbExp=3; IntAct=EBI-746041, EBI-1043191;
CC       Q8TC90; Q7Z3S9: NOTCH2NLA; NbExp=4; IntAct=EBI-746041, EBI-945833;
CC       Q8TC90; P0DPK4: NOTCH2NLC; NbExp=3; IntAct=EBI-746041, EBI-22310682;
CC       Q8TC90; Q7Z699: SPRED1; NbExp=3; IntAct=EBI-746041, EBI-5235340;
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DR   EMBL; BC024183; AAH24183.1; -; mRNA.
DR   EMBL; BC026075; AAH26075.1; -; mRNA.
DR   EMBL; BC027600; AAH27600.1; -; mRNA.
DR   EMBL; BC034491; AAH34491.1; -; mRNA.
DR   CCDS; CCDS9036.1; -.
DR   RefSeq; NP_689851.1; NM_152638.3.
DR   AlphaFoldDB; Q8TC90; -.
DR   SMR; Q8TC90; -.
DR   BioGRID; 128212; 14.
DR   IntAct; Q8TC90; 12.
DR   STRING; 9606.ENSP00000351727; -.
DR   iPTMnet; Q8TC90; -.
DR   PhosphoSitePlus; Q8TC90; -.
DR   BioMuta; CCER1; -.
DR   DMDM; 74730573; -.
DR   MassIVE; Q8TC90; -.
DR   PaxDb; Q8TC90; -.
DR   PeptideAtlas; Q8TC90; -.
DR   PRIDE; Q8TC90; -.
DR   ProteomicsDB; 74101; -.
DR   Antibodypedia; 66707; 4 antibodies from 4 providers.
DR   DNASU; 196477; -.
DR   Ensembl; ENST00000358859.3; ENSP00000351727.2; ENSG00000197651.4.
DR   GeneID; 196477; -.
DR   KEGG; hsa:196477; -.
DR   MANE-Select; ENST00000358859.3; ENSP00000351727.2; NM_152638.4; NP_689851.1.
DR   UCSC; uc001tbj.3; human.
DR   CTD; 196477; -.
DR   DisGeNET; 196477; -.
DR   GeneCards; CCER1; -.
DR   HGNC; HGNC:28373; CCER1.
DR   HPA; ENSG00000197651; Tissue enriched (testis).
DR   neXtProt; NX_Q8TC90; -.
DR   OpenTargets; ENSG00000197651; -.
DR   PharmGKB; PA142672294; -.
DR   VEuPathDB; HostDB:ENSG00000197651; -.
DR   eggNOG; ENOG502S11C; Eukaryota.
DR   GeneTree; ENSGT00730000111529; -.
DR   HOGENOM; CLU_794441_0_0_1; -.
DR   InParanoid; Q8TC90; -.
DR   OMA; PLCFCCC; -.
DR   OrthoDB; 1028614at2759; -.
DR   PhylomeDB; Q8TC90; -.
DR   PathwayCommons; Q8TC90; -.
DR   SignaLink; Q8TC90; -.
DR   BioGRID-ORCS; 196477; 18 hits in 1060 CRISPR screens.
DR   ChiTaRS; CCER1; human.
DR   GenomeRNAi; 196477; -.
DR   Pharos; Q8TC90; Tdark.
DR   PRO; PR:Q8TC90; -.
DR   Proteomes; UP000005640; Chromosome 12.
DR   RNAct; Q8TC90; protein.
DR   Bgee; ENSG00000197651; Expressed in sperm and 31 other tissues.
DR   ExpressionAtlas; Q8TC90; baseline and differential.
DR   Genevisible; Q8TC90; HS.
DR   InterPro; IPR027889; CCER1.
DR   Pfam; PF15482; CCER1; 1.
PE   1: Evidence at protein level;
KW   Coiled coil; Reference proteome.
FT   CHAIN           1..406
FT                   /note="Coiled-coil domain-containing glutamate-rich protein
FT                   1"
FT                   /id="PRO_0000288857"
FT   REGION          43..72
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          138..167
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          203..244
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          278..358
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COILED          199..225
FT                   /evidence="ECO:0000255"
FT   COILED          274..359
FT                   /evidence="ECO:0000255"
FT   COMPBIAS        138..157
FT                   /note="Basic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        280..350
FT                   /note="Acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   VARIANT         286
FT                   /note="D -> E (in dbSNP:rs11105882)"
FT                   /id="VAR_059617"
FT   VARIANT         379
FT                   /note="I -> M (in dbSNP:rs17855513)"
FT                   /evidence="ECO:0000269|PubMed:15489334"
FT                   /id="VAR_032512"
SQ   SEQUENCE   406 AA;  46482 MW;  FBB9072D7F976FE6 CRC64;
     MTQTLDTRED PLNLGGGGGG GCGCGWAHSA SLSSWSSCHR RRPGAPAYNR PHRYSPKTEY
     GPPRKQPKQQ HGPGFWFQPP VCSNWGCWGG PWRPPPPGFW KFPCPVQVFR VYGLHPLCFC
     CCSCWSGSWN PGWVKPPGRK KRWGRRGRGL RHHPRHSYPR SPPADVSTLP RPVKLYEWRE
     PGMRAPPNTT QFIMNQIYED MRQQEKVERQ QEALRAQKAT VSGEASPARS SGNDAPPGGS
     KETWGLQETL YGFVQNPSLA FSPNPEENQS LAPLLVEEEE EKKNDDEEEY DQEVCDAKEA
     SEEEEEVEDE EEEVEDEEEE EVEEAEYVEE GEEELEEEEL EEEEEVLEEN EQRGEEFHLP
     LEMPLSIFVE AEEKRENFIS CTFLNPEQII PKVPQESLFM AQDFNC