CCD80_DANRE
ID CCD80_DANRE Reviewed; 867 AA.
AC Q90X49; Q5EAQ8;
DT 03-APR-2007, integrated into UniProtKB/Swiss-Prot.
DT 01-DEC-2001, sequence version 1.
DT 03-AUG-2022, entry version 104.
DE RecName: Full=Coiled-coil domain-containing protein 80;
DE Flags: Precursor;
GN Name=ccdc80; Synonyms=ssg1; ORFNames=si:bz20i5.2, zgc:113236;
OS Danio rerio (Zebrafish) (Brachydanio rerio).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes;
OC Danionidae; Danioninae; Danio.
OX NCBI_TaxID=7955;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Tuebingen;
RX PubMed=23594743; DOI=10.1038/nature12111;
RA Howe K., Clark M.D., Torroja C.F., Torrance J., Berthelot C., Muffato M.,
RA Collins J.E., Humphray S., McLaren K., Matthews L., McLaren S., Sealy I.,
RA Caccamo M., Churcher C., Scott C., Barrett J.C., Koch R., Rauch G.J.,
RA White S., Chow W., Kilian B., Quintais L.T., Guerra-Assuncao J.A., Zhou Y.,
RA Gu Y., Yen J., Vogel J.H., Eyre T., Redmond S., Banerjee R., Chi J., Fu B.,
RA Langley E., Maguire S.F., Laird G.K., Lloyd D., Kenyon E., Donaldson S.,
RA Sehra H., Almeida-King J., Loveland J., Trevanion S., Jones M., Quail M.,
RA Willey D., Hunt A., Burton J., Sims S., McLay K., Plumb B., Davis J.,
RA Clee C., Oliver K., Clark R., Riddle C., Elliot D., Threadgold G.,
RA Harden G., Ware D., Begum S., Mortimore B., Kerry G., Heath P.,
RA Phillimore B., Tracey A., Corby N., Dunn M., Johnson C., Wood J., Clark S.,
RA Pelan S., Griffiths G., Smith M., Glithero R., Howden P., Barker N.,
RA Lloyd C., Stevens C., Harley J., Holt K., Panagiotidis G., Lovell J.,
RA Beasley H., Henderson C., Gordon D., Auger K., Wright D., Collins J.,
RA Raisen C., Dyer L., Leung K., Robertson L., Ambridge K., Leongamornlert D.,
RA McGuire S., Gilderthorp R., Griffiths C., Manthravadi D., Nichol S.,
RA Barker G., Whitehead S., Kay M., Brown J., Murnane C., Gray E.,
RA Humphries M., Sycamore N., Barker D., Saunders D., Wallis J., Babbage A.,
RA Hammond S., Mashreghi-Mohammadi M., Barr L., Martin S., Wray P.,
RA Ellington A., Matthews N., Ellwood M., Woodmansey R., Clark G., Cooper J.,
RA Tromans A., Grafham D., Skuce C., Pandian R., Andrews R., Harrison E.,
RA Kimberley A., Garnett J., Fosker N., Hall R., Garner P., Kelly D., Bird C.,
RA Palmer S., Gehring I., Berger A., Dooley C.M., Ersan-Urun Z., Eser C.,
RA Geiger H., Geisler M., Karotki L., Kirn A., Konantz J., Konantz M.,
RA Oberlander M., Rudolph-Geiger S., Teucke M., Lanz C., Raddatz G.,
RA Osoegawa K., Zhu B., Rapp A., Widaa S., Langford C., Yang F.,
RA Schuster S.C., Carter N.P., Harrow J., Ning Z., Herrero J., Searle S.M.,
RA Enright A., Geisler R., Plasterk R.H., Lee C., Westerfield M.,
RA de Jong P.J., Zon L.I., Postlethwait J.H., Nusslein-Volhard C.,
RA Hubbard T.J., Roest Crollius H., Rogers J., Stemple D.L.;
RT "The zebrafish reference genome sequence and its relationship to the human
RT genome.";
RL Nature 496:498-503(2013).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2).
RC TISSUE=Embryo;
RG NIH - Zebrafish Gene Collection (ZGC) project;
RL Submitted (FEB-2005) to the EMBL/GenBank/DDBJ databases.
CC -!- FUNCTION: Promotes cell adhesion and matrix assembly. {ECO:0000250}.
CC -!- SUBUNIT: Binds to various extracellular matrix proteins. {ECO:0000250}.
CC -!- SUBCELLULAR LOCATION: Secreted, extracellular space, extracellular
CC matrix {ECO:0000250}.
CC -!- ALTERNATIVE PRODUCTS:
CC Event=Alternative splicing; Named isoforms=2;
CC Name=1;
CC IsoId=Q90X49-1; Sequence=Displayed;
CC Name=2;
CC IsoId=Q90X49-2; Sequence=VSP_024139;
CC -!- SIMILARITY: Belongs to the CCDC80 family. {ECO:0000305}.
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DR EMBL; AL590146; CAC94894.1; -; Genomic_DNA.
DR EMBL; BC090295; AAH90295.1; -; mRNA.
DR RefSeq; NP_001007199.1; NM_001007198.1. [Q90X49-1]
DR AlphaFoldDB; Q90X49; -.
DR STRING; 7955.ENSDARP00000000005; -.
DR PaxDb; Q90X49; -.
DR PRIDE; Q90X49; -.
DR Ensembl; ENSDART00000000005; ENSDARP00000000005; ENSDARG00000000002. [Q90X49-1]
DR GeneID; 368419; -.
DR KEGG; dre:368419; -.
DR CTD; 151887; -.
DR ZFIN; ZDB-GENE-030616-56; ccdc80.
DR eggNOG; ENOG502QRG7; Eukaryota.
DR GeneTree; ENSGT00940000164470; -.
DR HOGENOM; CLU_013508_0_0_1; -.
DR InParanoid; Q90X49; -.
DR OMA; HQGYQEG; -.
DR PhylomeDB; Q90X49; -.
DR TreeFam; TF332926; -.
DR PRO; PR:Q90X49; -.
DR Proteomes; UP000000437; Genome assembly.
DR Proteomes; UP000814640; Chromosome 9.
DR Bgee; ENSDARG00000000002; Expressed in zone of skin and 28 other tissues.
DR ExpressionAtlas; Q90X49; baseline.
DR GO; GO:0005604; C:basement membrane; IBA:GO_Central.
DR GO; GO:0005576; C:extracellular region; IEA:UniProtKB-KW.
DR GO; GO:0030198; P:extracellular matrix organization; IBA:GO_Central.
DR GO; GO:0010811; P:positive regulation of cell-substrate adhesion; IBA:GO_Central.
DR GO; GO:0001756; P:somitogenesis; IMP:ZFIN.
DR InterPro; IPR025232; DUF4174.
DR Pfam; PF13778; DUF4174; 3.
PE 2: Evidence at transcript level;
KW Alternative splicing; Extracellular matrix; Reference proteome; Secreted;
KW Signal.
FT SIGNAL 1..18
FT /evidence="ECO:0000255"
FT CHAIN 19..867
FT /note="Coiled-coil domain-containing protein 80"
FT /id="PRO_0000282422"
FT REGION 83..121
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 282..539
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 286..300
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 301..375
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 388..402
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 403..419
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 454..473
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 480..525
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT VAR_SEQ 1..658
FT /note="Missing (in isoform 2)"
FT /evidence="ECO:0000303|Ref.2"
FT /id="VSP_024139"
FT CONFLICT 751
FT /note="L -> F (in Ref. 2; AAH90295)"
FT /evidence="ECO:0000305"
SQ SEQUENCE 867 AA; 99920 MW; 3589AEBE33F41200 CRC64;
MRARYMLGFG VLCLLTWAVY VSESSPTDKQ AKLRLMSVRR ARQNKSRQGQ IIKTRASSTW
INDKRQQMQG DEGVQFRRNV QSRKVLAQRR PAQGGTRNPI QQDDGTPGAR ARVSRMPSSA
GSPNLLASFA GKNRLLVISA PHDSDGYYRL MMSLLKPEVY CELAERHVHQ IVMFHQEGEL
GGKIRRITNE GKVMEEPLDT ALIPRLMTFL KLEKGKFGMV LLKKTLQVEE RYPYPVRLEA
MYEVIDQSPM RKMEKVRQKG FVQKCKGAGV EGQVVEGVLT TDSQVDPPTE RRKEIRKPIR
RPTTTTTPAP TRPTTTTTTT KATTTTTTRP PTTTRSTTTT TTTTTTTTRP TTTTTRTTTT
PRTTRANTTP QWIPAHKTTA EPYYYNRRDR YQTTSPPTDS ARYRDNHTSK KEYNHRHTNT
IPTQHKPTKV RPTKKKNGDK DISNAYEEKY DVGVPTDAYP EEKEEEIVPT KRGKGKTDKK
KKKDKTDKLS KKDKAERRGK DGKGGKKNGK KVPKILEKED YQKPTKRPPP PPPPKGTLAT
FLDYFESRRR LILITSPTEE NSMYIQQRDE YLEHVCEMAI RKVTIITIFG TFRNSTMKID
HYQLEKDKPM KGLRQEDLEN QDLIMELRKE YGMTYNDFYV VLTDLDMKAK QYYEVPIAMK
AVFDYIDTFS SRIREMEQQK RDGVTCKKED KPRSLENFLS RFRWRRRLFV ISAPNDEEWA
YQQQLYALTS QACNLGLRHV SVLKLVGTDL LDMGGVLELY PINGSATVER EGISATLVRD
IRNYFQISPE YFSMLLVGKD GNVKSWYPSP MWSMAIIYDL IDSMQLRRQE MAIQQSLGMR
CPEDEYGGYG YHHHEGYQEG YHQGYGY
