ID   ZYG11_XENLA             Reviewed;         732 AA.
AC   A0JMZ3;
DT   02-OCT-2007, integrated into UniProtKB/Swiss-Prot.
DT   12-DEC-2006, sequence version 1.
DT   03-AUG-2022, entry version 46.
DE   RecName: Full=Protein zyg-11 homolog;
GN   Name=zyg-11;
OS   Xenopus laevis (African clawed frog).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Amphibia;
OC   Batrachia; Anura; Pipoidea; Pipidae; Xenopodinae; Xenopus; Xenopus.
OX   NCBI_TaxID=8355;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   TISSUE=Oocyte;
RG   NIH - Xenopus Gene Collection (XGC) project;
RL   Submitted (OCT-2006) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: Serves as substrate adapter subunit in an E3 ubiquitin ligase
CC       complex zyg11-cul2-elongin BC. Targets substrates bearing N-terminal
CC       glycine degrons for proteasomal degradation.
CC       {ECO:0000250|UniProtKB:Q9C0D3}.
CC   -!- SIMILARITY: Belongs to the zyg-11 family. {ECO:0000305}.
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DR   EMBL; BC126059; AAI26060.1; -; mRNA.
DR   RefSeq; NP_001090447.1; NM_001096978.1.
DR   AlphaFoldDB; A0JMZ3; -.
DR   SMR; A0JMZ3; -.
DR   GeneID; 779359; -.
DR   KEGG; xla:779359; -.
DR   CTD; 779359; -.
DR   Xenbase; XB-GENE-5829609; zyg11b.L.
DR   OrthoDB; 374821at2759; -.
DR   Proteomes; UP000186698; Chromosome 4L.
DR   Bgee; 779359; Expressed in blastula and 18 other tissues.
DR   GO; GO:0031462; C:Cul2-RING ubiquitin ligase complex; IEA:InterPro.
DR   Gene3D; 1.25.10.10; -; 1.
DR   Gene3D; 3.80.10.10; -; 1.
DR   InterPro; IPR011989; ARM-like.
DR   InterPro; IPR016024; ARM-type_fold.
DR   InterPro; IPR032675; LRR_dom_sf.
DR   InterPro; IPR040367; ZYG11B.
DR   PANTHER; PTHR12904:SF21; PTHR12904:SF21; 1.
DR   SUPFAM; SSF48371; SSF48371; 1.
PE   2: Evidence at transcript level;
KW   Leucine-rich repeat; Reference proteome; Repeat; Ubl conjugation pathway.
FT   CHAIN           1..732
FT                   /note="Protein zyg-11 homolog"
FT                   /id="PRO_0000305090"
FT   REPEAT          128..149
FT                   /note="LRR 1"
FT   REPEAT          154..177
FT                   /note="LRR 2"
FT   REPEAT          178..199
FT                   /note="LRR 3"
FT   REPEAT          209..231
FT                   /note="LRR 4"
SQ   SEQUENCE   732 AA;  82962 MW;  729598AB6C4EB00A CRC64;
     MEESSPKSLL DITLLYLSTH LEKFCWERQD GTYCLQDAAI FPQEVADRLL QAMAVQRQLN
     EVTVGIFRGN QLRLKRACIR KAKISAVAFR KAFCHHKLIE LDATGVNADI TITDIISGLS
     SSKWIRENLQ CLVLNSLTLS LEDPYERCFS QLSGLRVLSI TNVLFYNEDL ADVASLPRLE
     SLDISNTSVT DITALVACKD ILKSLTMHHL KCLKMTTTQI LEVIRELKKL NHLDMSDDKQ
     FTSDIACRLL EQNDILLHLV SLDISGRKHV TDKAVEAFIR HRPQMQFVGL LATEAGYSEF
     LSGEGCVKVS GEANQTQIAE ALRRYSERSF FVREALFHLF SLTHVMDKAN PEMLKLVVIG
     MRNHPTNLPV QLAASACVFN LTKQDLAAGM PVKLLADVTH LLLEAMKHFP NHQQLQKNCL
     LSLCSDRILQ DVPFNRFDAA KLVMQWLCNH EDQNMQRMAV AIISILAAKL STEQTAQLGA
     ELFIVRQLLQ IVRQKTSQNM VDTTLKFTLS ALWNLTDESP TTCRHFIENQ GLELFMKVLE
     TFPSESSIQQ KVLGLLNNIA EVKELHTELM CKDFIDQISK LLHSVEVEVS YFAAGIIAHL
     VSRGEETWTL SSSMRETLLE QLHSAILSWP TPECEMVAYR SFNPFFPLLA CFRTPGVQLW
     AVWAMQHVCS KNPVRYCSML IEEGGLVRLH RIRDHMCADP DVLRITITIL DNLDRHLKKH
     GNPPCQKPPF TK