ID   ZYG11_DANRE             Reviewed;         746 AA.
AC   Q5TYQ1; Q5TYQ2;
DT   02-OCT-2007, integrated into UniProtKB/Swiss-Prot.
DT   07-DEC-2004, sequence version 1.
DT   03-AUG-2022, entry version 112.
DE   RecName: Full=Protein zyg-11 homolog;
GN   Name=zyg11; ORFNames=si:ch211-11m18.3, zgc:136612;
OS   Danio rerio (Zebrafish) (Brachydanio rerio).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes;
OC   Danionidae; Danioninae; Danio.
OX   NCBI_TaxID=7955;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=Tuebingen;
RX   PubMed=23594743; DOI=10.1038/nature12111;
RA   Howe K., Clark M.D., Torroja C.F., Torrance J., Berthelot C., Muffato M.,
RA   Collins J.E., Humphray S., McLaren K., Matthews L., McLaren S., Sealy I.,
RA   Caccamo M., Churcher C., Scott C., Barrett J.C., Koch R., Rauch G.J.,
RA   White S., Chow W., Kilian B., Quintais L.T., Guerra-Assuncao J.A., Zhou Y.,
RA   Gu Y., Yen J., Vogel J.H., Eyre T., Redmond S., Banerjee R., Chi J., Fu B.,
RA   Langley E., Maguire S.F., Laird G.K., Lloyd D., Kenyon E., Donaldson S.,
RA   Sehra H., Almeida-King J., Loveland J., Trevanion S., Jones M., Quail M.,
RA   Willey D., Hunt A., Burton J., Sims S., McLay K., Plumb B., Davis J.,
RA   Clee C., Oliver K., Clark R., Riddle C., Elliot D., Threadgold G.,
RA   Harden G., Ware D., Begum S., Mortimore B., Kerry G., Heath P.,
RA   Phillimore B., Tracey A., Corby N., Dunn M., Johnson C., Wood J., Clark S.,
RA   Pelan S., Griffiths G., Smith M., Glithero R., Howden P., Barker N.,
RA   Lloyd C., Stevens C., Harley J., Holt K., Panagiotidis G., Lovell J.,
RA   Beasley H., Henderson C., Gordon D., Auger K., Wright D., Collins J.,
RA   Raisen C., Dyer L., Leung K., Robertson L., Ambridge K., Leongamornlert D.,
RA   McGuire S., Gilderthorp R., Griffiths C., Manthravadi D., Nichol S.,
RA   Barker G., Whitehead S., Kay M., Brown J., Murnane C., Gray E.,
RA   Humphries M., Sycamore N., Barker D., Saunders D., Wallis J., Babbage A.,
RA   Hammond S., Mashreghi-Mohammadi M., Barr L., Martin S., Wray P.,
RA   Ellington A., Matthews N., Ellwood M., Woodmansey R., Clark G., Cooper J.,
RA   Tromans A., Grafham D., Skuce C., Pandian R., Andrews R., Harrison E.,
RA   Kimberley A., Garnett J., Fosker N., Hall R., Garner P., Kelly D., Bird C.,
RA   Palmer S., Gehring I., Berger A., Dooley C.M., Ersan-Urun Z., Eser C.,
RA   Geiger H., Geisler M., Karotki L., Kirn A., Konantz J., Konantz M.,
RA   Oberlander M., Rudolph-Geiger S., Teucke M., Lanz C., Raddatz G.,
RA   Osoegawa K., Zhu B., Rapp A., Widaa S., Langford C., Yang F.,
RA   Schuster S.C., Carter N.P., Harrow J., Ning Z., Herrero J., Searle S.M.,
RA   Enright A., Geisler R., Plasterk R.H., Lee C., Westerfield M.,
RA   de Jong P.J., Zon L.I., Postlethwait J.H., Nusslein-Volhard C.,
RA   Hubbard T.J., Roest Crollius H., Rogers J., Stemple D.L.;
RT   "The zebrafish reference genome sequence and its relationship to the human
RT   genome.";
RL   Nature 496:498-503(2013).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RG   NIH - Zebrafish Gene Collection (ZGC) project;
RL   Submitted (APR-2006) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: Serves as substrate adapter subunit in an E3 ubiquitin ligase
CC       complex zyg11-cul2-elongin BC. Targets substrates bearing N-terminal
CC       glycine degrons for proteasomal degradation.
CC       {ECO:0000250|UniProtKB:Q9C0D3}.
CC   -!- SIMILARITY: Belongs to the zyg-11 family. {ECO:0000305}.
CC   -!- SEQUENCE CAUTION:
CC       Sequence=CAH68868.1; Type=Erroneous gene model prediction; Evidence={ECO:0000305};
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DR   EMBL; BX942844; CAH68868.1; ALT_SEQ; Genomic_DNA.
DR   EMBL; BX942844; CAH68869.1; -; Genomic_DNA.
DR   EMBL; BC115195; AAI15196.1; -; mRNA.
DR   RefSeq; NP_001035422.1; NM_001040332.2.
DR   AlphaFoldDB; Q5TYQ1; -.
DR   SMR; Q5TYQ1; -.
DR   STRING; 7955.ENSDARP00000094887; -.
DR   PaxDb; Q5TYQ1; -.
DR   Ensembl; ENSDART00000104112; ENSDARP00000094887; ENSDARG00000007737.
DR   GeneID; 555349; -.
DR   KEGG; dre:555349; -.
DR   CTD; 555349; -.
DR   ZFIN; ZDB-GENE-041014-17; zyg11.
DR   eggNOG; KOG3665; Eukaryota.
DR   GeneTree; ENSGT00530000063187; -.
DR   HOGENOM; CLU_011533_1_0_1; -.
DR   InParanoid; Q5TYQ1; -.
DR   OMA; AYRSFHP; -.
DR   OrthoDB; 374821at2759; -.
DR   PhylomeDB; Q5TYQ1; -.
DR   TreeFam; TF313007; -.
DR   PRO; PR:Q5TYQ1; -.
DR   Proteomes; UP000000437; Genome assembly.
DR   Proteomes; UP000814640; Chromosome 20.
DR   Bgee; ENSDARG00000007737; Expressed in pharyngeal gill and 25 other tissues.
DR   ExpressionAtlas; Q5TYQ1; baseline and differential.
DR   GO; GO:0031462; C:Cul2-RING ubiquitin ligase complex; IBA:GO_Central.
DR   Gene3D; 1.25.10.10; -; 1.
DR   Gene3D; 3.80.10.10; -; 1.
DR   InterPro; IPR011989; ARM-like.
DR   InterPro; IPR016024; ARM-type_fold.
DR   InterPro; IPR000225; Armadillo.
DR   InterPro; IPR032675; LRR_dom_sf.
DR   InterPro; IPR040367; ZYG11B.
DR   PANTHER; PTHR12904:SF21; PTHR12904:SF21; 1.
DR   SMART; SM00185; ARM; 3.
DR   SUPFAM; SSF48371; SSF48371; 1.
PE   2: Evidence at transcript level;
KW   Leucine-rich repeat; Reference proteome; Repeat; Ubl conjugation pathway.
FT   CHAIN           1..746
FT                   /note="Protein zyg-11 homolog"
FT                   /id="PRO_0000305089"
FT   REPEAT          185..209
FT                   /note="LRR 1"
FT   REPEAT          216..241
FT                   /note="LRR 2"
FT   REPEAT          265..289
FT                   /note="LRR 3"
SQ   SEQUENCE   746 AA;  83666 MW;  D3C612B65A555FCB CRC64;
     MIHLSQTMDK SSLPSLSDLC MSLVSSRLEL FCEMRDDGSL SFREPLVFPQ ELADQLLCKM
     ATDGVLNDST VGIFRNCQQF RLRHACIRTA RISAEAFHRA LCPHRLVELD ASRVNADLTI
     ADILRGLSSN KSLQESLQRL VLNGLTMSSL EEPSRRCFSA MQGLRALSVS NVDFYDWGLA
     DVCLLPRLES LDISNTSVSN LTPLLGLRSR LRYLTMHQLK RLEMTTAQLL AVLSQLEVLQ
     HLDISDDKQF TSDVARQLLE TPGILPQLVS LDVSGRKQVT DAAVKAFVEA RPGMTFVGLL
     ATDAGFSEFL SGEGSLKVTG EANETQICEA LRRYSEREGF VREALFHLFS LTHAIEKPRP
     DILKLVALGM KNHPTTLNVQ LAASACVFNL TKQELAFGIP VRLLGNVTQQ LLEAMKTFPN
     HQQLQKNCLL SLCSDRILQE VPFNRFEAAK LVMQWLCNHE DQNMQRMAVA IISILAAKLS
     TEQTAQLGAE LFIVKQLLHI VRQKTCQSTV DATLKFTLSA LWNLTDESPT TCRHFIENQG
     LELFIKVLES FPSESSIQQK VLGLLNNIAE VSELHGELMV QSFLDHIRTL LHSPEVEVSY
     FAAGILAHLT SRGEKVWTLE LTLRNTLLQQ LHSAILKWPT PECEMVAYRS FNPFFPLLEC
     FQTPGVQLWA AWAMQHVCSK NAGRYCSMLL EEGGLQHLEA ITSHPKTHSD VRRLTESILD
     GLQRHRARTG YTAIPKTQAH REKCNP