ID   ZYG11_CAEEL             Reviewed;         799 AA.
AC   P21541;
DT   01-MAY-1991, integrated into UniProtKB/Swiss-Prot.
DT   01-MAY-1991, sequence version 1.
DT   03-AUG-2022, entry version 156.
DE   RecName: Full=Early embryogenesis protein zyg-11;
GN   Name=zyg-11; ORFNames=C08B11.1;
OS   Caenorhabditis elegans.
OC   Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida;
OC   Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae;
OC   Caenorhabditis.
OX   NCBI_TaxID=6239;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RC   STRAIN=Bristol N2;
RX   PubMed=2325632; DOI=10.1007/bf00280370;
RA   Carter P.W., Roos J.M., Kemphues K.J.;
RT   "Molecular analysis of zyg-11, a maternal-effect gene required for early
RT   embryogenesis of Caenorhabditis elegans.";
RL   Mol. Gen. Genet. 221:72-80(1990).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=Bristol N2;
RX   PubMed=9851916; DOI=10.1126/science.282.5396.2012;
RG   The C. elegans sequencing consortium;
RT   "Genome sequence of the nematode C. elegans: a platform for investigating
RT   biology.";
RL   Science 282:2012-2018(1998).
RN   [3]
RP   FUNCTION.
RX   PubMed=15215209; DOI=10.1242/dev.01245;
RA   Liu J., Vasudevan S., Kipreos E.T.;
RT   "CUL-2 and ZYG-11 promote meiotic anaphase II and the proper placement of
RT   the anterior-posterior axis in C. elegans.";
RL   Development 131:3513-3525(2004).
RN   [4]
RP   FUNCTION.
RX   PubMed=15215208; DOI=10.1242/dev.01244;
RA   Sonneville R., Goenczy P.;
RT   "Zyg-11 and cul-2 regulate progression through meiosis II and polarity
RT   establishment in C. elegans.";
RL   Development 131:3527-3543(2004).
RN   [5]
RP   FUNCTION, INTERACTION WITH ELC-1, IDENTIFICATION IN COMPLEX WITH CUL-2 AND
RP   ELC-1, AND MUTAGENESIS OF LEU-18; LEU-21 AND PRO-36.
RX   PubMed=17304241; DOI=10.1038/sj.embor.7400895;
RA   Vasudevan S., Starostina N.G., Kipreos E.T.;
RT   "The Caenorhabditis elegans cell-cycle regulator ZYG-11 defines a conserved
RT   family of CUL-2 complex components.";
RL   EMBO Rep. 8:279-286(2007).
CC   -!- FUNCTION: Acts as target recruitment subunit in the E3 ubiquitin ligase
CC       complex zyg-11-cul-2-elc-1. Required for metaphase to anaphase
CC       transition and M phase exit at meiosis II. Regulates polarity
CC       establishment. {ECO:0000269|PubMed:15215208,
CC       ECO:0000269|PubMed:15215209, ECO:0000269|PubMed:17304241}.
CC   -!- SUBUNIT: Interacts with elc-1. Part of an E3 ubiquitin ligase complex
CC       including zyg-11, cul-2 and elc-1. {ECO:0000269|PubMed:17304241}.
CC   -!- INTERACTION:
CC       P21541; Q17390: cul-2; NbExp=3; IntAct=EBI-314647, EBI-1811231;
CC       P21541; Q9BKS1: elc-1; NbExp=2; IntAct=EBI-314647, EBI-300574;
CC   -!- DEVELOPMENTAL STAGE: Maternally expressed but its transcription is not
CC       limited to the female germline.
CC   -!- SIMILARITY: Belongs to the zyg-11 family. {ECO:0000305}.
CC   ---------------------------------------------------------------------------
CC   Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC   Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC   ---------------------------------------------------------------------------
DR   EMBL; X16473; CAA34493.1; -; Genomic_DNA.
DR   EMBL; Z46676; CAA86661.1; -; Genomic_DNA.
DR   PIR; S14908; BVKWZ1.
DR   RefSeq; NP_495677.1; NM_063276.4.
DR   AlphaFoldDB; P21541; -.
DR   SMR; P21541; -.
DR   BioGRID; 39616; 9.
DR   DIP; DIP-25221N; -.
DR   IntAct; P21541; 3.
DR   MINT; P21541; -.
DR   STRING; 6239.C08B11.1; -.
DR   EPD; P21541; -.
DR   PaxDb; P21541; -.
DR   EnsemblMetazoa; C08B11.1.1; C08B11.1.1; WBGene00006996.
DR   GeneID; 174284; -.
DR   KEGG; cel:CELE_C08B11.1; -.
DR   UCSC; C08B11.1; c. elegans.
DR   CTD; 174284; -.
DR   WormBase; C08B11.1; CE01471; WBGene00006996; zyg-11.
DR   eggNOG; KOG3665; Eukaryota.
DR   GeneTree; ENSGT00530000063187; -.
DR   HOGENOM; CLU_011533_1_0_1; -.
DR   InParanoid; P21541; -.
DR   OMA; IQKWPSS; -.
DR   OrthoDB; 374821at2759; -.
DR   PhylomeDB; P21541; -.
DR   SignaLink; P21541; -.
DR   PRO; PR:P21541; -.
DR   Proteomes; UP000001940; Chromosome II.
DR   Bgee; WBGene00006996; Expressed in germ line (C elegans) and 4 other tissues.
DR   GO; GO:0031462; C:Cul2-RING ubiquitin ligase complex; IDA:UniProtKB.
DR   GO; GO:0030332; F:cyclin binding; IPI:WormBase.
DR   GO; GO:0031145; P:anaphase-promoting complex-dependent catabolic process; IMP:WormBase.
DR   GO; GO:0008595; P:anterior/posterior axis specification, embryo; IMP:WormBase.
DR   GO; GO:0009792; P:embryo development ending in birth or egg hatching; IMP:WormBase.
DR   GO; GO:0051321; P:meiotic cell cycle; IMP:WormBase.
DR   GO; GO:1902104; P:positive regulation of metaphase/anaphase transition of meiotic cell cycle; IMP:WormBase.
DR   GO; GO:0032436; P:positive regulation of proteasomal ubiquitin-dependent protein catabolic process; IMP:WormBase.
DR   GO; GO:0051759; P:sister chromosome movement towards spindle pole involved in meiotic sister chromatid segregation; IMP:WormBase.
DR   Gene3D; 1.25.10.10; -; 1.
DR   Gene3D; 3.80.10.10; -; 1.
DR   InterPro; IPR011989; ARM-like.
DR   InterPro; IPR016024; ARM-type_fold.
DR   InterPro; IPR032675; LRR_dom_sf.
DR   SUPFAM; SSF48371; SSF48371; 1.
PE   1: Evidence at protein level;
KW   Developmental protein; Meiosis; Reference proteome;
KW   Ubl conjugation pathway.
FT   CHAIN           1..799
FT                   /note="Early embryogenesis protein zyg-11"
FT                   /id="PRO_0000066597"
FT   REGION          1..131
FT                   /note="Interaction with elc-1"
FT   MUTAGEN         18
FT                   /note="L->S: Abolishes interaction with elc-1."
FT                   /evidence="ECO:0000269|PubMed:17304241"
FT   MUTAGEN         21
FT                   /note="L->S: Abolishes interaction with elc-1."
FT                   /evidence="ECO:0000269|PubMed:17304241"
FT   MUTAGEN         36
FT                   /note="P->S: No effect on interaction with elc-1."
FT                   /evidence="ECO:0000269|PubMed:17304241"
SQ   SEQUENCE   799 AA;  90780 MW;  B216E54C8F6374BD CRC64;
     MDHNAALTTC STSAIPRLAR LATERIAELI ENDALPEFDH KVIASCSNDI FEVLRQKKKL
     NHQTLQTMCS TSRFQINKID LMGNKVELQD LELCSNQNLV SFRLGDIDYF PNTNKIQVAD
     VLDTALNRTS RQQLRHLDLS GRHRITSNWP TYVARKLPRL ESLAFANRST ANETLSQIGA
     SLLNLRFLDI SSTCVTDISC ISSLRNLEVL IMYNLNILKG DVTETLSNLT KLRVLDISRK
     VNTDYLQETS QDAHLDLALG IYNRSVEAIE SGTATPWAEL RAIDMSGLSI VQFGTDRALA
     FVEKIIEAHP KLEQISLLAT PLDSSLIEIP NRNLQVINTV SRRSIIFALS HYANLDRPAF
     ITHALHSVYY QLQSGYDKFS QEELKECLRL VCISMQQGLN TLPVQIAGSA CLYHLCKMKR
     IKRLSVKEVN NCIERSLDAA EQYRSMTQLQ KNVWLTICND YLLHLDEIDF YRTCKVALDT
     MLLNRDASVE RMTIAIVSIV TPKMRPSEAK ILTTETKYVY HLVKIMNDYL EAYTREHRVG
     HERDNENALY TLKFTLSALW NLTDECPATC KAFLDAGGVQ IAFRILKAFD YHGNVQTKVL
     GILNNLAEVE ELHLGQLCKN EYISVLISCL DGSFNEVDSK GRYREVERSY FAAGILANLL
     TNTDGWESEN QRDEACEKLL ELIEQYPTLP SAMVSYKSFI PFSRIVRESN SNGAIMWCLW
     GVHHVLQHRE KNKAPTYEKG YIEMFMDSGL SPIVEDMSHG HSKHIHNLDI RVVHLAREII
     DIVSCHSLSS SPVRLVRRV