ID   ZY11A_MOUSE             Reviewed;         627 AA.
AC   A2BFL2; Q8VC01;
DT   02-OCT-2007, integrated into UniProtKB/Swiss-Prot.
DT   20-FEB-2007, sequence version 1.
DT   03-AUG-2022, entry version 90.
DE   RecName: Full=Protein zyg-11 homolog A;
GN   Name=Zyg11a;
OS   Mus musculus (Mouse).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC   Murinae; Mus; Mus.
OX   NCBI_TaxID=10090;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=C57BL/6J;
RX   PubMed=19468303; DOI=10.1371/journal.pbio.1000112;
RA   Church D.M., Goodstadt L., Hillier L.W., Zody M.C., Goldstein S., She X.,
RA   Bult C.J., Agarwala R., Cherry J.L., DiCuccio M., Hlavina W., Kapustin Y.,
RA   Meric P., Maglott D., Birtle Z., Marques A.C., Graves T., Zhou S.,
RA   Teague B., Potamousis K., Churas C., Place M., Herschleb J., Runnheim R.,
RA   Forrest D., Amos-Landgraf J., Schwartz D.C., Cheng Z., Lindblad-Toh K.,
RA   Eichler E.E., Ponting C.P.;
RT   "Lineage-specific biology revealed by a finished genome assembly of the
RT   mouse.";
RL   PLoS Biol. 7:E1000112-E1000112(2009).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 73-627.
RC   STRAIN=FVB/N; TISSUE=Liver;
RX   PubMed=15489334; DOI=10.1101/gr.2596504;
RG   The MGC Project Team;
RT   "The status, quality, and expansion of the NIH full-length cDNA project:
RT   the Mammalian Gene Collection (MGC).";
RL   Genome Res. 14:2121-2127(2004).
CC   -!- FUNCTION: Probably acts as target recruitment subunit in an E3
CC       ubiquitin ligase complex ZYGA-CUL2-elongin BC. {ECO:0000250}.
CC   -!- SIMILARITY: Belongs to the zyg-11 family. {ECO:0000305}.
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DR   EMBL; BX293563; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; BC022150; AAH22150.1; -; mRNA.
DR   AlphaFoldDB; A2BFL2; -.
DR   STRING; 10090.ENSMUSP00000038478; -.
DR   iPTMnet; A2BFL2; -.
DR   PhosphoSitePlus; A2BFL2; -.
DR   PaxDb; A2BFL2; -.
DR   PeptideAtlas; A2BFL2; -.
DR   PRIDE; A2BFL2; -.
DR   ProteomicsDB; 275320; -.
DR   MGI; MGI:2446208; Zyg11a.
DR   eggNOG; KOG3665; Eukaryota.
DR   HOGENOM; CLU_011533_1_0_1; -.
DR   InParanoid; A2BFL2; -.
DR   PhylomeDB; A2BFL2; -.
DR   ChiTaRS; Zyg11a; mouse.
DR   PRO; PR:A2BFL2; -.
DR   Proteomes; UP000000589; Unplaced.
DR   RNAct; A2BFL2; protein.
DR   Genevisible; A2BFL2; MM.
DR   GO; GO:0031462; C:Cul2-RING ubiquitin ligase complex; IBA:GO_Central.
DR   Gene3D; 1.25.10.10; -; 1.
DR   Gene3D; 3.80.10.10; -; 1.
DR   InterPro; IPR011989; ARM-like.
DR   InterPro; IPR016024; ARM-type_fold.
DR   InterPro; IPR000225; Armadillo.
DR   InterPro; IPR032675; LRR_dom_sf.
DR   SUPFAM; SSF48371; SSF48371; 1.
DR   PROSITE; PS50176; ARM_REPEAT; 1.
PE   2: Evidence at transcript level;
KW   Leucine-rich repeat; Reference proteome; Repeat; Ubl conjugation pathway.
FT   CHAIN           1..627
FT                   /note="Protein zyg-11 homolog A"
FT                   /id="PRO_0000305086"
FT   REPEAT          123..146
FT                   /note="LRR 1"
FT   REPEAT          203..227
FT                   /note="LRR 2"
FT   REPEAT          409..432
FT                   /note="LRR 3"
FT   CONFLICT        481
FT                   /note="A -> T (in Ref. 2; AAH22150)"
FT                   /evidence="ECO:0000305"
SQ   SEQUENCE   627 AA;  70404 MW;  0FE8FC37632F94B3 CRC64;
     MAWQGKLTDR TASIFQGKQM SLKLINIPRV KLSAAAFTKA FCHHKLIEVN ATSVDSELLA
     PDIIHALQSS AWIQKNLQCL VLDSVSIPPN SGLVALSHFT GLHTLSVANV SFCNEDLVSV
     SQLPNLGSLD ISNTLVTNIS ALLSCKNRLR SLTMHYLKCL AMNSPQVLAV IRQLKCLLHL
     DISDHQQLRS DLAFYLLQQK DILPNLTSLD ISGGTDVTDQ AVESFLQHRP AMRFVGLLYT
     DAGYSDFFTA KQGLKVAGGA NMSQISEALS RYRNRSCFVK EALFRLFTET LSLRAVLPVM
     LKLVAIGMRN HPLDLPVQFT ASACALNLTR QELARGMPVR LLAEITDLLF KATKNFPYYQ
     QLQKNCLLSL TSSRILMDVP FDRFDAAKLA LRWVCRRESP KLRTMAVSIT SILALKLSPE
     EMGQLQEELI MAIKELLTII RQKLAENLDD VTFLFTLKAL WNLTDECPLA CKYFMENEGL
     ATVIRVLETF SISVIQSKVL GLLNNVAEVR ELSSKLVTED VIERIISLLH SSNLEVSFLA
     AGVLAHLTCD RQHWLSRDLQ RTDLLRYLHL AIQNWPSSRC DMSVLVTYRS FKAFSPLLVN
     FSQPEVQRWA LWAIHHVCSK NPRPKDV