ZY11A_HUMAN
ID ZY11A_HUMAN Reviewed; 759 AA.
AC Q6WRX3; A6NCK5;
DT 02-OCT-2007, integrated into UniProtKB/Swiss-Prot.
DT 11-JAN-2011, sequence version 3.
DT 03-AUG-2022, entry version 123.
DE RecName: Full=Protein zyg-11 homolog A;
GN Name=ZYG11A; Synonyms=ZYG11;
OS Homo sapiens (Human).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC Homo.
OX NCBI_TaxID=9606;
RN [1]
RP NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 2).
RA Uzvolgyi E., Liang G., Sumegi J., Tang L., Ryder P.C., Talmadge C.B.,
RA Cohen S.M., Christman J.K., Jones P.A.;
RT "The human homolog of the Caenorhabditis elegans ZYG-11 gene is frequently
RT hypermethylated and suppressed in human tumor cells.";
RL Submitted (APR-2003) to the EMBL/GenBank/DDBJ databases.
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=16710414; DOI=10.1038/nature04727;
RA Gregory S.G., Barlow K.F., McLay K.E., Kaul R., Swarbreck D., Dunham A.,
RA Scott C.E., Howe K.L., Woodfine K., Spencer C.C.A., Jones M.C., Gillson C.,
RA Searle S., Zhou Y., Kokocinski F., McDonald L., Evans R., Phillips K.,
RA Atkinson A., Cooper R., Jones C., Hall R.E., Andrews T.D., Lloyd C.,
RA Ainscough R., Almeida J.P., Ambrose K.D., Anderson F., Andrew R.W.,
RA Ashwell R.I.S., Aubin K., Babbage A.K., Bagguley C.L., Bailey J.,
RA Beasley H., Bethel G., Bird C.P., Bray-Allen S., Brown J.Y., Brown A.J.,
RA Buckley D., Burton J., Bye J., Carder C., Chapman J.C., Clark S.Y.,
RA Clarke G., Clee C., Cobley V., Collier R.E., Corby N., Coville G.J.,
RA Davies J., Deadman R., Dunn M., Earthrowl M., Ellington A.G., Errington H.,
RA Frankish A., Frankland J., French L., Garner P., Garnett J., Gay L.,
RA Ghori M.R.J., Gibson R., Gilby L.M., Gillett W., Glithero R.J.,
RA Grafham D.V., Griffiths C., Griffiths-Jones S., Grocock R., Hammond S.,
RA Harrison E.S.I., Hart E., Haugen E., Heath P.D., Holmes S., Holt K.,
RA Howden P.J., Hunt A.R., Hunt S.E., Hunter G., Isherwood J., James R.,
RA Johnson C., Johnson D., Joy A., Kay M., Kershaw J.K., Kibukawa M.,
RA Kimberley A.M., King A., Knights A.J., Lad H., Laird G., Lawlor S.,
RA Leongamornlert D.A., Lloyd D.M., Loveland J., Lovell J., Lush M.J.,
RA Lyne R., Martin S., Mashreghi-Mohammadi M., Matthews L., Matthews N.S.W.,
RA McLaren S., Milne S., Mistry S., Moore M.J.F., Nickerson T., O'Dell C.N.,
RA Oliver K., Palmeiri A., Palmer S.A., Parker A., Patel D., Pearce A.V.,
RA Peck A.I., Pelan S., Phelps K., Phillimore B.J., Plumb R., Rajan J.,
RA Raymond C., Rouse G., Saenphimmachak C., Sehra H.K., Sheridan E.,
RA Shownkeen R., Sims S., Skuce C.D., Smith M., Steward C., Subramanian S.,
RA Sycamore N., Tracey A., Tromans A., Van Helmond Z., Wall M., Wallis J.M.,
RA White S., Whitehead S.L., Wilkinson J.E., Willey D.L., Williams H.,
RA Wilming L., Wray P.W., Wu Z., Coulson A., Vaudin M., Sulston J.E.,
RA Durbin R.M., Hubbard T., Wooster R., Dunham I., Carter N.P., McVean G.,
RA Ross M.T., Harrow J., Olson M.V., Beck S., Rogers J., Bentley D.R.;
RT "The DNA sequence and biological annotation of human chromosome 1.";
RL Nature 441:315-321(2006).
CC -!- FUNCTION: Probably acts as target recruitment subunit in an E3
CC ubiquitin ligase complex ZYGA-CUL2-elongin BC. {ECO:0000250}.
CC -!- ALTERNATIVE PRODUCTS:
CC Event=Alternative splicing; Named isoforms=2;
CC Name=1;
CC IsoId=Q6WRX3-1; Sequence=Displayed;
CC Name=2;
CC IsoId=Q6WRX3-2; Sequence=VSP_028223;
CC -!- SIMILARITY: Belongs to the zyg-11 family. {ECO:0000305}.
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DR EMBL; AY271826; AAQ01753.1; -; mRNA.
DR EMBL; AC099677; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR CCDS; CCDS44148.1; -. [Q6WRX3-1]
DR CCDS; CCDS76166.1; -. [Q6WRX3-2]
DR RefSeq; NP_001004339.2; NM_001004339.2. [Q6WRX3-1]
DR RefSeq; NP_001294860.1; NM_001307931.1. [Q6WRX3-2]
DR AlphaFoldDB; Q6WRX3; -.
DR SMR; Q6WRX3; -.
DR BioGRID; 136714; 20.
DR IntAct; Q6WRX3; 6.
DR STRING; 9606.ENSP00000360583; -.
DR iPTMnet; Q6WRX3; -.
DR PhosphoSitePlus; Q6WRX3; -.
DR BioMuta; ZYG11A; -.
DR DMDM; 317373488; -.
DR jPOST; Q6WRX3; -.
DR MassIVE; Q6WRX3; -.
DR MaxQB; Q6WRX3; -.
DR PaxDb; Q6WRX3; -.
DR PeptideAtlas; Q6WRX3; -.
DR PRIDE; Q6WRX3; -.
DR ProteomicsDB; 67777; -. [Q6WRX3-1]
DR ProteomicsDB; 67778; -. [Q6WRX3-2]
DR Antibodypedia; 33035; 82 antibodies from 18 providers.
DR DNASU; 440590; -.
DR Ensembl; ENST00000371528.2; ENSP00000360583.1; ENSG00000203995.10. [Q6WRX3-1]
DR Ensembl; ENST00000371532.5; ENSP00000360587.1; ENSG00000203995.10. [Q6WRX3-2]
DR Ensembl; ENST00000612017.4; ENSP00000482761.1; ENSG00000203995.10. [Q6WRX3-2]
DR GeneID; 440590; -.
DR KEGG; hsa:440590; -.
DR MANE-Select; ENST00000371528.2; ENSP00000360583.1; NM_001004339.3; NP_001004339.2.
DR UCSC; uc001cuk.3; human. [Q6WRX3-1]
DR CTD; 440590; -.
DR DisGeNET; 440590; -.
DR GeneCards; ZYG11A; -.
DR HGNC; HGNC:32058; ZYG11A.
DR HPA; ENSG00000203995; Tissue enhanced (kidney, testis, thyroid gland).
DR MIM; 618675; gene.
DR neXtProt; NX_Q6WRX3; -.
DR OpenTargets; ENSG00000203995; -.
DR PharmGKB; PA142670467; -.
DR VEuPathDB; HostDB:ENSG00000203995; -.
DR eggNOG; KOG3665; Eukaryota.
DR GeneTree; ENSGT00530000063187; -.
DR HOGENOM; CLU_011533_0_1_1; -.
DR InParanoid; Q6WRX3; -.
DR OMA; IQKWPSS; -.
DR OrthoDB; 374821at2759; -.
DR PhylomeDB; Q6WRX3; -.
DR TreeFam; TF313007; -.
DR PathwayCommons; Q6WRX3; -.
DR SignaLink; Q6WRX3; -.
DR BioGRID-ORCS; 440590; 11 hits in 1075 CRISPR screens.
DR GenomeRNAi; 440590; -.
DR Pharos; Q6WRX3; Tbio.
DR PRO; PR:Q6WRX3; -.
DR Proteomes; UP000005640; Chromosome 1.
DR RNAct; Q6WRX3; protein.
DR Bgee; ENSG00000203995; Expressed in oocyte and 44 other tissues.
DR Genevisible; Q6WRX3; HS.
DR GO; GO:0031462; C:Cul2-RING ubiquitin ligase complex; IBA:GO_Central.
DR Gene3D; 1.25.10.10; -; 1.
DR Gene3D; 3.80.10.10; -; 1.
DR InterPro; IPR011989; ARM-like.
DR InterPro; IPR016024; ARM-type_fold.
DR InterPro; IPR032675; LRR_dom_sf.
DR SUPFAM; SSF48371; SSF48371; 1.
PE 2: Evidence at transcript level;
KW Alternative splicing; Leucine-rich repeat; Reference proteome; Repeat;
KW Ubl conjugation pathway.
FT CHAIN 1..759
FT /note="Protein zyg-11 homolog A"
FT /id="PRO_0000305085"
FT REPEAT 204..227
FT /note="LRR 1"
FT REPEAT 235..260
FT /note="LRR 2"
FT REPEAT 490..513
FT /note="LRR 3"
FT VAR_SEQ 1..342
FT /note="Missing (in isoform 2)"
FT /evidence="ECO:0000303|Ref.1"
FT /id="VSP_028223"
SQ SEQUENCE 759 AA; 85808 MW; A7E681631070BFE0 CRC64;
MVHFLHPGHT PRNIVPPDAQ KDALGCCVVQ EEASPYTLVN ICLNVLIANL EKLCSERPDG
TLCLPEHWSF PQEVAERFLR VMTWQGKLTD RTASIFRGNQ MKLKLVNIQK AKISTAAFIK
AFCRHKLIEL NATAVHADLP VPDIISGLCS NRWIQQNLQC LLLDSTSIPQ NSRLLFFSQL
TGLRILSVFN VCFHTEDLAN VSQLPRLESL DISNTLVTDI SALLTCKDRL KSLTMHYLKC
LAMTKSQILA VIRELKCLLH LDISDHRQLK SDLAFHLLQQ KDILPNVVSL DISGGNCITD
EAVELFIRLR PAMQFVGLLA TDAGSSDFFT TKQGLRVAGG ASMSQISEAL SRYRNRSCFV
KEALHRLFTE TFSMEVTMPA ILKLVAIGMR NHPLDLRVQF TASACALNLT RQGLAKGMPV
RLLSEVTCLL FKALKNFPHY QQLQKNCLLS LTNSRILVDV PFDRFDAAKF VMRWLCKHEN
PKMQTMAVSV TSILALQLSP EQTAQLEELF MAVKELLAIV KQKTTENLDD VTFLFTLKAL
WNLTDGSPAA CKHFIENQGL QIFIQVLETF SESAIQSKVL GLLNNIAEVR ELSSKLVTED
VLKHINSLLC SREMEVSYFA AGIIAHLTSD RQLWISRDFQ RRTLLQDLHA TIQNWPSSSC
KMTALVTYRS FKTFFPLLGN FSQPEVQLWA LWAMYHVCSK NPSKYCKMLV EEEGLQLLCD
IQEHSEATPK AQQIAASILD DFRMHFMNYQ RPTLCQMPF
