ZXDB_MOUSE
ID ZXDB_MOUSE Reviewed; 873 AA.
AC A2CE44; Q3V1M7; Q8CEQ1;
DT 26-JUN-2007, integrated into UniProtKB/Swiss-Prot.
DT 20-FEB-2007, sequence version 1.
DT 03-AUG-2022, entry version 110.
DE RecName: Full=Zinc finger X-linked protein ZXDB;
GN Name=Zxdb;
OS Mus musculus (Mouse).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC Murinae; Mus; Mus.
OX NCBI_TaxID=10090;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=C57BL/6J;
RX PubMed=19468303; DOI=10.1371/journal.pbio.1000112;
RA Church D.M., Goodstadt L., Hillier L.W., Zody M.C., Goldstein S., She X.,
RA Bult C.J., Agarwala R., Cherry J.L., DiCuccio M., Hlavina W., Kapustin Y.,
RA Meric P., Maglott D., Birtle Z., Marques A.C., Graves T., Zhou S.,
RA Teague B., Potamousis K., Churas C., Place M., Herschleb J., Runnheim R.,
RA Forrest D., Amos-Landgraf J., Schwartz D.C., Cheng Z., Lindblad-Toh K.,
RA Eichler E.E., Ponting C.P.;
RT "Lineage-specific biology revealed by a finished genome assembly of the
RT mouse.";
RL PLoS Biol. 7:E1000112-E1000112(2009).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 252-873.
RC STRAIN=C57BL/6J; TISSUE=Head, and Testis;
RX PubMed=16141072; DOI=10.1126/science.1112014;
RA Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N.,
RA Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K.,
RA Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.,
RA Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R.,
RA Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T.,
RA Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A.,
RA Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B.,
RA Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M.,
RA Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S.,
RA Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E.,
RA Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D.,
RA Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M.,
RA Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H.,
RA Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V.,
RA Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S.,
RA Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H.,
RA Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N.,
RA Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F.,
RA Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G.,
RA Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z.,
RA Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C.,
RA Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y.,
RA Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S.,
RA Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K.,
RA Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R.,
RA van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H.,
RA Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M.,
RA Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C.,
RA Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S.,
RA Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K.,
RA Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M.,
RA Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C.,
RA Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A.,
RA Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.;
RT "The transcriptional landscape of the mammalian genome.";
RL Science 309:1559-1563(2005).
RN [3]
RP METHYLATION [LARGE SCALE ANALYSIS] AT ARG-89, AND IDENTIFICATION BY MASS
RP SPECTROMETRY [LARGE SCALE ANALYSIS].
RC TISSUE=Brain, and Embryo;
RX PubMed=24129315; DOI=10.1074/mcp.o113.027870;
RA Guo A., Gu H., Zhou J., Mulhern D., Wang Y., Lee K.A., Yang V., Aguiar M.,
RA Kornhauser J., Jia X., Ren J., Beausoleil S.A., Silva J.C., Vemulapalli V.,
RA Bedford M.T., Comb M.J.;
RT "Immunoaffinity enrichment and mass spectrometry analysis of protein
RT methylation.";
RL Mol. Cell. Proteomics 13:372-387(2014).
CC -!- FUNCTION: Cooperates with CIITA to promote transcription of MHC class I
CC and MHC class II genes. {ECO:0000250}.
CC -!- SUBUNIT: Self-associates. Interacts with ZXDC and CIITA (By
CC similarity). {ECO:0000250}.
CC -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000305}.
CC -!- SIMILARITY: Belongs to the ZXD family. {ECO:0000305}.
CC -!- SEQUENCE CAUTION:
CC Sequence=BAC25496.1; Type=Frameshift; Evidence={ECO:0000305};
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DR EMBL; CR293526; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AK016708; BAC25496.1; ALT_FRAME; mRNA.
DR EMBL; AK132358; BAE21123.1; -; mRNA.
DR CCDS; CCDS41065.1; -.
DR RefSeq; NP_001074942.1; NM_001081473.1.
DR AlphaFoldDB; A2CE44; -.
DR SMR; A2CE44; -.
DR STRING; 10090.ENSMUSP00000100524; -.
DR iPTMnet; A2CE44; -.
DR PhosphoSitePlus; A2CE44; -.
DR MaxQB; A2CE44; -.
DR PaxDb; A2CE44; -.
DR PeptideAtlas; A2CE44; -.
DR PRIDE; A2CE44; -.
DR ProteomicsDB; 275249; -.
DR Ensembl; ENSMUST00000101388; ENSMUSP00000100524; ENSMUSG00000073062.
DR GeneID; 668166; -.
DR KEGG; mmu:668166; -.
DR UCSC; uc009ttq.1; mouse.
DR CTD; 158586; -.
DR MGI; MGI:3694898; Zxdb.
DR VEuPathDB; HostDB:ENSMUSG00000073062; -.
DR eggNOG; KOG1721; Eukaryota.
DR GeneTree; ENSGT00940000162988; -.
DR HOGENOM; CLU_007312_0_0_1; -.
DR InParanoid; A2CE44; -.
DR OMA; KVEWNVH; -.
DR OrthoDB; 1318335at2759; -.
DR PhylomeDB; A2CE44; -.
DR TreeFam; TF330996; -.
DR BioGRID-ORCS; 668166; 5 hits in 69 CRISPR screens.
DR PRO; PR:A2CE44; -.
DR Proteomes; UP000000589; Chromosome X.
DR RNAct; A2CE44; protein.
DR Bgee; ENSMUSG00000073062; Expressed in caudate-putamen and 218 other tissues.
DR Genevisible; A2CE44; MM.
DR GO; GO:0005634; C:nucleus; IBA:GO_Central.
DR GO; GO:0070742; F:C2H2 zinc finger domain binding; ISS:UniProtKB.
DR GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR GO; GO:0003713; F:transcription coactivator activity; ISS:UniProtKB.
DR GO; GO:0003712; F:transcription coregulator activity; IBA:GO_Central.
DR GO; GO:0045893; P:positive regulation of transcription, DNA-templated; ISS:UniProtKB.
DR GO; GO:0006357; P:regulation of transcription by RNA polymerase II; IBA:GO_Central.
DR InterPro; IPR036236; Znf_C2H2_sf.
DR InterPro; IPR013087; Znf_C2H2_type.
DR Pfam; PF00096; zf-C2H2; 5.
DR SMART; SM00355; ZnF_C2H2; 10.
DR SUPFAM; SSF57667; SSF57667; 5.
DR PROSITE; PS00028; ZINC_FINGER_C2H2_1; 10.
DR PROSITE; PS50157; ZINC_FINGER_C2H2_2; 10.
PE 1: Evidence at protein level;
KW Activator; Metal-binding; Methylation; Nucleus; Reference proteome; Repeat;
KW Transcription; Transcription regulation; Zinc; Zinc-finger.
FT CHAIN 1..873
FT /note="Zinc finger X-linked protein ZXDB"
FT /id="PRO_0000292802"
FT ZN_FING 340..364
FT /note="C2H2-type 1"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT ZN_FING 373..397
FT /note="C2H2-type 2"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT ZN_FING 403..427
FT /note="C2H2-type 3"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT ZN_FING 433..455
FT /note="C2H2-type 4"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT ZN_FING 462..486
FT /note="C2H2-type 5"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT ZN_FING 493..517
FT /note="C2H2-type 6"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT ZN_FING 523..547
FT /note="C2H2-type 7"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT ZN_FING 553..577
FT /note="C2H2-type 8"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT ZN_FING 583..607
FT /note="C2H2-type 9"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT ZN_FING 616..641
FT /note="C2H2-type 10"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT REGION 1..23
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 48..120
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 138..184
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 240..259
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 301..330
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 340..646
FT /note="Required for interaction with ZXDC"
FT /evidence="ECO:0000250"
FT REGION 645..776
FT /note="Required for transcriptional activation"
FT /evidence="ECO:0000250"
FT COMPBIAS 240..258
FT /note="Pro residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT MOD_RES 89
FT /note="Omega-N-methylarginine"
FT /evidence="ECO:0007744|PubMed:24129315"
FT CONFLICT 271..280
FT /note="AAAAAAAAAA -> VAGGVVFFVG (in Ref. 2; BAE21123)"
FT /evidence="ECO:0000305"
FT CONFLICT 300
FT /note="P -> R (in Ref. 2; BAC25496)"
FT /evidence="ECO:0000305"
FT CONFLICT 631
FT /note="H -> P (in Ref. 2; BAC25496)"
FT /evidence="ECO:0000305"
FT CONFLICT 643
FT /note="L -> F (in Ref. 2; BAC25496)"
FT /evidence="ECO:0000305"
FT CONFLICT 651
FT /note="L -> I (in Ref. 2; BAC25496)"
FT /evidence="ECO:0000305"
FT CONFLICT 689
FT /note="A -> T (in Ref. 2; BAC25496)"
FT /evidence="ECO:0000305"
SQ SEQUENCE 873 AA; 90376 MW; 77E31C72C7098264 CRC64;
MEIPRLLPAR GTPQGAGGGG CPAGGGGVHR APASLACQAP TRRLLLLRGA QDGGPGPRSA
EAQRASRGLG PSLNRLAPRP DHRSSGGGRG GGAGGGGGGS GGGGGGGGGG GGGGGGGGSR
GGSDDFFLLL LDPVGGDVET VGTEQAGAPV RREEAGAGPR PERRQSAGPP AGRPEPGPRC
LSAVPAASPL PAAGPGPAAA AAAAAAAAFA GTITIHNQDL LLRFENGVLT LTTPPLPAWE
PGVAPFPQPQ PPPQPGALIA PQAAAAGFPP AAAAAAAAAA AGAQLGDCPE LPPDLLLAEP
AEPAACPAPP EEEAEAPAAA AAQSPRGPAG PGPGPGVVLY LCPEAQCGQT FAKKHQLKVH
LLTHSSSQGQ RPFKCPLSGC GWTFTTSYKL KRHLQSHDKL RPFGCPVQGC GKSFTTVYNL
KAHMKGHEQE NSFKCEVCEE SFPTQAKLST HQRSHFEPER PYQCAFSGCK KTFITVSALF
SHNRAHFREQ ELFACSFPGC SKQYDKACRL KIHLRSHTGE RPFLCDFDGC GWNFTSMSKL
LRHKRKHEDD RRFTCPVEGC GKSFTRAEHL KGHSITHLGT KPFVCPVEGC CARFSARSSL
YIHSKKHLQD VGAWKSRCPV PTCNKLFTSK HSMKTHMTKR HNLSQDLLAQ LEAANSLTPS
SELTSPGQSD LSGAELVSLF SDVPGHGSAA VLDTALVNSG ILTIDVASVN SSLAGSLPAD
NNSNNHSLGQ AAEPRALRGA PSDLPQSLDT SLFFGTSVAG YQHSPLDMDD VSAGNVGLFG
SLALKNSSLE PQALTPSNKL TVDTEALTPS STLCENSVSE LLTPAKAEWN VHPESDFFGH
EEETQFGFSH PTGSHGSQKD TDLITVTGTP FLV
