CC4L_HUMAN
ID CC4L_HUMAN Reviewed; 92 AA.
AC Q8NHW4; B2RUZ3; B7ZMA8; Q50EM1; Q50EM2; Q50EM3; Q50EM4; Q50EM5; Q50EM6;
AC Q50EM7; Q50EM8; Q569J2; Q6NSB0;
DT 18-MAR-2008, integrated into UniProtKB/Swiss-Prot.
DT 01-OCT-2002, sequence version 1.
DT 03-AUG-2022, entry version 157.
DE RecName: Full=C-C motif chemokine 4-like;
DE AltName: Full=Lymphocyte activation gene 1 protein;
DE Short=LAG-1;
DE AltName: Full=Macrophage inflammatory protein 1-beta;
DE Short=MIP-1-beta;
DE AltName: Full=Monocyte adherence-induced protein 5-alpha;
DE AltName: Full=Small-inducible cytokine A4-like;
DE Flags: Precursor;
GN Name=CCL4L1; Synonyms=CCL4L, LAG1, SCYA4L1;
GN and
GN Name=CCL4L2; Synonyms=CCL4L, SCYA4L2;
OS Homo sapiens (Human).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC Homo.
OX NCBI_TaxID=9606;
RN [1]
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA] (ISOFORM 1).
RA Nibbs R.J., Barcellos L.F., Townson J.R.;
RT "Variation in gene copy number of the human chemokines macrophage
RT inflammatory protein-1a/CCL3 and macrophage inflammatory protein-1b/CCL4.";
RL Submitted (FEB-2002) to the EMBL/GenBank/DDBJ databases.
RN [2]
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA / MRNA] (ISOFORMS 1; 2; 3; 4; 5; 6; 7; 8;
RP 9 AND 10).
RX PubMed=15843566; DOI=10.4049/jimmunol.174.9.5655;
RA Colobran R., Adreani P., Ashhab Y., Llano A., Este J.A., Dominguez O.,
RA Pujol-Borrell R., Juan M.;
RT "Multiple products derived from two CCL4 loci: high incidence of a new
RT polymorphism in HIV+ patients.";
RL J. Immunol. 174:5655-5664(2005).
RN [3]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 1 AND 5).
RC TISSUE=Blood, and Brain;
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RT "The status, quality, and expansion of the NIH full-length cDNA project:
RT the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
RN [4]
RP IDENTIFICATION.
RX PubMed=11685466; DOI=10.1007/s002510100366;
RA Modi W.S., Bergeron J., Sanford M.;
RT "The human MIP-1beta chemokine is encoded by two paralogous genes, ACT-2
RT and LAG-1.";
RL Immunogenetics 53:543-549(2001).
RN [5]
RP FUNCTION, INTERACTION WITH CCR5, AND GENOMIC DUPLICATION.
RX PubMed=15240137; DOI=10.1016/j.bbrc.2004.06.039;
RA Howard O.M.Z., Turpin J.A., Goldman R., Modi W.S.;
RT "Functional redundancy of the human CCL4 and CCL4L1 chemokine genes.";
RL Biochem. Biophys. Res. Commun. 320:927-931(2004).
RN [6]
RP IDENTIFICATION, AND GENOMIC DUPLICATION.
RX PubMed=15028295; DOI=10.1016/j.ygeno.2003.09.019;
RA Modi W.S.;
RT "CCL3L1 and CCL4L1 chemokine genes are located in a segmental duplication
RT at chromosome 17q12.";
RL Genomics 83:735-738(2004).
RN [7]
RP TISSUE SPECIFICITY.
RX PubMed=14673550; DOI=10.1007/s00251-003-0636-z;
RA Lu J., Honczarenko M., Sloan S.R.;
RT "Independent expression of the two paralogous CCL4 genes in monocytes and B
RT lymphocytes.";
RL Immunogenetics 55:706-711(2004).
RN [8]
RP IDENTIFICATION, AND POLYMORPHISM OF GENE COPY NUMBER.
RX PubMed=17330138; DOI=10.1038/sj.gene.6364378;
RA Shao W., Tang J., Song W., Wang C., Li Y., Wilson C.M., Kaslow R.A.;
RT "CCL3L1 and CCL4L1: variable gene copy number in adolescents with and
RT without human immunodeficiency virus type 1 (HIV-1) infection.";
RL Genes Immun. 8:224-231(2007).
CC -!- FUNCTION: Chemokine that induces chemotaxis of cells expressing CCR5 or
CC CCR1. Inhibits HIV replication in peripheral blood monocytes that
CC express CCR5. {ECO:0000269|PubMed:15240137}.
CC -!- SUBUNIT: Interacts with CCR5. {ECO:0000269|PubMed:15240137}.
CC -!- INTERACTION:
CC Q8NHW4; Q13520: AQP6; NbExp=3; IntAct=EBI-10271156, EBI-13059134;
CC Q8NHW4; Q3SXY8: ARL13B; NbExp=3; IntAct=EBI-10271156, EBI-11343438;
CC Q8NHW4; Q7RTX7: CATSPER4; NbExp=3; IntAct=EBI-10271156, EBI-21541251;
CC Q8NHW4; Q9HA82: CERS4; NbExp=3; IntAct=EBI-10271156, EBI-2622997;
CC Q8NHW4; P58418: CLRN1; NbExp=3; IntAct=EBI-10271156, EBI-17274839;
CC Q8NHW4; P21964: COMT; NbExp=3; IntAct=EBI-10271156, EBI-372265;
CC Q8NHW4; O75208: COQ9; NbExp=3; IntAct=EBI-10271156, EBI-724524;
CC Q8NHW4; Q7Z7G2: CPLX4; NbExp=3; IntAct=EBI-10271156, EBI-18013275;
CC Q8NHW4; Q96BA8: CREB3L1; NbExp=3; IntAct=EBI-10271156, EBI-6942903;
CC Q8NHW4; Q15125: EBP; NbExp=3; IntAct=EBI-10271156, EBI-3915253;
CC Q8NHW4; Q9GZR5: ELOVL4; NbExp=3; IntAct=EBI-10271156, EBI-18535450;
CC Q8NHW4; P60508: ERVFRD-1; NbExp=3; IntAct=EBI-10271156, EBI-17973325;
CC Q8NHW4; Q5JX71: FAM209A; NbExp=3; IntAct=EBI-10271156, EBI-18304435;
CC Q8NHW4; O00258: GET1; NbExp=3; IntAct=EBI-10271156, EBI-18908258;
CC Q8NHW4; Q8TDT2: GPR152; NbExp=3; IntAct=EBI-10271156, EBI-13345167;
CC Q8NHW4; O15529: GPR42; NbExp=3; IntAct=EBI-10271156, EBI-18076404;
CC Q8NHW4; Q9NQX7-3: ITM2C; NbExp=3; IntAct=EBI-10271156, EBI-12811565;
CC Q8NHW4; Q8N5M9: JAGN1; NbExp=3; IntAct=EBI-10271156, EBI-10266796;
CC Q8NHW4; Q5SR56: MFSD14B; NbExp=3; IntAct=EBI-10271156, EBI-373355;
CC Q8NHW4; Q6N075: MFSD5; NbExp=3; IntAct=EBI-10271156, EBI-3920969;
CC Q8NHW4; Q6IN84: MRM1; NbExp=3; IntAct=EBI-10271156, EBI-5454865;
CC Q8NHW4; Q9H6H4: REEP4; NbExp=3; IntAct=EBI-10271156, EBI-7545592;
CC Q8NHW4; Q86VR2: RETREG3; NbExp=3; IntAct=EBI-10271156, EBI-10192441;
CC Q8NHW4; O95470: SGPL1; NbExp=3; IntAct=EBI-10271156, EBI-1046170;
CC Q8NHW4; Q12908: SLC10A2; NbExp=3; IntAct=EBI-10271156, EBI-18114847;
CC Q8NHW4; P54219-3: SLC18A1; NbExp=3; IntAct=EBI-10271156, EBI-17595455;
CC Q8NHW4; Q9BRI3: SLC30A2; NbExp=3; IntAct=EBI-10271156, EBI-8644112;
CC Q8NHW4; P30825: SLC7A1; NbExp=3; IntAct=EBI-10271156, EBI-4289564;
CC Q8NHW4; Q8TBB6: SLC7A14; NbExp=3; IntAct=EBI-10271156, EBI-5235586;
CC Q8NHW4; Q8WWF3: SSMEM1; NbExp=3; IntAct=EBI-10271156, EBI-17280858;
CC Q8NHW4; Q7Z7N9: TMEM179B; NbExp=3; IntAct=EBI-10271156, EBI-11724423;
CC Q8NHW4; Q9NW97: TMEM51; NbExp=3; IntAct=EBI-10271156, EBI-726044;
CC Q8NHW4; Q9H7M9: VSIR; NbExp=3; IntAct=EBI-10271156, EBI-744988;
CC -!- SUBCELLULAR LOCATION: Secreted {ECO:0000250}.
CC -!- ALTERNATIVE PRODUCTS:
CC Event=Alternative splicing; Named isoforms=10;
CC Comment=CCL4L1 and CCL4L2 genes differ in their non-coding regions.
CC Thus, alternative splicing events differ between the two genes.;
CC Name=1;
CC IsoId=Q8NHW4-1; Sequence=Displayed;
CC Name=2; Synonyms=CCL4L2;
CC IsoId=Q8NHW4-2; Sequence=VSP_032633;
CC Name=3; Synonyms=CC4L2d;
CC IsoId=Q8NHW4-3; Sequence=VSP_032629;
CC Name=4; Synonyms=CC4L2f;
CC IsoId=Q8NHW4-4; Sequence=VSP_032630;
CC Name=5; Synonyms=CC4L2b1, CC4L2b2;
CC IsoId=Q8NHW4-5; Sequence=VSP_032631;
CC Name=6; Synonyms=CC4L2e;
CC IsoId=Q8NHW4-6; Sequence=VSP_032632;
CC Name=7; Synonyms=CC4L2d2;
CC IsoId=Q8NHW4-7; Sequence=VSP_032625;
CC Name=8; Synonyms=CC4L1d2;
CC IsoId=Q8NHW4-8; Sequence=VSP_032626;
CC Name=9; Synonyms=CC4L2bd2;
CC IsoId=Q8NHW4-9; Sequence=VSP_032627;
CC Name=10; Synonyms=CC44L2c;
CC IsoId=Q8NHW4-10; Sequence=VSP_032628;
CC -!- TISSUE SPECIFICITY: Detected in B-cells. {ECO:0000269|PubMed:14673550}.
CC -!- POLYMORPHISM: The copy number of the CC4L1 gene varies among
CC individuals; most individuals have 1 to 6 copies in the diploid genome.
CC {ECO:0000269|PubMed:17330138}.
CC -!- SIMILARITY: Belongs to the intercrine beta (chemokine CC) family.
CC {ECO:0000305}.
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DR EMBL; AY079147; AAL87008.1; -; Genomic_DNA.
DR EMBL; AY766460; AAX07294.1; -; Genomic_DNA.
DR EMBL; AY766460; AAX07295.1; -; Genomic_DNA.
DR EMBL; AY766461; AAX07296.1; -; Genomic_DNA.
DR EMBL; AY766461; AAX07297.1; -; Genomic_DNA.
DR EMBL; AY766461; AAX07298.1; -; Genomic_DNA.
DR EMBL; AY766461; AAX07299.1; -; Genomic_DNA.
DR EMBL; AY766461; AAX07300.1; -; Genomic_DNA.
DR EMBL; AY766461; AAX07301.1; -; Genomic_DNA.
DR EMBL; AY766461; AAX07302.1; -; Genomic_DNA.
DR EMBL; AY766461; AAX07303.1; -; Genomic_DNA.
DR EMBL; AY766461; AAX07304.1; -; Genomic_DNA.
DR EMBL; AY766447; AAX07306.1; -; mRNA.
DR EMBL; AY766449; AAX07308.1; -; mRNA.
DR EMBL; AY766450; AAX07309.1; -; mRNA.
DR EMBL; AY766451; AAX07310.1; -; mRNA.
DR EMBL; AY766452; AAX07311.1; -; mRNA.
DR EMBL; AY766453; AAX07312.1; -; mRNA.
DR EMBL; AY766454; AAX07313.1; -; mRNA.
DR EMBL; AY766455; AAX07314.1; -; mRNA.
DR EMBL; AY766456; AAX07315.1; -; mRNA.
DR EMBL; AY766457; AAX07316.1; -; mRNA.
DR EMBL; AY766458; AAX07317.1; -; mRNA.
DR EMBL; BC070310; AAH70310.1; -; mRNA.
DR EMBL; BC092445; AAH92445.1; -; mRNA.
DR EMBL; BC130456; AAI30457.1; -; mRNA.
DR EMBL; BC130458; AAI30459.1; -; mRNA.
DR EMBL; BC144393; AAI44394.1; -; mRNA.
DR EMBL; BC144394; AAI44395.1; -; mRNA.
DR EMBL; BC171864; AAI71864.1; -; mRNA.
DR EMBL; BC146944; AAI46945.1; -; mRNA.
DR EMBL; BC146958; AAI46959.1; -; mRNA.
DR PIR; C60407; C60407.
DR RefSeq; NP_001278397.1; NM_001291468.1. [Q8NHW4-2]
DR RefSeq; NP_001278398.1; NM_001291469.1. [Q8NHW4-5]
DR RefSeq; NP_001278399.1; NM_001291470.1. [Q8NHW4-5]
DR RefSeq; NP_001278400.1; NM_001291471.1. [Q8NHW4-10]
DR RefSeq; NP_001278401.1; NM_001291472.1. [Q8NHW4-3]
DR RefSeq; NP_001278402.1; NM_001291473.1. [Q8NHW4-6]
DR RefSeq; NP_001278403.1; NM_001291474.1. [Q8NHW4-9]
DR RefSeq; NP_001278404.1; NM_001291475.1. [Q8NHW4-4]
DR RefSeq; NP_996890.1; NM_207007.3. [Q8NHW4-1]
DR AlphaFoldDB; Q8NHW4; -.
DR SMR; Q8NHW4; -.
DR BioGRID; 114931; 33.
DR BioGRID; 132664; 24.
DR IntAct; Q8NHW4; 36.
DR STRING; 9606.ENSP00000483609; -.
DR BioMuta; HGNC:10631; -.
DR DMDM; 74727347; -.
DR MassIVE; Q8NHW4; -.
DR PaxDb; Q8NHW4; -.
DR PeptideAtlas; Q8NHW4; -.
DR PRIDE; Q8NHW4; -.
DR ProteomicsDB; 73770; -. [Q8NHW4-10]
DR ProteomicsDB; 73776; -. [Q8NHW4-7]
DR ProteomicsDB; 73777; -. [Q8NHW4-8]
DR TopDownProteomics; Q8NHW4-4; -. [Q8NHW4-4]
DR Antibodypedia; 72750; 109 antibodies from 20 providers.
DR DNASU; 9560; -.
DR Ensembl; ENST00000610565.4; ENSP00000484498.1; ENSG00000276070.5. [Q8NHW4-6]
DR Ensembl; ENST00000613173.4; ENSP00000484455.1; ENSG00000276070.5. [Q8NHW4-9]
DR Ensembl; ENST00000613828.2; ENSP00000484322.1; ENSG00000282604.1. [Q8NHW4-1]
DR Ensembl; ENST00000614182.4; ENSP00000482862.2; ENSG00000276125.4. [Q8NHW4-3]
DR Ensembl; ENST00000615418.4; ENSP00000483206.1; ENSG00000276070.5. [Q8NHW4-3]
DR Ensembl; ENST00000616100.4; ENSP00000484148.2; ENSG00000282604.1. [Q8NHW4-6]
DR Ensembl; ENST00000617405.5; ENSP00000483330.1; ENSG00000276070.5. [Q8NHW4-4]
DR Ensembl; ENST00000617416.4; ENSP00000480089.1; ENSG00000276070.5. [Q8NHW4-5]
DR Ensembl; ENST00000620055.4; ENSP00000481323.1; ENSG00000276070.5. [Q8NHW4-7]
DR Ensembl; ENST00000620063.3; ENSP00000478376.1; ENSG00000276125.4. [Q8NHW4-1]
DR Ensembl; ENST00000620098.4; ENSP00000479774.1; ENSG00000276070.5. [Q8NHW4-10]
DR Ensembl; ENST00000620250.1; ENSP00000483609.1; ENSG00000276070.5. [Q8NHW4-1]
DR Ensembl; ENST00000620576.4; ENSP00000479354.1; ENSG00000276070.5. [Q8NHW4-2]
DR Ensembl; ENST00000620708.1; ENSP00000479126.1; ENSG00000275313.5. [Q8NHW4-1]
DR Ensembl; ENST00000620732.4; ENSP00000481969.1; ENSG00000276070.5. [Q8NHW4-5]
DR Ensembl; ENST00000622783.2; ENSP00000479833.2; ENSG00000276125.4. [Q8NHW4-7]
DR Ensembl; ENST00000631554.1; ENSP00000487911.1; ENSG00000276125.4. [Q8NHW4-10]
DR Ensembl; ENST00000631660.1; ENSP00000488687.1; ENSG00000275313.5. [Q8NHW4-7]
DR Ensembl; ENST00000631768.1; ENSP00000488094.1; ENSG00000282604.1. [Q8NHW4-5]
DR Ensembl; ENST00000631782.1; ENSP00000488541.1; ENSG00000276125.4. [Q8NHW4-6]
DR Ensembl; ENST00000631808.1; ENSP00000487651.1; ENSG00000282604.1. [Q8NHW4-3]
DR Ensembl; ENST00000632416.1; ENSP00000487859.1; ENSG00000275313.5. [Q8NHW4-2]
DR Ensembl; ENST00000632480.1; ENSP00000488369.1; ENSG00000282604.1. [Q8NHW4-7]
DR Ensembl; ENST00000632699.1; ENSP00000488366.1; ENSG00000276125.4. [Q8NHW4-2]
DR Ensembl; ENST00000632710.1; ENSP00000488758.1; ENSG00000275313.5. [Q8NHW4-5]
DR Ensembl; ENST00000633309.1; ENSP00000488719.1; ENSG00000282604.1. [Q8NHW4-4]
DR Ensembl; ENST00000633550.1; ENSP00000488736.1; ENSG00000276125.4. [Q8NHW4-5]
DR Ensembl; ENST00000633849.1; ENSP00000487792.1; ENSG00000282604.1. [Q8NHW4-10]
DR Ensembl; ENST00000633897.1; ENSP00000488897.1; ENSG00000282604.1. [Q8NHW4-5]
DR Ensembl; ENST00000633927.1; ENSP00000488430.1; ENSG00000276125.4. [Q8NHW4-9]
DR Ensembl; ENST00000634027.1; ENSP00000488439.1; ENSG00000276125.4. [Q8NHW4-4]
DR Ensembl; ENST00000634078.1; ENSP00000488231.1; ENSG00000275313.5. [Q8NHW4-6]
DR Ensembl; ENST00000634191.1; ENSP00000487715.1; ENSG00000276125.4. [Q8NHW4-5]
DR GeneID; 388372; -.
DR GeneID; 9560; -.
DR KEGG; hsa:388372; -.
DR KEGG; hsa:9560; -.
DR MANE-Select; ENST00000617405.5; ENSP00000483330.1; NM_001291475.2; NP_001278404.1. [Q8NHW4-4]
DR UCSC; uc002hlh.2; human. [Q8NHW4-1]
DR CTD; 388372; -.
DR CTD; 9560; -.
DR DisGeNET; 388372; -.
DR DisGeNET; 9560; -.
DR GeneCards; CCL4L1; -.
DR GeneCards; CCL4L2; -.
DR HGNC; HGNC:10631; CCL4L1.
DR HGNC; HGNC:24066; CCL4L2.
DR HPA; ENSG00000276070; Tissue enhanced (bone marrow, lymphoid tissue).
DR MIM; 603782; gene.
DR MIM; 610757; gene.
DR neXtProt; NX_Q8NHW4; -.
DR OpenTargets; ENSG00000276070; -.
DR VEuPathDB; HostDB:ENSG00000276070; -.
DR eggNOG; ENOG502S8M4; Eukaryota.
DR GeneTree; ENSGT01050000244851; -.
DR HOGENOM; CLU_2793265_0_0_1; -.
DR InParanoid; Q8NHW4; -.
DR OMA; DWVQEYM; -.
DR OrthoDB; 1575018at2759; -.
DR PhylomeDB; Q8NHW4; -.
DR TreeFam; TF334888; -.
DR PathwayCommons; Q8NHW4; -.
DR Reactome; R-HSA-418594; G alpha (i) signalling events.
DR SignaLink; Q8NHW4; -.
DR SIGNOR; Q8NHW4; -.
DR BioGRID-ORCS; 388372; 8 hits in 179 CRISPR screens.
DR BioGRID-ORCS; 9560; 6 hits in 606 CRISPR screens.
DR ChiTaRS; CCL4L2; human.
DR Pharos; Q8NHW4; Tbio.
DR PRO; PR:Q8NHW4; -.
DR Proteomes; UP000005640; Chromosome 17.
DR RNAct; Q8NHW4; protein.
DR Bgee; ENSG00000276070; Expressed in bone marrow and 102 other tissues.
DR GO; GO:0005615; C:extracellular space; IBA:GO_Central.
DR GO; GO:0048020; F:CCR chemokine receptor binding; IBA:GO_Central.
DR GO; GO:0008009; F:chemokine activity; IBA:GO_Central.
DR GO; GO:0071346; P:cellular response to interferon-gamma; IBA:GO_Central.
DR GO; GO:0071347; P:cellular response to interleukin-1; IBA:GO_Central.
DR GO; GO:0071356; P:cellular response to tumor necrosis factor; IBA:GO_Central.
DR GO; GO:0070098; P:chemokine-mediated signaling pathway; IBA:GO_Central.
DR GO; GO:0048245; P:eosinophil chemotaxis; IBA:GO_Central.
DR GO; GO:0007186; P:G protein-coupled receptor signaling pathway; IBA:GO_Central.
DR GO; GO:0006954; P:inflammatory response; IBA:GO_Central.
DR GO; GO:0048247; P:lymphocyte chemotaxis; IBA:GO_Central.
DR GO; GO:0002548; P:monocyte chemotaxis; IBA:GO_Central.
DR GO; GO:0030593; P:neutrophil chemotaxis; IBA:GO_Central.
DR GO; GO:0070374; P:positive regulation of ERK1 and ERK2 cascade; IBA:GO_Central.
DR GO; GO:0043547; P:positive regulation of GTPase activity; IBA:GO_Central.
DR InterPro; IPR039809; Chemokine_b/g/d.
DR InterPro; IPR000827; Chemokine_CC_CS.
DR InterPro; IPR001811; Chemokine_IL8-like_dom.
DR InterPro; IPR036048; Interleukin_8-like_sf.
DR PANTHER; PTHR12015; PTHR12015; 1.
DR Pfam; PF00048; IL8; 1.
DR SMART; SM00199; SCY; 1.
DR SUPFAM; SSF54117; SSF54117; 1.
DR PROSITE; PS00472; SMALL_CYTOKINES_CC; 1.
PE 1: Evidence at protein level;
KW Alternative splicing; Chemotaxis; Cytokine; Disulfide bond;
KW Inflammatory response; Reference proteome; Secreted; Signal.
FT SIGNAL 1..23
FT /evidence="ECO:0000250"
FT CHAIN 24..92
FT /note="C-C motif chemokine 4-like"
FT /id="PRO_0000326234"
FT DISULFID 34..58
FT /evidence="ECO:0000250"
FT DISULFID 35..74
FT /evidence="ECO:0000250"
FT VAR_SEQ 26..92
FT /note="MGSDPPTACCFSYTARKLPRNFVVDYYETSSLCSQPAVVFQTKRGKQVCADP
FT SESWVQEYVYDLELN -> KASKSALTPVSPGSRSTCMTWN (in isoform 7)"
FT /evidence="ECO:0000303|PubMed:15843566"
FT /id="VSP_032625"
FT VAR_SEQ 26..92
FT /note="MGSDPPTACCFSYTARKLPRNFVVDYYETSSLCSQPAVVFQTKRGKQVCADP
FT SESWVQEYVYDLELN -> NSKPKEASKSALTPVSPGSRSTCMTWN (in isoform
FT 8)"
FT /evidence="ECO:0000303|PubMed:15843566"
FT /id="VSP_032626"
FT VAR_SEQ 26..92
FT /note="MGSDPPTACCFSYTARKLPRNFVVDYYETSSLCSQPAVVFQTKRGKQVCADP
FT SESWVQEYVYDLELN -> TKSSEWKLQGVCFQCCSGKDPIHQSCPTWTMVRQRKMPTT
FT GKG (in isoform 9)"
FT /evidence="ECO:0000303|PubMed:15843566"
FT /id="VSP_032627"
FT VAR_SEQ 65..92
FT /note="FQTKRGKQVCADPSESWVQEYVYDLELN -> YRESASSAAPGRIPSTRAAP
FT HGPWSGRGRCLPQARDKAR (in isoform 10)"
FT /evidence="ECO:0000303|PubMed:15843566"
FT /id="VSP_032628"
FT VAR_SEQ 65..92
FT /note="FQTKRGKQVCADPSESWVQEYVYDLELN -> AAPGRIPSTRAAPHGPWSGR
FT GRCLPQARDKAR (in isoform 3)"
FT /evidence="ECO:0000303|PubMed:15843566"
FT /id="VSP_032629"
FT VAR_SEQ 65..92
FT /note="FQTKRGKQVCADPSESWVQEYVYDLELN -> EWKLQGVCFQCCSGKDPIHQ
FT SCPTWTMVRQRKMPTTGKG (in isoform 4)"
FT /evidence="ECO:0000303|PubMed:15843566"
FT /id="VSP_032630"
FT VAR_SEQ 65..92
FT /note="Missing (in isoform 5)"
FT /evidence="ECO:0000303|PubMed:15489334,
FT ECO:0000303|PubMed:15843566"
FT /id="VSP_032631"
FT VAR_SEQ 65..92
FT /note="FQTKRGKQVCADPSESWVQEYVYDLELN -> AAPHGPWSGRGRCLPQARDK
FT AR (in isoform 6)"
FT /evidence="ECO:0000303|PubMed:15843566"
FT /id="VSP_032632"
FT VAR_SEQ 65..69
FT /note="Missing (in isoform 2)"
FT /evidence="ECO:0000303|PubMed:15843566"
FT /id="VSP_032633"
FT CONFLICT 45
FT /note="R -> H (in Ref. 3; AAH70310)"
FT /evidence="ECO:0000305"
SQ SEQUENCE 92 AA; 10166 MW; 4C8D01E926CDE882 CRC64;
MKLCVTVLSL LVLVAAFCSL ALSAPMGSDP PTACCFSYTA RKLPRNFVVD YYETSSLCSQ
PAVVFQTKRG KQVCADPSES WVQEYVYDLE LN
