ZITB_YERPE
ID ZITB_YERPE Reviewed; 312 AA.
AC Q8ZGY6; Q0WHR6;
DT 02-MAY-2002, integrated into UniProtKB/Swiss-Prot.
DT 01-MAR-2002, sequence version 1.
DT 25-MAY-2022, entry version 134.
DE RecName: Full=Zinc transporter ZitB {ECO:0000255|HAMAP-Rule:MF_00552};
GN Name=zitB {ECO:0000255|HAMAP-Rule:MF_00552};
GN OrderedLocusNames=YPO1129, y3050, YP_1027;
OS Yersinia pestis.
OC Bacteria; Proteobacteria; Gammaproteobacteria; Enterobacterales;
OC Yersiniaceae; Yersinia.
OX NCBI_TaxID=632;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=CO-92 / Biovar Orientalis;
RX PubMed=11586360; DOI=10.1038/35097083;
RA Parkhill J., Wren B.W., Thomson N.R., Titball R.W., Holden M.T.G.,
RA Prentice M.B., Sebaihia M., James K.D., Churcher C.M., Mungall K.L.,
RA Baker S., Basham D., Bentley S.D., Brooks K., Cerdeno-Tarraga A.-M.,
RA Chillingworth T., Cronin A., Davies R.M., Davis P., Dougan G., Feltwell T.,
RA Hamlin N., Holroyd S., Jagels K., Karlyshev A.V., Leather S., Moule S.,
RA Oyston P.C.F., Quail M.A., Rutherford K.M., Simmonds M., Skelton J.,
RA Stevens K., Whitehead S., Barrell B.G.;
RT "Genome sequence of Yersinia pestis, the causative agent of plague.";
RL Nature 413:523-527(2001).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=KIM10+ / Biovar Mediaevalis;
RX PubMed=12142430; DOI=10.1128/jb.184.16.4601-4611.2002;
RA Deng W., Burland V., Plunkett G. III, Boutin A., Mayhew G.F., Liss P.,
RA Perna N.T., Rose D.J., Mau B., Zhou S., Schwartz D.C., Fetherston J.D.,
RA Lindler L.E., Brubaker R.R., Plano G.V., Straley S.C., McDonough K.A.,
RA Nilles M.L., Matson J.S., Blattner F.R., Perry R.D.;
RT "Genome sequence of Yersinia pestis KIM.";
RL J. Bacteriol. 184:4601-4611(2002).
RN [3]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=91001 / Biovar Mediaevalis;
RX PubMed=15368893; DOI=10.1093/dnares/11.3.179;
RA Song Y., Tong Z., Wang J., Wang L., Guo Z., Han Y., Zhang J., Pei D.,
RA Zhou D., Qin H., Pang X., Han Y., Zhai J., Li M., Cui B., Qi Z., Jin L.,
RA Dai R., Chen F., Li S., Ye C., Du Z., Lin W., Wang J., Yu J., Yang H.,
RA Wang J., Huang P., Yang R.;
RT "Complete genome sequence of Yersinia pestis strain 91001, an isolate
RT avirulent to humans.";
RL DNA Res. 11:179-197(2004).
CC -!- FUNCTION: Involved in zinc efflux across the cytoplasmic membrane, thus
CC reducing zinc accumulation in the cytoplasm and rendering bacteria more
CC resistant to zinc. It may contribute to zinc homeostasis at low
CC concentrations of zinc. {ECO:0000255|HAMAP-Rule:MF_00552}.
CC -!- SUBCELLULAR LOCATION: Cell inner membrane {ECO:0000255|HAMAP-
CC Rule:MF_00552}; Multi-pass membrane protein {ECO:0000255|HAMAP-
CC Rule:MF_00552}.
CC -!- SIMILARITY: Belongs to the cation diffusion facilitator (CDF)
CC transporter (TC 2.A.4) family. SLC30A subfamily. {ECO:0000255|HAMAP-
CC Rule:MF_00552}.
CC ---------------------------------------------------------------------------
CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC ---------------------------------------------------------------------------
DR EMBL; AL590842; CAL19795.1; -; Genomic_DNA.
DR EMBL; AE009952; AAM86600.1; -; Genomic_DNA.
DR EMBL; AE017042; AAS61277.1; -; Genomic_DNA.
DR PIR; AI0138; AI0138.
DR RefSeq; WP_002210743.1; NZ_WUCM01000016.1.
DR RefSeq; YP_002346172.1; NC_003143.1.
DR AlphaFoldDB; Q8ZGY6; -.
DR SMR; Q8ZGY6; -.
DR STRING; 214092.YPO1129; -.
DR PaxDb; Q8ZGY6; -.
DR DNASU; 1147997; -.
DR EnsemblBacteria; AAM86600; AAM86600; y3050.
DR EnsemblBacteria; AAS61277; AAS61277; YP_1027.
DR GeneID; 57977268; -.
DR KEGG; ype:YPO1129; -.
DR KEGG; ypk:y3050; -.
DR KEGG; ypm:YP_1027; -.
DR PATRIC; fig|214092.21.peg.1422; -.
DR eggNOG; COG1230; Bacteria.
DR HOGENOM; CLU_013430_0_0_6; -.
DR OMA; GHEKMLH; -.
DR Proteomes; UP000000815; Chromosome.
DR Proteomes; UP000001019; Chromosome.
DR Proteomes; UP000002490; Chromosome.
DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR GO; GO:0005886; C:plasma membrane; IBA:GO_Central.
DR GO; GO:0005385; F:zinc ion transmembrane transporter activity; IBA:GO_Central.
DR GO; GO:0071577; P:zinc ion transmembrane transport; IBA:GO_Central.
DR Gene3D; 1.20.1510.10; -; 1.
DR HAMAP; MF_00552; ZitB; 1.
DR InterPro; IPR002524; Cation_efflux.
DR InterPro; IPR036837; Cation_efflux_CTD_sf.
DR InterPro; IPR027469; Cation_efflux_TMD_sf.
DR InterPro; IPR023500; Zn_transptr_ZitB.
DR Pfam; PF01545; Cation_efflux; 1.
DR SUPFAM; SSF160240; SSF160240; 1.
DR SUPFAM; SSF161111; SSF161111; 1.
DR TIGRFAMs; TIGR01297; CDF; 1.
PE 3: Inferred from homology;
KW Cell inner membrane; Cell membrane; Ion transport; Membrane;
KW Reference proteome; Transmembrane; Transmembrane helix; Transport; Zinc;
KW Zinc transport.
FT CHAIN 1..312
FT /note="Zinc transporter ZitB"
FT /id="PRO_0000206113"
FT TRANSMEM 16..36
FT /note="Helical"
FT /evidence="ECO:0000255|HAMAP-Rule:MF_00552"
FT TRANSMEM 40..60
FT /note="Helical"
FT /evidence="ECO:0000255|HAMAP-Rule:MF_00552"
FT TRANSMEM 81..101
FT /note="Helical"
FT /evidence="ECO:0000255|HAMAP-Rule:MF_00552"
FT TRANSMEM 117..137
FT /note="Helical"
FT /evidence="ECO:0000255|HAMAP-Rule:MF_00552"
FT TRANSMEM 153..173
FT /note="Helical"
FT /evidence="ECO:0000255|HAMAP-Rule:MF_00552"
FT TRANSMEM 177..197
FT /note="Helical"
FT /evidence="ECO:0000255|HAMAP-Rule:MF_00552"
SQ SEQUENCE 312 AA; 34828 MW; B727E66194A66705 CRC64;
MAVSTIFSQD SNSKRLLIAF AITTLFMVTE AIGGWLSGSL ALLADAGHML TDSAALFIAL
MAVHFSQRKP DPRHTFGYLR LTTLAAFVNA AALLLIVILI VWEAVHRFFS PHEVMGTPML
IIAIAGLLAN IFCFWILHKG EEEKNINVRA AALHVLSDLL GSVGAMIAAI VILTTGWTPI
DPILSVLVSV LILRSAWRLL KESFHELLEG APQEIDINKL RKDLCTNIYE VRNIHHVHLW
QVGEQRLMTL HAQVIPPLDH DALLQRIQDY LLHHYRISHA TVQMEYQHCG TPDCGINQAA
PADGHHRHHH HE
