ID   YYXA_BACSU              Reviewed;         400 AA.
AC   P39668;
DT   01-FEB-1995, integrated into UniProtKB/Swiss-Prot.
DT   01-OCT-1996, sequence version 2.
DT   03-AUG-2022, entry version 144.
DE   RecName: Full=Uncharacterized serine protease YyxA;
DE            EC=3.4.21.-;
GN   Name=yyxA; Synonyms=yycK; OrderedLocusNames=BSU40360;
OS   Bacillus subtilis (strain 168).
OC   Bacteria; Firmicutes; Bacilli; Bacillales; Bacillaceae; Bacillus.
OX   NCBI_TaxID=224308;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RC   STRAIN=168;
RX   PubMed=9205843; DOI=10.1093/dnares/4.2.155;
RA   Kasahara Y., Nakai S., Ogasawara N.;
RT   "Sequence analysis of the 36-kb region between gntZ and trnY genes of
RT   Bacillus subtilis genome.";
RL   DNA Res. 4:155-159(1997).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=168;
RX   PubMed=9384377; DOI=10.1038/36786;
RA   Kunst F., Ogasawara N., Moszer I., Albertini A.M., Alloni G., Azevedo V.,
RA   Bertero M.G., Bessieres P., Bolotin A., Borchert S., Borriss R.,
RA   Boursier L., Brans A., Braun M., Brignell S.C., Bron S., Brouillet S.,
RA   Bruschi C.V., Caldwell B., Capuano V., Carter N.M., Choi S.-K.,
RA   Codani J.-J., Connerton I.F., Cummings N.J., Daniel R.A., Denizot F.,
RA   Devine K.M., Duesterhoeft A., Ehrlich S.D., Emmerson P.T., Entian K.-D.,
RA   Errington J., Fabret C., Ferrari E., Foulger D., Fritz C., Fujita M.,
RA   Fujita Y., Fuma S., Galizzi A., Galleron N., Ghim S.-Y., Glaser P.,
RA   Goffeau A., Golightly E.J., Grandi G., Guiseppi G., Guy B.J., Haga K.,
RA   Haiech J., Harwood C.R., Henaut A., Hilbert H., Holsappel S., Hosono S.,
RA   Hullo M.-F., Itaya M., Jones L.-M., Joris B., Karamata D., Kasahara Y.,
RA   Klaerr-Blanchard M., Klein C., Kobayashi Y., Koetter P., Koningstein G.,
RA   Krogh S., Kumano M., Kurita K., Lapidus A., Lardinois S., Lauber J.,
RA   Lazarevic V., Lee S.-M., Levine A., Liu H., Masuda S., Mauel C.,
RA   Medigue C., Medina N., Mellado R.P., Mizuno M., Moestl D., Nakai S.,
RA   Noback M., Noone D., O'Reilly M., Ogawa K., Ogiwara A., Oudega B.,
RA   Park S.-H., Parro V., Pohl T.M., Portetelle D., Porwollik S.,
RA   Prescott A.M., Presecan E., Pujic P., Purnelle B., Rapoport G., Rey M.,
RA   Reynolds S., Rieger M., Rivolta C., Rocha E., Roche B., Rose M., Sadaie Y.,
RA   Sato T., Scanlan E., Schleich S., Schroeter R., Scoffone F., Sekiguchi J.,
RA   Sekowska A., Seror S.J., Serror P., Shin B.-S., Soldo B., Sorokin A.,
RA   Tacconi E., Takagi T., Takahashi H., Takemaru K., Takeuchi M.,
RA   Tamakoshi A., Tanaka T., Terpstra P., Tognoni A., Tosato V., Uchiyama S.,
RA   Vandenbol M., Vannier F., Vassarotti A., Viari A., Wambutt R., Wedler E.,
RA   Wedler H., Weitzenegger T., Winters P., Wipat A., Yamamoto H., Yamane K.,
RA   Yasumoto K., Yata K., Yoshida K., Yoshikawa H.-F., Zumstein E.,
RA   Yoshikawa H., Danchin A.;
RT   "The complete genome sequence of the Gram-positive bacterium Bacillus
RT   subtilis.";
RL   Nature 390:249-256(1997).
RN   [3]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 317-400.
RC   STRAIN=168 / Marburg / ATCC 6051 / DSM 10 / JCM 1465 / NBRC 13719 / NCIMB
RC   3610 / NRRL NRS-744 / VKM B-501;
RX   PubMed=8113162; DOI=10.1128/jb.176.5.1234-1241.1994;
RA   Calogero S., Gardan R., Glaser P., Schweitzer J., Rapoport G.,
RA   Debarbouille M.;
RT   "RocR, a novel regulatory protein controlling arginine utilization in
RT   Bacillus subtilis, belongs to the NtrC/NifA family of transcriptional
RT   activators.";
RL   J. Bacteriol. 176:1234-1241(1994).
CC   -!- SUBCELLULAR LOCATION: Cell membrane {ECO:0000305}; Single-pass membrane
CC       protein {ECO:0000305}.
CC   -!- SIMILARITY: Belongs to the peptidase S1C family. {ECO:0000305}.
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DR   EMBL; D78193; BAA11295.1; -; Genomic_DNA.
DR   EMBL; AL009126; CAB16073.1; -; Genomic_DNA.
DR   EMBL; L22006; -; NOT_ANNOTATED_CDS; Unassigned_DNA.
DR   PIR; B70092; B70092.
DR   RefSeq; NP_391916.1; NC_000964.3.
DR   RefSeq; WP_009969578.1; NZ_JNCM01000034.1.
DR   AlphaFoldDB; P39668; -.
DR   SMR; P39668; -.
DR   IntAct; P39668; 18.
DR   STRING; 224308.BSU40360; -.
DR   MEROPS; S01.364; -.
DR   PaxDb; P39668; -.
DR   PRIDE; P39668; -.
DR   DNASU; 937779; -.
DR   EnsemblBacteria; CAB16073; CAB16073; BSU_40360.
DR   GeneID; 937779; -.
DR   KEGG; bsu:BSU40360; -.
DR   PATRIC; fig|224308.179.peg.4369; -.
DR   eggNOG; COG0265; Bacteria.
DR   InParanoid; P39668; -.
DR   OMA; DTRHFDY; -.
DR   PhylomeDB; P39668; -.
DR   BioCyc; BSUB:BSU40360-MON; -.
DR   Proteomes; UP000001570; Chromosome.
DR   GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR   GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
DR   GO; GO:0004252; F:serine-type endopeptidase activity; IEA:InterPro.
DR   GO; GO:0006508; P:proteolysis; IEA:UniProtKB-KW.
DR   Gene3D; 2.30.42.10; -; 1.
DR   Gene3D; 2.40.10.10; -; 2.
DR   InterPro; IPR001478; PDZ.
DR   InterPro; IPR036034; PDZ_sf.
DR   InterPro; IPR009003; Peptidase_S1_PA.
DR   InterPro; IPR043504; Peptidase_S1_PA_chymotrypsin.
DR   InterPro; IPR001940; Peptidase_S1C.
DR   Pfam; PF13180; PDZ_2; 1.
DR   PRINTS; PR00834; PROTEASES2C.
DR   SMART; SM00228; PDZ; 1.
DR   SUPFAM; SSF50156; SSF50156; 1.
DR   SUPFAM; SSF50494; SSF50494; 1.
PE   3: Inferred from homology;
KW   Cell membrane; Hydrolase; Membrane; Protease; Reference proteome;
KW   Serine protease; Transmembrane; Transmembrane helix.
FT   CHAIN           1..400
FT                   /note="Uncharacterized serine protease YyxA"
FT                   /id="PRO_0000093868"
FT   TRANSMEM        22..42
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   DOMAIN          283..383
FT                   /note="PDZ"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00143"
FT   ACT_SITE        129
FT                   /note="Charge relay system"
FT                   /evidence="ECO:0000255"
FT   ACT_SITE        159
FT                   /note="Charge relay system"
FT                   /evidence="ECO:0000255"
FT   ACT_SITE        243
FT                   /note="Charge relay system"
FT                   /evidence="ECO:0000255"
SQ   SEQUENCE   400 AA;  42789 MW;  91A6E0E897B6F64C CRC64;
     MVDYEREEEH TTPEQPKRSK KGYFLSSLIG VIVGAVLMAF IMPYLSNEGL DTGALDQQQN
     NNGRESIRTV NVSVNNAVTK IVSNMSPAVV GVVNIQKSDI WGESGEAGSG SGVIYKKNDH
     SAYVVTNHHV IEGASQIEIS LKDGSRVSAD LVGSDQLMDL AVLRVKSDKI KAVADFGNSD
     KVKSGEPVIA IGNPLGLEFA GSVTQGVISG TERAIPVDSN GDGQPDWNAE VLQTDAAINP
     GNSGGALLNM DGKVIGINSM KIAESAVEGI GLSIPSKLVI PVIEDLERYG KVKRPFLGIE
     MKSLSDIASY HWDETLKLPK NVTNGAVVMG VDAFSPAGKA GLKELDVITE FDGYKVNDIV
     DLRKRLYQKK VGDRVKVKFY RGGKEKSVDI KLSSADQLGS