ID   YVRL_BACSU              Reviewed;         136 AA.
AC   O34686;
DT   25-JUL-2003, integrated into UniProtKB/Swiss-Prot.
DT   01-JAN-1998, sequence version 1.
DT   03-AUG-2022, entry version 95.
DE   RecName: Full=Membrane-bound negative regulator YvrL;
GN   Name=yvrL; OrderedLocusNames=BSU33250;
OS   Bacillus subtilis (strain 168).
OC   Bacteria; Firmicutes; Bacilli; Bacillales; Bacillaceae; Bacillus.
OX   NCBI_TaxID=224308;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RC   STRAIN=168;
RX   PubMed=9639930; DOI=10.1099/00221287-144-6-1593;
RA   Wipat A., Brignell C.S., Guy J.B., Rose M., Emmerson P.T., Harwood C.R.;
RT   "The yvsA-yvqA (293 degrees - 289 degrees) region of the Bacillus subtilis
RT   chromosome containing genes involved in metal ion uptake and a putative
RT   sigma factor.";
RL   Microbiology 144:1593-1600(1998).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=168;
RX   PubMed=9384377; DOI=10.1038/36786;
RA   Kunst F., Ogasawara N., Moszer I., Albertini A.M., Alloni G., Azevedo V.,
RA   Bertero M.G., Bessieres P., Bolotin A., Borchert S., Borriss R.,
RA   Boursier L., Brans A., Braun M., Brignell S.C., Bron S., Brouillet S.,
RA   Bruschi C.V., Caldwell B., Capuano V., Carter N.M., Choi S.-K.,
RA   Codani J.-J., Connerton I.F., Cummings N.J., Daniel R.A., Denizot F.,
RA   Devine K.M., Duesterhoeft A., Ehrlich S.D., Emmerson P.T., Entian K.-D.,
RA   Errington J., Fabret C., Ferrari E., Foulger D., Fritz C., Fujita M.,
RA   Fujita Y., Fuma S., Galizzi A., Galleron N., Ghim S.-Y., Glaser P.,
RA   Goffeau A., Golightly E.J., Grandi G., Guiseppi G., Guy B.J., Haga K.,
RA   Haiech J., Harwood C.R., Henaut A., Hilbert H., Holsappel S., Hosono S.,
RA   Hullo M.-F., Itaya M., Jones L.-M., Joris B., Karamata D., Kasahara Y.,
RA   Klaerr-Blanchard M., Klein C., Kobayashi Y., Koetter P., Koningstein G.,
RA   Krogh S., Kumano M., Kurita K., Lapidus A., Lardinois S., Lauber J.,
RA   Lazarevic V., Lee S.-M., Levine A., Liu H., Masuda S., Mauel C.,
RA   Medigue C., Medina N., Mellado R.P., Mizuno M., Moestl D., Nakai S.,
RA   Noback M., Noone D., O'Reilly M., Ogawa K., Ogiwara A., Oudega B.,
RA   Park S.-H., Parro V., Pohl T.M., Portetelle D., Porwollik S.,
RA   Prescott A.M., Presecan E., Pujic P., Purnelle B., Rapoport G., Rey M.,
RA   Reynolds S., Rieger M., Rivolta C., Rocha E., Roche B., Rose M., Sadaie Y.,
RA   Sato T., Scanlan E., Schleich S., Schroeter R., Scoffone F., Sekiguchi J.,
RA   Sekowska A., Seror S.J., Serror P., Shin B.-S., Soldo B., Sorokin A.,
RA   Tacconi E., Takagi T., Takahashi H., Takemaru K., Takeuchi M.,
RA   Tamakoshi A., Tanaka T., Terpstra P., Tognoni A., Tosato V., Uchiyama S.,
RA   Vandenbol M., Vannier F., Vassarotti A., Viari A., Wambutt R., Wedler E.,
RA   Wedler H., Weitzenegger T., Winters P., Wipat A., Yamamoto H., Yamane K.,
RA   Yasumoto K., Yata K., Yoshida K., Yoshikawa H.-F., Zumstein E.,
RA   Yoshikawa H., Danchin A.;
RT   "The complete genome sequence of the Gram-positive bacterium Bacillus
RT   subtilis.";
RL   Nature 390:249-256(1997).
RN   [3]
RP   DEVELOPMENTAL STAGE, INDUCTION, AND DISRUPTION PHENOTYPE.
RC   STRAIN=168;
RX   PubMed=11918817; DOI=10.1046/j.1365-2958.2002.02833.x;
RA   Berka R.M., Hahn J., Albano M., Draskovic I., Persuh M., Cui X., Sloma A.,
RA   Widner W., Dubnau D.;
RT   "Microarray analysis of the Bacillus subtilis K-state: genome-wide
RT   expression changes dependent on ComK.";
RL   Mol. Microbiol. 43:1331-1345(2002).
RN   [4]
RP   FUNCTION AS A NEGATIVE REGULATOR OF SIGO, AND INDUCTION.
RC   STRAIN=168 / CU1065;
RX   PubMed=18573182; DOI=10.1111/j.1365-2958.2008.06331.x;
RA   MacLellan S.R., Wecke T., Helmann J.D.;
RT   "A previously unidentified sigma factor and two accessory proteins regulate
RT   oxalate decarboxylase expression in Bacillus subtilis.";
RL   Mol. Microbiol. 69:954-967(2008).
RN   [5]
RP   FUNCTION IN OXDC EXPRESSION, AND DISRUPTION PHENOTYPE.
RC   STRAIN=168 / CU1065;
RX   PubMed=19047353; DOI=10.1128/jb.01435-08;
RA   MacLellan S.R., Helmann J.D., Antelmann H.;
RT   "The yvrI alternative sigma factor is essential for acid stress induction
RT   of oxalate decarboxylase in Bacillus subtilis.";
RL   J. Bacteriol. 191:931-939(2009).
CC   -!- FUNCTION: Negatively regulates RNA polymerase sigma factor SigO-
CC       dependent transcription. Prevents the expression or secretion of OxdC
CC       under nonstress conditions. May act as an anti-sigma factor.
CC       {ECO:0000269|PubMed:18573182, ECO:0000269|PubMed:19047353}.
CC   -!- SUBCELLULAR LOCATION: Cell membrane {ECO:0000305}; Multi-pass membrane
CC       protein {ECO:0000305}.
CC   -!- DEVELOPMENTAL STAGE: Preferentially expressed in cells competent for
CC       DNA transformation; that is 5-15% of the population (PubMed:11918817).
CC       {ECO:0000269|PubMed:11918817}.
CC   -!- INDUCTION: Expression activated by ComK (PubMed:11918817). Positively
CC       regulated by SigO and its coactivator RsoA.
CC       {ECO:0000269|PubMed:11918817, ECO:0000269|PubMed:18573182}.
CC   -!- DISRUPTION PHENOTYPE: Cells lacking this gene exhibit a slight increase
CC       in OxdC accumulation under acidic growth conditions and a huge increase
CC       under nonstress growth conditions. {ECO:0000269|PubMed:19047353}.
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DR   EMBL; AJ223978; CAA11726.1; -; Genomic_DNA.
DR   EMBL; AL009126; CAB15315.1; -; Genomic_DNA.
DR   PIR; F70047; F70047.
DR   RefSeq; NP_391205.1; NC_000964.3.
DR   RefSeq; WP_003243579.1; NZ_JNCM01000033.1.
DR   AlphaFoldDB; O34686; -.
DR   STRING; 224308.BSU33250; -.
DR   PaxDb; O34686; -.
DR   EnsemblBacteria; CAB15315; CAB15315; BSU_33250.
DR   GeneID; 935982; -.
DR   KEGG; bsu:BSU33250; -.
DR   PATRIC; fig|224308.179.peg.3609; -.
DR   eggNOG; ENOG5030CKY; Bacteria.
DR   OMA; EPFERLM; -.
DR   BioCyc; BSUB:BSU33250-MON; -.
DR   Proteomes; UP000001570; Chromosome.
DR   GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR   GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
DR   InterPro; IPR025912; YrvL.
DR   Pfam; PF14184; YrvL; 1.
PE   1: Evidence at protein level;
KW   Cell membrane; Membrane; Reference proteome; Repressor; Transmembrane;
KW   Transmembrane helix.
FT   CHAIN           1..136
FT                   /note="Membrane-bound negative regulator YvrL"
FT                   /id="PRO_0000049944"
FT   TRANSMEM        18..38
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        46..66
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        83..103
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        106..126
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
SQ   SEQUENCE   136 AA;  15360 MW;  E18D273DF9A18371 CRC64;
     MKHQNPSKRL LRLSIKYLLA AAAVVLTYFA VIYILFSLAG TSYRSAAHVL LFAVVFLVLG
     LCFEPFERLM IHSFTFFKTG KRLFILLAGI VQLLFLWMTA HTTDQLISDI WLSTTEEMIV
     AAVFLILDKC NSALPS