YOPN_YERPE
ID YOPN_YERPE Reviewed; 293 AA.
AC P68640; P16160;
DT 07-DEC-2004, integrated into UniProtKB/Swiss-Prot.
DT 23-JAN-2007, sequence version 2.
DT 25-MAY-2022, entry version 114.
DE RecName: Full=Outer membrane protein YopN;
DE AltName: Full=LcrE;
DE AltName: Full=Yop4b;
GN Name=yopN; Synonyms=lcrE;
GN OrderedLocusNames=YPCD1.39c, y5039, y0042, YP_pCD44;
OS Yersinia pestis.
OG Plasmid pCD1.
OC Bacteria; Proteobacteria; Gammaproteobacteria; Enterobacterales;
OC Yersiniaceae; Yersinia.
OX NCBI_TaxID=632;
RN [1]
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RC STRAIN=KIM5 / Biovar Mediaevalis;
RX PubMed=9746557; DOI=10.1128/iai.66.10.4611-4623.1998;
RA Perry R.D., Straley S.C., Fetherston J.D., Rose D.J., Gregor J.,
RA Blattner F.R.;
RT "DNA sequencing and analysis of the low-Ca2+-response plasmid pCD1 of
RT Yersinia pestis KIM5.";
RL Infect. Immun. 66:4611-4623(1998).
RN [2]
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RC STRAIN=KIM5 / Biovar Mediaevalis;
RX PubMed=9748454; DOI=10.1128/jb.180.19.5192-5202.1998;
RA Hu P., Elliott J., McCready P., Skowronski E., Garnes J., Kobayashi A.,
RA Brubaker R.R., Garcia E.;
RT "Structural organization of virulence-associated plasmids of Yersinia
RT pestis.";
RL J. Bacteriol. 180:5192-5202(1998).
RN [3]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=CO-92 / Biovar Orientalis;
RX PubMed=11586360; DOI=10.1038/35097083;
RA Parkhill J., Wren B.W., Thomson N.R., Titball R.W., Holden M.T.G.,
RA Prentice M.B., Sebaihia M., James K.D., Churcher C.M., Mungall K.L.,
RA Baker S., Basham D., Bentley S.D., Brooks K., Cerdeno-Tarraga A.-M.,
RA Chillingworth T., Cronin A., Davies R.M., Davis P., Dougan G., Feltwell T.,
RA Hamlin N., Holroyd S., Jagels K., Karlyshev A.V., Leather S., Moule S.,
RA Oyston P.C.F., Quail M.A., Rutherford K.M., Simmonds M., Skelton J.,
RA Stevens K., Whitehead S., Barrell B.G.;
RT "Genome sequence of Yersinia pestis, the causative agent of plague.";
RL Nature 413:523-527(2001).
RN [4]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=91001 / Biovar Mediaevalis;
RX PubMed=15368893; DOI=10.1093/dnares/11.3.179;
RA Song Y., Tong Z., Wang J., Wang L., Guo Z., Han Y., Zhang J., Pei D.,
RA Zhou D., Qin H., Pang X., Han Y., Zhai J., Li M., Cui B., Qi Z., Jin L.,
RA Dai R., Chen F., Li S., Ye C., Du Z., Lin W., Wang J., Yu J., Yang H.,
RA Wang J., Huang P., Yang R.;
RT "Complete genome sequence of Yersinia pestis strain 91001, an isolate
RT avirulent to humans.";
RL DNA Res. 11:179-197(2004).
CC -!- FUNCTION: Plays a major role in regulation of the low-calcium response.
CC Seems to sense the calcium concentration and to transmit a signal to
CC shut off yop transcription when the calcium concentration is high (By
CC similarity). {ECO:0000250}.
CC -!- SUBCELLULAR LOCATION: Cell outer membrane {ECO:0000250}; Peripheral
CC membrane protein {ECO:0000250}.
CC -!- SIMILARITY: Belongs to the HrpJ/YopN family. {ECO:0000305}.
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DR EMBL; AF074612; AAC69792.1; -; Genomic_DNA.
DR EMBL; AF053946; AAC62565.1; -; Genomic_DNA.
DR EMBL; AL117189; CAB54916.1; -; Genomic_DNA.
DR EMBL; AE017043; AAS58563.1; -; Genomic_DNA.
DR PIR; T43586; T43586.
DR RefSeq; NP_395173.1; NC_003131.1.
DR RefSeq; NP_857743.1; NC_004836.1.
DR RefSeq; NP_857938.1; NC_004839.1.
DR RefSeq; WP_002212958.1; NZ_WUCM01000070.1.
DR PDB; 1XKP; X-ray; 1.70 A; A=33-277.
DR PDB; 1XL3; X-ray; 2.20 A; A/B=76-293.
DR PDBsum; 1XKP; -.
DR PDBsum; 1XL3; -.
DR AlphaFoldDB; P68640; -.
DR SMR; P68640; -.
DR IntAct; P68640; 6.
DR MINT; P68640; -.
DR STRING; 214092.5832459; -.
DR DNASU; 1149302; -.
DR EnsemblBacteria; AAS58563; AAS58563; YP_pCD44.
DR KEGG; ype:YPCD1.39c; -.
DR KEGG; ypm:YP_pCD44; -.
DR PATRIC; fig|214092.21.peg.50; -.
DR eggNOG; ENOG5032VH1; Bacteria.
DR HOGENOM; CLU_061811_0_0_6; -.
DR OMA; GINAIWS; -.
DR EvolutionaryTrace; P68640; -.
DR Proteomes; UP000000815; Plasmid pCD1.
DR Proteomes; UP000001019; Plasmid pCD1.
DR GO; GO:0009279; C:cell outer membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0009986; C:cell surface; IEA:InterPro.
DR GO; GO:0050709; P:negative regulation of protein secretion; IEA:InterPro.
DR GO; GO:0030254; P:protein secretion by the type III secretion system; IEA:InterPro.
DR InterPro; IPR010812; HrpJ-like.
DR InterPro; IPR013401; T3SS_LcrE.
DR Pfam; PF07201; HrpJ; 1.
DR TIGRFAMs; TIGR02568; LcrE; 1.
PE 1: Evidence at protein level;
KW 3D-structure; Calcium; Cell outer membrane; Membrane; Plasmid;
KW Reference proteome; Virulence.
FT INIT_MET 1
FT /note="Removed"
FT /evidence="ECO:0000250"
FT CHAIN 2..293
FT /note="Outer membrane protein YopN"
FT /id="PRO_0000066371"
FT CONFLICT 66
FT /note="L -> F (in Ref. 4; AAS58563)"
FT /evidence="ECO:0000305"
FT STRAND 39..42
FT /evidence="ECO:0007829|PDB:1XKP"
FT HELIX 49..56
FT /evidence="ECO:0007829|PDB:1XKP"
FT STRAND 73..75
FT /evidence="ECO:0007829|PDB:1XKP"
FT HELIX 76..91
FT /evidence="ECO:0007829|PDB:1XKP"
FT HELIX 102..110
FT /evidence="ECO:0007829|PDB:1XKP"
FT HELIX 118..121
FT /evidence="ECO:0007829|PDB:1XKP"
FT HELIX 124..127
FT /evidence="ECO:0007829|PDB:1XKP"
FT HELIX 132..136
FT /evidence="ECO:0007829|PDB:1XKP"
FT HELIX 139..146
FT /evidence="ECO:0007829|PDB:1XKP"
FT HELIX 150..152
FT /evidence="ECO:0007829|PDB:1XKP"
FT HELIX 153..188
FT /evidence="ECO:0007829|PDB:1XKP"
FT STRAND 191..193
FT /evidence="ECO:0007829|PDB:1XL3"
FT HELIX 195..207
FT /evidence="ECO:0007829|PDB:1XKP"
FT HELIX 212..220
FT /evidence="ECO:0007829|PDB:1XKP"
FT HELIX 228..236
FT /evidence="ECO:0007829|PDB:1XKP"
FT HELIX 239..245
FT /evidence="ECO:0007829|PDB:1XKP"
FT HELIX 250..253
FT /evidence="ECO:0007829|PDB:1XKP"
FT HELIX 256..263
FT /evidence="ECO:0007829|PDB:1XKP"
FT HELIX 272..275
FT /evidence="ECO:0007829|PDB:1XL3"
FT HELIX 278..282
FT /evidence="ECO:0007829|PDB:1XL3"
SQ SEQUENCE 293 AA; 32670 MW; 89AF200F36B4382C CRC64;
MTTLHNLSYG NTPLHNERPE IASSQIVNQT LGQFRGESVQ IVSGTLQSIA DMAEEVTFVF
SERKELSLDK RKLSDSQARV SDVEEQVNQY LSKVPELEQK QNVSELLSLL SNSPNISLSQ
LKAYLEGKSE EPSEQFKMLC GLRDALKGRP ELAHLSHLVE QALVSMAEEQ GETIVLGARI
TPEAYRESQS GVNPLQPLRD TYRDAVMGYQ GIYAIWSDLQ KRFPNGDIDS VILFLQKALS
ADLQSQQSGS GREKLGIVIS DLQKLKEFGS VSDQVKGFWQ FFSEGKTNGV RPF
