ID   YOPE_YEREN              Reviewed;         219 AA.
AC   P31492;
DT   01-JUL-1993, integrated into UniProtKB/Swiss-Prot.
DT   01-JUL-1993, sequence version 1.
DT   25-MAY-2022, entry version 92.
DE   RecName: Full=Outer membrane virulence protein YopE;
GN   Name=yopE; Synonyms=yop25;
OS   Yersinia enterocolitica.
OG   Plasmid pYV.
OC   Bacteria; Proteobacteria; Gammaproteobacteria; Enterobacterales;
OC   Yersiniaceae; Yersinia.
OX   NCBI_TaxID=630;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RX   PubMed=2129533; DOI=10.1128/iai.58.9.2840-2849.1990;
RA   Michiels T., Wattiau P., Brasseur R., Ruysschaert J.M., Cornelis G.;
RT   "Secretion of Yop proteins by Yersiniae.";
RL   Infect. Immun. 58:2840-2849(1990).
CC   -!- FUNCTION: Essential virulence determinant; cytotoxic effector, involved
CC       in resistance to phagocytosis.
CC   -!- SUBCELLULAR LOCATION: Cell outer membrane.
CC   -!- INDUCTION: At 37 degrees Celsius in the absence of calcium.
CC   -!- MISCELLANEOUS: N-terminal is important for export, C-terminal is
CC       indispensable for virulence.
CC   -!- SIMILARITY: Belongs to the YopE family. {ECO:0000305}.
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DR   EMBL; M92066; AAA19862.1; -; Unassigned_DNA.
DR   PIR; S14242; S14242.
DR   RefSeq; WP_010891237.1; NZ_SJZK01000009.1.
DR   AlphaFoldDB; P31492; -.
DR   SMR; P31492; -.
DR   GO; GO:0009279; C:cell outer membrane; IEA:UniProtKB-SubCell.
DR   GO; GO:0005096; F:GTPase activator activity; IEA:InterPro.
DR   GO; GO:0050765; P:negative regulation of phagocytosis; IEA:InterPro.
DR   CDD; cd00219; ToxGAP; 1.
DR   Gene3D; 1.20.120.260; -; 1.
DR   InterPro; IPR003537; YopE-like.
DR   InterPro; IPR014773; YopE_GAP_dom.
DR   InterPro; IPR037168; YopE_GAP_dom_sf.
DR   InterPro; IPR015110; YopE_N_dom.
DR   Pfam; PF03545; YopE; 1.
DR   Pfam; PF09020; YopE_N; 1.
DR   PRINTS; PR01372; YERSINIAYOPE.
DR   SUPFAM; SSF47233; SSF47233; 1.
PE   2: Evidence at transcript level;
KW   Cell outer membrane; Membrane; Plasmid; Virulence.
FT   CHAIN           1..219
FT                   /note="Outer membrane virulence protein YopE"
FT                   /id="PRO_0000066365"
FT   REGION          1..54
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   219 AA;  22947 MW;  08B02AFAE0FB1D24 CRC64;
     MKISSFISTS LPLPASVSGS SSVGEMSGRS VSQQKSDQYA NNLAGRTESP QGSSLASRII
     ERLSSMAHSV IGFIQRMFSE GSHKPVVTPA LTPAQMPSPT SFSDSIKQLA AETLPKYMQQ
     LSSLDAETLQ KNHDQFATGS GPLRGSITQC QGLMQFCGGE LQAEASAILN TPVCGIPFSQ
     WGTVGGAASA YVASGVDLTQ AANEIKGLGQ QMQQLLSLM