ID   YOP1_DEBHA              Reviewed;         177 AA.
AC   Q6BWH8;
DT   30-AUG-2005, integrated into UniProtKB/Swiss-Prot.
DT   16-AUG-2004, sequence version 1.
DT   03-AUG-2022, entry version 80.
DE   RecName: Full=Protein YOP1;
GN   Name=YOP1; OrderedLocusNames=DEHA2B11264g;
OS   Debaryomyces hansenii (strain ATCC 36239 / CBS 767 / BCRC 21394 / JCM 1990
OS   / NBRC 0083 / IGC 2968) (Yeast) (Torulaspora hansenii).
OC   Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes;
OC   Saccharomycetales; Debaryomycetaceae; Debaryomyces.
OX   NCBI_TaxID=284592;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC 36239 / CBS 767 / BCRC 21394 / JCM 1990 / NBRC 0083 / IGC 2968;
RX   PubMed=15229592; DOI=10.1038/nature02579;
RA   Dujon B., Sherman D., Fischer G., Durrens P., Casaregola S., Lafontaine I.,
RA   de Montigny J., Marck C., Neuveglise C., Talla E., Goffard N., Frangeul L.,
RA   Aigle M., Anthouard V., Babour A., Barbe V., Barnay S., Blanchin S.,
RA   Beckerich J.-M., Beyne E., Bleykasten C., Boisrame A., Boyer J.,
RA   Cattolico L., Confanioleri F., de Daruvar A., Despons L., Fabre E.,
RA   Fairhead C., Ferry-Dumazet H., Groppi A., Hantraye F., Hennequin C.,
RA   Jauniaux N., Joyet P., Kachouri R., Kerrest A., Koszul R., Lemaire M.,
RA   Lesur I., Ma L., Muller H., Nicaud J.-M., Nikolski M., Oztas S.,
RA   Ozier-Kalogeropoulos O., Pellenz S., Potier S., Richard G.-F.,
RA   Straub M.-L., Suleau A., Swennen D., Tekaia F., Wesolowski-Louvel M.,
RA   Westhof E., Wirth B., Zeniou-Meyer M., Zivanovic Y., Bolotin-Fukuhara M.,
RA   Thierry A., Bouchier C., Caudron B., Scarpelli C., Gaillardin C.,
RA   Weissenbach J., Wincker P., Souciet J.-L.;
RT   "Genome evolution in yeasts.";
RL   Nature 430:35-44(2004).
CC   -!- FUNCTION: Required to generate and maintain the structure of the
CC       tubular endoplasmic reticulum network and the vacuole. Induces high
CC       curvature in membranes and causes membrane tubule formation. Involved
CC       in membrane/vesicle trafficking. {ECO:0000250|UniProtKB:Q12402}.
CC   -!- SUBUNIT: Oligomer. {ECO:0000250|UniProtKB:Q12402}.
CC   -!- SUBCELLULAR LOCATION: Endoplasmic reticulum membrane
CC       {ECO:0000250|UniProtKB:Q12402}; Multi-pass membrane protein
CC       {ECO:0000250|UniProtKB:Q12402}. Golgi apparatus membrane
CC       {ECO:0000250|UniProtKB:Q12402}; Multi-pass membrane protein
CC       {ECO:0000255}.
CC   -!- DOMAIN: The short lumenal loops between transmembrane domains 1 and 2
CC       and between transmembrane domains 3 and 4 may impart a wedge-like
CC       configuration, thus deforming membranes.
CC       {ECO:0000250|UniProtKB:Q12402}.
CC   -!- SIMILARITY: Belongs to the DP1 family. {ECO:0000305}.
CC   -!- SEQUENCE CAUTION:
CC       Sequence=CAG85445.2; Type=Erroneous gene model prediction; Evidence={ECO:0000305};
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DR   EMBL; CR382134; CAG85445.2; ALT_SEQ; Genomic_DNA.
DR   RefSeq; XP_457441.2; XM_457441.2.
DR   AlphaFoldDB; Q6BWH8; -.
DR   STRING; 4959.XP_457441.2; -.
DR   EnsemblFungi; CAG85445; CAG85445; DEHA2B11264g.
DR   GeneID; 2913376; -.
DR   KEGG; dha:DEHA2B11264g; -.
DR   eggNOG; KOG1725; Eukaryota.
DR   HOGENOM; CLU_028431_2_1_1; -.
DR   InParanoid; Q6BWH8; -.
DR   OrthoDB; 1473891at2759; -.
DR   Proteomes; UP000000599; Chromosome B.
DR   GO; GO:0005789; C:endoplasmic reticulum membrane; IEA:UniProtKB-SubCell.
DR   GO; GO:0000139; C:Golgi membrane; IEA:UniProtKB-SubCell.
DR   GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR   InterPro; IPR004345; TB2_DP1_HVA22.
DR   PANTHER; PTHR12300; PTHR12300; 1.
DR   Pfam; PF03134; TB2_DP1_HVA22; 1.
PE   3: Inferred from homology;
KW   Endoplasmic reticulum; Golgi apparatus; Membrane; Reference proteome;
KW   Transmembrane; Transmembrane helix.
FT   CHAIN           1..177
FT                   /note="Protein YOP1"
FT                   /id="PRO_0000101851"
FT   TOPO_DOM        1..34
FT                   /note="Cytoplasmic"
FT                   /evidence="ECO:0000250|UniProtKB:Q12402"
FT   TRANSMEM        35..54
FT                   /note="Helical"
FT                   /evidence="ECO:0000250|UniProtKB:Q12402"
FT   TOPO_DOM        55..56
FT                   /note="Lumenal"
FT                   /evidence="ECO:0000250|UniProtKB:Q12402"
FT   TRANSMEM        57..76
FT                   /note="Helical"
FT                   /evidence="ECO:0000250|UniProtKB:Q12402"
FT   TOPO_DOM        77..87
FT                   /note="Cytoplasmic"
FT                   /evidence="ECO:0000250|UniProtKB:Q12402"
FT   TRANSMEM        88..104
FT                   /note="Helical"
FT                   /evidence="ECO:0000250|UniProtKB:Q12402"
FT   TOPO_DOM        105..107
FT                   /note="Lumenal"
FT                   /evidence="ECO:0000250|UniProtKB:Q12402"
FT   TRANSMEM        108..126
FT                   /note="Helical"
FT                   /evidence="ECO:0000250|UniProtKB:Q12402"
FT   TOPO_DOM        127..177
FT                   /note="Cytoplasmic"
FT                   /evidence="ECO:0000250|UniProtKB:Q12402"
SQ   SEQUENCE   177 AA;  19747 MW;  786CC8FD5A25C5EF CRC64;
     MSYQNQAKSF LSTIDEKTKD LQILRQFELK TGLPRSYAIL GGFGLYFVLI FLNIGGVGQL
     LSNIAGLVIP GYFSLLALES TTTSDDTQLL TYWVVFATFN VVEFWSKAIL YWIPFYYLFK
     TVFLVYIGIP STGGAVTVYN AAIKPFSRRY IVNNKKFAQD INNAAQGVSS SVELLAS