ID   YMGA_ECOLI              Reviewed;          90 AA.
AC   P75992; Q2MBH0;
DT   15-JUL-1998, integrated into UniProtKB/Swiss-Prot.
DT   01-FEB-1997, sequence version 1.
DT   03-AUG-2022, entry version 107.
DE   RecName: Full=Probable two-component-system connector protein YmgA;
GN   Name=ymgA; OrderedLocusNames=b1165, JW1152;
OS   Escherichia coli (strain K12).
OC   Bacteria; Proteobacteria; Gammaproteobacteria; Enterobacterales;
OC   Enterobacteriaceae; Escherichia.
OX   NCBI_TaxID=83333;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=K12 / MG1655 / ATCC 47076;
RX   PubMed=9278503; DOI=10.1126/science.277.5331.1453;
RA   Blattner F.R., Plunkett G. III, Bloch C.A., Perna N.T., Burland V.,
RA   Riley M., Collado-Vides J., Glasner J.D., Rode C.K., Mayhew G.F.,
RA   Gregor J., Davis N.W., Kirkpatrick H.A., Goeden M.A., Rose D.J., Mau B.,
RA   Shao Y.;
RT   "The complete genome sequence of Escherichia coli K-12.";
RL   Science 277:1453-1462(1997).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=K12 / W3110 / ATCC 27325 / DSM 5911;
RX   PubMed=16738553; DOI=10.1038/msb4100049;
RA   Hayashi K., Morooka N., Yamamoto Y., Fujita K., Isono K., Choi S.,
RA   Ohtsubo E., Baba T., Wanner B.L., Mori H., Horiuchi T.;
RT   "Highly accurate genome sequences of Escherichia coli K-12 strains MG1655
RT   and W3110.";
RL   Mol. Syst. Biol. 2:E1-E5(2006).
RN   [3]
RP   INDUCTION BY LOW TEMPERATURE, AND RPOS-DEPENDENCE.
RC   STRAIN=K12 / MC4100;
RX   PubMed=18174134; DOI=10.1099/mic.0.2007/012021-0;
RA   White-Ziegler C.A., Um S., Perez N.M., Berns A.L., Malhowski A.J.,
RA   Young S.;
RT   "Low temperature (23 degrees C) increases expression of biofilm-, cold-
RT   shock- and RpoS-dependent genes in Escherichia coli K-12.";
RL   Microbiology 154:148-166(2008).
RN   [4]
RP   INDUCTION BY 5-FLUOROURACIL.
RC   STRAIN=K12 / ATCC 25404 / DSM 5698 / NCIMB 11290;
RX   PubMed=19172264; DOI=10.1007/s00253-009-1860-8;
RA   Attila C., Ueda A., Wood T.K.;
RT   "5-Fluorouracil reduces biofilm formation in Escherichia coli K-12 through
RT   global regulator AriR as an antivirulence compound.";
RL   Appl. Microbiol. Biotechnol. 82:525-533(2009).
RN   [5]
RP   INDUCTION BY COLD, RPOS-DEPENDENCE, REPRESSION BY YCGE, AND OPERON
RP   STRUCTURE.
RC   STRAIN=K12 / MC4100;
RX   PubMed=19240136; DOI=10.1101/gad.499409;
RA   Tschowri N., Busse S., Hengge R.;
RT   "The BLUF-EAL protein YcgF acts as a direct anti-repressor in a blue-light
RT   response of Escherichia coli.";
RL   Genes Dev. 23:522-534(2009).
CC   -!- FUNCTION: Probably a connector protein for RcsB/C regulation of biofilm
CC       formation, providing additional signal input into the two-component
CC       signaling pathway. May serve to stimulate biofilm maturation, probably
CC       via the Rcs phosphorelay. Mild overexpression at 16 degrees Celsius
CC       increases the production of colanic acid, an exopolysaccharide and
CC       matrix component, and reduces adhesive curli fimbriae expression. Both
CC       of these effects require RcsB.
CC   -!- INDUCTION: Induced by 5-fluorouracil. Strongly induced at 16 degrees
CC       Celsius. Expression is dependent on RpoS, repressed by YcgE. At 16
CC       degrees Celsius with blue light irradiation, expression of this operon
CC       is absolutely dependent on YcgF for relief from YcgE repression. Part
CC       of the ycgZ-ymgA-ariR-ymgC operon. {ECO:0000269|PubMed:18174134,
CC       ECO:0000269|PubMed:19172264, ECO:0000269|PubMed:19240136}.
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DR   EMBL; U00096; AAC74249.1; -; Genomic_DNA.
DR   EMBL; AP009048; BAE76386.1; -; Genomic_DNA.
DR   PIR; B64862; B64862.
DR   RefSeq; NP_415683.1; NC_000913.3.
DR   RefSeq; WP_000858002.1; NZ_STEB01000023.1.
DR   AlphaFoldDB; P75992; -.
DR   SMR; P75992; -.
DR   BioGRID; 4259445; 8.
DR   IntAct; P75992; 18.
DR   STRING; 511145.b1165; -.
DR   jPOST; P75992; -.
DR   PaxDb; P75992; -.
DR   PRIDE; P75992; -.
DR   EnsemblBacteria; AAC74249; AAC74249; b1165.
DR   EnsemblBacteria; BAE76386; BAE76386; BAE76386.
DR   GeneID; 948991; -.
DR   KEGG; ecj:JW1152; -.
DR   KEGG; eco:b1165; -.
DR   PATRIC; fig|83333.103.peg.1955; -.
DR   EchoBASE; EB4037; -.
DR   eggNOG; ENOG502ZPHM; Bacteria.
DR   HOGENOM; CLU_2436104_0_0_6; -.
DR   OMA; GEPNRRT; -.
DR   BioCyc; EcoCyc:G6605-MON; -.
DR   PRO; PR:P75992; -.
DR   Proteomes; UP000000318; Chromosome.
DR   Proteomes; UP000000625; Chromosome.
DR   GO; GO:1900191; P:negative regulation of single-species biofilm formation; IMP:EcoCyc.
PE   2: Evidence at transcript level;
KW   Reference proteome.
FT   CHAIN           1..90
FT                   /note="Probable two-component-system connector protein
FT                   YmgA"
FT                   /id="PRO_0000168862"
FT   REGION          63..90
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        63..81
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   90 AA;  10345 MW;  D704E90B5184DBD0 CRC64;
     MKTSDNERIK YEITGQAVLQ ILRMKINFSL QTLIKQLLVM KSAEEDAFRR DLIDSIIRDF
     SNSDSGGPNR RTATADNKSM FNGKKINRIH