YHHT_ECOLI
ID YHHT_ECOLI Reviewed; 349 AA.
AC P0AGM0; P37622; P76700; Q2M7D7; Q8X6P3;
DT 20-DEC-2005, integrated into UniProtKB/Swiss-Prot.
DT 20-DEC-2005, sequence version 1.
DT 03-AUG-2022, entry version 103.
DE RecName: Full=Putative transport protein YhhT;
GN Name=yhhT; OrderedLocusNames=b3474, JW5680;
OS Escherichia coli (strain K12).
OC Bacteria; Proteobacteria; Gammaproteobacteria; Enterobacterales;
OC Enterobacteriaceae; Escherichia.
OX NCBI_TaxID=83333;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=K12 / MG1655 / ATCC 47076;
RX PubMed=8041620; DOI=10.1093/nar/22.13.2576;
RA Sofia H.J., Burland V., Daniels D.L., Plunkett G. III, Blattner F.R.;
RT "Analysis of the Escherichia coli genome. V. DNA sequence of the region
RT from 76.0 to 81.5 minutes.";
RL Nucleic Acids Res. 22:2576-2586(1994).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=K12 / MG1655 / ATCC 47076;
RX PubMed=9278503; DOI=10.1126/science.277.5331.1453;
RA Blattner F.R., Plunkett G. III, Bloch C.A., Perna N.T., Burland V.,
RA Riley M., Collado-Vides J., Glasner J.D., Rode C.K., Mayhew G.F.,
RA Gregor J., Davis N.W., Kirkpatrick H.A., Goeden M.A., Rose D.J., Mau B.,
RA Shao Y.;
RT "The complete genome sequence of Escherichia coli K-12.";
RL Science 277:1453-1462(1997).
RN [3]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=K12 / W3110 / ATCC 27325 / DSM 5911;
RX PubMed=16738553; DOI=10.1038/msb4100049;
RA Hayashi K., Morooka N., Yamamoto Y., Fujita K., Isono K., Choi S.,
RA Ohtsubo E., Baba T., Wanner B.L., Mori H., Horiuchi T.;
RT "Highly accurate genome sequences of Escherichia coli K-12 strains MG1655
RT and W3110.";
RL Mol. Syst. Biol. 2:E1-E5(2006).
RN [4]
RP TOPOLOGY [LARGE SCALE ANALYSIS].
RC STRAIN=K12 / MG1655 / ATCC 47076;
RX PubMed=15919996; DOI=10.1126/science.1109730;
RA Daley D.O., Rapp M., Granseth E., Melen K., Drew D., von Heijne G.;
RT "Global topology analysis of the Escherichia coli inner membrane
RT proteome.";
RL Science 308:1321-1323(2005).
CC -!- SUBCELLULAR LOCATION: Cell inner membrane; Multi-pass membrane protein.
CC -!- SIMILARITY: Belongs to the autoinducer-2 exporter (AI-2E) (TC 2.A.86)
CC family. {ECO:0000305}.
CC -!- SEQUENCE CAUTION:
CC Sequence=AAB18449.1; Type=Erroneous initiation; Note=Extended N-terminus.; Evidence={ECO:0000305};
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DR EMBL; U00039; AAB18449.1; ALT_INIT; Genomic_DNA.
DR EMBL; U00096; AAC76499.2; -; Genomic_DNA.
DR EMBL; AP009048; BAE77819.1; -; Genomic_DNA.
DR PIR; S47693; S47693.
DR RefSeq; NP_417931.4; NC_000913.3.
DR RefSeq; WP_001300885.1; NZ_SSZK01000008.1.
DR AlphaFoldDB; P0AGM0; -.
DR BioGRID; 4262490; 7.
DR STRING; 511145.b3474; -.
DR TCDB; 2.A.86.1.2; the autoinducer-2 exporter (ai-2e) family (formerly the perm family, tc #9,b,22).
DR PaxDb; P0AGM0; -.
DR PRIDE; P0AGM0; -.
DR EnsemblBacteria; AAC76499; AAC76499; b3474.
DR EnsemblBacteria; BAE77819; BAE77819; BAE77819.
DR GeneID; 58462541; -.
DR GeneID; 947980; -.
DR KEGG; ecj:JW5680; -.
DR KEGG; eco:b3474; -.
DR PATRIC; fig|511145.12.peg.3573; -.
DR EchoBASE; EB2134; -.
DR eggNOG; COG0628; Bacteria.
DR HOGENOM; CLU_031275_0_3_6; -.
DR InParanoid; P0AGM0; -.
DR OMA; ATTLMTQ; -.
DR PhylomeDB; P0AGM0; -.
DR BioCyc; EcoCyc:EG12220-MON; -.
DR PRO; PR:P0AGM0; -.
DR Proteomes; UP000000318; Chromosome.
DR Proteomes; UP000000625; Chromosome.
DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR GO; GO:0005886; C:plasma membrane; IDA:EcoCyc.
DR GO; GO:0055085; P:transmembrane transport; IBA:GO_Central.
DR InterPro; IPR002549; AI-2E-like.
DR PANTHER; PTHR21716; PTHR21716; 1.
DR Pfam; PF01594; AI-2E_transport; 1.
PE 1: Evidence at protein level;
KW Cell inner membrane; Cell membrane; Membrane; Reference proteome;
KW Transmembrane; Transmembrane helix; Transport.
FT CHAIN 1..349
FT /note="Putative transport protein YhhT"
FT /id="PRO_0000148301"
FT TOPO_DOM 1..10
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 11..31
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 32
FT /note="Periplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 33..53
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 54..62
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 63..83
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 84..142
FT /note="Periplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 143..163
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 164..208
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 209..229
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 230..234
FT /note="Periplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 235..255
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 256..257
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 258..278
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 279..292
FT /note="Periplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 293..313
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 314..349
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
SQ SEQUENCE 349 AA; 38522 MW; 275ADBAD4FD58257 CRC64;
METPQPDKTG MHILLKLASL VVILAGIHAA ADIIVQLLLA LFFAIVLNPL VTWFIRRGVQ
RPVAITIVVV VMLIALTALV GVLAASFNEF ISMLPKFNKE LTRKLFKLQE MLPFLNLHMS
PERMLQRMDS EKVVTFTTAL MTGLSGAMAS VLLLVMTVVF MLFEVRHVPY KMRFALNNPQ
IHIAGLHRAL KGVSHYLALK TLLSLWTGVI VWLGLELMGV QFALMWAVLA FLLNYVPNIG
AVISAVPPMI QVLLFNGVYE CILVGALFLV VHMVIGNILE PRMMGHRLGM STMVVFLSLL
IWGWLLGPVG MLLSVPLTSV CKIWMETTKG GSKLAILLGP GRPKSRLPG
