YFE0_YEAST
ID YFE0_YEAST Reviewed; 540 AA.
AC P43562; D6VTJ0;
DT 01-NOV-1995, integrated into UniProtKB/Swiss-Prot.
DT 01-NOV-1995, sequence version 1.
DT 03-AUG-2022, entry version 170.
DE RecName: Full=Probable metabolite transport protein YFL040W;
GN OrderedLocusNames=YFL040W;
OS Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast).
OC Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes;
OC Saccharomycetales; Saccharomycetaceae; Saccharomyces.
OX NCBI_TaxID=559292;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=ATCC 204508 / S288c;
RX PubMed=7670463; DOI=10.1038/ng0795-261;
RA Murakami Y., Naitou M., Hagiwara H., Shibata T., Ozawa M., Sasanuma S.,
RA Sasanuma M., Tsuchiya Y., Soeda E., Yokoyama K., Yamazaki M., Tashiro H.,
RA Eki T.;
RT "Analysis of the nucleotide sequence of chromosome VI from Saccharomyces
RT cerevisiae.";
RL Nat. Genet. 10:261-268(1995).
RN [2]
RP GENOME REANNOTATION.
RC STRAIN=ATCC 204508 / S288c;
RX PubMed=24374639; DOI=10.1534/g3.113.008995;
RA Engel S.R., Dietrich F.S., Fisk D.G., Binkley G., Balakrishnan R.,
RA Costanzo M.C., Dwight S.S., Hitz B.C., Karra K., Nash R.S., Weng S.,
RA Wong E.D., Lloyd P., Skrzypek M.S., Miyasato S.R., Simison M., Cherry J.M.;
RT "The reference genome sequence of Saccharomyces cerevisiae: Then and now.";
RL G3 (Bethesda) 4:389-398(2014).
RN [3]
RP TOPOLOGY [LARGE SCALE ANALYSIS].
RC STRAIN=ATCC 208353 / W303-1A;
RX PubMed=16847258; DOI=10.1073/pnas.0604075103;
RA Kim H., Melen K., Oesterberg M., von Heijne G.;
RT "A global topology map of the Saccharomyces cerevisiae membrane proteome.";
RL Proc. Natl. Acad. Sci. U.S.A. 103:11142-11147(2006).
CC -!- SUBCELLULAR LOCATION: Membrane; Multi-pass membrane protein.
CC -!- SIMILARITY: Belongs to the major facilitator superfamily. Sugar
CC transporter (TC 2.A.1.1) family. {ECO:0000305}.
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DR EMBL; D50617; BAA09200.1; -; Genomic_DNA.
DR EMBL; BK006940; DAA12400.1; -; Genomic_DNA.
DR PIR; S56215; S56215.
DR RefSeq; NP_116613.1; NM_001179926.1.
DR AlphaFoldDB; P43562; -.
DR SMR; P43562; -.
DR BioGRID; 31106; 31.
DR DIP; DIP-4427N; -.
DR IntAct; P43562; 4.
DR MINT; P43562; -.
DR STRING; 4932.YFL040W; -.
DR TCDB; 2.A.1.1.100; the major facilitator superfamily (mfs).
DR PaxDb; P43562; -.
DR PRIDE; P43562; -.
DR EnsemblFungi; YFL040W_mRNA; YFL040W; YFL040W.
DR GeneID; 850503; -.
DR KEGG; sce:YFL040W; -.
DR SGD; S000001854; YFL040W.
DR VEuPathDB; FungiDB:YFL040W; -.
DR eggNOG; KOG0254; Eukaryota.
DR HOGENOM; CLU_001265_30_12_1; -.
DR InParanoid; P43562; -.
DR OMA; YICEMAG; -.
DR BioCyc; YEAST:G3O-30422-MON; -.
DR PRO; PR:P43562; -.
DR Proteomes; UP000002311; Chromosome VI.
DR RNAct; P43562; protein.
DR GO; GO:0000324; C:fungal-type vacuole; HDA:SGD.
DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR GO; GO:0016020; C:membrane; ISS:SGD.
DR GO; GO:0005628; C:prospore membrane; HDA:SGD.
DR GO; GO:0005366; F:myo-inositol:proton symporter activity; IBA:GO_Central.
DR GO; GO:0022857; F:transmembrane transporter activity; ISS:SGD.
DR GO; GO:1904679; P:myo-inositol import across plasma membrane; IBA:GO_Central.
DR GO; GO:0055085; P:transmembrane transport; ISS:SGD.
DR Gene3D; 1.20.1250.20; -; 1.
DR InterPro; IPR020846; MFS_dom.
DR InterPro; IPR005828; MFS_sugar_transport-like.
DR InterPro; IPR036259; MFS_trans_sf.
DR InterPro; IPR005829; Sugar_transporter_CS.
DR Pfam; PF00083; Sugar_tr; 1.
DR SUPFAM; SSF103473; SSF103473; 1.
DR PROSITE; PS50850; MFS; 1.
DR PROSITE; PS00217; SUGAR_TRANSPORT_2; 1.
PE 1: Evidence at protein level;
KW Glycoprotein; Membrane; Reference proteome; Repeat; Transmembrane;
KW Transmembrane helix; Transport.
FT CHAIN 1..540
FT /note="Probable metabolite transport protein YFL040W"
FT /id="PRO_0000050464"
FT TOPO_DOM 1..29
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 30..50
FT /note="Helical; Name=1"
FT /evidence="ECO:0000255"
FT TOPO_DOM 51..67
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 68..88
FT /note="Helical; Name=2"
FT /evidence="ECO:0000255"
FT TOPO_DOM 89..101
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 102..122
FT /note="Helical; Name=3"
FT /evidence="ECO:0000255"
FT TOPO_DOM 123..126
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 127..147
FT /note="Helical; Name=4"
FT /evidence="ECO:0000255"
FT TOPO_DOM 148..158
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 159..179
FT /note="Helical; Name=5"
FT /evidence="ECO:0000255"
FT TOPO_DOM 180..187
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 188..208
FT /note="Helical; Name=6"
FT /evidence="ECO:0000255"
FT TOPO_DOM 209..275
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 276..296
FT /note="Helical; Name=7"
FT /evidence="ECO:0000255"
FT TOPO_DOM 297..313
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 314..334
FT /note="Helical; Name=8"
FT /evidence="ECO:0000255"
FT TOPO_DOM 335..341
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 342..362
FT /note="Helical; Name=9"
FT /evidence="ECO:0000255"
FT TOPO_DOM 363..385
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 386..406
FT /note="Helical; Name=10"
FT /evidence="ECO:0000255"
FT TOPO_DOM 407..428
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 429..449
FT /note="Helical; Name=11"
FT /evidence="ECO:0000255"
FT TOPO_DOM 450..455
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 456..476
FT /note="Helical; Name=12"
FT /evidence="ECO:0000255"
FT TOPO_DOM 477..540
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT REGION 499..540
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 505..525
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 526..540
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT CARBOHYD 52
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT CARBOHYD 374
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
SQ SEQUENCE 540 AA; 60610 MW; A43B6B58134C38AE CRC64;
MTAMKAIVWR LPKMPKIKIT KTYEVTKITA ILTLVGFIMG LEVPSLATFL TNKTFNEYFK
YPTPLQQGLL MGSTPLGGIM GCFICCIMND RFSRIYQFQS GIIIWNIVTL LNFCIWDILG
LLICRMIKGM ILGNFSILVA SYANEVIPRG KRGSTMSYIQ LCLTIGILVM HYLCIALSLW
DSHFAFRIAW CIGIIPGLLF WMASYALPES YHWLVLHGKM SEAQEIQHNL AKKFNESQPR
DAVPEMSKIE LAGDFWIGVN DLDFSKKLPR GSFKPLILGM TLQLLVQFSG INIILGYITY
ICEIVGLEGN VKLFTSSIPY FINMVLSLLP ITFIDYTSRK LITLLGGFPI SGLLITIGAL
FVKYGQDTKP IDGNRSLVWS IGENPFVGGW ILTLCFLIVG IFAMSLSSIP WVYTNEMLPS
RVKVKGFAIC VTFGWLGNFI LTFLCPVMIE RLKGTTFIIF GSLTFLISLS VLIWFPETKG
MSIEDIDKFF EFESKEGTNL HGEKGIKTPD SNSNGGSTRS SQEGQLHKPI KLKSDEEMII
