YFCA_ECOLI
ID YFCA_ECOLI Reviewed; 269 AA.
AC P0AD30; P14008;
DT 22-NOV-2005, integrated into UniProtKB/Swiss-Prot.
DT 22-NOV-2005, sequence version 1.
DT 03-AUG-2022, entry version 111.
DE RecName: Full=Probable membrane transporter protein YfcA;
GN Name=yfcA; OrderedLocusNames=b2327, JW2324;
OS Escherichia coli (strain K12).
OC Bacteria; Proteobacteria; Gammaproteobacteria; Enterobacterales;
OC Enterobacteriaceae; Escherichia.
OX NCBI_TaxID=83333;
RN [1]
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RC STRAIN=K12;
RX PubMed=2187143; DOI=10.1111/j.1365-2958.1990.tb00588.x;
RA Keck W., van Leeuwen A.M., Huber M., Goodell E.W.;
RT "Cloning and characterization of mepA, the structural gene of the
RT penicillin-insensitive murein endopeptidase from Escherichia coli.";
RL Mol. Microbiol. 4:209-219(1990).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=K12 / W3110 / ATCC 27325 / DSM 5911;
RX PubMed=9205837; DOI=10.1093/dnares/4.2.91;
RA Yamamoto Y., Aiba H., Baba T., Hayashi K., Inada T., Isono K., Itoh T.,
RA Kimura S., Kitagawa M., Makino K., Miki T., Mitsuhashi N., Mizobuchi K.,
RA Mori H., Nakade S., Nakamura Y., Nashimoto H., Oshima T., Oyama S.,
RA Saito N., Sampei G., Satoh Y., Sivasundaram S., Tagami H., Takahashi H.,
RA Takeda J., Takemoto K., Uehara K., Wada C., Yamagata S., Horiuchi T.;
RT "Construction of a contiguous 874-kb sequence of the Escherichia coli-K12
RT genome corresponding to 50.0-68.8 min on the linkage map and analysis of
RT its sequence features.";
RL DNA Res. 4:91-113(1997).
RN [3]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=K12 / MG1655 / ATCC 47076;
RX PubMed=9278503; DOI=10.1126/science.277.5331.1453;
RA Blattner F.R., Plunkett G. III, Bloch C.A., Perna N.T., Burland V.,
RA Riley M., Collado-Vides J., Glasner J.D., Rode C.K., Mayhew G.F.,
RA Gregor J., Davis N.W., Kirkpatrick H.A., Goeden M.A., Rose D.J., Mau B.,
RA Shao Y.;
RT "The complete genome sequence of Escherichia coli K-12.";
RL Science 277:1453-1462(1997).
RN [4]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=K12 / W3110 / ATCC 27325 / DSM 5911;
RX PubMed=16738553; DOI=10.1038/msb4100049;
RA Hayashi K., Morooka N., Yamamoto Y., Fujita K., Isono K., Choi S.,
RA Ohtsubo E., Baba T., Wanner B.L., Mori H., Horiuchi T.;
RT "Highly accurate genome sequences of Escherichia coli K-12 strains MG1655
RT and W3110.";
RL Mol. Syst. Biol. 2:E1-E5(2006).
RN [5]
RP TOPOLOGY [LARGE SCALE ANALYSIS].
RC STRAIN=K12 / MG1655 / ATCC 47076;
RX PubMed=15919996; DOI=10.1126/science.1109730;
RA Daley D.O., Rapp M., Granseth E., Melen K., Drew D., von Heijne G.;
RT "Global topology analysis of the Escherichia coli inner membrane
RT proteome.";
RL Science 308:1321-1323(2005).
CC -!- SUBCELLULAR LOCATION: Cell inner membrane; Multi-pass membrane protein.
CC -!- SIMILARITY: Belongs to the 4-toluene sulfonate uptake permease (TSUP)
CC (TC 2.A.102) family. {ECO:0000305}.
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DR EMBL; X16909; CAA34783.1; -; mRNA.
DR EMBL; U00096; AAC75387.1; -; Genomic_DNA.
DR EMBL; AP009048; BAA16183.1; -; Genomic_DNA.
DR PIR; S08346; S08346.
DR RefSeq; NP_416830.1; NC_000913.3.
DR RefSeq; WP_000447361.1; NZ_SSUR01000012.1.
DR AlphaFoldDB; P0AD30; -.
DR BioGRID; 4259583; 18.
DR IntAct; P0AD30; 2.
DR STRING; 511145.b2327; -.
DR TCDB; 2.A.102.3.1; the 4-toluene sulfonate uptake permease (tsup) family.
DR PaxDb; P0AD30; -.
DR PRIDE; P0AD30; -.
DR EnsemblBacteria; AAC75387; AAC75387; b2327.
DR EnsemblBacteria; BAA16183; BAA16183; BAA16183.
DR GeneID; 67416757; -.
DR GeneID; 946808; -.
DR KEGG; ecj:JW2324; -.
DR KEGG; eco:b2327; -.
DR PATRIC; fig|1411691.4.peg.4405; -.
DR EchoBASE; EB1134; -.
DR eggNOG; COG0730; Bacteria.
DR HOGENOM; CLU_045498_2_1_6; -.
DR InParanoid; P0AD30; -.
DR OMA; YAYGFIM; -.
DR PhylomeDB; P0AD30; -.
DR BioCyc; EcoCyc:EG11144-MON; -.
DR PRO; PR:P0AD30; -.
DR Proteomes; UP000000318; Chromosome.
DR Proteomes; UP000000625; Chromosome.
DR GO; GO:0005887; C:integral component of plasma membrane; ISM:EcoCyc.
DR GO; GO:0009408; P:response to heat; IMP:EcoCyc.
DR InterPro; IPR002781; TM_pro_TauE-like.
DR Pfam; PF01925; TauE; 1.
PE 1: Evidence at protein level;
KW Cell inner membrane; Cell membrane; Membrane; Reference proteome;
KW Transmembrane; Transmembrane helix; Transport.
FT CHAIN 1..269
FT /note="Probable membrane transporter protein YfcA"
FT /id="PRO_0000169187"
FT TOPO_DOM 1..7
FT /note="Periplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 8..28
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 29..30
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 31..51
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 52..84
FT /note="Periplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 85..105
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 106..111
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 112..132
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 133..156
FT /note="Periplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 157..177
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 178..197
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 198..218
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 219..269
FT /note="Periplasmic"
FT /evidence="ECO:0000255"
SQ SEQUENCE 269 AA; 28643 MW; B640B0EBFF1BF7ED CRC64;
METFNSLFMV SPLLLGVLFF VAMLAGFIDS IAGGGGLLTI PALMAAGMSP ANALATNKLQ
ACGGSISATI YFIRRKVVSL SDQKLNIAMT FVGSMSGALL VQYVQADVLR QILPILVICI
GLYFLLMPKL GEEDRQRRMY GLPFALIAGG CVGFYDGFFG PAAGSFYALA FVTLCGFNLA
KATAHAKLLN ATSNIGGLLL FILGGKVIWA TGFVMLVGQF LGARMGSRLV LSKGQKLIRP
MIVIVSAVMS AKLLYDSHGQ EILHWLGMN
