YF2E_SCHPO
ID YF2E_SCHPO Reviewed; 617 AA.
AC O13779; O13763;
DT 25-OCT-2005, integrated into UniProtKB/Swiss-Prot.
DT 25-OCT-2005, sequence version 4.
DT 03-AUG-2022, entry version 121.
DE RecName: Full=Putative metal ion transporter C17A12.14;
GN ORFNames=SPAC17A2.14, SPAC17G6.01;
OS Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast).
OC Eukaryota; Fungi; Dikarya; Ascomycota; Taphrinomycotina;
OC Schizosaccharomycetes; Schizosaccharomycetales; Schizosaccharomycetaceae;
OC Schizosaccharomyces.
OX NCBI_TaxID=284812;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=972 / ATCC 24843;
RX PubMed=11859360; DOI=10.1038/nature724;
RA Wood V., Gwilliam R., Rajandream M.A., Lyne M.H., Lyne R., Stewart A.,
RA Sgouros J.G., Peat N., Hayles J., Baker S.G., Basham D., Bowman S.,
RA Brooks K., Brown D., Brown S., Chillingworth T., Churcher C.M., Collins M.,
RA Connor R., Cronin A., Davis P., Feltwell T., Fraser A., Gentles S.,
RA Goble A., Hamlin N., Harris D.E., Hidalgo J., Hodgson G., Holroyd S.,
RA Hornsby T., Howarth S., Huckle E.J., Hunt S., Jagels K., James K.D.,
RA Jones L., Jones M., Leather S., McDonald S., McLean J., Mooney P.,
RA Moule S., Mungall K.L., Murphy L.D., Niblett D., Odell C., Oliver K.,
RA O'Neil S., Pearson D., Quail M.A., Rabbinowitsch E., Rutherford K.M.,
RA Rutter S., Saunders D., Seeger K., Sharp S., Skelton J., Simmonds M.N.,
RA Squares R., Squares S., Stevens K., Taylor K., Taylor R.G., Tivey A.,
RA Walsh S.V., Warren T., Whitehead S., Woodward J.R., Volckaert G., Aert R.,
RA Robben J., Grymonprez B., Weltjens I., Vanstreels E., Rieger M.,
RA Schaefer M., Mueller-Auer S., Gabel C., Fuchs M., Duesterhoeft A.,
RA Fritzc C., Holzer E., Moestl D., Hilbert H., Borzym K., Langer I., Beck A.,
RA Lehrach H., Reinhardt R., Pohl T.M., Eger P., Zimmermann W., Wedler H.,
RA Wambutt R., Purnelle B., Goffeau A., Cadieu E., Dreano S., Gloux S.,
RA Lelaure V., Mottier S., Galibert F., Aves S.J., Xiang Z., Hunt C.,
RA Moore K., Hurst S.M., Lucas M., Rochet M., Gaillardin C., Tallada V.A.,
RA Garzon A., Thode G., Daga R.R., Cruzado L., Jimenez J., Sanchez M.,
RA del Rey F., Benito J., Dominguez A., Revuelta J.L., Moreno S.,
RA Armstrong J., Forsburg S.L., Cerutti L., Lowe T., McCombie W.R.,
RA Paulsen I., Potashkin J., Shpakovski G.V., Ussery D., Barrell B.G.,
RA Nurse P.;
RT "The genome sequence of Schizosaccharomyces pombe.";
RL Nature 415:871-880(2002).
RN [2]
RP INTERACTION WITH SAD1.
RX PubMed=14655046; DOI=10.1007/s00438-003-0938-8;
RA Miki F., Kurabayashi A., Tange Y., Okazaki K., Shimanuki M., Niwa O.;
RT "Two-hybrid search for proteins that interact with Sad1 and Kms1, two
RT membrane-bound components of the spindle pole body in fission yeast.";
RL Mol. Genet. Genomics 270:449-461(2004).
RN [3]
RP PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-105; SER-152; SER-162;
RP SER-226 AND SER-241, AND IDENTIFICATION BY MASS SPECTROMETRY.
RX PubMed=18257517; DOI=10.1021/pr7006335;
RA Wilson-Grady J.T., Villen J., Gygi S.P.;
RT "Phosphoproteome analysis of fission yeast.";
RL J. Proteome Res. 7:1088-1097(2008).
CC -!- SUBUNIT: Interacts with sad1. {ECO:0000269|PubMed:14655046}.
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000305}; Multi-pass membrane
CC protein {ECO:0000305}.
CC -!- SIMILARITY: Belongs to the CorA metal ion transporter (MIT) (TC 1.A.35)
CC family. {ECO:0000305}.
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DR EMBL; CU329670; CAB16566.1; -; Genomic_DNA.
DR PIR; T37815; T37815.
DR PIR; T37833; T37833.
DR RefSeq; XP_001713086.1; XM_001713034.2.
DR AlphaFoldDB; O13779; -.
DR SMR; O13779; -.
DR BioGRID; 858055; 10.
DR IntAct; O13779; 1.
DR STRING; 4896.SPAC17A2.14.1; -.
DR iPTMnet; O13779; -.
DR SwissPalm; O13779; -.
DR MaxQB; O13779; -.
DR PaxDb; O13779; -.
DR PRIDE; O13779; -.
DR EnsemblFungi; SPAC17A2.14.1; SPAC17A2.14.1:pep; SPAC17A2.14.
DR PomBase; SPAC17A2.14; -.
DR VEuPathDB; FungiDB:SPAC17A2.14; -.
DR eggNOG; ENOG502QPTQ; Eukaryota.
DR HOGENOM; CLU_413973_0_0_1; -.
DR InParanoid; O13779; -.
DR OMA; SHEMWEL; -.
DR PhylomeDB; O13779; -.
DR PRO; PR:O13779; -.
DR Proteomes; UP000002485; Chromosome I.
DR GO; GO:0005737; C:cytoplasm; HDA:PomBase.
DR GO; GO:0000329; C:fungal-type vacuole membrane; ISO:PomBase.
DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR GO; GO:0016020; C:membrane; IBA:GO_Central.
DR GO; GO:0005886; C:plasma membrane; IBA:GO_Central.
DR GO; GO:1990816; C:vacuole-mitochondrion membrane contact site; ISO:PomBase.
DR GO; GO:0015095; F:magnesium ion transmembrane transporter activity; IMP:PomBase.
DR GO; GO:0010961; P:cellular magnesium ion homeostasis; IBA:GO_Central.
DR GO; GO:1903830; P:magnesium ion transmembrane transport; IMP:PomBase.
DR CDD; cd12829; Alr1p-like; 1.
DR InterPro; IPR044089; Alr1-like.
DR InterPro; IPR045861; CorA_cytoplasmic_dom.
DR InterPro; IPR045863; CorA_TM1_TM2.
DR InterPro; IPR002523; MgTranspt_CorA/ZnTranspt_ZntB.
DR Pfam; PF01544; CorA; 1.
DR SUPFAM; SSF143865; SSF143865; 1.
DR SUPFAM; SSF144083; SSF144083; 1.
PE 1: Evidence at protein level;
KW Membrane; Phosphoprotein; Reference proteome; Transmembrane;
KW Transmembrane helix; Transport.
FT CHAIN 1..617
FT /note="Putative metal ion transporter C17A12.14"
FT /id="PRO_0000201538"
FT TRANSMEM 560..580
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 590..610
FT /note="Helical"
FT /evidence="ECO:0000255"
FT REGION 1..141
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1..22
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 36..50
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 80..98
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 99..133
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT MOD_RES 105
FT /note="Phosphoserine"
FT /evidence="ECO:0000269|PubMed:18257517"
FT MOD_RES 152
FT /note="Phosphoserine"
FT /evidence="ECO:0000269|PubMed:18257517"
FT MOD_RES 162
FT /note="Phosphoserine"
FT /evidence="ECO:0000269|PubMed:18257517"
FT MOD_RES 226
FT /note="Phosphoserine"
FT /evidence="ECO:0000269|PubMed:18257517"
FT MOD_RES 241
FT /note="Phosphoserine"
FT /evidence="ECO:0000269|PubMed:18257517"
SQ SEQUENCE 617 AA; 71198 MW; 99BA5F8A5E691249 CRC64;
MPSNTSRSVP TGFYYKQNAR MQNRPRFSDR KHSSKSKHRF PVDPSLQPDE ADEGTRLLGN
SDSDLLEPPS EHSSNGEDDK DINNPPSMPS SVCSSPKSPH RHYESDEDIE NISLPESHPE
DIQRKEFETE NGKNTRDQPS PLAEVSDFAI SSPHVYPKSA NSHDSHYEQF ANNDVTESAV
DDHPATRKLS RDELYLPISP NNAQEPKFSV LDEWTKKMVA NFEEYSVEDV DKRRERNRKL
SEPLLVNGRY RVRDRWAQFR KSEIEKPYRF TFFTDELPST IHSHEMWELV HDGQSFEDLF
HSGGTWWLDV SCPKEEEIRV LAKAFGIHPL TVEDITLEED REKVELFRTY YFVTFRSFNQ
LPSNSEYLKP LNFYLVVFRD GIITFHMNPT PHPANVRRRI RQLNGYLTVN ADWIAYALLD
DTTDAFAPFI EQIEDEVDTI DSMILSIHYD HVMEVKPQER MLQRVGECRK LIMSLLRLLA
NKADVVRGLS KRCNESWQVA PRGEIALYLG DVQDHIVTMV QNLNHYEKIL SRSHSNYLAQ
ISINMTLVSN ETNEVLSRLT ILGTILIPLN LVTGLWGMNV KVPGQDVPGL GWFFSILGSL
MIFAISSFIL CKWYKVI
