ID   YF1BB_XENLA             Reviewed;         300 AA.
AC   Q4FZQ0; Q6INH2;
DT   23-OCT-2007, integrated into UniProtKB/Swiss-Prot.
DT   30-AUG-2005, sequence version 1.
DT   03-AUG-2022, entry version 43.
DE   RecName: Full=Protein YIF1B-B;
DE   AltName: Full=YIP1-interacting factor homolog B-B;
GN   Name=yif1b-b;
OS   Xenopus laevis (African clawed frog).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Amphibia;
OC   Batrachia; Anura; Pipoidea; Pipidae; Xenopodinae; Xenopus; Xenopus.
OX   NCBI_TaxID=8355;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   TISSUE=Embryo, and Ovary;
RG   NIH - Xenopus Gene Collection (XGC) project;
RL   Submitted (JUL-2005) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: Functions in endoplasmic reticulum to Golgi vesicle-mediated
CC       transport and regulates the proper organization of the endoplasmic
CC       reticulum and the Golgi (By similarity). Plays a key role in targeting
CC       to neuronal dendrites receptors such as HTR1A (By similarity). Plays
CC       also a role in primary cilium and sperm flagellum assembly probably
CC       through protein transport to these compartments (By similarity).
CC       {ECO:0000250|UniProtKB:Q6PEC3, ECO:0000250|UniProtKB:Q9CX30}.
CC   -!- SUBCELLULAR LOCATION: Endoplasmic reticulum membrane
CC       {ECO:0000250|UniProtKB:Q5BJH7}; Multi-pass membrane protein
CC       {ECO:0000255}. Golgi apparatus membrane {ECO:0000250|UniProtKB:Q5BJH7};
CC       Multi-pass membrane protein {ECO:0000255}. Endoplasmic reticulum-Golgi
CC       intermediate compartment membrane {ECO:0000250|UniProtKB:Q5BJH7};
CC       Multi-pass membrane protein {ECO:0000255}. Note=Shuttles between the
CC       endoplasmic reticulum, the intermediate compartment and the Golgi
CC       apparatus. {ECO:0000250|UniProtKB:Q5BJH7}.
CC   -!- SIMILARITY: Belongs to the YIF1 family. {ECO:0000305}.
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DR   EMBL; BC072309; AAH72309.1; -; mRNA.
DR   EMBL; BC099271; AAH99271.1; -; mRNA.
DR   RefSeq; NP_001085082.1; NM_001091613.1.
DR   AlphaFoldDB; Q4FZQ0; -.
DR   SMR; Q4FZQ0; -.
DR   DNASU; 432153; -.
DR   GeneID; 432153; -.
DR   KEGG; xla:432153; -.
DR   CTD; 432153; -.
DR   Xenbase; XB-GENE-922895; yif1b.L.
DR   OrthoDB; 1256839at2759; -.
DR   Proteomes; UP000186698; Chromosome 8L.
DR   Bgee; 432153; Expressed in testis and 19 other tissues.
DR   GO; GO:0005783; C:endoplasmic reticulum; ISS:UniProtKB.
DR   GO; GO:0005789; C:endoplasmic reticulum membrane; IEA:UniProtKB-SubCell.
DR   GO; GO:0005793; C:endoplasmic reticulum-Golgi intermediate compartment; ISS:UniProtKB.
DR   GO; GO:0033116; C:endoplasmic reticulum-Golgi intermediate compartment membrane; IEA:UniProtKB-SubCell.
DR   GO; GO:0005794; C:Golgi apparatus; ISS:UniProtKB.
DR   GO; GO:0000139; C:Golgi membrane; IEA:UniProtKB-SubCell.
DR   GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR   GO; GO:0060271; P:cilium assembly; ISS:UniProtKB.
DR   GO; GO:0006888; P:endoplasmic reticulum to Golgi vesicle-mediated transport; ISS:UniProtKB.
DR   GO; GO:0015031; P:protein transport; IEA:UniProtKB-KW.
DR   GO; GO:0120316; P:sperm flagellum assembly; ISS:UniProtKB.
DR   InterPro; IPR005578; Yif1_fam.
DR   PANTHER; PTHR14083; PTHR14083; 1.
DR   Pfam; PF03878; YIF1; 1.
PE   2: Evidence at transcript level;
KW   Endoplasmic reticulum; Golgi apparatus; Membrane; Protein transport;
KW   Reference proteome; Transmembrane; Transmembrane helix; Transport.
FT   CHAIN           1..300
FT                   /note="Protein YIF1B-B"
FT                   /id="PRO_0000307263"
FT   TOPO_DOM        1..142
FT                   /note="Cytoplasmic"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        143..163
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        164..178
FT                   /note="Extracellular"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        179..199
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        200..205
FT                   /note="Cytoplasmic"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        206..226
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        227
FT                   /note="Extracellular"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        228..248
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        249..278
FT                   /note="Cytoplasmic"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        279..299
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        300
FT                   /note="Extracellular"
FT                   /evidence="ECO:0000255"
FT   REGION          1..46
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   300 AA;  33300 MW;  277B09A0422EDBBC CRC64;
     MNQESSFRAP PKRRVRGSNP NISNPHQLFD DTSGGPVPHG GDFPNHSSPA LGIPAQAFLS
     EPMSNFAMAY GSSLASQGKE MMDKNIDRII PVSKIKYYFA VDTVYVGKKI GLLMFPYMHQ
     DWEVRYQQDT PVAPRFDINA PDLYIPVMAF ITYILVAGLA LGTQSRFSPE ILGMQASSAL
     AWLIVEVLAI LLSLYLVTVN TDLTTVDLVA FSGYKYVGMI SGVIAGLLFG NTGYYVVLAW
     CCISIVFFMI RTLRLKILSE AAAEGVLVRG ARNQLRMYLT MAIAAVQPIF MYWLTYHLVR