YD286_MOUSE
ID YD286_MOUSE Reviewed; 115 AA.
AC Q9CWB7;
DT 08-APR-2008, integrated into UniProtKB/Swiss-Prot.
DT 01-JUN-2001, sequence version 1.
DT 03-AUG-2022, entry version 131.
DE RecName: Full=Glutaredoxin-like protein C5orf63 homolog;
OS Mus musculus (Mouse).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC Murinae; Mus; Mus.
OX NCBI_TaxID=10090;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC STRAIN=C57BL/6J; TISSUE=Corpora quadrigemina;
RX PubMed=16141072; DOI=10.1126/science.1112014;
RA Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N.,
RA Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K.,
RA Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.,
RA Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R.,
RA Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T.,
RA Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A.,
RA Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B.,
RA Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M.,
RA Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S.,
RA Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E.,
RA Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D.,
RA Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M.,
RA Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H.,
RA Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V.,
RA Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S.,
RA Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H.,
RA Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N.,
RA Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F.,
RA Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G.,
RA Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z.,
RA Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C.,
RA Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y.,
RA Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S.,
RA Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K.,
RA Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R.,
RA van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H.,
RA Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M.,
RA Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C.,
RA Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S.,
RA Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K.,
RA Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M.,
RA Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C.,
RA Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A.,
RA Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.;
RT "The transcriptional landscape of the mammalian genome.";
RL Science 309:1559-1563(2005).
RN [2]
RP IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
RC TISSUE=Heart;
RX PubMed=21183079; DOI=10.1016/j.cell.2010.12.001;
RA Huttlin E.L., Jedrychowski M.P., Elias J.E., Goswami T., Rad R.,
RA Beausoleil S.A., Villen J., Haas W., Sowa M.E., Gygi S.P.;
RT "A tissue-specific atlas of mouse protein phosphorylation and expression.";
RL Cell 143:1174-1189(2010).
RN [3]
RP STRUCTURE BY NMR OF 21-107.
RG RIKEN structural genomics initiative (RSGI);
RT "Solution structure of hypothetical protein C330018D20Rik from Mus
RT musculus.";
RL Submitted (FEB-2009) to the PDB data bank.
CC -!- SIMILARITY: Belongs to the glutaredoxin family. YDR286C subfamily.
CC {ECO:0000305}.
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DR EMBL; AK021208; BAB32329.1; -; mRNA.
DR EMBL; AK140255; BAE24301.1; -; mRNA.
DR CCDS; CCDS50293.1; -.
DR RefSeq; NP_084185.1; NM_029909.1.
DR RefSeq; XP_006526410.1; XM_006526347.3.
DR RefSeq; XP_006526411.1; XM_006526348.3.
DR RefSeq; XP_006526412.1; XM_006526349.3.
DR RefSeq; XP_006526413.1; XM_006526350.3.
DR RefSeq; XP_006526414.1; XM_006526351.3.
DR PDB; 1WJK; NMR; -; A=21-107.
DR PDBsum; 1WJK; -.
DR AlphaFoldDB; Q9CWB7; -.
DR SMR; Q9CWB7; -.
DR IntAct; Q9CWB7; 1.
DR MINT; Q9CWB7; -.
DR STRING; 10090.ENSMUSP00000025488; -.
DR PhosphoSitePlus; Q9CWB7; -.
DR MaxQB; Q9CWB7; -.
DR PaxDb; Q9CWB7; -.
DR PeptideAtlas; Q9CWB7; -.
DR PRIDE; Q9CWB7; -.
DR Antibodypedia; 76266; 5 antibodies from 5 providers.
DR Ensembl; ENSMUST00000025488; ENSMUSP00000025488; ENSMUSG00000024592.
DR Ensembl; ENSMUST00000139243; ENSMUSP00000116181; ENSMUSG00000024592.
DR GeneID; 77422; -.
DR KEGG; mmu:77422; -.
DR UCSC; uc008eyx.2; mouse.
DR MGI; MGI:1924672; C330018D20Rik.
DR VEuPathDB; HostDB:ENSMUSG00000024592; -.
DR eggNOG; ENOG502S4BD; Eukaryota.
DR GeneTree; ENSGT00390000014940; -.
DR HOGENOM; CLU_125054_0_1_1; -.
DR InParanoid; Q9CWB7; -.
DR OMA; HRFILQQ; -.
DR OrthoDB; 1630037at2759; -.
DR PhylomeDB; Q9CWB7; -.
DR BioGRID-ORCS; 77422; 1 hit in 75 CRISPR screens.
DR EvolutionaryTrace; Q9CWB7; -.
DR PRO; PR:Q9CWB7; -.
DR Proteomes; UP000000589; Chromosome 18.
DR RNAct; Q9CWB7; protein.
DR Bgee; ENSMUSG00000024592; Expressed in interventricular septum and 227 other tissues.
DR Genevisible; Q9CWB7; MM.
DR GO; GO:0005739; C:mitochondrion; HDA:MGI.
DR InterPro; IPR008554; Glutaredoxin-like.
DR InterPro; IPR036249; Thioredoxin-like_sf.
DR Pfam; PF05768; Glrx-like; 1.
DR SUPFAM; SSF52833; SSF52833; 1.
PE 1: Evidence at protein level;
KW 3D-structure; Disulfide bond; Electron transport; Reference proteome;
KW Transport.
FT CHAIN 1..115
FT /note="Glutaredoxin-like protein C5orf63 homolog"
FT /id="PRO_0000328757"
FT DISULFID 40..43
FT /note="Redox-active"
FT /evidence="ECO:0000250"
FT STRAND 31..36
FT /evidence="ECO:0007829|PDB:1WJK"
FT HELIX 41..49
FT /evidence="ECO:0007829|PDB:1WJK"
FT STRAND 54..63
FT /evidence="ECO:0007829|PDB:1WJK"
FT HELIX 70..75
FT /evidence="ECO:0007829|PDB:1WJK"
FT STRAND 76..79
FT /evidence="ECO:0007829|PDB:1WJK"
FT STRAND 81..94
FT /evidence="ECO:0007829|PDB:1WJK"
FT HELIX 97..105
FT /evidence="ECO:0007829|PDB:1WJK"
SQ SEQUENCE 115 AA; 13430 MW; E2C3E423DB56451A CRC64;
MLWFQGKSLQ IAKSSFGLLR NLSASNRALP VLTLFTKAPC PLCDEAKEVL QPYKDRFILQ
EVDITLPENS TWYERYKFDI PVFHLNGQFL MMHRVNTSKL EKQLRKLEQQ VLATN
