YD286_HUMAN
ID YD286_HUMAN Reviewed; 138 AA.
AC A6NC05; G3V557;
DT 08-APR-2008, integrated into UniProtKB/Swiss-Prot.
DT 06-FEB-2013, sequence version 3.
DT 03-AUG-2022, entry version 92.
DE RecName: Full=Glutaredoxin-like protein C5orf63;
GN Name=C5orf63;
OS Homo sapiens (Human).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC Homo.
OX NCBI_TaxID=9606;
RN [1]
RP NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1).
RC TISSUE=Pancreatic islet;
RA Melton D., Brown J., Kenty G., Permutt A., Lee C., Kaestner K.,
RA Lemishka I., Scearce M., Brestelli J., Gradwohl G., Clifton S., Hillier L.,
RA Marra M., Pape D., Wylie T., Martin J., Blistain A., Schmitt A.,
RA Theising B., Ritter E., Ronko I., Bennett J., Cardenas M., Gibbons M.,
RA McCann R., Cole R., Tsagareishvili R., Williams T., Jackson Y., Bowers Y.;
RT "Endocrine pancreas consortium.";
RL Submitted (MAY-2002) to the EMBL/GenBank/DDBJ databases.
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=15372022; DOI=10.1038/nature02919;
RA Schmutz J., Martin J., Terry A., Couronne O., Grimwood J., Lowry S.,
RA Gordon L.A., Scott D., Xie G., Huang W., Hellsten U., Tran-Gyamfi M.,
RA She X., Prabhakar S., Aerts A., Altherr M., Bajorek E., Black S.,
RA Branscomb E., Caoile C., Challacombe J.F., Chan Y.M., Denys M.,
RA Detter J.C., Escobar J., Flowers D., Fotopulos D., Glavina T., Gomez M.,
RA Gonzales E., Goodstein D., Grigoriev I., Groza M., Hammon N., Hawkins T.,
RA Haydu L., Israni S., Jett J., Kadner K., Kimball H., Kobayashi A.,
RA Lopez F., Lou Y., Martinez D., Medina C., Morgan J., Nandkeshwar R.,
RA Noonan J.P., Pitluck S., Pollard M., Predki P., Priest J., Ramirez L.,
RA Retterer J., Rodriguez A., Rogers S., Salamov A., Salazar A., Thayer N.,
RA Tice H., Tsai M., Ustaszewska A., Vo N., Wheeler J., Wu K., Yang J.,
RA Dickson M., Cheng J.-F., Eichler E.E., Olsen A., Pennacchio L.A.,
RA Rokhsar D.S., Richardson P., Lucas S.M., Myers R.M., Rubin E.M.;
RT "The DNA sequence and comparative analysis of human chromosome 5.";
RL Nature 431:268-274(2004).
CC -!- ALTERNATIVE PRODUCTS:
CC Event=Alternative splicing; Named isoforms=2;
CC Name=1;
CC IsoId=A6NC05-1; Sequence=Displayed;
CC Name=2;
CC IsoId=A6NC05-2; Sequence=VSP_044904;
CC -!- SIMILARITY: Belongs to the glutaredoxin family. YDR286C subfamily.
CC {ECO:0000305}.
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DR EMBL; BQ269742; -; NOT_ANNOTATED_CDS; mRNA.
DR EMBL; AC004507; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AC005915; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR CCDS; CCDS54895.1; -. [A6NC05-1]
DR CCDS; CCDS54896.1; -. [A6NC05-2]
DR RefSeq; NP_001157950.1; NM_001164478.1. [A6NC05-2]
DR RefSeq; NP_001157951.1; NM_001164479.1. [A6NC05-1]
DR AlphaFoldDB; A6NC05; -.
DR SMR; A6NC05; -.
DR BioGRID; 134974; 1.
DR STRING; 9606.ENSP00000454153; -.
DR iPTMnet; A6NC05; -.
DR PhosphoSitePlus; A6NC05; -.
DR BioMuta; C5orf63; -.
DR MassIVE; A6NC05; -.
DR PaxDb; A6NC05; -.
DR PeptideAtlas; A6NC05; -.
DR PRIDE; A6NC05; -.
DR ProteomicsDB; 33428; -.
DR ProteomicsDB; 794; -. [A6NC05-1]
DR Antibodypedia; 76266; 5 antibodies from 5 providers.
DR DNASU; 401207; -.
DR Ensembl; ENST00000296662.10; ENSP00000453964.1; ENSG00000164241.14. [A6NC05-2]
DR Ensembl; ENST00000535381.6; ENSP00000454153.1; ENSG00000164241.14. [A6NC05-1]
DR GeneID; 401207; -.
DR KEGG; hsa:401207; -.
DR MANE-Select; ENST00000296662.10; ENSP00000453964.1; NM_001164478.2; NP_001157950.1. [A6NC05-2]
DR UCSC; uc021ydb.1; human. [A6NC05-1]
DR CTD; 401207; -.
DR DisGeNET; 401207; -.
DR GeneCards; C5orf63; -.
DR HGNC; HGNC:40051; C5orf63.
DR HPA; ENSG00000164241; Group enriched (brain, choroid plexus).
DR neXtProt; NX_A6NC05; -.
DR OpenTargets; ENSG00000164241; -.
DR VEuPathDB; HostDB:ENSG00000164241; -.
DR eggNOG; ENOG502S4BD; Eukaryota.
DR GeneTree; ENSGT00390000014940; -.
DR HOGENOM; CLU_1854541_0_0_1; -.
DR OMA; HRFILQQ; -.
DR OrthoDB; 1630037at2759; -.
DR PhylomeDB; A6NC05; -.
DR PathwayCommons; A6NC05; -.
DR BioGRID-ORCS; 401207; 7 hits in 1028 CRISPR screens.
DR ChiTaRS; C5orf63; human.
DR GenomeRNAi; 401207; -.
DR Pharos; A6NC05; Tdark.
DR PRO; PR:A6NC05; -.
DR Proteomes; UP000005640; Chromosome 5.
DR RNAct; A6NC05; protein.
DR Bgee; ENSG00000164241; Expressed in tendon of biceps brachii and 158 other tissues.
DR ExpressionAtlas; A6NC05; baseline and differential.
DR Genevisible; A6NC05; HS.
DR InterPro; IPR008554; Glutaredoxin-like.
DR InterPro; IPR036249; Thioredoxin-like_sf.
DR Pfam; PF05768; Glrx-like; 1.
DR SUPFAM; SSF52833; SSF52833; 1.
PE 2: Evidence at transcript level;
KW Alternative splicing; Disulfide bond; Electron transport;
KW Reference proteome; Transport.
FT CHAIN 1..138
FT /note="Glutaredoxin-like protein C5orf63"
FT /id="PRO_0000328756"
FT REGION 55..88
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 55..69
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 70..88
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT DISULFID 41..44
FT /note="Redox-active"
FT /evidence="ECO:0000250"
FT VAR_SEQ 58..138
FT /note="QPYKDQKLPGTRRRRSPSSPSHPHMASQSGKRYNLTLNQVLSFDYDMGLDAP
FT KTISSDCGAFYCLRMFKSPDMTCCFYPKQ -> FILQEVNITLPENSVWYERYKFDIPV
FT FHLNGQFLMMHRVNTSKLEKQLLKLEQQSTGG (in isoform 2)"
FT /evidence="ECO:0000305"
FT /id="VSP_044904"
SQ SEQUENCE 138 AA; 15764 MW; 20D0DF3CBEEDACEB CRC64;
MLWFQGNSMQ LARSSFGLFL RNCSASKTTL PVLTLFTKDP CPLCDEAKEV LKPYENRQPY
KDQKLPGTRR RRSPSSPSHP HMASQSGKRY NLTLNQVLSF DYDMGLDAPK TISSDCGAFY
CLRMFKSPDM TCCFYPKQ
