CAYP2_MOUSE
ID CAYP2_MOUSE Reviewed; 550 AA.
AC Q8BUG5; G3X9M5; Q8C1J6;
DT 05-JUL-2005, integrated into UniProtKB/Swiss-Prot.
DT 18-SEP-2013, sequence version 2.
DT 03-AUG-2022, entry version 126.
DE RecName: Full=Calcyphosin-2;
DE AltName: Full=Calcyphosine-2;
GN Name=Caps2;
OS Mus musculus (Mouse).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC Murinae; Mus; Mus.
OX NCBI_TaxID=10090;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 1 AND 2).
RC STRAIN=C57BL/6J; TISSUE=Kidney, and Testis;
RX PubMed=16141072; DOI=10.1126/science.1112014;
RA Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N.,
RA Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K.,
RA Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.,
RA Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R.,
RA Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T.,
RA Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A.,
RA Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B.,
RA Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M.,
RA Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S.,
RA Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E.,
RA Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D.,
RA Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M.,
RA Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H.,
RA Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V.,
RA Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S.,
RA Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H.,
RA Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N.,
RA Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F.,
RA Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G.,
RA Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z.,
RA Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C.,
RA Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y.,
RA Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S.,
RA Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K.,
RA Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R.,
RA van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H.,
RA Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M.,
RA Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C.,
RA Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S.,
RA Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K.,
RA Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M.,
RA Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C.,
RA Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A.,
RA Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.;
RT "The transcriptional landscape of the mammalian genome.";
RL Science 309:1559-1563(2005).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=C57BL/6J;
RX PubMed=19468303; DOI=10.1371/journal.pbio.1000112;
RA Church D.M., Goodstadt L., Hillier L.W., Zody M.C., Goldstein S., She X.,
RA Bult C.J., Agarwala R., Cherry J.L., DiCuccio M., Hlavina W., Kapustin Y.,
RA Meric P., Maglott D., Birtle Z., Marques A.C., Graves T., Zhou S.,
RA Teague B., Potamousis K., Churas C., Place M., Herschleb J., Runnheim R.,
RA Forrest D., Amos-Landgraf J., Schwartz D.C., Cheng Z., Lindblad-Toh K.,
RA Eichler E.E., Ponting C.P.;
RT "Lineage-specific biology revealed by a finished genome assembly of the
RT mouse.";
RL PLoS Biol. 7:E1000112-E1000112(2009).
RN [3]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RA Mural R.J., Adams M.D., Myers E.W., Smith H.O., Venter J.C.;
RL Submitted (JUL-2005) to the EMBL/GenBank/DDBJ databases.
CC -!- ALTERNATIVE PRODUCTS:
CC Event=Alternative splicing; Named isoforms=2;
CC Name=1;
CC IsoId=Q8BUG5-1; Sequence=Displayed;
CC Name=2;
CC IsoId=Q8BUG5-2; Sequence=VSP_014411, VSP_014412;
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DR EMBL; AK015008; BAC25455.1; -; mRNA.
DR EMBL; AK085286; BAC39412.1; -; mRNA.
DR EMBL; AC166263; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; CH466539; EDL21750.1; -; Genomic_DNA.
DR CCDS; CCDS78896.1; -. [Q8BUG5-1]
DR RefSeq; NP_001297604.1; NM_001310675.1. [Q8BUG5-1]
DR RefSeq; NP_840062.2; NM_178278.4.
DR AlphaFoldDB; Q8BUG5; -.
DR SMR; Q8BUG5; -.
DR STRING; 10090.ENSMUSP00000129887; -.
DR iPTMnet; Q8BUG5; -.
DR PhosphoSitePlus; Q8BUG5; -.
DR PaxDb; Q8BUG5; -.
DR PRIDE; Q8BUG5; -.
DR ProteomicsDB; 265673; -. [Q8BUG5-1]
DR ProteomicsDB; 265674; -. [Q8BUG5-2]
DR Antibodypedia; 29581; 110 antibodies from 22 providers.
DR Ensembl; ENSMUST00000092176; ENSMUSP00000089815; ENSMUSG00000035694. [Q8BUG5-1]
DR GeneID; 353025; -.
DR KEGG; mmu:353025; -.
DR UCSC; uc011xni.1; mouse. [Q8BUG5-2]
DR CTD; 84698; -.
DR MGI; MGI:2441980; Caps2.
DR VEuPathDB; HostDB:ENSMUSG00000035694; -.
DR eggNOG; KOG0032; Eukaryota.
DR GeneTree; ENSGT00940000159670; -.
DR HOGENOM; CLU_036726_3_0_1; -.
DR InParanoid; Q8BUG5; -.
DR OrthoDB; 562989at2759; -.
DR BioGRID-ORCS; 353025; 0 hits in 71 CRISPR screens.
DR ChiTaRS; Caps2; mouse.
DR PRO; PR:Q8BUG5; -.
DR Proteomes; UP000000589; Chromosome 10.
DR RNAct; Q8BUG5; protein.
DR Bgee; ENSMUSG00000035694; Expressed in choroid plexus epithelium and 75 other tissues.
DR ExpressionAtlas; Q8BUG5; baseline and differential.
DR Genevisible; Q8BUG5; MM.
DR GO; GO:0005509; F:calcium ion binding; IEA:InterPro.
DR InterPro; IPR011992; EF-hand-dom_pair.
DR InterPro; IPR018247; EF_Hand_1_Ca_BS.
DR InterPro; IPR002048; EF_hand_dom.
DR SUPFAM; SSF47473; SSF47473; 1.
DR PROSITE; PS00018; EF_HAND_1; 1.
DR PROSITE; PS50222; EF_HAND_2; 2.
PE 2: Evidence at transcript level;
KW Alternative splicing; Calcium; Metal-binding; Reference proteome; Repeat.
FT CHAIN 1..550
FT /note="Calcyphosin-2"
FT /id="PRO_0000073542"
FT DOMAIN 379..414
FT /note="EF-hand 1"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00448"
FT DOMAIN 415..452
FT /note="EF-hand 2"
FT /evidence="ECO:0000305"
FT DOMAIN 453..488
FT /note="EF-hand 3"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00448"
FT REGION 1..20
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 175..198
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT BINDING 466
FT /ligand="Ca(2+)"
FT /ligand_id="ChEBI:CHEBI:29108"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00448"
FT BINDING 468
FT /ligand="Ca(2+)"
FT /ligand_id="ChEBI:CHEBI:29108"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00448"
FT BINDING 470
FT /ligand="Ca(2+)"
FT /ligand_id="ChEBI:CHEBI:29108"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00448"
FT BINDING 477
FT /ligand="Ca(2+)"
FT /ligand_id="ChEBI:CHEBI:29108"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00448"
FT VAR_SEQ 1..84
FT /note="Missing (in isoform 2)"
FT /evidence="ECO:0000303|PubMed:16141072"
FT /id="VSP_014411"
FT VAR_SEQ 173..212
FT /note="Missing (in isoform 2)"
FT /evidence="ECO:0000303|PubMed:16141072"
FT /id="VSP_014412"
FT CONFLICT 443
FT /note="K -> R (in Ref. 1; BAC39412)"
FT /evidence="ECO:0000305"
FT CONFLICT 469
FT /note="K -> Q (in Ref. 1; BAC39412)"
FT /evidence="ECO:0000305"
FT CONFLICT 482
FT /note="Y -> C (in Ref. 1; BAC39412)"
FT /evidence="ECO:0000305"
SQ SEQUENCE 550 AA; 62726 MW; 635CD0448CFC0D98 CRC64;
MVPPLDLGSL VDSDEEDNFS QTARGTVHVH LNPPRSEPAL GWVLPCQRPN SQHRLQEVEQ
DVIPEDLPAP TGKYRLKYQQ YASEMKDGYK QYIQRSTEKP KAASRPEATE KVEGASLDDL
MTLDRKALLQ QGYADSPYGR QSITRKSDVE TVAIEKKKQT VAEQMMMDHL SRAVISDPEQ
DLNTKNQESS RVPPDSERAP LRVRRRTLHE TKIRTNSALT ENDLSQKVEF DGRVLSRNGR
DACRELIGFF FAHDQSLTVY EYRMFGKNRT SVLPFIKKDI YHHQCGRRKG KQYELGDVYT
GATLTFLSCD QPSLPKTIKE NALLRLRITN IDQVALNSLK AASAEHGEEE AVSPEAHDQL
VLQAIQDKLK EQLHKKGARI LTGLGRYFQG LDKEGNGLLE KADFQQALKT FHLEVSEQDF
ESFWLILQGY GHSKNKVDYG EFKRAIFGEM NEYRKSFVRK AFMQLDFNKT GIVSVIDIRK
CYCAKKHPRV ISGHSTEEEI KSSFLETLKG TCSKCDEVSY GEFEDYYEGL SIGVAGDEDF
VNILRIPWRI
