ID   CATL3_HUMAN             Reviewed;         218 AA.
AC   Q5NE16;
DT   15-MAY-2007, integrated into UniProtKB/Swiss-Prot.
DT   01-FEB-2005, sequence version 1.
DT   03-AUG-2022, entry version 92.
DE   RecName: Full=Putative inactive cathepsin L-like protein CTSL3P;
DE   AltName: Full=Cathepsin L3 pseudogene;
DE   AltName: Full=HCTSL-s;
GN   Name=CTSL3P; Synonyms=CTSL3;
OS   Homo sapiens (Human).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC   Homo.
OX   NCBI_TaxID=9606;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [MRNA].
RA   Xiao K., Dandekar T.;
RT   "Human and mouse cathepsins: partial overlap of function, genome-wide
RT   distribution and potential inhibitory peptides.";
RL   Submitted (OCT-2004) to the EMBL/GenBank/DDBJ databases.
CC   -!- SIMILARITY: Belongs to the peptidase C1 family. {ECO:0000305}.
CC   -!- CAUTION: Could be the product of a pseudogene. Lacks the region
CC       corresponding to the signal sequence and the propeptide. Has mutations
CC       in all 3 active site positions. {ECO:0000305}.
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DR   EMBL; AJ851862; CAH65460.1; -; mRNA.
DR   AlphaFoldDB; Q5NE16; -.
DR   SMR; Q5NE16; -.
DR   IntAct; Q5NE16; 1.
DR   MEROPS; I29.001; -.
DR   iPTMnet; Q5NE16; -.
DR   PhosphoSitePlus; Q5NE16; -.
DR   BioMuta; HGNC:33132; -.
DR   DMDM; 74708101; -.
DR   jPOST; Q5NE16; -.
DR   MassIVE; Q5NE16; -.
DR   MaxQB; Q5NE16; -.
DR   PeptideAtlas; Q5NE16; -.
DR   PRIDE; Q5NE16; -.
DR   ProteomicsDB; 63597; -.
DR   GeneCards; CTSL3P; -.
DR   HGNC; HGNC:33132; CTSL3P.
DR   neXtProt; NX_Q5NE16; -.
DR   InParanoid; Q5NE16; -.
DR   PhylomeDB; Q5NE16; -.
DR   PathwayCommons; Q5NE16; -.
DR   SignaLink; Q5NE16; -.
DR   ChiTaRS; CTSL3P; human.
DR   Pharos; Q5NE16; Tdark.
DR   Proteomes; UP000005640; Unplaced.
DR   RNAct; Q5NE16; protein.
DR   GO; GO:0005615; C:extracellular space; IBA:GO_Central.
DR   GO; GO:0005764; C:lysosome; IBA:GO_Central.
DR   GO; GO:0004197; F:cysteine-type endopeptidase activity; IBA:GO_Central.
DR   GO; GO:0051603; P:proteolysis involved in protein catabolic process; IBA:GO_Central.
DR   InterPro; IPR038765; Papain-like_cys_pep_sf.
DR   SUPFAM; SSF54001; SSF54001; 1.
PE   5: Uncertain;
KW   Reference proteome.
FT   CHAIN           1..218
FT                   /note="Putative inactive cathepsin L-like protein CTSL3P"
FT                   /id="PRO_0000287870"
FT   REGION          144..173
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          195..218
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        159..173
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        195..210
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   VARIANT         123
FT                   /note="S -> G (in dbSNP:rs11141967)"
FT                   /id="VAR_057040"
SQ   SEQUENCE   218 AA;  25059 MW;  157A3A0955295AF6 CRC64;
     MKMIEQHNQE YREGKHSFTM AMNAFGEMTS EEFRQVVNGF QNQKHRKGKV LQEPLLHDIR
     KSVDWREKGY VTPVKDQCNW GSVRTDVRKT EKLVSLSVQT WWTALGFKAM LAAFLENHYF
     ASSMLPTMEA WTLRKPFHMK KSSGDWKVQG HRGASGESLL ASGESQQSPE VAQYSGKHQV
     QCHLIEEALQ MLSGGDEDHD EDKWPHDMRN HLAGEAQV