YAMB_SCHPO
ID YAMB_SCHPO Reviewed; 3655 AA.
AC Q10064;
DT 01-FEB-1996, integrated into UniProtKB/Swiss-Prot.
DT 01-FEB-1996, sequence version 1.
DT 03-AUG-2022, entry version 143.
DE RecName: Full=Uncharacterized PI3/PI4-kinase family protein C1F5.11c;
DE EC=2.7.1.-;
GN ORFNames=SPAC1F5.11c;
OS Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast).
OC Eukaryota; Fungi; Dikarya; Ascomycota; Taphrinomycotina;
OC Schizosaccharomycetes; Schizosaccharomycetales; Schizosaccharomycetaceae;
OC Schizosaccharomyces.
OX NCBI_TaxID=284812;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=972 / ATCC 24843;
RX PubMed=11859360; DOI=10.1038/nature724;
RA Wood V., Gwilliam R., Rajandream M.A., Lyne M.H., Lyne R., Stewart A.,
RA Sgouros J.G., Peat N., Hayles J., Baker S.G., Basham D., Bowman S.,
RA Brooks K., Brown D., Brown S., Chillingworth T., Churcher C.M., Collins M.,
RA Connor R., Cronin A., Davis P., Feltwell T., Fraser A., Gentles S.,
RA Goble A., Hamlin N., Harris D.E., Hidalgo J., Hodgson G., Holroyd S.,
RA Hornsby T., Howarth S., Huckle E.J., Hunt S., Jagels K., James K.D.,
RA Jones L., Jones M., Leather S., McDonald S., McLean J., Mooney P.,
RA Moule S., Mungall K.L., Murphy L.D., Niblett D., Odell C., Oliver K.,
RA O'Neil S., Pearson D., Quail M.A., Rabbinowitsch E., Rutherford K.M.,
RA Rutter S., Saunders D., Seeger K., Sharp S., Skelton J., Simmonds M.N.,
RA Squares R., Squares S., Stevens K., Taylor K., Taylor R.G., Tivey A.,
RA Walsh S.V., Warren T., Whitehead S., Woodward J.R., Volckaert G., Aert R.,
RA Robben J., Grymonprez B., Weltjens I., Vanstreels E., Rieger M.,
RA Schaefer M., Mueller-Auer S., Gabel C., Fuchs M., Duesterhoeft A.,
RA Fritzc C., Holzer E., Moestl D., Hilbert H., Borzym K., Langer I., Beck A.,
RA Lehrach H., Reinhardt R., Pohl T.M., Eger P., Zimmermann W., Wedler H.,
RA Wambutt R., Purnelle B., Goffeau A., Cadieu E., Dreano S., Gloux S.,
RA Lelaure V., Mottier S., Galibert F., Aves S.J., Xiang Z., Hunt C.,
RA Moore K., Hurst S.M., Lucas M., Rochet M., Gaillardin C., Tallada V.A.,
RA Garzon A., Thode G., Daga R.R., Cruzado L., Jimenez J., Sanchez M.,
RA del Rey F., Benito J., Dominguez A., Revuelta J.L., Moreno S.,
RA Armstrong J., Forsburg S.L., Cerutti L., Lowe T., McCombie W.R.,
RA Paulsen I., Potashkin J., Shpakovski G.V., Ussery D., Barrell B.G.,
RA Nurse P.;
RT "The genome sequence of Schizosaccharomyces pombe.";
RL Nature 415:871-880(2002).
CC -!- SIMILARITY: Belongs to the PI3/PI4-kinase family. {ECO:0000305}.
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DR EMBL; CU329670; CAA92239.1; -; Genomic_DNA.
DR PIR; T38084; T38084.
DR RefSeq; NP_592862.1; NM_001018262.2.
DR SMR; Q10064; -.
DR BioGRID; 278155; 12.
DR IntAct; Q10064; 11.
DR MINT; Q10064; -.
DR STRING; 4896.SPAC1F5.11c.1; -.
DR iPTMnet; Q10064; -.
DR MaxQB; Q10064; -.
DR PaxDb; Q10064; -.
DR PRIDE; Q10064; -.
DR EnsemblFungi; SPAC1F5.11c.1; SPAC1F5.11c.1:pep; SPAC1F5.11c.
DR GeneID; 2541659; -.
DR KEGG; spo:SPAC1F5.11c; -.
DR PomBase; SPAC1F5.11c; -.
DR VEuPathDB; FungiDB:SPAC1F5.11c; -.
DR eggNOG; KOG0889; Eukaryota.
DR HOGENOM; CLU_000129_1_0_1; -.
DR InParanoid; Q10064; -.
DR OMA; NEWNQMQ; -.
DR PhylomeDB; Q10064; -.
DR PRO; PR:Q10064; -.
DR Proteomes; UP000002485; Chromosome I.
DR GO; GO:0035267; C:NuA4 histone acetyltransferase complex; IDA:PomBase.
DR GO; GO:0005634; C:nucleus; IBA:GO_Central.
DR GO; GO:0016301; F:kinase activity; IEA:UniProtKB-KW.
DR GO; GO:0006281; P:DNA repair; ISO:PomBase.
DR GO; GO:0016573; P:histone acetylation; IEA:InterPro.
DR GO; GO:0016310; P:phosphorylation; IEA:UniProtKB-KW.
DR Gene3D; 1.10.1070.11; -; 1.
DR InterPro; IPR016024; ARM-type_fold.
DR InterPro; IPR003152; FATC_dom.
DR InterPro; IPR011009; Kinase-like_dom_sf.
DR InterPro; IPR000403; PI3/4_kinase_cat_dom.
DR InterPro; IPR036940; PI3/4_kinase_cat_sf.
DR InterPro; IPR003151; PIK-rel_kinase_FAT.
DR InterPro; IPR014009; PIK_FAT.
DR InterPro; IPR033317; TRA1/TRRAP.
DR PANTHER; PTHR11139:SF1; PTHR11139:SF1; 2.
DR Pfam; PF02259; FAT; 1.
DR Pfam; PF02260; FATC; 1.
DR Pfam; PF00454; PI3_PI4_kinase; 1.
DR SMART; SM01343; FATC; 1.
DR SMART; SM00146; PI3Kc; 1.
DR SUPFAM; SSF48371; SSF48371; 3.
DR SUPFAM; SSF56112; SSF56112; 1.
DR PROSITE; PS51189; FAT; 1.
DR PROSITE; PS51190; FATC; 1.
DR PROSITE; PS50290; PI3_4_KINASE_3; 1.
PE 3: Inferred from homology;
KW Kinase; Reference proteome; Transferase.
FT CHAIN 1..3655
FT /note="Uncharacterized PI3/PI4-kinase family protein
FT C1F5.11c"
FT /id="PRO_0000088855"
FT DOMAIN 2484..3045
FT /note="FAT"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00534"
FT DOMAIN 3285..3625
FT /note="PI3K/PI4K catalytic"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00269"
FT DOMAIN 3623..3655
FT /note="FATC"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00534,
FT ECO:0000255|PROSITE-ProRule:PRU00535"
FT REGION 3059..3105
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 3291..3297
FT /note="G-loop"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00269"
FT REGION 3491..3499
FT /note="Catalytic loop"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00269"
FT REGION 3511..3536
FT /note="Activation loop"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00269"
FT COMPBIAS 3074..3105
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 3655 AA; 420782 MW; 50475E3F3FC2124A CRC64;
MEDGFEKSLS SSIELLKAES TEIEEKIKLT KILITKVSSI SSDASQLYAE LIPLLLDFLR
NTEVNLYRNS SVNELKIEAL TLIQSCAHRD EFKQYAQSCV LSFISLIKAD NEEVAVFCLK
VIMDIFKTFK FCIESTAQPF FDLVLELSTN LPYLIPSIFV ENPKSNEEEN TTLAFGSYLS
TETSIIQQRV NSLAISTQPL ELASQSFRVY VECPVIIVLI LQAYRQAAFP GVQAIIPCFL
KMVQIDVPID IASYAMIEKD SSIDFIEFIR NKYQYRNFFM AQVKTLSFLA YILRTHPNTL
SEKDIIPDIV IKLLRRCPFD MCFARKELLV ATRHILSTNL KSLFVKKLDF LLDLNILLGN
GVGTQKLLRP LAFSTLADLL HHVRDELNET QIRKSIMIYS TNMHDLTLSI GLQTMGARLI
LNMVDRMISL PSIPDAIFLL LSIFDSFVNK FSELNDSLDQ FFKKKYEEEI KETKSPTRSS
PRDLSSFSTS VNDGSFLFKN LMFGLRALMY GLRTCKSRCI EIGGEQFSGF LTNIKPFEAV
TFQKLFFEVG KGFSYFRPEQ VYLETFFCCE EESLDRPAIS TLPRNKDEKD CLEVFATIFI
HLEPSIFLKV FETNLPTFFD QLKKNLTLFH IPQFLLSNES TSSKFLNILL RFLLSRIEEL
GSSDIRHGSV LLRLFRLSFV TVSMFATENE PVLRPYVSEI IVKCMKLAPN SANSLNYYYL
LRALFRGIGG GRFESLYKEV MPLLHALLEA FNSLLISART PKEKDLFTEL CLTIPVRLSL
LLPYMSYLMR PLVMSLKSSQ ELVSQGLRTF ELCLDNLTPD FLDPIMAPYI EDLMNALWSH
LQPLPYNYNH SHTALKILGK LGGRNRKLLD RVQSLKNSPE PNNDFTLLLS IKGVKQPQLL
HYTQYVDEAV NLLSSPSSDL EVKQQAFTYV CNISKLYVYK SDATNSLASS IRCTADKISK
SNFDFRRPYS VIPSRMTGRS SFTQLSDDSD ETIILASATY GLFFATTVDE LREEAYFWLE
KLAVNVIVHD IFYAFDVIQG NHSKFTTNLQ KEVIISPHYF AHCLSEVVCN DNSKMGDAVK
HVLKFMFSFL ESIFENPERA FILPIFEVLL SDFRHKCYDP HWYKKYGGCF GLECLIEQDH
SSKWLFDRQV DILTALFFTL KDTTSEVPTV CKDHVMDVLK QLFRKIYASK DTEIAPGILG
HLVLELSNHN SVVRSSTQKL LSLLSELSNT PIVKLVSPFK ERLLSPIFAK PLRALPFHIQ
IGHIDAVNYC ISLGSELITF SDELIRLIHE TTALAEADDD ALIGIGKTSH FKNAALLIRL
RVVCVELLST CILKIDFNNP QHAHLREGII VVFFKSLYAK SKELIEAASL GLKNALQEDQ
KLSKELLQTT LRPILYNISD YRRLSVAGLE GLGRLLRLLT NYFKVEIGRK LLDHLKALLE
NVDFQKVSSL PLFCQTEMKI VRALIDLFHL LPNNANRFMD ELLICVVEFS LRLQRTFPNY
FSEPLLKYVN RYPEDAWKFF MVRYDEAAFT SVFVELLRLK DSDPLLSVVK DNWLFFQTIL
TNEINTVTAN RYSFALDSAI VILQRDPSFF KDKNDFFRGS MDAVLAISHL VENESILESM
VFWNDLLVRT STFLLEVYDL CIYNYDDGLK LLSCFHMYKN SLAKNLVSDL TAHLVKKIEE
PDLENNVKLI LNLILSKDYG FLLKENLAGI LLTYLNQNVS SLEKCNQIFS IFYEVFFQHP
STNVYANDEG IKIGALQIIS FFLKNVPEIT VQHQTEMLKM CSLFGNSEDV MIKQLSIYVM
SLFILRSQFP YELVNVVYMA LLKSSPIEVR HLVKSSFDNI FSYIFSEEPE SKKSPIWFEL
PLQVISSQSQ NISQLLNVYD FISSHSDIFI EHRGRYVPIL IDSLYKFGAI PNPNPEIRAL
SLGLIKVLLE WNDLQLKVDQ KEIFSNNQKR AILSYLFRFV CLFSEPFTEG LCSEAISLLE
RLLSSGTWAS LGMKLSFFTK SITHFDATDA NSVMFANSLR TLSIVVGHSD SAWIEENLSD
LKFLLEKSLE NESVGVQSAI GNFVSTILTL SNTHPSIAGN PIFNDIWTSI ASWTERRLQS
CSQIEVTLPC VECFFKYKKD ALHTLLPGFM RCFHKVAKEF LSLGSQPSGN SLNLQIVNAV
DERVSILKSM IELGCSYISY LGDQRRWFLS ALVQIIEKSS SYEICNYLLE IVRGWIMNSP
VPVPTVKEKA ALLLKMVTFE GRFSQNEQND LFNKYLSFIA DIYEMEPYKN SELTFRLEAV
YLLGTRVANK KLKERFIKGL NSSFPSDLFS RFQFLLGSQH WESLSNTYWI VQLNIFLSRC
FDLNQRCQFY KKPKLFSCFS IYCREFDEDL TSQAQDTEML HNNLLKYGII DFNQNSMLVS
DFVLPVLSLQ FSNSKIAEYL WRDFFNASVC SFTKDEIPLC IGSIISFLSR EYHIRLLGKT
PNVLETILTS IVSSDMPIPL PPHLLVYLSK TYGLHHYCIL LLENSLQNNP GLSEDELTVY
HKSCLDALSD IYYSLDEHDL YHGLWRRRAN FLETEVATSH EQCHEWEKAQ LVYEHAQLKV
CTGSLPYSPT EHGFWLDHWI LCAQKLNQWD VLFDFSKQEG CAELYLECAW RLSDWSTEQD
TLEKATKSLS PFTSLRRHTA DALLYLNKTQ RKMGSVTEFS RIIDECMQFS LRRWQQLPKR
VYQSHVSLLH HFQEIVELQE AFGIYSQLND TNIHNIDNKL RDIKVVLQGW RERLPNVWDD
IDIWSDLIAW RQSVFKSINK VFLPLVSIAQ QSTNKSNTNS VSYLYRGYHE LAWIINRFAH
VARVHHLPEV CINQLTKIYT LPNIEIQEAF LKLREQAECH YESPSEMQLG LEVINNTNLM
YFRNRQKAEF FTLKGMFQNR LGEKDEANQA FATAVQIDIG SGKAWSEWGL YHDELFQANP
QEIHHACNAV SCFLQASSLL SSSNSKPLLT RVLWLLSVDD SHGSVSEVVS SFKSEIPTWN
WIPFIPQLLS ALSHRESIHA RAILIQIAKT YPQSLHFQLR TAYEDFLMLK KQQAANVLRG
NSRLRENDSS SDNKSKDLSP SGSFSSVSQF NSKNGSPSSI DSSEKHQIST VKPAWELIAD
VTSILKTAYP LLALTMETMV DQIHTRLKSF PEEDAYRLIV ALLNDGLQYI SRLGVVSKNT
FQLPMSQANI QRFAENVLPV SVREAFLRDF VETKLDLLTY VDKLRMWRKK FENILDQRPK
FLHLEQCSLY LSEFQHQKFD EVEIPGQYLL DKNNNNDFVR LERFVPNVDL VRGHTMCYKR
LTLRGYDGKL YPFALQYPAT RHSRREERML QLLGTFNTVL RSKIEIQNRN FSFQIPSSIP
LSSHMRIIAD KPSYVTMQTI SDEYCKNRGM PLDYGIRFYF DRLQTGLIQL KRASASMLSN
STVEEKKQIF RQRALQLRMQ LLETLNSSVF PESIYYDYFY KTFERYCDFW FFRRTFTTQY
AYMIIMTYVF NIGGRSPQKL FIVKDSGQVM SQDLLPSMTS NQPVFHNTEA VPFRLTPPIQ
YLISDLGVEG LLSGLVMSIA QSLSSPTTDI KQYLSLYVRD EVFWWSKQQR KPIPQGIQLF
ETVKVNVELL FRRISVISHN VPEDLPLNQT LVDLVSQATN PQQLAQMDQL WQAWL
