ID   Y462_NEIMF              Reviewed;         408 AA.
AC   A1KSD3;
DT   15-JAN-2008, integrated into UniProtKB/Swiss-Prot.
DT   06-FEB-2007, sequence version 1.
DT   25-MAY-2022, entry version 76.
DE   RecName: Full=UPF0761 membrane protein NMC0462 {ECO:0000255|HAMAP-Rule:MF_00672};
GN   OrderedLocusNames=NMC0462;
OS   Neisseria meningitidis serogroup C / serotype 2a (strain ATCC 700532 / DSM
OS   15464 / FAM18).
OC   Bacteria; Proteobacteria; Betaproteobacteria; Neisseriales; Neisseriaceae;
OC   Neisseria.
OX   NCBI_TaxID=272831;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC 700532 / DSM 15464 / FAM18;
RX   PubMed=17305430; DOI=10.1371/journal.pgen.0030023;
RA   Bentley S.D., Vernikos G.S., Snyder L.A.S., Churcher C., Arrowsmith C.,
RA   Chillingworth T., Cronin A., Davis P.H., Holroyd N.E., Jagels K.,
RA   Maddison M., Moule S., Rabbinowitsch E., Sharp S., Unwin L., Whitehead S.,
RA   Quail M.A., Achtman M., Barrell B.G., Saunders N.J., Parkhill J.;
RT   "Meningococcal genetic variation mechanisms viewed through comparative
RT   analysis of serogroup C strain FAM18.";
RL   PLoS Genet. 3:230-240(2007).
CC   -!- SUBCELLULAR LOCATION: Cell inner membrane {ECO:0000255|HAMAP-
CC       Rule:MF_00672}; Multi-pass membrane protein {ECO:0000255|HAMAP-
CC       Rule:MF_00672}.
CC   -!- SIMILARITY: Belongs to the UPF0761 family. {ECO:0000255|HAMAP-
CC       Rule:MF_00672}.
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DR   EMBL; AM421808; CAM09763.1; -; Genomic_DNA.
DR   RefSeq; WP_002234642.1; NC_008767.1.
DR   AlphaFoldDB; A1KSD3; -.
DR   SMR; A1KSD3; -.
DR   EnsemblBacteria; CAM09763; CAM09763; NMC0462.
DR   KEGG; nmc:NMC0462; -.
DR   HOGENOM; CLU_032288_1_0_4; -.
DR   OMA; MTMMTIE; -.
DR   OrthoDB; 1421045at2; -.
DR   Proteomes; UP000002286; Chromosome.
DR   GO; GO:0005887; C:integral component of plasma membrane; IEA:UniProtKB-UniRule.
DR   HAMAP; MF_00672; UPF0761; 1.
DR   InterPro; IPR023679; UPF0761_bac.
DR   InterPro; IPR017039; Virul_fac_BrkB.
DR   PANTHER; PTHR30213; PTHR30213; 1.
DR   Pfam; PF03631; Virul_fac_BrkB; 1.
DR   TIGRFAMs; TIGR00765; yihY_not_rbn; 1.
PE   3: Inferred from homology;
KW   Cell inner membrane; Cell membrane; Membrane; Transmembrane;
KW   Transmembrane helix.
FT   CHAIN           1..408
FT                   /note="UPF0761 membrane protein NMC0462"
FT                   /id="PRO_1000044721"
FT   TRANSMEM        43..63
FT                   /note="Helical"
FT                   /evidence="ECO:0000255|HAMAP-Rule:MF_00672"
FT   TRANSMEM        100..120
FT                   /note="Helical"
FT                   /evidence="ECO:0000255|HAMAP-Rule:MF_00672"
FT   TRANSMEM        139..159
FT                   /note="Helical"
FT                   /evidence="ECO:0000255|HAMAP-Rule:MF_00672"
FT   TRANSMEM        176..196
FT                   /note="Helical"
FT                   /evidence="ECO:0000255|HAMAP-Rule:MF_00672"
FT   TRANSMEM        210..230
FT                   /note="Helical"
FT                   /evidence="ECO:0000255|HAMAP-Rule:MF_00672"
FT   TRANSMEM        248..268
FT                   /note="Helical"
FT                   /evidence="ECO:0000255|HAMAP-Rule:MF_00672"
SQ   SEQUENCE   408 AA;  46103 MW;  F31BE9EC4197AA4E CRC64;
     MTFLQRLQGL ADNKICAFAW FVVRRFDEER VPQAAASMTF TTLLALVPVL TVMVAVASIF
     PVFDRWSDSF VSFVNQTIVP QGADMVFDYI NAFREQANRL TAIGSVMLVV TSLMLIRTID
     NTFNRIWRVN SQRPWMMQFL VYWALLTFGP LSLGVGISFM VGSVQDAALA SGAPQWSGAL
     RTAATLTFMT LLLWGLYRFV PNRFVPARQA FVGALATAFC LETARSLFTW YMGNFDGYRS
     IYGAFAAVPF FLLWLNLLWT LVLGGAVLTS SLSYWRGEAF RRGFDSRGRF DDVLKILLLL
     DAAQKEGKAL PVQEFRRHIN MGYDELGELL EKLARHGYIY SGRQGWVLKT GADSIELNEL
     FKLFVYRPLP VERDHVNQAV DAVMTPCLQT LNMTLAEFDA QAKKQQQS