ID   Y274C_MYCTU             Reviewed;         277 AA.
AC   O33285; F2GPI0; I6X591;
DT   07-OCT-2020, integrated into UniProtKB/Swiss-Prot.
DT   05-JUL-2004, sequence version 3.
DT   25-MAY-2022, entry version 99.
DE   RecName: Full=Putative envelope-preserving system protein Rv2742c {ECO:0000305};
GN   OrderedLocusNames=Rv2742c {ECO:0000312|EMBL:CCP45541.1};
OS   Mycobacterium tuberculosis (strain ATCC 25618 / H37Rv).
OC   Bacteria; Actinobacteria; Corynebacteriales; Mycobacteriaceae;
OC   Mycobacterium; Mycobacterium tuberculosis complex.
OX   NCBI_TaxID=83332;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC 25618 / H37Rv;
RX   PubMed=9634230; DOI=10.1038/31159;
RA   Cole S.T., Brosch R., Parkhill J., Garnier T., Churcher C.M., Harris D.E.,
RA   Gordon S.V., Eiglmeier K., Gas S., Barry C.E. III, Tekaia F., Badcock K.,
RA   Basham D., Brown D., Chillingworth T., Connor R., Davies R.M., Devlin K.,
RA   Feltwell T., Gentles S., Hamlin N., Holroyd S., Hornsby T., Jagels K.,
RA   Krogh A., McLean J., Moule S., Murphy L.D., Oliver S., Osborne J.,
RA   Quail M.A., Rajandream M.A., Rogers J., Rutter S., Seeger K., Skelton S.,
RA   Squares S., Squares R., Sulston J.E., Taylor K., Whitehead S.,
RA   Barrell B.G.;
RT   "Deciphering the biology of Mycobacterium tuberculosis from the complete
RT   genome sequence.";
RL   Nature 393:537-544(1998).
RN   [2]
RP   FUNCTION, INTERACTION WITH RV2743C, INDUCTION, AND DISRUPTION PHENOTYPE.
RX   PubMed=25899163; DOI=10.1111/mmi.13037;
RA   Datta P., Ravi J., Guerrini V., Chauhan R., Neiditch M.B., Shell S.S.,
RA   Fortune S.M., Hancioglu B., Igoshin O.A., Gennaro M.L.;
RT   "The Psp system of Mycobacterium tuberculosis integrates envelope stress-
RT   sensing and envelope-preserving functions.";
RL   Mol. Microbiol. 97:408-422(2015).
CC   -!- FUNCTION: Involved in preservation of envelope integrity and tolerance
CC       to surface stress (PubMed:25899163). Reverses the inhibitory effect of
CC       PspA on ClgR activity (PubMed:25899163). Facilitates intracellular
CC       growth of M.tuberculosis (PubMed:25899163).
CC       {ECO:0000269|PubMed:25899163}.
CC   -!- SUBUNIT: Interacts with Rv2743c. {ECO:0000269|PubMed:25899163}.
CC   -!- INDUCTION: Expression is regulated by ClgR.
CC       {ECO:0000269|PubMed:25899163}.
CC   -!- DISRUPTION PHENOTYPE: The Rv2743c-Rv2742c double mutation reduces
CC       intracellular ATP levels under surface-stress conditions to less than
CC       60% of wild-type levels. {ECO:0000269|PubMed:25899163}.
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DR   EMBL; AL123456; CCP45541.1; -; Genomic_DNA.
DR   RefSeq; NP_217258.1; NC_000962.3.
DR   RefSeq; WP_003414020.1; NC_000962.3.
DR   AlphaFoldDB; O33285; -.
DR   STRING; 83332.Rv2742c; -.
DR   PaxDb; O33285; -.
DR   DNASU; 888332; -.
DR   GeneID; 888332; -.
DR   KEGG; mtu:Rv2742c; -.
DR   PATRIC; fig|83332.111.peg.3050; -.
DR   TubercuList; Rv2742c; -.
DR   eggNOG; ENOG5032295; Bacteria.
DR   Proteomes; UP000001584; Chromosome.
DR   GO; GO:0005886; C:plasma membrane; HDA:MTBBASE.
DR   InterPro; IPR021408; DUF3046.
DR   Pfam; PF11248; DUF3046; 1.
PE   1: Evidence at protein level;
KW   Reference proteome; Stress response.
FT   CHAIN           1..277
FT                   /note="Putative envelope-preserving system protein Rv2742c"
FT                   /id="PRO_0000450867"
FT   REGION          31..70
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          113..133
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          180..210
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        31..69
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   277 AA;  30883 MW;  25F5A4C23E1F4263 CRC64;
     MLVDELGVKI VHAQHVPAPY LVQRMREIHE RDENRQRHAQ VDVQRRRDQP ERGQHQHRRN
     RDADHHPDGR TLAGQIVAHP VSHRVRQPRP VAIADVLPRV GPRADCVVAH SLQGSPRRRE
     RRRGQTAHQR LGRRSGNAIA CPLYLENAAG PEPDTKRAEG RRFGAFGGGD LRWMADRVPR
     QGSGRRGLGS RSGAGVPQGA DARGWRHTAD GVPRVGQPAI RRGVPGFWCW LDHVLTGFGG
     RNAICAIEDG VEPRVAWWAL CTDFDVPRSM GRRTPGG