ID   Y2345_DEIRA             Reviewed;         305 AA.
AC   Q9RRY7;
DT   27-APR-2001, integrated into UniProtKB/Swiss-Prot.
DT   01-MAY-2000, sequence version 1.
DT   03-AUG-2022, entry version 114.
DE   RecName: Full=Uncharacterized metallophosphoesterase DR_2345;
DE   Flags: Precursor;
GN   OrderedLocusNames=DR_2345;
OS   Deinococcus radiodurans (strain ATCC 13939 / DSM 20539 / JCM 16871 / LMG
OS   4051 / NBRC 15346 / NCIMB 9279 / R1 / VKM B-1422).
OC   Bacteria; Deinococcus-Thermus; Deinococci; Deinococcales; Deinococcaceae;
OC   Deinococcus.
OX   NCBI_TaxID=243230;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC 13939 / DSM 20539 / JCM 16871 / LMG 4051 / NBRC 15346 / NCIMB
RC   9279 / R1 / VKM B-1422;
RX   PubMed=10567266; DOI=10.1126/science.286.5444.1571;
RA   White O., Eisen J.A., Heidelberg J.F., Hickey E.K., Peterson J.D.,
RA   Dodson R.J., Haft D.H., Gwinn M.L., Nelson W.C., Richardson D.L.,
RA   Moffat K.S., Qin H., Jiang L., Pamphile W., Crosby M., Shen M.,
RA   Vamathevan J.J., Lam P., McDonald L.A., Utterback T.R., Zalewski C.,
RA   Makarova K.S., Aravind L., Daly M.J., Minton K.W., Fleischmann R.D.,
RA   Ketchum K.A., Nelson K.E., Salzberg S.L., Smith H.O., Venter J.C.,
RA   Fraser C.M.;
RT   "Genome sequence of the radioresistant bacterium Deinococcus radiodurans
RT   R1.";
RL   Science 286:1571-1577(1999).
CC   -!- COFACTOR:
CC       Name=a divalent metal cation; Xref=ChEBI:CHEBI:60240;
CC         Evidence={ECO:0000250};
CC       Note=Binds 2 divalent metal cations. {ECO:0000250};
CC   -!- PTM: Predicted to be exported by the Tat system. The position of the
CC       signal peptide cleavage has not been experimentally proven.
CC   -!- SIMILARITY: Belongs to the metallophosphoesterase superfamily.
CC       {ECO:0000305}.
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DR   EMBL; AE000513; AAF11890.1; -; Genomic_DNA.
DR   PIR; H75285; H75285.
DR   RefSeq; NP_296066.1; NC_001263.1.
DR   RefSeq; WP_010888971.1; NZ_CP015081.1.
DR   AlphaFoldDB; Q9RRY7; -.
DR   STRING; 243230.DR_2345; -.
DR   PRIDE; Q9RRY7; -.
DR   EnsemblBacteria; AAF11890; AAF11890; DR_2345.
DR   KEGG; dra:DR_2345; -.
DR   PATRIC; fig|243230.17.peg.2578; -.
DR   eggNOG; COG1408; Bacteria.
DR   HOGENOM; CLU_025443_3_1_0; -.
DR   InParanoid; Q9RRY7; -.
DR   OMA; LGDYPAG; -.
DR   OrthoDB; 1690667at2; -.
DR   Proteomes; UP000002524; Chromosome I.
DR   GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR   GO; GO:0008758; F:UDP-2,3-diacylglucosamine hydrolase activity; IBA:GO_Central.
DR   GO; GO:0009245; P:lipid A biosynthetic process; IBA:GO_Central.
DR   Gene3D; 3.60.21.10; -; 1.
DR   InterPro; IPR004843; Calcineurin-like_PHP_ApaH.
DR   InterPro; IPR029052; Metallo-depent_PP-like.
DR   InterPro; IPR006311; TAT_signal.
DR   Pfam; PF00149; Metallophos; 1.
DR   SUPFAM; SSF56300; SSF56300; 1.
DR   PROSITE; PS51318; TAT; 1.
PE   3: Inferred from homology;
KW   Hydrolase; Metal-binding; Reference proteome; Signal.
FT   SIGNAL          1..40
FT                   /note="Tat-type signal"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00648"
FT   CHAIN           41..305
FT                   /note="Uncharacterized metallophosphoesterase DR_2345"
FT                   /id="PRO_0000172854"
FT   BINDING         68
FT                   /ligand="a divalent metal cation"
FT                   /ligand_id="ChEBI:CHEBI:60240"
FT                   /ligand_label="1"
FT                   /evidence="ECO:0000250"
FT   BINDING         70
FT                   /ligand="a divalent metal cation"
FT                   /ligand_id="ChEBI:CHEBI:60240"
FT                   /ligand_label="1"
FT                   /evidence="ECO:0000250"
FT   BINDING         100
FT                   /ligand="a divalent metal cation"
FT                   /ligand_id="ChEBI:CHEBI:60240"
FT                   /ligand_label="1"
FT                   /evidence="ECO:0000250"
FT   BINDING         100
FT                   /ligand="a divalent metal cation"
FT                   /ligand_id="ChEBI:CHEBI:60240"
FT                   /ligand_label="2"
FT                   /evidence="ECO:0000250"
FT   BINDING         137
FT                   /ligand="a divalent metal cation"
FT                   /ligand_id="ChEBI:CHEBI:60240"
FT                   /ligand_label="2"
FT                   /evidence="ECO:0000250"
FT   BINDING         239
FT                   /ligand="a divalent metal cation"
FT                   /ligand_id="ChEBI:CHEBI:60240"
FT                   /ligand_label="2"
FT                   /evidence="ECO:0000250"
FT   BINDING         241
FT                   /ligand="a divalent metal cation"
FT                   /ligand_id="ChEBI:CHEBI:60240"
FT                   /ligand_label="1"
FT                   /evidence="ECO:0000250"
SQ   SEQUENCE   305 AA;  32238 MW;  F8F59ADE18CA0F88 CRC64;
     MSVVSPDPAP VPHDPQRRAL LRWLVGGGAL AGGLGVSAVA QGYRFGVTHE QWNLVGLTRP
     VRLALLTDLH YGLYIGAGSV RRWVDATLAE CPDLILLGGD LVDSHFDAAA RPQQTAALLA
     ELGRLRAPLG VYAVWGNHDY GSFGRSISQS PEASRADWAA RRDALRAGLA GQGVTVLLNE
     GRSLRDDLWL GGVDDLRMGE ADSVAALRGS GTRATVLLAH NPDVLLRLRS APGLVLSGHT
     HGGQVRLPLL GALKVPADPR FTMGWVRGPQ GIPAYVSRGL GMSGLPVRNL CEPEITLLTL
     LPPGA