CAR10_HUMAN
ID CAR10_HUMAN Reviewed; 1032 AA.
AC Q9BWT7; Q14CQ8; Q5TFG6; Q8NC81; Q9UGR5; Q9UGR6; Q9Y3H0;
DT 31-JAN-2002, integrated into UniProtKB/Swiss-Prot.
DT 17-OCT-2006, sequence version 2.
DT 03-AUG-2022, entry version 170.
DE RecName: Full=Caspase recruitment domain-containing protein 10;
DE AltName: Full=CARD-containing MAGUK protein 3;
DE Short=Carma 3;
GN Name=CARD10; Synonyms=CARMA3;
OS Homo sapiens (Human).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC Homo.
OX NCBI_TaxID=9606;
RN [1]
RP NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1), AND VARIANT GLN-289.
RX PubMed=11259443; DOI=10.1074/jbc.m102488200;
RA Wang L., Guo Y., Huang W.-J., Ke X., Poyet J.-L., Manji G.A., Merriam S.,
RA Glucksmann M.A., DiStefano P.S., Alnemri E.S., Bertin J.;
RT "CARD10 is a novel caspase recruitment domain/membrane-associated guanylate
RT kinase family member that interacts with Bcl10 and activates NF-kappa B.";
RL J. Biol. Chem. 276:21405-21409(2001).
RN [2]
RP NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1), AND VARIANT GLN-289.
RX PubMed=11356195; DOI=10.1016/s0014-5793(01)02414-0;
RA Gaide O., Martinon F., Micheau O., Bonnet D., Thome M., Tschopp J.;
RT "Carma1, a CARD-containing binding partner of Bcl10, induces Bcl10
RT phosphorylation and NF-kappaB activation.";
RL FEBS Lett. 496:121-127(2001).
RN [3]
RP ERRATUM OF PUBMED:11356195.
RA Gaide O., Martinon F., Micheau O., Bonnet D., Thome M., Tschopp J.;
RL FEBS Lett. 505:198-198(2001).
RN [4]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2).
RX PubMed=14702039; DOI=10.1038/ng1285;
RA Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R.,
RA Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H.,
RA Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.,
RA Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K.,
RA Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H.,
RA Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M.,
RA Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K.,
RA Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T.,
RA Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M.,
RA Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S.,
RA Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H.,
RA Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K.,
RA Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N.,
RA Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S.,
RA Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O.,
RA Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H.,
RA Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B.,
RA Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y.,
RA Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K.,
RA Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T.,
RA Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T.,
RA Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y.,
RA Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H.,
RA Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y.,
RA Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H.,
RA Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O.,
RA Isogai T., Sugano S.;
RT "Complete sequencing and characterization of 21,243 full-length human
RT cDNAs.";
RL Nat. Genet. 36:40-45(2004).
RN [5]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=10591208; DOI=10.1038/990031;
RA Dunham I., Hunt A.R., Collins J.E., Bruskiewich R., Beare D.M., Clamp M.,
RA Smink L.J., Ainscough R., Almeida J.P., Babbage A.K., Bagguley C.,
RA Bailey J., Barlow K.F., Bates K.N., Beasley O.P., Bird C.P., Blakey S.E.,
RA Bridgeman A.M., Buck D., Burgess J., Burrill W.D., Burton J., Carder C.,
RA Carter N.P., Chen Y., Clark G., Clegg S.M., Cobley V.E., Cole C.G.,
RA Collier R.E., Connor R., Conroy D., Corby N.R., Coville G.J., Cox A.V.,
RA Davis J., Dawson E., Dhami P.D., Dockree C., Dodsworth S.J., Durbin R.M.,
RA Ellington A.G., Evans K.L., Fey J.M., Fleming K., French L., Garner A.A.,
RA Gilbert J.G.R., Goward M.E., Grafham D.V., Griffiths M.N.D., Hall C.,
RA Hall R.E., Hall-Tamlyn G., Heathcott R.W., Ho S., Holmes S., Hunt S.E.,
RA Jones M.C., Kershaw J., Kimberley A.M., King A., Laird G.K., Langford C.F.,
RA Leversha M.A., Lloyd C., Lloyd D.M., Martyn I.D., Mashreghi-Mohammadi M.,
RA Matthews L.H., Mccann O.T., Mcclay J., Mclaren S., McMurray A.A.,
RA Milne S.A., Mortimore B.J., Odell C.N., Pavitt R., Pearce A.V., Pearson D.,
RA Phillimore B.J.C.T., Phillips S.H., Plumb R.W., Ramsay H., Ramsey Y.,
RA Rogers L., Ross M.T., Scott C.E., Sehra H.K., Skuce C.D., Smalley S.,
RA Smith M.L., Soderlund C., Spragon L., Steward C.A., Sulston J.E.,
RA Swann R.M., Vaudin M., Wall M., Wallis J.M., Whiteley M.N., Willey D.L.,
RA Williams L., Williams S.A., Williamson H., Wilmer T.E., Wilming L.,
RA Wright C.L., Hubbard T., Bentley D.R., Beck S., Rogers J., Shimizu N.,
RA Minoshima S., Kawasaki K., Sasaki T., Asakawa S., Kudoh J., Shintani A.,
RA Shibuya K., Yoshizaki Y., Aoki N., Mitsuyama S., Roe B.A., Chen F., Chu L.,
RA Crabtree J., Deschamps S., Do A., Do T., Dorman A., Fang F., Fu Y., Hu P.,
RA Hua A., Kenton S., Lai H., Lao H.I., Lewis J., Lewis S., Lin S.-P., Loh P.,
RA Malaj E., Nguyen T., Pan H., Phan S., Qi S., Qian Y., Ray L., Ren Q.,
RA Shaull S., Sloan D., Song L., Wang Q., Wang Y., Wang Z., White J.,
RA Willingham D., Wu H., Yao Z., Zhan M., Zhang G., Chissoe S., Murray J.,
RA Miller N., Minx P., Fulton R., Johnson D., Bemis G., Bentley D.,
RA Bradshaw H., Bourne S., Cordes M., Du Z., Fulton L., Goela D., Graves T.,
RA Hawkins J., Hinds K., Kemp K., Latreille P., Layman D., Ozersky P.,
RA Rohlfing T., Scheet P., Walker C., Wamsley A., Wohldmann P., Pepin K.,
RA Nelson J., Korf I., Bedell J.A., Hillier L.W., Mardis E., Waterston R.,
RA Wilson R., Emanuel B.S., Shaikh T., Kurahashi H., Saitta S., Budarf M.L.,
RA McDermid H.E., Johnson A., Wong A.C.C., Morrow B.E., Edelmann L., Kim U.J.,
RA Shizuya H., Simon M.I., Dumanski J.P., Peyrard M., Kedra D., Seroussi E.,
RA Fransson I., Tapia I., Bruder C.E., O'Brien K.P., Wilkinson P.,
RA Bodenteich A., Hartman K., Hu X., Khan A.S., Lane L., Tilahun Y.,
RA Wright H.;
RT "The DNA sequence of human chromosome 22.";
RL Nature 402:489-495(1999).
RN [6]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
RC TISSUE=Liver;
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RT "The status, quality, and expansion of the NIH full-length cDNA project:
RT the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
RN [7]
RP FUNCTION, AND INTERACTION WITH TMEM43.
RX PubMed=27991920; DOI=10.1038/onc.2016.430;
RA Jiang C., Zhu Y., Zhou Z., Gumin J., Bengtsson L., Wu W., Songyang Z.,
RA Lang F.F., Lin X.;
RT "TMEM43/LUMA is a key signaling component mediating EGFR-induced NF-kappaB
RT activation and tumor progression.";
RL Oncogene 36:2813-2823(2017).
RN [8]
RP VARIANT IMD89 CYS-420, CHARACTERIZATION OF VARIANT IMD89 CYS-420, AND
RP INVOLVEMENT IN IMD89.
RX PubMed=32238915; DOI=10.1038/s41423-020-0423-x;
RA Yang D.H., Guo T., Yuan Z.Z., Lei C., Ding S.Z., Yang Y.F., Tan Z.P.,
RA Luo H.;
RT "Mutant CARD10 in a family with progressive immunodeficiency and
RT autoimmunity.";
RL Cell. Mol. Immunol. 17:782-784(2020).
CC -!- FUNCTION: Scaffold protein that plays an important role in mediating
CC the activation of NF-kappa-B via BCL10 or EGFR.
CC {ECO:0000269|PubMed:27991920}.
CC -!- SUBUNIT: CARD10 and BCL10 bind to each other by CARD-CARD interaction.
CC They both participate in a complex with MALT1, where MALT1 binds to
CC BCL10 (By similarity). Interacts with TMEM43; this interaction is
CC essential for EGFR-mediated NF-kappa-B activation (PubMed:27991920).
CC {ECO:0000250|UniProtKB:P58660, ECO:0000269|PubMed:27991920}.
CC -!- INTERACTION:
CC Q9BWT7; Q8TBE0: BAHD1; NbExp=3; IntAct=EBI-3866279, EBI-742750;
CC Q9BWT7; A8KA13: BCL6B; NbExp=3; IntAct=EBI-3866279, EBI-10174813;
CC Q9BWT7; Q96LM5: C4orf45; NbExp=3; IntAct=EBI-3866279, EBI-12020542;
CC Q9BWT7; Q96LL4: C8orf48; NbExp=3; IntAct=EBI-3866279, EBI-751596;
CC Q9BWT7; Q9H257-2: CARD9; NbExp=3; IntAct=EBI-3866279, EBI-11530605;
CC Q9BWT7; Q8NEC5: CATSPER1; NbExp=3; IntAct=EBI-3866279, EBI-744545;
CC Q9BWT7; Q9HC52: CBX8; NbExp=3; IntAct=EBI-3866279, EBI-712912;
CC Q9BWT7; Q8IYX3: CCDC116; NbExp=3; IntAct=EBI-3866279, EBI-744311;
CC Q9BWT7; Q16543: CDC37; NbExp=3; IntAct=EBI-3866279, EBI-295634;
CC Q9BWT7; Q96GE4: CEP95; NbExp=3; IntAct=EBI-3866279, EBI-372775;
CC Q9BWT7; Q9UKJ5: CHIC2; NbExp=3; IntAct=EBI-3866279, EBI-741528;
CC Q9BWT7; Q8NE01: CNNM3; NbExp=3; IntAct=EBI-3866279, EBI-741032;
CC Q9BWT7; Q2TBE0: CWF19L2; NbExp=3; IntAct=EBI-3866279, EBI-5453285;
CC Q9BWT7; A8MQ03: CYSRT1; NbExp=3; IntAct=EBI-3866279, EBI-3867333;
CC Q9BWT7; Q6P158: DHX57; NbExp=3; IntAct=EBI-3866279, EBI-1051531;
CC Q9BWT7; Q92608: DOCK2; NbExp=3; IntAct=EBI-3866279, EBI-448771;
CC Q9BWT7; Q9BV47: DUSP26; NbExp=3; IntAct=EBI-3866279, EBI-2924519;
CC Q9BWT7; Q8NA70: FAM47B; NbExp=3; IntAct=EBI-3866279, EBI-9247344;
CC Q9BWT7; Q6VB84: FOXD4L3; NbExp=3; IntAct=EBI-3866279, EBI-11961494;
CC Q9BWT7; Q8TAE8: GADD45GIP1; NbExp=3; IntAct=EBI-3866279, EBI-372506;
CC Q9BWT7; O95995: GAS8; NbExp=3; IntAct=EBI-3866279, EBI-1052570;
CC Q9BWT7; P14136: GFAP; NbExp=3; IntAct=EBI-3866279, EBI-744302;
CC Q9BWT7; Q9NWQ4-1: GPATCH2L; NbExp=3; IntAct=EBI-3866279, EBI-11959863;
CC Q9BWT7; Q14687: GSE1; NbExp=3; IntAct=EBI-3866279, EBI-372619;
CC Q9BWT7; P09211: GSTP1; NbExp=3; IntAct=EBI-3866279, EBI-353467;
CC Q9BWT7; P02008: HBZ; NbExp=3; IntAct=EBI-3866279, EBI-719843;
CC Q9BWT7; P17482: HOXB9; NbExp=3; IntAct=EBI-3866279, EBI-745290;
CC Q9BWT7; Q14005-2: IL16; NbExp=3; IntAct=EBI-3866279, EBI-17178971;
CC Q9BWT7; Q15040: JOSD1; NbExp=3; IntAct=EBI-3866279, EBI-2510602;
CC Q9BWT7; Q63ZY3: KANK2; NbExp=3; IntAct=EBI-3866279, EBI-2556193;
CC Q9BWT7; O60341: KDM1A; NbExp=3; IntAct=EBI-3866279, EBI-710124;
CC Q9BWT7; Q14145: KEAP1; NbExp=3; IntAct=EBI-3866279, EBI-751001;
CC Q9BWT7; O95678: KRT75; NbExp=3; IntAct=EBI-3866279, EBI-2949715;
CC Q9BWT7; P60410: KRTAP10-8; NbExp=3; IntAct=EBI-3866279, EBI-10171774;
CC Q9BWT7; P60328: KRTAP12-3; NbExp=3; IntAct=EBI-3866279, EBI-11953334;
CC Q9BWT7; Q6PEX3: KRTAP26-1; NbExp=3; IntAct=EBI-3866279, EBI-3957672;
CC Q9BWT7; Q9BYQ4: KRTAP9-2; NbExp=3; IntAct=EBI-3866279, EBI-1044640;
CC Q9BWT7; Q9BYQ3: KRTAP9-3; NbExp=3; IntAct=EBI-3866279, EBI-1043191;
CC Q9BWT7; Q96BZ8: LENG1; NbExp=3; IntAct=EBI-3866279, EBI-726510;
CC Q9BWT7; Q96A72: MAGOHB; NbExp=3; IntAct=EBI-3866279, EBI-746778;
CC Q9BWT7; Q9H7H0-2: METTL17; NbExp=3; IntAct=EBI-3866279, EBI-11098807;
CC Q9BWT7; Q8IVT4: MGC50722; NbExp=3; IntAct=EBI-3866279, EBI-14086479;
CC Q9BWT7; Q8WV92: MITD1; NbExp=3; IntAct=EBI-3866279, EBI-2691489;
CC Q9BWT7; Q86VE0: MYPOP; NbExp=3; IntAct=EBI-3866279, EBI-2858213;
CC Q9BWT7; Q9Y5B8: NME7; NbExp=3; IntAct=EBI-3866279, EBI-744782;
CC Q9BWT7; Q7RTU3: OLIG3; NbExp=3; IntAct=EBI-3866279, EBI-10225049;
CC Q9BWT7; Q4G0R1: PIBF1; NbExp=3; IntAct=EBI-3866279, EBI-14066006;
CC Q9BWT7; Q13835-2: PKP1; NbExp=3; IntAct=EBI-3866279, EBI-9087684;
CC Q9BWT7; Q96T60: PNKP; NbExp=3; IntAct=EBI-3866279, EBI-1045072;
CC Q9BWT7; Q9GZV8: PRDM14; NbExp=3; IntAct=EBI-3866279, EBI-3957793;
CC Q9BWT7; Q99633: PRPF18; NbExp=3; IntAct=EBI-3866279, EBI-2798416;
CC Q9BWT7; O43395: PRPF3; NbExp=3; IntAct=EBI-3866279, EBI-744322;
CC Q9BWT7; P0CG20: PRR35; NbExp=3; IntAct=EBI-3866279, EBI-11986293;
CC Q9BWT7; O75127: PTCD1; NbExp=3; IntAct=EBI-3866279, EBI-2560233;
CC Q9BWT7; P41222: PTGDS; NbExp=3; IntAct=EBI-3866279, EBI-948821;
CC Q9BWT7; Q13671: RIN1; NbExp=3; IntAct=EBI-3866279, EBI-366017;
CC Q9BWT7; Q9BWG6: SCNM1; NbExp=3; IntAct=EBI-3866279, EBI-748391;
CC Q9BWT7; Q13214-2: SEMA3B; NbExp=3; IntAct=EBI-3866279, EBI-11017428;
CC Q9BWT7; Q8TC71: SPATA18; NbExp=3; IntAct=EBI-3866279, EBI-11334239;
CC Q9BWT7; Q9NU19: TBC1D22B; NbExp=3; IntAct=EBI-3866279, EBI-8787464;
CC Q9BWT7; Q7Z6R9: TFAP2D; NbExp=3; IntAct=EBI-3866279, EBI-11952651;
CC Q9BWT7; P14373: TRIM27; NbExp=3; IntAct=EBI-3866279, EBI-719493;
CC Q9BWT7; Q8WV44: TRIM41; NbExp=3; IntAct=EBI-3866279, EBI-725997;
CC Q9BWT7; Q70EL1-9: USP54; NbExp=3; IntAct=EBI-3866279, EBI-11975223;
CC Q9BWT7; Q5TAP6: UTP14C; NbExp=3; IntAct=EBI-3866279, EBI-11737646;
CC Q9BWT7; Q9HCK0: ZBTB26; NbExp=3; IntAct=EBI-3866279, EBI-3918996;
CC Q9BWT7; Q6P2D0: ZFP1; NbExp=3; IntAct=EBI-3866279, EBI-2555749;
CC Q9BWT7; P21506: ZNF10; NbExp=3; IntAct=EBI-3866279, EBI-1105324;
CC Q9BWT7; P17014: ZNF12; NbExp=3; IntAct=EBI-3866279, EBI-11278550;
CC Q9BWT7; P49910: ZNF165; NbExp=3; IntAct=EBI-3866279, EBI-741694;
CC Q9BWT7; Q9UJW8-4: ZNF180; NbExp=3; IntAct=EBI-3866279, EBI-12055755;
CC Q9BWT7; O95125: ZNF202; NbExp=3; IntAct=EBI-3866279, EBI-751960;
CC Q9BWT7; Q9UK11: ZNF223; NbExp=3; IntAct=EBI-3866279, EBI-10322867;
CC Q9BWT7; Q16600: ZNF239; NbExp=3; IntAct=EBI-3866279, EBI-8787052;
CC Q9BWT7; P15622-3: ZNF250; NbExp=3; IntAct=EBI-3866279, EBI-10177272;
CC Q9BWT7; Q96NJ3: ZNF285; NbExp=3; IntAct=EBI-3866279, EBI-18064466;
CC Q9BWT7; Q9HBT8: ZNF286A; NbExp=3; IntAct=EBI-3866279, EBI-10754950;
CC Q9BWT7; P17041: ZNF32; NbExp=3; IntAct=EBI-3866279, EBI-1965483;
CC Q9BWT7; Q86UD4: ZNF329; NbExp=3; IntAct=EBI-3866279, EBI-7233259;
CC Q9BWT7; Q8N895: ZNF366; NbExp=3; IntAct=EBI-3866279, EBI-2813661;
CC Q9BWT7; Q96IQ9: ZNF414; NbExp=3; IntAct=EBI-3866279, EBI-744257;
CC Q9BWT7; Q09FC8-4: ZNF415; NbExp=3; IntAct=EBI-3866279, EBI-12273744;
CC Q9BWT7; Q8NDP4: ZNF439; NbExp=3; IntAct=EBI-3866279, EBI-747580;
CC Q9BWT7; Q8IYI8: ZNF440; NbExp=3; IntAct=EBI-3866279, EBI-726439;
CC Q9BWT7; Q96C55: ZNF524; NbExp=3; IntAct=EBI-3866279, EBI-10283126;
CC Q9BWT7; Q9H707: ZNF552; NbExp=3; IntAct=EBI-3866279, EBI-2555731;
CC Q9BWT7; Q9BR84: ZNF559; NbExp=3; IntAct=EBI-3866279, EBI-746605;
CC Q9BWT7; Q8TBZ8: ZNF564; NbExp=3; IntAct=EBI-3866279, EBI-10273713;
CC Q9BWT7; Q86XF7: ZNF575; NbExp=3; IntAct=EBI-3866279, EBI-14069183;
CC Q9BWT7; Q9P0T4: ZNF581; NbExp=3; IntAct=EBI-3866279, EBI-745520;
CC Q9BWT7; Q96SQ5: ZNF587; NbExp=3; IntAct=EBI-3866279, EBI-6427977;
CC Q9BWT7; Q6PF04: ZNF613; NbExp=3; IntAct=EBI-3866279, EBI-12062855;
CC Q9BWT7; Q9BS34: ZNF670; NbExp=3; IntAct=EBI-3866279, EBI-745276;
CC Q9BWT7; Q96BV0: ZNF775; NbExp=3; IntAct=EBI-3866279, EBI-7149881;
CC Q9BWT7; P51504: ZNF80; NbExp=3; IntAct=EBI-3866279, EBI-12013828;
CC Q9BWT7; Q96EG3: ZNF837; NbExp=3; IntAct=EBI-3866279, EBI-11962574;
CC Q9BWT7; Q6NSZ9-2: ZSCAN25; NbExp=3; IntAct=EBI-3866279, EBI-14650477;
CC -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000250}.
CC -!- ALTERNATIVE PRODUCTS:
CC Event=Alternative splicing; Named isoforms=2;
CC Name=1;
CC IsoId=Q9BWT7-1; Sequence=Displayed;
CC Name=2;
CC IsoId=Q9BWT7-2; Sequence=VSP_055523, VSP_055524;
CC -!- TISSUE SPECIFICITY: Detected in adult heart, kidney and liver; lower
CC levels in intestine, placenta, muscle and lung. Also found in fetal
CC lung, liver and kidney.
CC -!- DISEASE: Immunodeficiency 89 and autoimmunity (IMD89) [MIM:619632]: An
CC autosomal recessive disorder characterized by adult onset of recurrent
CC infections, allergies, microcytic anemia, and Crohn disease.
CC {ECO:0000269|PubMed:32238915}. Note=The disease may be caused by
CC variants affecting the gene represented in this entry.
CC -!- CAUTION: Supposed to contain a SH3, a PDZ and a guanylate kinase-like
CC domain. But none of these 3 domains are detected by PROSITE, Pfam or
CC SMART. {ECO:0000305}.
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DR EMBL; AY028896; AAK26165.1; -; mRNA.
DR EMBL; AY032928; AAK54454.1; -; mRNA.
DR EMBL; AK074906; BAC11282.1; -; mRNA.
DR EMBL; AL022315; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; FP325335; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; BC113659; AAI13660.1; -; mRNA.
DR CCDS; CCDS13948.1; -. [Q9BWT7-1]
DR RefSeq; NP_055365.2; NM_014550.3. [Q9BWT7-1]
DR AlphaFoldDB; Q9BWT7; -.
DR SMR; Q9BWT7; -.
DR BioGRID; 118908; 129.
DR IntAct; Q9BWT7; 112.
DR MINT; Q9BWT7; -.
DR STRING; 9606.ENSP00000384570; -.
DR iPTMnet; Q9BWT7; -.
DR PhosphoSitePlus; Q9BWT7; -.
DR BioMuta; CARD10; -.
DR DMDM; 116241281; -.
DR EPD; Q9BWT7; -.
DR jPOST; Q9BWT7; -.
DR MassIVE; Q9BWT7; -.
DR MaxQB; Q9BWT7; -.
DR PaxDb; Q9BWT7; -.
DR PeptideAtlas; Q9BWT7; -.
DR PRIDE; Q9BWT7; -.
DR ProteomicsDB; 72861; -.
DR ProteomicsDB; 79315; -. [Q9BWT7-1]
DR Antibodypedia; 25967; 241 antibodies from 29 providers.
DR DNASU; 29775; -.
DR Ensembl; ENST00000251973.10; ENSP00000251973.5; ENSG00000100065.15. [Q9BWT7-1]
DR Ensembl; ENST00000403299.5; ENSP00000384570.1; ENSG00000100065.15. [Q9BWT7-1]
DR Ensembl; ENST00000406271.7; ENSP00000385799.3; ENSG00000100065.15. [Q9BWT7-2]
DR GeneID; 29775; -.
DR KEGG; hsa:29775; -.
DR MANE-Select; ENST00000251973.10; ENSP00000251973.5; NM_014550.4; NP_055365.2.
DR UCSC; uc003asw.2; human. [Q9BWT7-1]
DR CTD; 29775; -.
DR DisGeNET; 29775; -.
DR GeneCards; CARD10; -.
DR HGNC; HGNC:16422; CARD10.
DR HPA; ENSG00000100065; Tissue enhanced (intestine).
DR MIM; 607209; gene.
DR MIM; 619632; phenotype.
DR neXtProt; NX_Q9BWT7; -.
DR OpenTargets; ENSG00000100065; -.
DR PharmGKB; PA134927444; -.
DR VEuPathDB; HostDB:ENSG00000100065; -.
DR eggNOG; KOG0708; Eukaryota.
DR GeneTree; ENSGT00940000157763; -.
DR HOGENOM; CLU_009760_1_0_1; -.
DR InParanoid; Q9BWT7; -.
DR OMA; WWTEPST; -.
DR OrthoDB; 115953at2759; -.
DR PhylomeDB; Q9BWT7; -.
DR TreeFam; TF351139; -.
DR PathwayCommons; Q9BWT7; -.
DR SignaLink; Q9BWT7; -.
DR BioGRID-ORCS; 29775; 28 hits in 1075 CRISPR screens.
DR ChiTaRS; CARD10; human.
DR GeneWiki; CARD10; -.
DR GenomeRNAi; 29775; -.
DR Pharos; Q9BWT7; Tbio.
DR PRO; PR:Q9BWT7; -.
DR Proteomes; UP000005640; Chromosome 22.
DR RNAct; Q9BWT7; protein.
DR Bgee; ENSG00000100065; Expressed in parotid gland and 168 other tissues.
DR ExpressionAtlas; Q9BWT7; baseline and differential.
DR Genevisible; Q9BWT7; HS.
DR GO; GO:0032449; C:CBM complex; NAS:UniProtKB.
DR GO; GO:0005737; C:cytoplasm; IBA:GO_Central.
DR GO; GO:0050700; F:CARD domain binding; IBA:GO_Central.
DR GO; GO:0030159; F:signaling receptor complex adaptor activity; NAS:UniProtKB.
DR GO; GO:0007250; P:activation of NF-kappaB-inducing kinase activity; IDA:UniProtKB.
DR GO; GO:0090051; P:negative regulation of cell migration involved in sprouting angiogenesis; IMP:BHF-UCL.
DR GO; GO:1900182; P:positive regulation of protein localization to nucleus; IMP:BHF-UCL.
DR GO; GO:0065003; P:protein-containing complex assembly; NAS:UniProtKB.
DR GO; GO:0042981; P:regulation of apoptotic process; IEA:InterPro.
DR CDD; cd08807; CARD_CARD10_CARMA3; 1.
DR Gene3D; 1.10.533.10; -; 1.
DR Gene3D; 3.40.50.300; -; 1.
DR InterPro; IPR001315; CARD.
DR InterPro; IPR042140; CARD_CARD10.
DR InterPro; IPR011029; DEATH-like_dom_sf.
DR InterPro; IPR027417; P-loop_NTPase.
DR Pfam; PF00619; CARD; 1.
DR SUPFAM; SSF47986; SSF47986; 1.
DR PROSITE; PS50209; CARD; 1.
PE 1: Evidence at protein level;
KW Alternative splicing; Coiled coil; Cytoplasm; Phosphoprotein;
KW Reference proteome.
FT CHAIN 1..1032
FT /note="Caspase recruitment domain-containing protein 10"
FT /id="PRO_0000144084"
FT DOMAIN 23..115
FT /note="CARD"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00046"
FT REGION 1..23
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 253..276
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 481..553
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COILED 138..456
FT /evidence="ECO:0000255"
FT MOD_RES 18
FT /note="Phosphoserine"
FT /evidence="ECO:0000250|UniProtKB:P58660"
FT VAR_SEQ 1..17
FT /note="MPGRAEAGEAEEEAGAG -> MGVGVGLGNGLRLLPWM (in isoform
FT 2)"
FT /evidence="ECO:0000303|PubMed:14702039"
FT /id="VSP_055523"
FT VAR_SEQ 18..303
FT /note="Missing (in isoform 2)"
FT /evidence="ECO:0000303|PubMed:14702039"
FT /id="VSP_055524"
FT VARIANT 289
FT /note="R -> Q (in dbSNP:rs9610775)"
FT /evidence="ECO:0000269|PubMed:11259443,
FT ECO:0000269|PubMed:11356195"
FT /id="VAR_028116"
FT VARIANT 420
FT /note="R -> C (in IMD89; unknown pathological significance;
FT decreased protein expression compared to wild type when
FT transfected in HEK293T cells)"
FT /evidence="ECO:0000269|PubMed:32238915"
FT /id="VAR_086467"
FT CONFLICT 932
FT /note="L -> R (in Ref. 1; AAK26165 and 2; AAK54454)"
FT /evidence="ECO:0000305"
SQ SEQUENCE 1032 AA; 115931 MW; 298AAC132778376A CRC64;
MPGRAEAGEA EEEAGAGSGS EAEEDALWER IEGVRHRLAR ALNPAKLTPY LRQCRVIDEQ
DEEEVLSTYR FPCRVNRTGR LMDILRCRGK RGYEAFLEAL EFYYPEHFTL LTGQEPAQRC
SMILDEEGPE GLTQFLMTEV RRLREARKSQ LQREQQLQAR GRVLEEERAG LEQRLRDQQQ
AQERCQRLRE DWEAGSLELL RLKDENYMIA MRLAQLSEEK NSAVLRSRDL QLAVDQLKLK
VSRLEEECAL LRRARGPPPG AEEKEKEKEK EKEPDNVDLV SELRAENQRL TASLRELQEG
LQQEASRPGA PGSERILLDI LEHDWREAQD SRQELCQKLH AVQGELQWAE ELRDQYLQEM
EDLRLKHRTL QKDCDLYKHR MATVLAQLEE IEKERDQAIQ SRDRIQLQYS QSLIEKDQYR
KQVRGLEAER DELLTTLTSL EGTKALLEVQ LQRAQGGTCL KACASSHSLC SNLSSTWSLS
EFPSPLGGPE ATGEAAVMGG PEPHNSEEAT DSEKEINRLS ILPFPPSAGS ILRRQREEDP
APPKRSFSSM SDITGSVTLK PWSPGLSSSS SSDSVWPLGK PEGLLARGCG LDFLNRSLAI
RVSGRSPPGG PEPQDKGPDG LSFYGDRWSG AVVRRVLSGP GSARMEPREQ RVEAAGLEGA
CLEAEAQQRT LLWNQGSTLP SLMDSKACQS FHEALEAWAK GPGAEPFYIR ANLTLPERAD
PHALCVKAQE ILRLVDSAYK RRQEWFCTRV DPLTLRDLDR GTVPNYQRAQ QLLEVQEKCL
PSSRHRGPRS NLKKRALDQL RLVRPKPVGA PAGDSPDQLL LEPCAEPERS LRPYSLVRPL
LVSALRPVVL LPECLAPRLI RNLLDLPSSR LDFQVCPAES LSGEELCPSS APGAPKAQPA
TPGLGSRIRA IQESVGKKHC LLELGARGVR ELVQNEIYPI VIHVEVTEKN VREVRGLLGR
PGWRDSELLR QCRGSEQVLW GLPCSWVQVP AHEWGHAEEL AKVVRGRILQ EQARLVWVEC
GSSRGCPSSS EA
