ID   CAPSP_ADEP3             Reviewed;         484 AA.
AC   Q84176; Q9YTR9;
DT   11-JUL-2001, integrated into UniProtKB/Swiss-Prot.
DT   01-NOV-1996, sequence version 1.
DT   25-MAY-2022, entry version 68.
DE   RecName: Full=Penton protein {ECO:0000255|HAMAP-Rule:MF_04052};
DE            Short=CP-P {ECO:0000255|HAMAP-Rule:MF_04052};
DE   AltName: Full=Penton base protein {ECO:0000255|HAMAP-Rule:MF_04052};
DE   AltName: Full=Protein III {ECO:0000255|HAMAP-Rule:MF_04052};
GN   Name=L2 {ECO:0000255|HAMAP-Rule:MF_04052};
OS   Porcine adenovirus A serotype 3 (PAdV-3) (Porcine adenovirus 3).
OC   Viruses; Varidnaviria; Bamfordvirae; Preplasmiviricota; Tectiliviricetes;
OC   Rowavirales; Adenoviridae; Mastadenovirus; Porcine mastadenovirus A.
OX   NCBI_TaxID=35265;
OH   NCBI_TaxID=9823; Sus scrofa (Pig).
RN   [1]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RA   McCoy R.J., Johnson M.A., Sheppard M.;
RL   Submitted (APR-1995) to the EMBL/GenBank/DDBJ databases.
RN   [2]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RC   STRAIN=6618;
RX   PubMed=9837805; DOI=10.1006/viro.1998.9418;
RA   Reddy P.S., Idamakanti N., Song J.Y., Lee J.B., Hyun B.H., Park J.H.,
RA   Cha S.H., Bae Y.T., Tikoo S.K., Babiuk L.A.;
RT   "Nucleotide sequence and transcription map of porcine adenovirus type 3.";
RL   Virology 251:414-426(1998).
RN   [3]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=6618 / IAF;
RA   Larocque D., Malenfant F., Massie B., Dea S.;
RT   "Porcine adenovirus serotype 3, complete genome.";
RL   Submitted (FEB-1999) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: Major capsid protein that self-associates to form penton base
CC       pentamers, each in the shape of a pentagon, situated at the 12 vertices
CC       of the pseudo T=25 capsid. Involved in virus secondary attachment to
CC       host cell after initial attachment by the fiber protein, and in
CC       endocytosis of virions. As the virus enters the host cell, penton
CC       proteins are shed concomitant with virion acidification in the
CC       endosome. {ECO:0000255|HAMAP-Rule:MF_04052}.
CC   -!- SUBUNIT: Interacts with the fiber protein (via N-terminal tail region).
CC       Interacts with the capsid vertex protein; this interaction binds the
CC       penton base to neighboring peripentonal hexons. {ECO:0000255|HAMAP-
CC       Rule:MF_04052}.
CC   -!- SUBCELLULAR LOCATION: Virion {ECO:0000255|HAMAP-Rule:MF_04052}. Host
CC       nucleus {ECO:0000255|HAMAP-Rule:MF_04052}. Note=Located at each vertex
CC       of the virion. {ECO:0000255|HAMAP-Rule:MF_04052}.
CC   -!- INDUCTION: Expressed in the late phase of the viral replicative cycle.
CC       {ECO:0000255|HAMAP-Rule:MF_04052}.
CC   -!- MISCELLANEOUS: All late proteins expressed from the major late promoter
CC       are produced by alternative splicing and alternative polyadenylation of
CC       the same gene giving rise to non-overlapping ORFs. A leader sequence is
CC       present in the N-terminus of all these mRNAs and is recognized by the
CC       viral shutoff protein to provide expression although conventional
CC       translation via ribosome scanning from the cap has been shut off in the
CC       host cell. {ECO:0000255|HAMAP-Rule:MF_04052}.
CC   -!- SIMILARITY: Belongs to the adenoviridae penton family.
CC       {ECO:0000255|HAMAP-Rule:MF_04052}.
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DR   EMBL; U24432; AAB38490.1; -; Genomic_DNA.
DR   EMBL; AF083132; AAC99444.1; -; Genomic_DNA.
DR   EMBL; AJ237815; CAB41028.1; -; Genomic_DNA.
DR   EMBL; AB026117; BAA76966.1; -; Genomic_DNA.
DR   RefSeq; YP_009205.1; AC_000189.1.
DR   SMR; Q84176; -.
DR   GO; GO:0042025; C:host cell nucleus; IEA:UniProtKB-SubCell.
DR   GO; GO:0039623; C:T=25 icosahedral viral capsid; IEA:UniProtKB-UniRule.
DR   GO; GO:0005198; F:structural molecule activity; IEA:UniProtKB-UniRule.
DR   GO; GO:0075509; P:endocytosis involved in viral entry into host cell; IEA:UniProtKB-KW.
DR   GO; GO:0019062; P:virion attachment to host cell; IEA:UniProtKB-UniRule.
DR   HAMAP; MF_04052; ADV_CAPSP; 1.
DR   InterPro; IPR002605; Adeno_Penton_B.
DR   Pfam; PF01686; Adeno_Penton_B; 1.
PE   3: Inferred from homology;
KW   Capsid protein; Host nucleus; Host-virus interaction; Late protein;
KW   T=25 icosahedral capsid protein; Viral attachment to host cell;
KW   Viral penetration into host cytoplasm; Virion; Virus endocytosis by host;
KW   Virus entry into host cell.
FT   CHAIN           1..484
FT                   /note="Penton protein"
FT                   /id="PRO_0000221882"
FT   REGION          1..24
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   484 AA;  54370 MW;  87C74DB710B57163 CRC64;
     MRRMMPAAPP QGASPPPSYE SVVGSSLTEP LYVPPRYLGP TEGRNSIRYS QLPPLYDTTK
     IYLIDNKSAD IASLNYQNNH SDFLTSVVQN SDFTPMEAST QTINLDERSR WGGEFKSILT
     TNIPNVTQYM FSNSFRVRLM SARDKETNAP TYEWFTLTLP EGNFSDIAVI DLMNNAIVEN
     YLAVGRQQGV KEEDIGVKID TRNFRLGYDP ETKLVMPGSY TNMAFHPDVV LAPGCAIDFT
     FSRLNNLLGI RKRYPYQEGF MLTYEDLAGG NIPALLDLTT YDQENSSTIK PLKQDSKGRS
     YHVGEDPEAG DTFTYYRSWY LAYNYGDPAT GTASQTLLVS PDVTCGVEQV YWSLPDLMQD
     PVTFRPSQTP SNYPVVATEL LPLRSRAFYN TQAVYSQLLQ QATNNTLVFN RFPENQILLR
     PPESTITSIS ENVPSLTDHG TLPLRNSIPG VQRVTVTDAR RRVCPYVYKS LGVVTPRVLS
     SRTF