ID   XPTA_EMENI              Reviewed;         446 AA.
AC   Q5AY46; A0A1U8QK76; C8V273;
DT   30-AUG-2017, integrated into UniProtKB/Swiss-Prot.
DT   26-APR-2005, sequence version 1.
DT   25-MAY-2022, entry version 86.
DE   RecName: Full=Xanthone prenyltransferase A {ECO:0000303|PubMed:21351751};
DE            EC=2.5.1.- {ECO:0000305|PubMed:21351751};
GN   Name=xptA {ECO:0000303|PubMed:21351751}; ORFNames=AN6784;
OS   Emericella nidulans (strain FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 /
OS   M139) (Aspergillus nidulans).
OC   Eukaryota; Fungi; Dikarya; Ascomycota; Pezizomycotina; Eurotiomycetes;
OC   Eurotiomycetidae; Eurotiales; Aspergillaceae; Aspergillus;
OC   Aspergillus subgen. Nidulantes.
OX   NCBI_TaxID=227321;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139;
RX   PubMed=16372000; DOI=10.1038/nature04341;
RA   Galagan J.E., Calvo S.E., Cuomo C., Ma L.-J., Wortman J.R., Batzoglou S.,
RA   Lee S.-I., Bastuerkmen M., Spevak C.C., Clutterbuck J., Kapitonov V.,
RA   Jurka J., Scazzocchio C., Farman M.L., Butler J., Purcell S., Harris S.,
RA   Braus G.H., Draht O., Busch S., D'Enfert C., Bouchier C., Goldman G.H.,
RA   Bell-Pedersen D., Griffiths-Jones S., Doonan J.H., Yu J., Vienken K.,
RA   Pain A., Freitag M., Selker E.U., Archer D.B., Penalva M.A., Oakley B.R.,
RA   Momany M., Tanaka T., Kumagai T., Asai K., Machida M., Nierman W.C.,
RA   Denning D.W., Caddick M.X., Hynes M., Paoletti M., Fischer R., Miller B.L.,
RA   Dyer P.S., Sachs M.S., Osmani S.A., Birren B.W.;
RT   "Sequencing of Aspergillus nidulans and comparative analysis with A.
RT   fumigatus and A. oryzae.";
RL   Nature 438:1105-1115(2005).
RN   [2]
RP   GENOME REANNOTATION.
RC   STRAIN=FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139;
RX   PubMed=19146970; DOI=10.1016/j.fgb.2008.12.003;
RA   Wortman J.R., Gilsenan J.M., Joardar V., Deegan J., Clutterbuck J.,
RA   Andersen M.R., Archer D., Bencina M., Braus G., Coutinho P., von Dohren H.,
RA   Doonan J., Driessen A.J., Durek P., Espeso E., Fekete E., Flipphi M.,
RA   Estrada C.G., Geysens S., Goldman G., de Groot P.W., Hansen K.,
RA   Harris S.D., Heinekamp T., Helmstaedt K., Henrissat B., Hofmann G.,
RA   Homan T., Horio T., Horiuchi H., James S., Jones M., Karaffa L.,
RA   Karanyi Z., Kato M., Keller N., Kelly D.E., Kiel J.A., Kim J.M.,
RA   van der Klei I.J., Klis F.M., Kovalchuk A., Krasevec N., Kubicek C.P.,
RA   Liu B., Maccabe A., Meyer V., Mirabito P., Miskei M., Mos M., Mullins J.,
RA   Nelson D.R., Nielsen J., Oakley B.R., Osmani S.A., Pakula T., Paszewski A.,
RA   Paulsen I., Pilsyk S., Pocsi I., Punt P.J., Ram A.F., Ren Q., Robellet X.,
RA   Robson G., Seiboth B., van Solingen P., Specht T., Sun J.,
RA   Taheri-Talesh N., Takeshita N., Ussery D., vanKuyk P.A., Visser H.,
RA   van de Vondervoort P.J., de Vries R.P., Walton J., Xiang X., Xiong Y.,
RA   Zeng A.P., Brandt B.W., Cornell M.J., van den Hondel C.A., Visser J.,
RA   Oliver S.G., Turner G.;
RT   "The 2008 update of the Aspergillus nidulans genome annotation: a community
RT   effort.";
RL   Fungal Genet. Biol. 46:S2-13(2009).
RN   [3]
RP   FUNCTION, DISRUPTION PHENOTYPE, AND PATHWAY.
RX   PubMed=21351751; DOI=10.1021/ja1096682;
RA   Sanchez J.F., Entwistle R., Hung J.H., Yaegashi J., Jain S., Chiang Y.M.,
RA   Wang C.C., Oakley B.R.;
RT   "Genome-based deletion analysis reveals the prenyl xanthone biosynthesis
RT   pathway in Aspergillus nidulans.";
RL   J. Am. Chem. Soc. 133:4010-4017(2011).
RN   [4]
RP   FUNCTION.
RX   PubMed=22730213; DOI=10.1002/cbic.201200014;
RA   Simpson T.J.;
RT   "Genetic and biosynthetic studies of the fungal prenylated xanthone
RT   shamixanthone and related metabolites in Aspergillus spp. revisited.";
RL   ChemBioChem 13:1680-1688(2012).
RN   [5]
RP   FUNCTION.
RX   PubMed=23150454; DOI=10.1002/cbic.201200545;
RA   Pockrandt D., Ludwig L., Fan A., Koenig G.M., Li S.M.;
RT   "New insights into the biosynthesis of prenylated xanthones: Xptb from
RT   Aspergillus nidulans catalyses an O-prenylation of xanthones.";
RL   ChemBioChem 13:2764-2771(2012).
CC   -!- FUNCTION: Dehydrogenase involved in the conversion of monodictyphenone
CC       to the prenyl xanthones such as emericellin, shamixanthone and
CC       epishamixanthone (PubMed:21351751, PubMed:22730213). Monodictyphenone
CC       is first converted to variecoxanthone A via a paeciloxanthone
CC       intermediate by the consecutive actions of the FAD-dependent
CC       monooxygenase mdpD and the xanthone prenyltransferase xptB
CC       (PubMed:21351751). XptB catalyzes regular O-prenylation at the hydroxy
CC       group of C-7 of the xanthone ring (PubMed:23150454). Variecoxanthone A
CC       is further prenylated to emericellin by xptA before being reduced to
CC       shamixanthone and epishamixanthone by the dehydrogenase xptC
CC       (PubMed:21351751). {ECO:0000269|PubMed:21351751,
CC       ECO:0000269|PubMed:22730213, ECO:0000269|PubMed:23150454}.
CC   -!- PATHWAY: Secondary metabolite biosynthesis.
CC       {ECO:0000269|PubMed:21351751}.
CC   -!- DISRUPTION PHENOTYPE: Impairs the production of the xanthones
CC       shamixanthone, emericellin and epishamixanthone; and accumulates
CC       variecoxanthone A (PubMed:21351751). {ECO:0000269|PubMed:21351751}.
CC   -!- SIMILARITY: Belongs to the tryptophan dimethylallyltransferase family.
CC       {ECO:0000305}.
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DR   EMBL; BN001301; CBF71451.1; -; Genomic_DNA.
DR   EMBL; AACD01000112; EAA58602.1; -; Genomic_DNA.
DR   RefSeq; XP_664388.1; XM_659296.1.
DR   AlphaFoldDB; Q5AY46; -.
DR   SMR; Q5AY46; -.
DR   STRING; 227321.Q5AY46; -.
DR   EnsemblFungi; CBF71451; CBF71451; ANIA_06784.
DR   EnsemblFungi; EAA58602; EAA58602; AN6784.2.
DR   GeneID; 2870313; -.
DR   KEGG; ani:AN6784.2; -.
DR   VEuPathDB; FungiDB:AN6784; -.
DR   eggNOG; ENOG502S2XP; Eukaryota.
DR   HOGENOM; CLU_037431_2_0_1; -.
DR   InParanoid; Q5AY46; -.
DR   OMA; REIMTMG; -.
DR   OrthoDB; 1531660at2759; -.
DR   Proteomes; UP000000560; Chromosome I.
DR   Proteomes; UP000005890; Unassembled WGS sequence.
DR   GO; GO:0004659; F:prenyltransferase activity; IMP:AspGD.
DR   GO; GO:0009820; P:alkaloid metabolic process; IEA:InterPro.
DR   GO; GO:1900793; P:shamixanthone biosynthetic process; IMP:AspGD.
DR   CDD; cd13929; PT-DMATS_CymD; 1.
DR   InterPro; IPR033964; Aro_prenylTrfase.
DR   InterPro; IPR017795; Aro_prenylTrfase_DMATS.
DR   InterPro; IPR012148; DMATS-type_fun.
DR   PANTHER; PTHR40627; PTHR40627; 1.
DR   Pfam; PF11991; Trp_DMAT; 1.
DR   PIRSF; PIRSF000509; Trp_DMAT; 1.
DR   SFLD; SFLDS00036; Aromatic_Prenyltransferase; 1.
DR   TIGRFAMs; TIGR03429; arom_pren_DMATS; 1.
PE   3: Inferred from homology;
KW   Reference proteome; Transferase.
FT   CHAIN           1..446
FT                   /note="Xanthone prenyltransferase A"
FT                   /id="PRO_0000441129"
SQ   SEQUENCE   446 AA;  49673 MW;  64B33F329CDB1CF2 CRC64;
     MLKHSSAATK ENDSPKLKVL DIVSKLEPSL DHSHTHWWKL TSPQLALMLE AADYSIEKQF
     ETLLFHYHWV VPYLGPKPDA DGNFKWRSLV SDVGIPLEYS WKWDTATSGP DVRLTIEPIN
     ELSGTRVDPL NQAPSLELLH RLAEILPRLD VSWASHFLST FYDHDKLKYI KESESETGMP
     LRSTMLVCFE FGRNGITTKT YMSPRKLGQQ GFAPLSDYHS AIAALGPSCA LDAVTEFLNN
     SPEGPHLSPF MLAVDNIIPC SSRLKLYFAT PRTSYNSIRE VLTLGGRLST VTLESKLRAI
     HELVKAIMPF PPDLPDDADI PFPEQVLSPT VQDLAESSDM ANQRPAFVAG YQYYFDIAPG
     ASLPDIKFYI PIRKAQMNDQ AVATGLTNWM RAQGRGAFCN AYTRVLEGLA GGRDLSKCHG
     LHTHICVMLK GNGEFDVTSY LAPGCK